REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IRF7 Interferon regulatory factor 7 [1] -10.45[2] -9.33[3] -8.32[4] -4.13[5] -4.43[6] -1.28[7]
2 IRF3 Interferon regulatory factor 3 [8] -0.92[9] -0.63[10] 0.01[11] -0.63[12] -1.08[13] -2.39[14]
3 TRIM4 E3 ubiquitin-protein ligase TRIM4 [15] -1.51[16] -1.19[17] -1.10[18] -2.30[19] -1.73[20] -0.81[21]
4 TBK1 Serine/threonine-protein kinase TBK1 [22] -1.86[23] -0.06[24] -1.00[25] -0.49[26] -0.45[27] -0.73[28]
5 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 [29] 0.92[30] 0.67[31] 0.42[32] -0.10[33] 0.51[34] 0.61[35]
6 IFIH1 Interferon-induced helicase C domain-containing protein 1 [36] -3.19[37] -2.98[38] -7.18[39] -2.21[40] -2.02[41] -0.95[42]
7 DDX58 Probable ATP-dependent RNA helicase DDX58 [43] -1.92[44] -1.81[45] -2.73[46] -1.77[47] -1.25[48] -0.09[49]
8 SIKE1 Suppressor of IKBKE 1 [50] -0.44[51] 0.79[52] 1.32[53] 0.76[54] 0.64[55] 0.58[56]
9 EP300 Histone acetyltransferase p300 [57] 1.50[58] 1.22[59] 2.02[60] 1.59[61] 1.60[62] 1.55[63]
10 MAVS Mitochondrial antiviral-signaling protein [64] 3.06[65] 2.79[66] 2.30[67] 2.75[68] 2.30[69] 2.14[70]
11 CREBBP CREB-binding protein [71] 1.68[72] 1.02[73] 1.54[74] 1.77[75] 1.74[76] 2.03[77]
12 TRAF3 TNF receptor-associated factor 3 [78] 1.67[79] 1.21[80] 0.73[81] 1.85[82] 2.22[83] 0.72[84]
13 RNF135 E3 ubiquitin-protein ligase RNF135 [85] -8.53[86] -8.01[87] -6.82[88] -8.46[89] 0.42[90] -0.34[91]
14 IKBKE Inhibitor of nuclear factor kappa-B kinase subunit epsilon [92] 0.50[93] 0.49[94] -0.70[95] 1.58[96] 1.09[97] -1.44[98]
15 IFNB1 Interferon beta [99] [100] [101] [102] [103] [104] [105]
[1]
ref_hepatocyte IRF7
Mean 11.7
Standard deviation 10
Values 0 3.4 11 20 24
[2]
HepG2 IRF7
Mean 0.0429
Standard deviation 0.012
Values 0.034 0.051
[3]
HepG2.C3A IRF7
Mean 0.0764
Standard deviation 0.0019
Values 0.078 0.075
[4]
HuH.7 IRF7
Mean 0.158
Standard deviation 0.13
Values 0.16 0.29 0.028
[5]
SNU475 IRF7
Mean 2.42
Standard deviation 0.34
Values 2.2 2.7
[6]
THLE IRF7
Mean 2.27
Standard deviation 0.44
Values 2 2.6
[7]
liver IRF7
Mean 15.8
Standard deviation 4.5
Values 16 9.6 20 18
[8]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[9]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[10]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[11]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[12]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[13]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[14]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[15]
ref_hepatocyte TRIM4
Mean 7
Standard deviation 3.2
Values 13 4.2 5.9 5.7 6.7
[16]
HepG2 TRIM4
Mean 12.7
Standard deviation 1.4
Values 12 14
[17]
HepG2.C3A TRIM4
Mean 12.9
Standard deviation 5.9
Values 17 8.8
[18]
HuH.7 TRIM4
Mean 14.1
Standard deviation 1.8
Values 14 16 12
[19]
SNU475 TRIM4
Mean 5.17
Standard deviation 0.5
Values 5.5 4.8
[20]
THLE TRIM4
Mean 8.85
Standard deviation 0.71
Values 8.3 9.4
[21]
liver TRIM4
Mean 13.1
Standard deviation 2.9
Values 17 12 13 10
[22]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[23]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[24]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[25]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[26]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[27]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[28]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[29]
ref_hepatocyte TRIM25
Mean 6.54
Standard deviation 4.3
Values 10 11 7.2 2.2 1.9
[30]
HepG2 TRIM25
Mean 63.4
Standard deviation 2.6
Values 65 62
[31]
HepG2.C3A TRIM25
Mean 43.9
Standard deviation 3.5
Values 41 46
[32]
HuH.7 TRIM25
Mean 37.6
Standard deviation 5.8
Values 42 39 31
[33]
SNU475 TRIM25
Mean 22.1
Standard deviation 1.8
Values 23 21
[34]
THLE TRIM25
Mean 39
Standard deviation 5.5
Values 35 43
[35]
liver TRIM25
Mean 32.7
Standard deviation 17
Values 20 44 16 51
[36]
ref_hepatocyte IFIH1
Mean 4.45
Standard deviation 2
Values 7.6 4.6 2.9 2.5 4.6
[37]
HepG2 IFIH1
Mean 2.51
Standard deviation 0.64
Values 2.1 3
[38]
HepG2.C3A IFIH1
Mean 2.38
Standard deviation 0.31
Values 2.6 2.2
[39]
HuH.7 IFIH1
Mean 0.132
Standard deviation 0.058
Values 0.16 0.17 0.066
[40]
SNU475 IFIH1
Mean 3.48
Standard deviation 0.87
Values 4.1 2.9
[41]
THLE IFIH1
Mean 4.58
Standard deviation 1.1
Values 5.3 3.8
[42]
liver IFIH1
Mean 7.55
Standard deviation 1.8
Values 10 7.5 5.9 6.7
[43]
ref_hepatocyte DDX58
Mean 3.45
Standard deviation 3
Values 1.2 7.5 5.8 1.2 1.7
[44]
HepG2 DDX58
Mean 4.68
Standard deviation 1.6
Values 3.5 5.8
[45]
HepG2.C3A DDX58
Mean 4.13
Standard deviation 1.1
Values 3.4 4.9
[46]
HuH.7 DDX58
Mean 2.24
Standard deviation 0.73
Values 1.8 3.1 1.9
[47]
SNU475 DDX58
Mean 3.67
Standard deviation 0.0023
Values 3.7 3.7
[48]
THLE DDX58
Mean 6.07
Standard deviation 0.0034
Values 6.1 6.1
[49]
liver DDX58
Mean 10.6
Standard deviation 2.3
Values 13 12 10 7.7
[50]
ref_hepatocyte SIKE1
Mean 2.92
Standard deviation 0.19
Values 3.1 3 3 2.6 2.9
[51]
HepG2 SIKE1
Mean 11.1
Standard deviation 3.6
Values 8.5 14
[52]
HepG2.C3A SIKE1
Mean 21.2
Standard deviation 1.5
Values 20 22
[53]
HuH.7 SIKE1
Mean 31.3
Standard deviation 5
Values 36 26 32
[54]
SNU475 SIKE1
Mean 18
Standard deviation 2.2
Values 19 16
[55]
THLE SIKE1
Mean 19
Standard deviation 2.5
Values 21 17
[56]
liver SIKE1
Mean 14.3
Standard deviation 1.9
Values 13 16 16 12
[57]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[58]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[59]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[60]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[61]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[62]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[63]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[64]
ref_hepatocyte MAVS
Mean 2.3
Standard deviation 1.1
Values 4.3 1.9 1.7 1.8 1.9
[65]
HepG2 MAVS
Mean 98.5
Standard deviation 2.4
Values 97 1e+02
[66]
HepG2.C3A MAVS
Mean 66.9
Standard deviation 0.12
Values 67 67
[67]
HuH.7 MAVS
Mean 48.8
Standard deviation 7.5
Values 56 50 41
[68]
SNU475 MAVS
Mean 56.1
Standard deviation 14
Values 66 46
[69]
THLE MAVS
Mean 47.4
Standard deviation 9.4
Values 41 54
[70]
liver MAVS
Mean 33.3
Standard deviation 8
Values 26 34 29 44
[71]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[72]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[73]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[74]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[75]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[76]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[77]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[78]
ref_hepatocyte TRAF3
Mean 1.27
Standard deviation 0.83
Values 0.98 2.5 1.7 0.56 0.6
[79]
HepG2 TRAF3
Mean 20.8
Standard deviation 3.9
Values 24 18
[80]
HepG2.C3A TRAF3
Mean 12.4
Standard deviation 0.058
Values 12 12
[81]
HuH.7 TRAF3
Mean 9.05
Standard deviation 1.3
Values 10 8.7 7.9
[82]
SNU475 TRAF3
Mean 16.6
Standard deviation 0.54
Values 17 16
[83]
THLE TRAF3
Mean 24.7
Standard deviation 3.8
Values 22 27
[84]
liver TRAF3
Mean 6.87
Standard deviation 4
Values 4.4 9.3 2.6 11
[85]
ref_hepatocyte RNF135
Mean 0.925
Standard deviation 0.88
Values 0 1.1 0.45 0.78 2.3
[86]
HepG2 RNF135
Mean 0.0129
Standard deviation 0.0061
Values 0.017 0.0086
[87]
HepG2.C3A RNF135
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[88]
HuH.7 RNF135
Mean 0.0351
Standard deviation 0.018
Values 0.016 0.051 0.037
[89]
SNU475 RNF135
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[90]
THLE RNF135
Mean 5.16
Standard deviation 0.15
Values 5.1 5.3
[91]
liver RNF135
Mean 2.39
Standard deviation 0.75
Values 3.2 1.6 2.8 1.9
[92]
ref_hepatocyte IKBKE
Mean 0.818
Standard deviation 0.8
Values 0.91 2.2 0.36 0.25 0.39
[93]
HepG2 IKBKE
Mean 5.94
Standard deviation 0.2
Values 5.8 6.1
[94]
HepG2.C3A IKBKE
Mean 4.84
Standard deviation 0.7
Values 4.3 5.3
[95]
HuH.7 IKBKE
Mean 2.16
Standard deviation 0.28
Values 2.3 1.8 2.3
[96]
SNU475 IKBKE
Mean 8.87
Standard deviation 0.19
Values 8.7 9
[97]
THLE IKBKE
Mean 7.27
Standard deviation 2.9
Values 5.2 9.3
[98]
liver IKBKE
Mean 0.988
Standard deviation 0.21
Values 1.2 0.98 1.1 0.69
[99]
ref_hepatocyte IFNB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 IFNB1
Missing
[101]
HepG2.C3A IFNB1
Missing
[102]
HuH.7 IFNB1
Missing
[103]
SNU475 IFNB1
Missing
[104]
THLE IFNB1
Missing
[105]
liver IFNB1
Missing