REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G2_CELL_CYCLE_ARREST Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GADD45A Growth arrest and DNA damage-inducible protein GADD45 alpha [1] -2.72[2] -3.91[3] -3.51[4] -3.67[5] -2.35[6] -1.54[7]
2 SFN 14-3-3 protein sigma [8] -2.62[9] -3.08[10] -2.48[11] -7.51[12] -8.86[13] -8.62[14]
3 PRMT1 Protein arginine N-methyltransferase 1 [15] -0.01[16] -0.07[17] 0.61[18] -0.76[19] -1.05[20] -0.48[21]
4 PCNA Proliferating cell nuclear antigen [22] 0.63[23] 0.51[24] -0.69[25] 0.10[26] -0.03[27] -1.60[28]
5 BAX Apoptosis regulator BAX [29] 0.08[30] -0.82[31] -1.08[32] -1.28[33] -1.32[34] -2.48[35]
6 TFDP1 Transcription factor Dp-1 [36] 0.41[37] -0.36[38] -0.09[39] 0.92[40] 1.08[41] 0.33[42]
7 E2F4 Transcription factor E2F4 [43] 0.88[44] 0.89[45] 0.11[46] 0.74[47] 0.32[48] 1.23[49]
8 CCNB1 G2/mitotic-specific cyclin-B1 [50] 1.59[51] 1.72[52] 2.11[53] 1.93[54] 2.49[55] -0.87[56]
9 CARM1 Histone-arginine methyltransferase CARM1 [57] 1.20[58] 0.54[59] 1.07[60] 0.07[61] 0.45[62] 0.45[63]
10 AURKA Aurora kinase A [64] 1.45[65] 1.61[66] 1.31[67] 1.94[68] 1.43[69] -1.33[70]
11 RBL2 Retinoblastoma-like protein 2 [71] 0.58[72] 1.33[73] 1.58[74] 1.55[75] 0.84[76] 3.61[77]
12 CDK1 Cyclin-dependent kinase 1 [78] 1.00[79] 2.96[80] 1.89[81] 2.59[82] 2.99[83] -1.00[84]
13 TP53 Cellular tumor antigen p53 [85] 1.38[86] 0.84[87] 1.80[88] 1.61[89] 0.86[90] 1.43[91]
14 EP300 Histone acetyltransferase p300 [92] 2.47[93] 1.96[94] 3.05[95] 2.89[96] 2.53[97] 4.22[98]
15 TFDP2 Transcription factor Dp-2 [99] 1.65[100] 2.24[101] 2.46[102] 2.71[103] 2.52[104] 3.82[105]
16 RBL1 Retinoblastoma-like protein 1 [106] 1.52[107] 2.29[108] 1.12[109] 3.13[110] 3.05[111] 2.15[112]
17 ZNF385A Zinc finger protein 385A [113] 1.30[114] -1.86[115] -0.74[116] 1.91[117] 1.56[118] 1.08[119]
18 CDC25C M-phase inducer phosphatase 3 [120] 1.68[121] 2.73[122] 2.96[123] 2.25[124] 2.68[125] 0.05[126]
[1]
ref_hepatocyte GADD45A
Mean 72.7
Standard deviation 61
Values 28 1.5e+02 1.2e+02 23 36
[2]
HepG2 GADD45A
Mean 29
Standard deviation 18
Values 42 16
[3]
HepG2.C3A GADD45A
Mean 12.2
Standard deviation 0.97
Values 13 12
[4]
HuH.7 GADD45A
Mean 13.4
Standard deviation 4.4
Values 9.2 18 13
[5]
SNU475 GADD45A
Mean 8.43
Standard deviation 3
Values 6.3 11
[6]
THLE GADD45A
Mean 31.4
Standard deviation 0.034
Values 31 31
[7]
liver GADD45A
Mean 12.8
Standard deviation 5.7
Values 15 5.8 19 11
[8]
ref_hepatocyte SFN
Mean 59.2
Standard deviation 90
Values 6.3 2.1e+02 78 1.8 0.87
[9]
HepG2 SFN
Mean 25.4
Standard deviation 7.7
Values 31 20
[10]
HepG2.C3A SFN
Mean 17.7
Standard deviation 2.5
Values 16 19
[11]
HuH.7 SFN
Mean 22.3
Standard deviation 9.2
Values 25 12 30
[12]
SNU475 SFN
Mean 0.477
Standard deviation 0.46
Values 0.15 0.81
[13]
THLE SFN
Mean 0.281
Standard deviation 0.029
Values 0.3 0.26
[14]
liver SFN
Mean 0.0769
Standard deviation 0.053
Values 0 0.086 0.1 0.12
[15]
ref_hepatocyte PRMT1
Mean 40.1
Standard deviation 17
Values 45 56 53 32 15
[16]
HepG2 PRMT1
Mean 105
Standard deviation 22
Values 1.2e+02 90
[17]
HepG2.C3A PRMT1
Mean 96.5
Standard deviation 1.5
Values 98 95
[18]
HuH.7 PRMT1
Mean 128
Standard deviation 40
Values 1.4e+02 83 1.6e+02
[19]
SNU475 PRMT1
Mean 34.9
Standard deviation 0.11
Values 35 35
[20]
THLE PRMT1
Mean 42.7
Standard deviation 5.5
Values 39 47
[21]
liver PRMT1
Mean 14.8
Standard deviation 4.4
Values 19 11 18 11
[22]
ref_hepatocyte PCNA
Mean 36
Standard deviation 33
Values 92 37 14 19 17
[23]
HepG2 PCNA
Mean 147
Standard deviation 54
Values 1.1e+02 1.9e+02
[24]
HepG2.C3A PCNA
Mean 130
Standard deviation 86
Values 69 1.9e+02
[25]
HuH.7 PCNA
Mean 46.8
Standard deviation 33
Values 53 10 76
[26]
SNU475 PCNA
Mean 56.8
Standard deviation 7.7
Values 51 62
[27]
THLE PCNA
Mean 77.4
Standard deviation 13
Values 68 86
[28]
liver PCNA
Mean 6.07
Standard deviation 2.5
Values 7.3 5.2 8.8 3
[29]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 30 21 34 27 11
[30]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 80 58
[31]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 38 33
[32]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 26 14 34
[33]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 14 16
[34]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[35]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 2.3 2.5 2.9 1.4
[36]
ref_hepatocyte TFDP1
Mean 14.3
Standard deviation 8.3
Values 23 24 5.8 10 9.4
[37]
HepG2 TFDP1
Mean 50.2
Standard deviation 7.6
Values 45 56
[38]
HepG2.C3A TFDP1
Mean 28.1
Standard deviation 13
Values 19 38
[39]
HuH.7 TFDP1
Mean 28.3
Standard deviation 13
Values 35 13 37
[40]
SNU475 TFDP1
Mean 40
Standard deviation 3.2
Values 42 38
[41]
THLE TFDP1
Mean 67
Standard deviation 13
Values 58 76
[42]
liver TFDP1
Mean 9.23
Standard deviation 0.4
Values 9.3 9.6 8.7 9.3
[43]
ref_hepatocyte E2F4
Mean 10.4
Standard deviation 9.6
Values 7.5 5.1 27 7.8 4.3
[44]
HepG2 E2F4
Mean 50.4
Standard deviation 3
Values 48 53
[45]
HepG2.C3A E2F4
Mean 48.5
Standard deviation 4.6
Values 45 52
[46]
HuH.7 E2F4
Mean 23.7
Standard deviation 7.6
Values 26 15 30
[47]
SNU475 E2F4
Mean 25.6
Standard deviation 0.41
Values 26 25
[48]
THLE E2F4
Mean 28.5
Standard deviation 3.3
Values 31 26
[49]
liver E2F4
Mean 12.5
Standard deviation 3.7
Values 14 8.5 17 11
[50]
ref_hepatocyte CCNB1
Mean 8.2
Standard deviation 8.6
Values 15 20 1.8 3.1 1.3
[51]
HepG2 CCNB1
Mean 65.1
Standard deviation 21
Values 50 80
[52]
HepG2.C3A CCNB1
Mean 68.3
Standard deviation 39
Values 41 96
[53]
HuH.7 CCNB1
Mean 74.2
Standard deviation 37
Values 87 33 1e+02
[54]
SNU475 CCNB1
Mean 45.8
Standard deviation 3.3
Values 48 44
[55]
THLE CCNB1
Mean 101
Standard deviation 30
Values 80 1.2e+02
[56]
liver CCNB1
Mean 2.29
Standard deviation 1.6
Values 2.3 2.4 4.2 0.28
[57]
ref_hepatocyte CARM1
Mean 8
Standard deviation 2.2
Values 5.9 8.2 11 8.8 5.9
[58]
HepG2 CARM1
Mean 48.4
Standard deviation 14
Values 58 38
[59]
HepG2.C3A CARM1
Mean 29.4
Standard deviation 7.1
Values 34 24
[60]
HuH.7 CARM1
Mean 35.4
Standard deviation 7.6
Values 42 27 38
[61]
SNU475 CARM1
Mean 12.4
Standard deviation 1.6
Values 13 11
[62]
THLE CARM1
Mean 24
Standard deviation 2.8
Values 22 26
[63]
liver CARM1
Mean 5.61
Standard deviation 1.3
Values 5.9 5.1 4.1 7.3
[64]
ref_hepatocyte AURKA
Mean 7.42
Standard deviation 11
Values 26 8.2 0.15 2.1 0.46
[65]
HepG2 AURKA
Mean 53.6
Standard deviation 17
Values 41 66
[66]
HepG2.C3A AURKA
Mean 57
Standard deviation 33
Values 34 80
[67]
HuH.7 AURKA
Mean 38.7
Standard deviation 12
Values 44 25 47
[68]
SNU475 AURKA
Mean 41.8
Standard deviation 0.16
Values 42 42
[69]
THLE AURKA
Mean 44.1
Standard deviation 15
Values 34 54
[70]
liver AURKA
Mean 1.51
Standard deviation 1
Values 0.87 1.8 2.8 0.56
[71]
ref_hepatocyte RBL2
Mean 6.31
Standard deviation 3.1
Values 6.8 4 4.2 5 12
[72]
HepG2 RBL2
Mean 24.9
Standard deviation 4.6
Values 22 28
[73]
HepG2.C3A RBL2
Mean 39.8
Standard deviation 0.53
Values 39 40
[74]
HuH.7 RBL2
Mean 39.7
Standard deviation 1.6
Values 42 39 39
[75]
SNU475 RBL2
Mean 27.1
Standard deviation 11
Values 35 19
[76]
THLE RBL2
Mean 24.9
Standard deviation 0.58
Values 25 24
[77]
liver RBL2
Mean 39.5
Standard deviation 5.1
Values 37 41 34 46
[78]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 13 14 0.06 1.6 0.72
[79]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 21 40
[80]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 53 1.7e+02
[81]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 55 21 60
[82]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 48 55
[83]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[84]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 1 1.4 3.4 0.013
[85]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[86]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[87]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[88]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[89]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[90]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[91]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[92]
ref_hepatocyte EP300
Mean 2.46
Standard deviation 1.2
Values 3 1.8 4.4 1.4 1.8
[93]
HepG2 EP300
Mean 35.9
Standard deviation 5.7
Values 32 40
[94]
HepG2.C3A EP300
Mean 24.1
Standard deviation 1.4
Values 23 25
[95]
HuH.7 EP300
Mean 43
Standard deviation 15
Values 55 48 26
[96]
SNU475 EP300
Mean 26.9
Standard deviation 1.3
Values 28 26
[97]
THLE EP300
Mean 31.2
Standard deviation 11
Values 23 39
[98]
liver EP300
Mean 23.6
Standard deviation 8
Values 20 27 15 33
[99]
ref_hepatocyte TFDP2
Mean 1.97
Standard deviation 0.83
Values 3.4 2.1 1.3 1.4 1.7
[100]
HepG2 TFDP2
Mean 16.3
Standard deviation 2.5
Values 15 18
[101]
HepG2.C3A TFDP2
Mean 23.5
Standard deviation 2.1
Values 22 25
[102]
HuH.7 TFDP2
Mean 22.8
Standard deviation 3.1
Values 26 20 22
[103]
SNU475 TFDP2
Mean 18.9
Standard deviation 4.1
Values 22 16
[104]
THLE TFDP2
Mean 24.9
Standard deviation 1.2
Values 24 26
[105]
liver TFDP2
Mean 14.3
Standard deviation 3.4
Values 17 14 9.6 16
[106]
ref_hepatocyte RBL1
Mean 0.836
Standard deviation 0.94
Values 2.4 0.96 0.44 0.14 0.22
[107]
HepG2 RBL1
Mean 6.34
Standard deviation 2.4
Values 4.6 8
[108]
HepG2.C3A RBL1
Mean 10.3
Standard deviation 8.7
Values 4.2 16
[109]
HuH.7 RBL1
Mean 3.82
Standard deviation 1.7
Values 5.6 2.2 3.6
[110]
SNU475 RBL1
Mean 10.8
Standard deviation 2.6
Values 8.9 13
[111]
THLE RBL1
Mean 15.2
Standard deviation 0.62
Values 15 16
[112]
liver RBL1
Mean 1.9
Standard deviation 0.74
Values 1.3 2.9 1.5 2
[113]
ref_hepatocyte ZNF385A
Mean 0.819
Standard deviation 0.82
Values 0.052 0 2 1 1
[114]
HepG2 ZNF385A
Mean 5.3
Standard deviation 1.7
Values 6.5 4.1
[115]
HepG2.C3A ZNF385A
Mean 0.57
Standard deviation 0.12
Values 0.49 0.65
[116]
HuH.7 ZNF385A
Mean 1.03
Standard deviation 0.19
Values 1.2 0.96 0.89
[117]
SNU475 ZNF385A
Mean 4.51
Standard deviation 0.36
Values 4.3 4.8
[118]
THLE ZNF385A
Mean 5.33
Standard deviation 0.13
Values 5.2 5.4
[119]
liver ZNF385A
Mean 0.887
Standard deviation 0.63
Values 1.6 0.21 1.2 0.53
[120]
ref_hepatocyte CDC25C
Mean 0.731
Standard deviation 0.89
Values 2 1.3 0.11 0.078 0.13
[121]
HepG2 CDC25C
Mean 6.16
Standard deviation 0.58
Values 5.7 6.6
[122]
HepG2.C3A CDC25C
Mean 12.2
Standard deviation 6.2
Values 7.8 17
[123]
HuH.7 CDC25C
Mean 12
Standard deviation 5.4
Values 14 5.9 16
[124]
SNU475 CDC25C
Mean 5.11
Standard deviation 0.28
Values 5.3 4.9
[125]
THLE CDC25C
Mean 10.3
Standard deviation 1.8
Values 9 12
[126]
liver CDC25C
Mean 0.389
Standard deviation 0.27
Values 0.45 0.43 0.67 0.013