REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PRELID1 | PRELI domain-containing protein 1, mitochondrial | [1] | -2.64[2] | -2.28[3] | -2.42[4] | -2.89[5] | -2.24[6] | -2.86[7] |
2 | RABGGTB | Geranylgeranyl transferase type-2 subunit beta | [8] | -1.61[9] | -0.40[10] | -0.84[11] | -2.05[12] | -1.37[13] | -2.31[14] |
3 | PERP | p53 apoptosis effector related to PMP-22 | [15] | 0.26[16] | 0.35[17] | -0.04[18] | 0.23[19] | 0.28[20] | 0.21[21] |
4 | TMEM219 | Insulin-like growth factor-binding protein 3 receptor | [22] | -1.34[23] | -0.96[24] | -1.33[25] | -1.58[26] | -1.81[27] | -1.54[28] |
5 | TRIAP1 | TP53-regulated inhibitor of apoptosis 1 | [29] | -1.34[30] | -0.98[31] | -2.25[32] | -2.01[33] | -1.39[34] | -2.06[35] |
6 | STEAP3 | Metalloreductase STEAP3 | [36] | -1.78[37] | -2.40[38] | -4.39[39] | -0.73[40] | -1.64[41] | 1.71[42] |
7 | BAX | Apoptosis regulator BAX | [43] | 0.02[44] | -0.68[45] | -0.95[46] | -0.94[47] | -0.57[48] | -3.96[49] |
8 | NDRG1 | Protein NDRG1 | [50] | 2.54[51] | 1.95[52] | 2.73[53] | 0.61[54] | 1.02[55] | -0.53[56] |
9 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [57] | 1.68[58] | 1.65[59] | 1.65[60] | 0.33[61] | 1.93[62] | 0.03[63] |
10 | BID | BH3-interacting domain death agonist | [64] | -0.58[65] | -0.38[66] | -0.56[67] | 0.38[68] | -0.17[69] | 0.17[70] |
11 | CRADD | Death domain-containing protein CRADD | [71] | -2.45[72] | -1.04[73] | -3.27[74] | -1.93[75] | -2.59[76] | -0.84[77] |
12 | FAS | Tumor necrosis factor receptor superfamily member 6 | [78] | -1.91[79] | -1.03[80] | -8.85[81] | -1.08[82] | -0.57[83] | -1.72[84] |
13 | TP53I3 | Quinone oxidoreductase PIG3 | [85] | 0.09[86] | -0.53[87] | -2.19[88] | 0.99[89] | -0.12[90] | -1.78[91] |
14 | AIFM2 | Apoptosis-inducing factor 2 | [92] | 1.95[93] | 1.46[94] | -2.22[95] | 0.91[96] | 0.74[97] | -0.25[98] |
15 | CASP6 | Caspase-6 | [99] | -1.58[100] | -1.27[101] | -0.72[102] | -0.28[103] | -0.62[104] | -0.88[105] |
16 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10A | [106] | -1.75[107] | -2.12[108] | -1.91[109] | -2.36[110] | -2.62[111] | -1.71[112] |
17 | TP53INP1 | Tumor protein p53-inducible nuclear protein 1 | [113] | 0.05[114] | 0.38[115] | -0.17[116] | 0.87[117] | -0.06[118] | 3.02[119] |
18 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [120] | 1.26[121] | 1.81[122] | 1.96[123] | 1.35[124] | 2.16[125] | -2.31[126] |
19 | BCL6 | B-cell lymphoma 6 protein | [127] | -1.21[128] | 1.14[129] | -0.19[130] | 0.12[131] | 0.85[132] | 0.03[133] |
20 | TP53BP2 | Apoptosis-stimulating of p53 protein 2 | [134] | -0.92[135] | -0.49[136] | 1.28[137] | 1.92[138] | 1.20[139] | 0.06[140] |
21 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10D | [141] | 1.44[142] | 1.58[143] | 2.33[144] | 1.08[145] | 0.23[146] | 0.02[147] |
22 | TP53 | Cellular tumor antigen p53 | [148] | 1.33[149] | 0.99[150] | 1.94[151] | 1.96[152] | 1.61[153] | -0.04[154] |
23 | RABGGTA | Geranylgeranyl transferase type-2 subunit alpha | [155] | 0.81[156] | -0.22[157] | -0.43[158] | 0.24[159] | 0.26[160] | -0.19[161] |
24 | CHM | Rab proteins geranylgeranyltransferase component A 1 | [162] | -0.40[163] | 0.93[164] | -2.23[165] | 2.01[166] | 1.79[167] | 0.49[168] |
25 | BNIP3L | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like | [169] | 1.97[170] | 2.03[171] | 2.77[172] | 3.06[173] | 2.48[174] | 1.64[175] |
26 | BBC3 | Bcl-2-binding component 3 | [176] | 0.43[177] | 0.41[178] | 0.10[179] | -2.14[180] | -1.39[181] | -4.33[182] |
27 | IGFBP3 | Insulin-like growth factor-binding protein 3 | [183] | 2.73[184] | -2.05[185] | -2.39[186] | 1.11[187] | 0.12[188] | 4.23[189] |
28 | CASP1 | Caspase-1 | [190] | -3.34[191] | -6.64[192] | -4.92[193] | 0.75[194] | 0.89[195] | -0.73[196] |
29 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [197] | -0.26[198] | -3.52[199] | 0.21[200] | 2.95[201] | 2.16[202] | -4.30[203] |
30 | PPP1R13B | Apoptosis-stimulating of p53 protein 1 | [204] | 1.23[205] | 0.63[206] | -0.10[207] | 1.61[208] | 1.46[209] | 0.99[210] |
31 | CREBBP | CREB-binding protein | [211] | 2.59[212] | 1.91[213] | 2.70[214] | 3.42[215] | 3.42[216] | 3.24[217] |
32 | CASP10 | Caspase-10 | [218] | 0.91[219] | 2.30[220] | 1.45[221] | 1.09[222] | 1.13[223] | 1.07[224] |
33 | CASP2 | Caspase-2 | [225] | 1.39[226] | 1.12[227] | 2.11[228] | 2.54[229] | 2.96[230] | 1.58[231] |
34 | APAF1 | Apoptotic protease-activating factor 1 | [232] | 1.35[233] | 1.87[234] | 2.31[235] | 3.29[236] | 2.38[237] | 1.49[238] |
35 | ATM | Serine-protein kinase ATM | [239] | 2.72[240] | 4.42[241] | 4.34[242] | 4.82[243] | 4.29[244] | 4.99[245] |
36 | ZNF420 | Zinc finger protein 420 | [246] | -0.74[247] | 0.76[248] | 1.34[249] | 1.80[250] | 1.74[251] | 1.68[252] |
37 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10C | [253] | -2.34[254] | -1.33[255] | -2.72[256] | -2.65[257] | -3.30[258] | 0.40[259] |
38 | BCL2L14 | Apoptosis facilitator Bcl-2-like protein 14 | [260] | -3.43[261] | -2.36[262] | 3.99[263] | -3.50[264] | -4.26[265] | -0.06[266] |
39 | TP73 | Tumor protein p73 | [267] | 0.41[268] | 3.07[269] | 2.18[270] | 1.34[271] | 2.46[272] | 0.65[273] |
40 | NLRC4 | NLR family CARD domain-containing protein 4 | [274] | -1.17[275] | 1.75[276] | 1.27[277] | 1.61[278] | 0.56[279] | 3.04[280] |
41 | TP63 | Tumor protein 63 | [281] | [282] | [283] | -2.09[284] | -0.71[285] | -4.30[286] | -1.48[287] |
42 | TP53AIP1 | p53-regulated apoptosis-inducing protein 1 | [288] | -0.39[289] | -0.16[290] | -0.71[291] | 0.14[292] | -0.22[293] | 0.34[294] |
43 | PIDD1 | p53-induced death domain-containing protein 1 | [295] | [296] | [297] | [298] | [299] | [300] | [301] |
44 | PRELID3A | PRELI domain containing protein 3A | [302] | [303] | [304] | [305] | [306] | [307] | [308] |