REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_G1_CELL_CYCLE_ARREST Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -0.30[2] -1.42[3] -3.78[4] -1.99[5] -0.40[6] -0.35[7]
2 CDKN1B Cyclin-dependent kinase inhibitor 1B [8] -1.23[9] -0.51[10] 0.01[11] -1.11[12] -1.61[13] 0.57[14]
3 CDK2 Cyclin-dependent kinase 2 [15] -1.56[16] -1.11[17] -0.41[18] -0.02[19] -0.40[20] -0.71[21]
4 TP53 Cellular tumor antigen p53 [22] 0.49[23] 0.33[24] 1.42[25] 1.29[26] -0.01[27] 1.44[28]
5 PCBP4 Poly(rC)-binding protein 4 [29] 1.66[30] 1.18[31] 0.64[32] 0.32[33] -0.09[34] 0.18[35]
6 CCNE1 G1/S-specific cyclin-E1 [36] 0.09[37] 0.48[38] -1.00[39] -0.41[40] -0.78[41] -3.15[42]
7 CCNA2 Cyclin-A2 [43] 1.06[44] 2.35[45] 2.02[46] 2.00[47] 2.42[48] 0.25[49]
8 ARID3A AT-rich interactive domain-containing protein 3A [50] 1.53[51] 2.18[52] 2.56[53] -0.41[54] -2.80[55] -0.91[56]
9 E2F1 Transcription factor E2F1 [57] 0.80[58] 0.94[59] 1.39[60] 1.86[61] 1.33[62] -2.13[63]
10 CCNE2 G1/S-specific cyclin-E2 [64] -0.72[65] -0.05[66] -0.19[67] 3.04[68] 1.97[69] 1.13[70]
11 ZNF385A Zinc finger protein 385A [71] 0.41[72] -2.36[73] -1.12[74] 1.58[75] 0.69[76] 1.09[77]
12 E2F8 Transcription factor E2F8 [78] 1.97[79] 2.44[80] 3.17[81] 3.71[82] 2.21[83] 1.60[84]
13 E2F7 Transcription factor E2F7 [85] 3.66[86] 3.61[87] 1.63[88] 5.28[89] 4.98[90] 2.56[91]
14 CCNA1 Cyclin-A1 [92] [93] -4.26[94] [95] -0.80[96] 5.65[97] [98]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 23 13 7.5 10 15
[9]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 31 26
[10]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 34 36
[11]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 35 42 37
[12]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 14 9.7
[13]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[14]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 9.9 14 5.8 12
[15]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 19 28 3.3 5.7 4.6
[16]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 18 22
[17]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 14 26
[18]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 30 11 33
[19]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 20 24
[20]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[21]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 4.4 2.3 5.2 3.2
[22]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[23]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[24]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[25]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[26]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[27]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[28]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[29]
ref_hepatocyte PCBP4
Mean 3.72
Standard deviation 1.5
Values 5.9 3.3 4 3.5 1.9
[30]
HepG2 PCBP4
Mean 57.4
Standard deviation 6.4
Values 62 53
[31]
HepG2.C3A PCBP4
Mean 30.2
Standard deviation 1.3
Values 31 29
[32]
HuH.7 PCBP4
Mean 16
Standard deviation 0.35
Values 16 16 16
[33]
SNU475 PCBP4
Mean 8.57
Standard deviation 2.4
Values 10 6.9
[34]
THLE PCBP4
Mean 14.1
Standard deviation 2.1
Values 16 13
[35]
liver PCBP4
Mean 2.15
Standard deviation 0.53
Values 2.3 1.8 2.8 1.6
[36]
ref_hepatocyte CCNE1
Mean 3.4
Standard deviation 4.5
Values 11 4.2 1.1 0.65 0.21
[37]
HepG2 CCNE1
Mean 17.7
Standard deviation 1.7
Values 17 19
[38]
HepG2.C3A CCNE1
Mean 17
Standard deviation 7.4
Values 12 22
[39]
HuH.7 CCNE1
Mean 4.65
Standard deviation 2.3
Values 5.5 2 6.5
[40]
SNU475 CCNE1
Mean 4.72
Standard deviation 1.8
Values 3.5 6
[41]
THLE CCNE1
Mean 8.01
Standard deviation 0.79
Values 7.4 8.6
[42]
liver CCNE1
Mean 0.195
Standard deviation 0.1
Values 0.19 0.26 0.28 0.053
[43]
ref_hepatocyte CCNA2
Mean 3.28
Standard deviation 3.7
Values 7 7.5 0.2 1.1 0.57
[44]
HepG2 CCNA2
Mean 33.4
Standard deviation 16
Values 22 44
[45]
HepG2.C3A CCNA2
Mean 60.1
Standard deviation 42
Values 30 90
[46]
HuH.7 CCNA2
Mean 36.5
Standard deviation 15
Values 47 20 43
[47]
SNU475 CCNA2
Mean 24.1
Standard deviation 0.4
Values 24 24
[48]
THLE CCNA2
Mean 71
Standard deviation 9.4
Values 64 78
[49]
liver CCNA2
Mean 1.99
Standard deviation 1.7
Values 0.85 3.4 3.5 0.21
[50]
ref_hepatocyte ARID3A
Mean 3.14
Standard deviation 5
Values 12 0.21 3.3 0.21 0.31
[51]
HepG2 ARID3A
Mean 44.3
Standard deviation 18
Values 57 32
[52]
HepG2.C3A ARID3A
Mean 51
Standard deviation 11
Values 59 43
[53]
HuH.7 ARID3A
Mean 50.7
Standard deviation 8.2
Values 58 53 42
[54]
SNU475 ARID3A
Mean 4.34
Standard deviation 0.66
Values 3.9 4.8
[55]
THLE ARID3A
Mean 1.81
Standard deviation 0.28
Values 1.6 2
[56]
liver ARID3A
Mean 0.852
Standard deviation 0.54
Values 0.89 0.66 0.28 1.6
[57]
ref_hepatocyte E2F1
Mean 2.5
Standard deviation 3.1
Values 7.9 2.2 0.64 1.2 0.54
[58]
HepG2 E2F1
Mean 21.3
Standard deviation 1.8
Values 20 23
[59]
HepG2.C3A E2F1
Mean 17.2
Standard deviation 4.9
Values 14 21
[60]
HuH.7 E2F1
Mean 18
Standard deviation 12
Values 21 5.1 28
[61]
SNU475 E2F1
Mean 16.7
Standard deviation 4.8
Values 13 20
[62]
THLE E2F1
Mean 25.4
Standard deviation 2.4
Values 24 27
[63]
liver E2F1
Mean 0.29
Standard deviation 0.19
Values 0.12 0.49 0.41 0.15
[64]
ref_hepatocyte CCNE2
Mean 0.86
Standard deviation 0.73
Values 1.2 2 0.44 0.36 0.28
[65]
HepG2 CCNE2
Mean 2.55
Standard deviation 1.9
Values 1.2 3.9
[66]
HepG2.C3A CCNE2
Mean 2.99
Standard deviation 2.8
Values 1 5
[67]
HuH.7 CCNE2
Mean 2.08
Standard deviation 1
Values 2.8 0.93 2.5
[68]
SNU475 CCNE2
Mean 13
Standard deviation 3.7
Values 10 16
[69]
THLE CCNE2
Mean 13.6
Standard deviation 1.4
Values 13 15
[70]
liver CCNE2
Mean 0.957
Standard deviation 0.34
Values 0.63 1 1.4 0.78
[71]
ref_hepatocyte ZNF385A
Mean 0.819
Standard deviation 0.82
Values 0.052 0 2 1 1
[72]
HepG2 ZNF385A
Mean 5.3
Standard deviation 1.7
Values 6.5 4.1
[73]
HepG2.C3A ZNF385A
Mean 0.57
Standard deviation 0.12
Values 0.49 0.65
[74]
HuH.7 ZNF385A
Mean 1.03
Standard deviation 0.19
Values 1.2 0.96 0.89
[75]
SNU475 ZNF385A
Mean 4.51
Standard deviation 0.36
Values 4.3 4.8
[76]
THLE ZNF385A
Mean 5.33
Standard deviation 0.13
Values 5.2 5.4
[77]
liver ZNF385A
Mean 0.887
Standard deviation 0.63
Values 1.6 0.21 1.2 0.53
[78]
ref_hepatocyte E2F8
Mean 0.221
Standard deviation 0.17
Values 0.4 0.38 0 0.16 0.16
[79]
HepG2 E2F8
Mean 4.23
Standard deviation 2.3
Values 2.6 5.9
[80]
HepG2.C3A E2F8
Mean 4.31
Standard deviation 3.7
Values 1.7 6.9
[81]
HuH.7 E2F8
Mean 5.46
Standard deviation 3.6
Values 7.3 1.3 7.7
[82]
SNU475 E2F8
Mean 5.34
Standard deviation 1.7
Values 4.1 6.5
[83]
THLE E2F8
Mean 4.13
Standard deviation 1.4
Values 3.1 5.1
[84]
liver E2F8
Mean 0.342
Standard deviation 0.3
Values 0.24 0.41 0.72 0
[85]
ref_hepatocyte E2F7
Mean 0.101
Standard deviation 0.13
Values 0.33 0.06 0.062 0 0.057
[86]
HepG2 E2F7
Mean 6.24
Standard deviation 2.5
Values 4.5 8
[87]
HepG2.C3A E2F7
Mean 4.44
Standard deviation 3.9
Values 1.7 7.2
[88]
HuH.7 E2F7
Mean 0.858
Standard deviation 0.54
Values 1.3 0.24 1.1
[89]
SNU475 E2F7
Mean 7.23
Standard deviation 1.4
Values 6.3 8.2
[90]
THLE E2F7
Mean 12.9
Standard deviation 2.7
Values 11 15
[91]
liver E2F7
Mean 0.304
Standard deviation 0.25
Values 0.19 0.51 0.51 0
[92]
ref_hepatocyte CCNA1
Mean 0.0259
Standard deviation 0.058
Values 0.13 0 0 0 0
[93]
HepG2 CCNA1
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A CCNA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 CCNA1
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 CCNA1
Mean 0.0274
Standard deviation 0.026
Values 0.0093 0.046
[97]
THLE CCNA1
Mean 5.22
Standard deviation 2.3
Values 3.6 6.9
[98]
liver CCNA1
Mean 0
Standard deviation 0
Values 0 0 0 0