REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PRELID1 PRELI domain-containing protein 1, mitochondrial [1] -2.12[2] -1.73[3] -1.79[4] -2.86[5] -1.92[6] -2.98[7]
2 TRIAP1 TP53-regulated inhibitor of apoptosis 1 [8] -0.81[9] -0.44[10] -1.61[11] -1.98[12] -1.07[13] -2.18[14]
3 STEAP3 Metalloreductase STEAP3 [15] -1.25[16] -1.85[17] -3.76[18] -0.70[19] -1.32[20] 1.59[21]
4 BAX Apoptosis regulator BAX [22] 0.55[23] -0.13[24] -0.32[25] -0.91[26] -0.25[27] -4.08[28]
5 BID BH3-interacting domain death agonist [29] -0.05[30] 0.17[31] 0.07[32] 0.41[33] 0.14[34] 0.05[35]
6 AIFM2 Apoptosis-inducing factor 2 [36] 2.48[37] 2.00[38] -1.59[39] 0.94[40] 1.05[41] -0.37[42]
7 TP53INP1 Tumor protein p53-inducible nuclear protein 1 [43] 0.57[44] 0.93[45] 0.46[46] 0.90[47] 0.25[48] 2.90[49]
8 TP53BP2 Apoptosis-stimulating of p53 protein 2 [50] -0.39[51] 0.06[52] 1.92[53] 1.95[54] 1.51[55] -0.06[56]
9 TP53 Cellular tumor antigen p53 [57] 1.85[58] 1.53[59] 2.57[60] 1.99[61] 1.92[62] -0.16[63]
10 BNIP3L BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [64] 2.50[65] 2.58[66] 3.41[67] 3.09[68] 2.80[69] 1.52[70]
11 BBC3 Bcl-2-binding component 3 [71] 0.95[72] 0.96[73] 0.73[74] -2.11[75] -1.08[76] -4.46[77]
12 PMAIP1 Phorbol-12-myristate-13-acetate-induced protein 1 [78] 0.27[79] -2.98[80] 0.85[81] 2.98[82] 2.47[83] -4.42[84]
13 PPP1R13B Apoptosis-stimulating of p53 protein 1 [85] 1.76[86] 1.18[87] 0.53[88] 1.64[89] 1.77[90] 0.87[91]
14 CREBBP CREB-binding protein [92] 3.12[93] 2.45[94] 3.34[95] 3.45[96] 3.73[97] 3.12[98]
15 ATM Serine-protein kinase ATM [99] 3.25[100] 4.97[101] 4.97[102] 4.85[103] 4.61[104] 4.87[105]
16 ZNF420 Zinc finger protein 420 [106] -0.21[107] 1.30[108] 1.97[109] 1.83[110] 2.05[111] 1.56[112]
17 TP73 Tumor protein p73 [113] 0.94[114] 3.61[115] 2.81[116] 1.37[117] 2.78[118] 0.53[119]
18 TP63 Tumor protein 63 [120] [121] [122] -1.46[123] -0.68[124] -3.98[125] -1.60[126]
19 TP53AIP1 p53-regulated apoptosis-inducing protein 1 [127] 0.14[128] 0.39[129] -0.07[130] 0.17[131] 0.09[132] 0.22[133]
20 PRELID3A PRELI domain containing protein 3A [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte PRELID1
Mean 120
Standard deviation 75
Values 57 1.1e+02 2.5e+02 1.2e+02 68
[2]
HepG2 PRELID1
Mean 52.4
Standard deviation 6.7
Values 57 48
[3]
HepG2.C3A PRELID1
Mean 56.2
Standard deviation 16
Values 45 68
[4]
HuH.7 PRELID1
Mean 42.8
Standard deviation 15
Values 48 26 54
[5]
SNU475 PRELID1
Mean 18.7
Standard deviation 0.86
Values 19 18
[6]
THLE PRELID1
Mean 33.1
Standard deviation 7.1
Values 28 38
[7]
liver PRELID1
Mean 23.5
Standard deviation 21
Values 46 5.4 36 5.6
[8]
ref_hepatocyte TRIAP1
Mean 33.7
Standard deviation 21
Values 56 54 9.9 21 26
[9]
HepG2 TRIAP1
Mean 36.4
Standard deviation 4.1
Values 33 39
[10]
HepG2.C3A TRIAP1
Mean 38.8
Standard deviation 22
Values 23 55
[11]
HuH.7 TRIAP1
Mean 13.6
Standard deviation 4.7
Values 13 9.4 19
[12]
SNU475 TRIAP1
Mean 9.66
Standard deviation 0.93
Values 10 9
[13]
THLE TRIAP1
Mean 16.9
Standard deviation 1.4
Values 16 18
[14]
liver TRIAP1
Mean 11.4
Standard deviation 9.9
Values 21 3.2 19 2.7
[15]
ref_hepatocyte STEAP3
Mean 29.1
Standard deviation 31
Values 2.5 10 7.5 62 63
[16]
HepG2 STEAP3
Mean 23.2
Standard deviation 1.8
Values 24 22
[17]
HepG2.C3A STEAP3
Mean 12.5
Standard deviation 1.6
Values 11 14
[18]
HuH.7 STEAP3
Mean 2.64
Standard deviation 1.2
Values 3.6 1.3 3
[19]
SNU475 STEAP3
Mean 20.3
Standard deviation 7.9
Values 26 15
[20]
THLE STEAP3
Mean 12.2
Standard deviation 1.5
Values 11 13
[21]
liver STEAP3
Mean 135
Standard deviation 39
Values 1.4e+02 95 1.9e+02 1.2e+02
[22]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 30 21 34 27 11
[23]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 80 58
[24]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 38 33
[25]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 26 14 34
[26]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 14 16
[27]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[28]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 2.3 2.5 2.9 1.4
[29]
ref_hepatocyte BID
Mean 12.3
Standard deviation 4.8
Values 4.5 12 17 15 12
[30]
HepG2 BID
Mean 22.5
Standard deviation 0.74
Values 22 23
[31]
HepG2.C3A BID
Mean 21.5
Standard deviation 4.7
Values 18 25
[32]
HuH.7 BID
Mean 15.9
Standard deviation 4.6
Values 15 12 21
[33]
SNU475 BID
Mean 18.5
Standard deviation 1.4
Values 19 17
[34]
THLE BID
Mean 14.3
Standard deviation 1.7
Values 13 15
[35]
liver BID
Mean 19.7
Standard deviation 11
Values 30 9.4 29 10
[36]
ref_hepatocyte AIFM2
Mean 9.54
Standard deviation 2.7
Values 11 9.1 13 9.5 5.4
[37]
HepG2 AIFM2
Mean 101
Standard deviation 21
Values 1.2e+02 86
[38]
HepG2.C3A AIFM2
Mean 59.7
Standard deviation 9.4
Values 53 66
[39]
HuH.7 AIFM2
Mean 3.92
Standard deviation 0.71
Values 4.1 3.1 4.5
[40]
SNU475 AIFM2
Mean 20.7
Standard deviation 0.96
Values 21 20
[41]
THLE AIFM2
Mean 20.8
Standard deviation 2
Values 19 22
[42]
liver AIFM2
Mean 11.4
Standard deviation 6.6
Values 13 7.4 20 5.1
[43]
ref_hepatocyte TP53INP1
Mean 8.04
Standard deviation 4.6
Values 14 5.4 2.6 7 11
[44]
HepG2 TP53INP1
Mean 22.7
Standard deviation 5.3
Values 19 26
[45]
HepG2.C3A TP53INP1
Mean 23.9
Standard deviation 3.9
Values 27 21
[46]
HuH.7 TP53INP1
Mean 13.7
Standard deviation 12
Values 6.7 28 6.4
[47]
SNU475 TP53INP1
Mean 17
Standard deviation 13
Values 26 7.9
[48]
THLE TP53INP1
Mean 10.1
Standard deviation 0.81
Values 11 9.5
[49]
liver TP53INP1
Mean 92.8
Standard deviation 38
Values 1.2e+02 64 55 1.3e+02
[50]
ref_hepatocyte TP53BP2
Mean 6.24
Standard deviation 6.5
Values 2.6 7.1 17 2.4 2
[51]
HepG2 TP53BP2
Mean 9.07
Standard deviation 1.2
Values 8.2 9.9
[52]
HepG2.C3A TP53BP2
Mean 10.2
Standard deviation 0.052
Values 10 10
[53]
HuH.7 TP53BP2
Mean 29.1
Standard deviation 12
Values 24 43 20
[54]
SNU475 TP53BP2
Mean 27.4
Standard deviation 1.5
Values 26 28
[55]
THLE TP53BP2
Mean 18.7
Standard deviation 0.31
Values 19 19
[56]
liver TP53BP2
Mean 9.23
Standard deviation 1.2
Values 8.3 11 8.1 9.9
[57]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[58]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[59]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[60]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[61]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[62]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[63]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[64]
ref_hepatocyte BNIP3L
Mean 4.71
Standard deviation 0.77
Values 5.2 4.2 3.7 5.5 4.9
[65]
HepG2 BNIP3L
Mean 50.7
Standard deviation 1.6
Values 50 52
[66]
HepG2.C3A BNIP3L
Mean 43.8
Standard deviation 3
Values 42 46
[67]
HuH.7 BNIP3L
Mean 61.6
Standard deviation 15
Values 54 79 52
[68]
SNU475 BNIP3L
Mean 45.6
Standard deviation 13
Values 54 37
[69]
THLE BNIP3L
Mean 34.5
Standard deviation 4.1
Values 37 32
[70]
liver BNIP3L
Mean 20.8
Standard deviation 9.3
Values 23 19 32 9.3
[71]
ref_hepatocyte BBC3
Mean 4.09
Standard deviation 4.3
Values 3.6 0.92 11 3.2 1.3
[72]
HepG2 BBC3
Mean 15.1
Standard deviation 11
Values 23 7
[73]
HepG2.C3A BBC3
Mean 12.4
Standard deviation 9.8
Values 19 5.5
[74]
HuH.7 BBC3
Mean 8.39
Standard deviation 3.1
Values 5.7 12 7.8
[75]
SNU475 BBC3
Mean 1.08
Standard deviation 0.44
Values 1.4 0.77
[76]
THLE BBC3
Mean 2.04
Standard deviation 0.082
Values 2.1 2
[77]
liver BBC3
Mean 0.288
Standard deviation 0.11
Values 0.24 0.3 0.18 0.44
[78]
ref_hepatocyte PMAIP1
Mean 2.2
Standard deviation 2.9
Values 0.061 3.5 6.7 0.22 0.54
[79]
HepG2 PMAIP1
Mean 5.03
Standard deviation 2.9
Values 7.1 3
[80]
HepG2.C3A PMAIP1
Mean 0.435
Standard deviation 0.037
Values 0.41 0.46
[81]
HuH.7 PMAIP1
Mean 4.88
Standard deviation 0.84
Values 4.6 5.8 4.2
[82]
SNU475 PMAIP1
Mean 19.7
Standard deviation 2.1
Values 18 21
[83]
THLE PMAIP1
Mean 12.8
Standard deviation 1
Values 14 12
[84]
liver PMAIP1
Mean 0.159
Standard deviation 0.092
Values 0.21 0.11 0.26 0.053
[85]
ref_hepatocyte PPP1R13B
Mean 1.88
Standard deviation 0.66
Values 2.2 2 2.8 1.3 1.2
[86]
HepG2 PPP1R13B
Mean 12.1
Standard deviation 1.7
Values 11 13
[87]
HepG2.C3A PPP1R13B
Mean 6.62
Standard deviation 0.98
Values 7.3 5.9
[88]
HuH.7 PPP1R13B
Mean 3.36
Standard deviation 0.41
Values 3.6 2.9 3.6
[89]
SNU475 PPP1R13B
Mean 6.65
Standard deviation 1.5
Values 7.7 5.6
[90]
THLE PPP1R13B
Mean 6.74
Standard deviation 0.32
Values 6.5 7
[91]
liver PPP1R13B
Mean 5.29
Standard deviation 1.2
Values 6.1 5.5 3.5 6.1
[92]
ref_hepatocyte CREBBP
Mean 1.78
Standard deviation 0.69
Values 1.8 0.72 2.6 1.9 1.9
[93]
HepG2 CREBBP
Mean 29.3
Standard deviation 2.8
Values 27 31
[94]
HepG2.C3A CREBBP
Mean 15.2
Standard deviation 1
Values 16 14
[95]
HuH.7 CREBBP
Mean 22.2
Standard deviation 7.2
Values 28 24 14
[96]
SNU475 CREBBP
Mean 22.1
Standard deviation 0.2
Values 22 22
[97]
THLE CREBBP
Mean 24.9
Standard deviation 7.3
Values 20 30
[98]
liver CREBBP
Mean 23.8
Standard deviation 6
Values 30 21 17 28
[99]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 2.1 0.69 0.27 0.7 1.1
[100]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 12 23
[101]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 44 51
[102]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 41 44 27
[103]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 38 26
[104]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[105]
liver ATM
Mean 43.7
Standard deviation 31
Values 17 76 17 64
[106]
ref_hepatocyte ZNF420
Mean 0.541
Standard deviation 0.31
Values 0.63 0.94 0.68 0.18 0.27
[107]
HepG2 ZNF420
Mean 0.887
Standard deviation 0.087
Values 0.83 0.95
[108]
HepG2.C3A ZNF420
Mean 2.09
Standard deviation 0.3
Values 1.9 2.3
[109]
HuH.7 ZNF420
Mean 2.61
Standard deviation 1.2
Values 2.2 4 1.7
[110]
SNU475 ZNF420
Mean 2.18
Standard deviation 0.18
Values 2 2.3
[111]
THLE ZNF420
Mean 2.36
Standard deviation 0.57
Values 2.8 2
[112]
liver ZNF420
Mean 2.46
Standard deviation 0.74
Values 1.6 2.9 3.2 2.1
[113]
ref_hepatocyte TP73
Mean 0.183
Standard deviation 0.15
Values 0.4 0 0.19 0.23 0.098
[114]
HepG2 TP73
Mean 0.666
Standard deviation 0.13
Values 0.57 0.76
[115]
HepG2.C3A TP73
Mean 3.48
Standard deviation 0.49
Values 3.1 3.8
[116]
HuH.7 TP73
Mean 1.58
Standard deviation 0.41
Values 2.1 1.4 1.3
[117]
SNU475 TP73
Mean 0.537
Standard deviation 0.035
Values 0.56 0.51
[118]
THLE TP73
Mean 1.32
Standard deviation 0.075
Values 1.3 1.4
[119]
liver TP73
Mean 0.407
Standard deviation 0.19
Values 0.19 0.47 0.33 0.64
[120]
ref_hepatocyte TP63
Mean 0.0845
Standard deviation 0.17
Values 0 0.026 0.4 0 0
[121]
HepG2 TP63
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A TP63
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 TP63
Mean 0.038
Standard deviation 0.033
Values 0 0.058 0.056
[124]
SNU475 TP63
Mean 0.06
Standard deviation 0.059
Values 0.019 0.1
[125]
THLE TP63
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[126]
liver TP63
Mean 0.0431
Standard deviation 0.045
Values 0.024 0.043 0 0.11
[127]
ref_hepatocyte TP53AIP1
Mean 0.0174
Standard deviation 0.039
Values 0.087 0 0 0 0
[128]
HepG2 TP53AIP1
Mean 0.0365
Standard deviation 0.021
Values 0.052 0.021
[129]
HepG2.C3A TP53AIP1
Mean 0.0355
Standard deviation 0.0047
Values 0.039 0.032
[130]
HuH.7 TP53AIP1
Mean 0.0204
Standard deviation 0.023
Values 0.016 0.045 0
[131]
SNU475 TP53AIP1
Mean 0.0222
Standard deviation 0.012
Values 0.014 0.03
[132]
THLE TP53AIP1
Mean 0.0195
Standard deviation 0.0025
Values 0.018 0.021
[133]
liver TP53AIP1
Mean 0.0312
Standard deviation 0.023
Values 0.047 0 0.051 0.026
[134]
ref_hepatocyte PRELID3A
Missing
[135]
HepG2 PRELID3A
Missing
[136]
HepG2.C3A PRELID3A
Missing
[137]
HuH.7 PRELID3A
Missing
[138]
SNU475 PRELID3A
Missing
[139]
THLE PRELID3A
Missing
[140]
liver PRELID3A
Missing