REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NPM1 | Nucleophosmin | [1] | -1.46[2] | -0.87[3] | -0.43[4] | -1.54[5] | -1.84[6] | -2.07[7] |
2 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [8] | -2.04[9] | -3.40[10] | -3.44[11] | -3.05[12] | -1.64[13] | -1.14[14] |
3 | SFN | 14-3-3 protein sigma | [15] | -1.93[16] | -2.57[17] | -2.41[18] | -6.90[19] | -8.15[20] | -8.22[21] |
4 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [22] | 1.27[23] | -0.40[24] | -3.33[25] | -1.05[26] | 1.18[27] | 0.04[28] |
5 | PRMT1 | Protein arginine N-methyltransferase 1 | [29] | 0.67[30] | 0.44[31] | 0.68[32] | -0.14[33] | -0.34[34] | -0.07[35] |
6 | PCNA | Proliferating cell nuclear antigen | [36] | 1.32[37] | 1.02[38] | -0.62[39] | 0.72[40] | 0.68[41] | -1.20[42] |
7 | PLK2 | Serine/threonine-protein kinase PLK2 | [43] | -2.44[44] | -4.73[45] | -6.12[46] | 1.22[47] | -2.14[48] | -0.75[49] |
8 | BAX | Apoptosis regulator BAX | [50] | 0.76[51] | -0.32[52] | -1.01[53] | -0.67[54] | -0.60[55] | -2.08[56] |
9 | CNOT7 | CCR4-NOT transcription complex subunit 7 | [57] | 0.30[58] | 0.54[59] | 0.72[60] | 0.29[61] | 0.03[62] | 1.77[63] |
10 | TFDP1 | Transcription factor Dp-1 | [64] | 1.09[65] | 0.15[66] | -0.02[67] | 1.54[68] | 1.79[69] | 0.73[70] |
11 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [71] | 0.34[72] | 0.51[73] | 0.47[74] | -0.17[75] | -0.03[76] | 0.97[77] |
12 | CDK2 | Cyclin-dependent kinase 2 | [78] | 0.01[79] | -0.10[80] | 0.04[81] | 0.92[82] | 1.18[83] | -0.31[84] |
13 | TNKS1BP1 | 182 kDa tankyrase-1-binding protein | [85] | 0.63[86] | -0.56[87] | -0.35[88] | 2.17[89] | 1.76[90] | 2.47[91] |
14 | E2F4 | Transcription factor E2F4 | [92] | 1.56[93] | 1.39[94] | 0.18[95] | 1.36[96] | 1.03[97] | 1.63[98] |
15 | CNOT8 | CCR4-NOT transcription complex subunit 8 | [99] | 0.77[100] | 1.08[101] | 1.47[102] | 1.24[103] | 1.15[104] | 1.63[105] |
16 | CNOT1 | CCR4-NOT transcription complex subunit 1 | [106] | 3.33[107] | 3.17[108] | 3.37[109] | 3.28[110] | 3.54[111] | 4.45[112] |
17 | CCNB1 | G2/mitotic-specific cyclin-B1 | [113] | 2.27[114] | 2.23[115] | 2.18[116] | 2.54[117] | 3.20[118] | -0.47[119] |
18 | CARM1 | Histone-arginine methyltransferase CARM1 | [120] | 1.88[121] | 1.05[122] | 1.14[123] | 0.69[124] | 1.16[125] | 0.86[126] |
19 | AURKA | Aurora kinase A | [127] | 2.14[128] | 2.12[129] | 1.38[130] | 2.55[131] | 2.14[132] | -0.93[133] |
20 | CNOT2 | CCR4-NOT transcription complex subunit 2 | [134] | 0.74[135] | 1.27[136] | 0.97[137] | 1.75[138] | 1.29[139] | 2.63[140] |
21 | CNOT3 | CCR4-NOT transcription complex subunit 3 | [141] | 0.61[142] | 0.07[143] | 1.09[144] | 1.52[145] | 0.90[146] | 0.53[147] |
22 | RBL2 | Retinoblastoma-like protein 2 | [148] | 1.27[149] | 1.83[150] | 1.65[151] | 2.17[152] | 1.55[153] | 4.02[154] |
23 | CDK1 | Cyclin-dependent kinase 1 | [155] | 1.68[156] | 3.46[157] | 1.96[158] | 3.20[159] | 3.70[160] | -0.60[161] |
24 | TP53 | Cellular tumor antigen p53 | [162] | 2.06[163] | 1.35[164] | 1.87[165] | 2.23[166] | 1.57[167] | 1.83[168] |
25 | CNOT10 | CCR4-NOT transcription complex subunit 10 | [169] | 0.53[170] | 0.96[171] | 1.77[172] | 1.02[173] | 1.47[174] | 2.22[175] |
26 | BTG2 | Protein BTG2 | [176] | 1.77[177] | 0.38[178] | 0.40[179] | -0.92[180] | 0.09[181] | 1.08[182] |
27 | PCBP4 | Poly(rC)-binding protein 4 | [183] | 3.23[184] | 2.19[185] | 1.10[186] | 1.26[187] | 1.49[188] | 0.57[189] |
28 | CNOT4 | CCR4-NOT transcription complex subunit 4 | [190] | -0.24[191] | -0.54[192] | -0.11[193] | 1.09[194] | 0.59[195] | 2.40[196] |
29 | CCNE1 | G1/S-specific cyclin-E1 | [197] | 1.67[198] | 1.50[199] | -0.55[200] | 0.53[201] | 0.81[202] | -2.76[203] |
30 | CCNA2 | Cyclin-A2 | [204] | 2.63[205] | 3.37[206] | 2.47[207] | 2.94[208] | 4.01[209] | 0.65[210] |
31 | ARID3A | AT-rich interactive domain-containing protein 3A | [211] | 3.11[212] | 3.20[213] | 3.01[214] | 0.53[215] | -1.22[216] | -0.51[217] |
32 | E2F1 | Transcription factor E2F1 | [218] | 2.37[219] | 1.95[220] | 1.84[221] | 2.80[222] | 2.92[223] | -1.74[224] |
33 | EP300 | Histone acetyltransferase p300 | [225] | 3.15[226] | 2.46[227] | 3.12[228] | 3.51[229] | 3.24[230] | 4.63[231] |
34 | PLK3 | Serine/threonine-protein kinase PLK3 | [232] | 1.12[233] | 0.72[234] | -2.56[235] | 0.01[236] | 0.91[237] | 0.57[238] |
35 | TFDP2 | Transcription factor Dp-2 | [239] | 2.33[240] | 2.75[241] | 2.53[242] | 3.32[243] | 3.23[244] | 4.23[245] |
36 | CNOT6L | CCR4-NOT transcription complex subunit 6-like | [246] | 1.81[247] | 2.65[248] | 2.06[249] | 2.52[250] | 2.44[251] | 4.99[252] |
37 | CNOT6 | CCR4-NOT transcription complex subunit 6 | [253] | 2.90[254] | 2.96[255] | 3.61[256] | 3.97[257] | 3.49[258] | 3.52[259] |
38 | CCNE2 | G1/S-specific cyclin-E2 | [260] | 0.85[261] | 0.97[262] | 0.27[263] | 3.98[264] | 3.55[265] | 1.52[266] |
39 | RBL1 | Retinoblastoma-like protein 1 | [267] | 2.21[268] | 2.80[269] | 1.19[270] | 3.75[271] | 3.76[272] | 2.55[273] |
40 | ZNF385A | Zinc finger protein 385A | [274] | 1.98[275] | -1.35[276] | -0.67[277] | 2.52[278] | 2.27[279] | 1.48[280] |
41 | CENPJ | Centromere protein J | [281] | 0.91[282] | 2.40[283] | 2.32[284] | 3.76[285] | 2.77[286] | 2.68[287] |
42 | CDC25C | M-phase inducer phosphatase 3 | [288] | 2.36[289] | 3.24[290] | 3.03[291] | 2.86[292] | 3.39[293] | 0.46[294] |
43 | RGCC | Regulator of cell cycle RGCC | [295] | -0.09[296] | -1.21[297] | -0.79[298] | -5.72[299] | -4.03[300] | 0.70[301] |
44 | E2F8 | Transcription factor E2F8 | [302] | 3.54[303] | 3.45[304] | 3.62[305] | 4.65[306] | 3.79[307] | 1.99[308] |
45 | PLAGL1 | Zinc finger protein PLAGL1 | [309] | 1.87[310] | 1.21[311] | 3.25[312] | -4.22[313] | 5.34[314] | 3.82[315] |
46 | E2F7 | Transcription factor E2F7 | [316] | 5.23[317] | 4.63[318] | 2.08[319] | 6.22[320] | 6.57[321] | 2.95[322] |
47 | CCNA1 | Cyclin-A1 | [323] | [324] | -3.24[325] | [326] | 0.14[327] | 7.23[328] | [329] |
48 | CNOT9 | CCR4-NOT transcription complex subunit 9 | [330] | [331] | [332] | [333] | [334] | [335] | [336] |
49 | CNOT11 | CCR4-NOT transcription complex subunit 11 | [337] | [338] | [339] | [340] | [341] | [342] | [343] |