REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_SEVERAL_ADDITIONAL_CELL_DEATH_GENES_WHOSE_SPECIFIC_ROLES_IN_P53_DEPENDENT_APOPTOSIS_REMAIN_UNCERTAIN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RABGGTB Geranylgeranyl transferase type-2 subunit beta [1] -2.18[2] -1.01[3] -1.62[4] -2.46[5] -1.85[6] -1.75[7]
2 PERP p53 apoptosis effector related to PMP-22 [8] -0.32[9] -0.27[10] -0.83[11] -0.18[12] -0.20[13] 0.77[14]
3 NDRG1 Protein NDRG1 [15] 1.96[16] 1.33[17] 1.94[18] 0.20[19] 0.54[20] 0.03[21]
4 TP53I3 Quinone oxidoreductase PIG3 [22] -0.48[23] -1.14[24] -2.98[25] 0.58[26] -0.61[27] -1.21[28]
5 BIRC5 Baculoviral IAP repeat-containing protein 5 [29] 0.69[30] 1.20[31] 1.17[32] 0.93[33] 1.68[34] -1.75[35]
6 BCL6 B-cell lymphoma 6 protein [36] -1.78[37] 0.53[38] -0.98[39] -0.29[40] 0.37[41] 0.59[42]
7 TP53BP2 Apoptosis-stimulating of p53 protein 2 [43] -1.49[44] -1.10[45] 0.50[46] 1.51[47] 0.71[48] 0.62[49]
8 TP53 Cellular tumor antigen p53 [50] 0.75[51] 0.37[52] 1.15[53] 1.54[54] 1.13[55] 0.52[56]
9 RABGGTA Geranylgeranyl transferase type-2 subunit alpha [57] 0.24[58] -0.84[59] -1.22[60] -0.17[61] -0.22[62] 0.37[63]
10 CHM Rab proteins geranylgeranyltransferase component A 1 [64] -0.97[65] 0.31[66] -3.02[67] 1.59[68] 1.31[69] 1.06[70]
11 PPP1R13B Apoptosis-stimulating of p53 protein 1 [71] 0.66[72] 0.02[73] -0.89[74] 1.20[75] 0.97[76] 1.55[77]
12 BCL2L14 Apoptosis facilitator Bcl-2-like protein 14 [78] -4.00[79] -2.98[80] 3.20[81] -3.92[82] -4.74[83] 0.50[84]
13 TP73 Tumor protein p73 [85] -0.16[86] 2.45[87] 1.39[88] 0.93[89] 1.98[90] 1.21[91]
14 TP63 Tumor protein 63 [92] [93] [94] -2.88[95] -1.12[96] -4.78[97] -0.92[98]
[1]
ref_hepatocyte RABGGTB
Mean 50.5
Standard deviation 19
Values 69 53 67 37 26
[2]
HepG2 RABGGTB
Mean 45.2
Standard deviation 3.3
Values 43 48
[3]
HepG2.C3A RABGGTB
Mean 87.4
Standard deviation 12
Values 79 96
[4]
HuH.7 RABGGTB
Mean 54.2
Standard deviation 7.9
Values 45 59 58
[5]
SNU475 RABGGTB
Mean 14.2
Standard deviation 1.2
Values 13 15
[6]
THLE RABGGTB
Mean 25.6
Standard deviation 0.12
Values 25 26
[7]
liver RABGGTB
Mean 14.5
Standard deviation 3
Values 15 15 18 10
[8]
ref_hepatocyte PERP
Mean 36.5
Standard deviation 21
Values 45 70 18 24 26
[9]
HepG2 PERP
Mean 119
Standard deviation 31
Values 1.4e+02 98
[10]
HepG2.C3A PERP
Mean 106
Standard deviation 11
Values 1.1e+02 98
[11]
HuH.7 PERP
Mean 67.8
Standard deviation 13
Values 63 83 58
[12]
SNU475 PERP
Mean 49.6
Standard deviation 3.2
Values 52 47
[13]
THLE PERP
Mean 58.2
Standard deviation 8.6
Values 52 64
[14]
liver PERP
Mean 59.9
Standard deviation 52
Values 74 26 1.3e+02 12
[15]
ref_hepatocyte NDRG1
Mean 17.5
Standard deviation 7.7
Values 26 9.1 26 16 11
[16]
HepG2 NDRG1
Mean 279
Standard deviation 2.2e+02
Values 4.3e+02 1.2e+02
[17]
HepG2.C3A NDRG1
Mean 154
Standard deviation 98
Values 2.2e+02 85
[18]
HuH.7 NDRG1
Mean 222
Standard deviation 1.4e+02
Values 1.5e+02 3.8e+02 1.4e+02
[19]
SNU475 NDRG1
Mean 31
Standard deviation 1.2
Values 30 32
[20]
THLE NDRG1
Mean 46.6
Standard deviation 3.7
Values 49 44
[21]
liver NDRG1
Mean 17.3
Standard deviation 1.3
Values 19 18 16 16
[22]
ref_hepatocyte TP53I3
Mean 9.71
Standard deviation 7
Values 11 21 6.5 7.7 2.7
[23]
HepG2 TP53I3
Mean 28.4
Standard deviation 7.2
Values 23 33
[24]
HepG2.C3A TP53I3
Mean 15.3
Standard deviation 8.2
Values 9.5 21
[25]
HuH.7 TP53I3
Mean 4.07
Standard deviation 1
Values 4 3.1 5.1
[26]
SNU475 TP53I3
Mean 22.4
Standard deviation 1.9
Values 24 21
[27]
THLE TP53I3
Mean 11.7
Standard deviation 0.7
Values 11 12
[28]
liver TP53I3
Mean 4.03
Standard deviation 2.4
Values 6.8 1.1 3.3 4.8
[29]
ref_hepatocyte BIRC5
Mean 7.26
Standard deviation 8.2
Values 14 18 1 2 1.1
[30]
HepG2 BIRC5
Mean 47.8
Standard deviation 8.4
Values 42 54
[31]
HepG2.C3A BIRC5
Mean 58.1
Standard deviation 26
Values 40 76
[32]
HuH.7 BIRC5
Mean 54.2
Standard deviation 26
Values 66 25 72
[33]
SNU475 BIRC5
Mean 21.4
Standard deviation 0.081
Values 21 21
[34]
THLE BIRC5
Mean 42.6
Standard deviation 11
Values 35 50
[35]
liver BIRC5
Mean 2.07
Standard deviation 2
Values 2.1 1.3 4.8 0.12
[36]
ref_hepatocyte BCL6
Mean 7.16
Standard deviation 3.9
Values 12 2 4.6 10 7.3
[37]
HepG2 BCL6
Mean 8.5
Standard deviation 0.79
Values 9.1 7.9
[38]
HepG2.C3A BCL6
Mean 36
Standard deviation 26
Values 55 17
[39]
HuH.7 BCL6
Mean 12
Standard deviation 6.8
Values 8.1 20 8.1
[40]
SNU475 BCL6
Mean 9.02
Standard deviation 1.2
Values 8.2 9.9
[41]
THLE BCL6
Mean 16.9
Standard deviation 0.91
Values 18 16
[42]
liver BCL6
Mean 10.4
Standard deviation 5.1
Values 7.1 11 6.1 17
[43]
ref_hepatocyte TP53BP2
Mean 6.24
Standard deviation 6.5
Values 2.6 7.1 17 2.4 2
[44]
HepG2 TP53BP2
Mean 9.07
Standard deviation 1.2
Values 8.2 9.9
[45]
HepG2.C3A TP53BP2
Mean 10.2
Standard deviation 0.052
Values 10 10
[46]
HuH.7 TP53BP2
Mean 29.1
Standard deviation 12
Values 24 43 20
[47]
SNU475 TP53BP2
Mean 27.4
Standard deviation 1.5
Values 26 28
[48]
THLE TP53BP2
Mean 18.7
Standard deviation 0.31
Values 19 19
[49]
liver TP53BP2
Mean 9.23
Standard deviation 1.2
Values 8.3 11 8.1 9.9
[50]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[51]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[52]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[53]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[54]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[55]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[56]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[57]
ref_hepatocyte RABGGTA
Mean 5.1
Standard deviation 1.4
Values 5.9 4.5 4.3 7.2 3.6
[58]
HepG2 RABGGTA
Mean 24.5
Standard deviation 1.5
Values 23 26
[59]
HepG2.C3A RABGGTA
Mean 9.96
Standard deviation 1.9
Values 11 8.6
[60]
HuH.7 RABGGTA
Mean 7.25
Standard deviation 1.2
Values 6.9 6.3 8.6
[61]
SNU475 RABGGTA
Mean 6.98
Standard deviation 0.75
Values 7.5 6.4
[62]
THLE RABGGTA
Mean 8
Standard deviation 0.19
Values 7.9 8.1
[63]
liver RABGGTA
Mean 6.34
Standard deviation 2.2
Values 7.8 3.8 8.5 5.2
[64]
ref_hepatocyte CHM
Mean 4.78
Standard deviation 3.1
Values 9.5 5.9 4.2 1.9 2.4
[65]
HepG2 CHM
Mean 9.93
Standard deviation 3.7
Values 7.3 13
[66]
HepG2.C3A CHM
Mean 20.7
Standard deviation 6.6
Values 16 25
[67]
HuH.7 CHM
Mean 1.94
Standard deviation 0.18
Values 2.1 1.7 2
[68]
SNU475 CHM
Mean 22.2
Standard deviation 5
Values 26 19
[69]
THLE CHM
Mean 21.6
Standard deviation 2.7
Values 24 20
[70]
liver CHM
Mean 9.56
Standard deviation 1.4
Values 8.7 12 9.5 8.6
[71]
ref_hepatocyte PPP1R13B
Mean 1.88
Standard deviation 0.66
Values 2.2 2 2.8 1.3 1.2
[72]
HepG2 PPP1R13B
Mean 12.1
Standard deviation 1.7
Values 11 13
[73]
HepG2.C3A PPP1R13B
Mean 6.62
Standard deviation 0.98
Values 7.3 5.9
[74]
HuH.7 PPP1R13B
Mean 3.36
Standard deviation 0.41
Values 3.6 2.9 3.6
[75]
SNU475 PPP1R13B
Mean 6.65
Standard deviation 1.5
Values 7.7 5.6
[76]
THLE PPP1R13B
Mean 6.74
Standard deviation 0.32
Values 6.5 7
[77]
liver PPP1R13B
Mean 5.29
Standard deviation 1.2
Values 6.1 5.5 3.5 6.1
[78]
ref_hepatocyte BCL2L14
Mean 0.242
Standard deviation 0.43
Values 0 1 0 0 0.21
[79]
HepG2 BCL2L14
Mean 0.0616
Standard deviation 0.051
Values 0.097 0.026
[80]
HepG2.C3A BCL2L14
Mean 0.107
Standard deviation 0.00023
Values 0.11 0.11
[81]
HuH.7 BCL2L14
Mean 7.33
Standard deviation 1.2
Values 7.2 8.6 6.2
[82]
SNU475 BCL2L14
Mean 0.0247
Standard deviation 0.015
Values 0.014 0.035
[83]
THLE BCL2L14
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[84]
liver BCL2L14
Mean 0.328
Standard deviation 0.35
Values 0.094 0.4 0.026 0.79
[85]
ref_hepatocyte TP73
Mean 0.183
Standard deviation 0.15
Values 0.4 0 0.19 0.23 0.098
[86]
HepG2 TP73
Mean 0.666
Standard deviation 0.13
Values 0.57 0.76
[87]
HepG2.C3A TP73
Mean 3.48
Standard deviation 0.49
Values 3.1 3.8
[88]
HuH.7 TP73
Mean 1.58
Standard deviation 0.41
Values 2.1 1.4 1.3
[89]
SNU475 TP73
Mean 0.537
Standard deviation 0.035
Values 0.56 0.51
[90]
THLE TP73
Mean 1.32
Standard deviation 0.075
Values 1.3 1.4
[91]
liver TP73
Mean 0.407
Standard deviation 0.19
Values 0.19 0.47 0.33 0.64
[92]
ref_hepatocyte TP63
Mean 0.0845
Standard deviation 0.17
Values 0 0.026 0.4 0 0
[93]
HepG2 TP63
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A TP63
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 TP63
Mean 0.038
Standard deviation 0.033
Values 0 0.058 0.056
[96]
SNU475 TP63
Mean 0.06
Standard deviation 0.059
Values 0.019 0.1
[97]
THLE TP63
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[98]
liver TP63
Mean 0.0431
Standard deviation 0.045
Values 0.024 0.043 0 0.11