REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CASPASE_ACTIVATORS_AND_CASPASES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CRADD Death domain-containing protein CRADD [1] -2.48[2] -1.79[3] -4.17[4] -3.29[5] -3.64[6] -1.67[7]
2 CASP6 Caspase-6 [8] -1.61[9] -2.02[10] -1.61[11] -1.65[12] -1.68[13] -1.71[14]
3 TP53 Cellular tumor antigen p53 [15] 1.30[16] 0.24[17] 1.04[18] 0.59[19] 0.56[20] -0.87[21]
4 CASP1 Caspase-1 [22] -3.37[23] -7.40[24] -5.82[25] -0.62[26] -0.16[27] -1.56[28]
5 CASP10 Caspase-10 [29] 0.88[30] 1.54[31] 0.55[32] -0.28[33] 0.08[34] 0.24[35]
6 CASP2 Caspase-2 [36] 1.36[37] 0.37[38] 1.22[39] 1.17[40] 1.90[41] 0.75[42]
7 APAF1 Apoptotic protease-activating factor 1 [43] 1.32[44] 1.12[45] 1.42[46] 1.93[47] 1.33[48] 0.66[49]
8 ATM Serine-protein kinase ATM [50] 2.69[51] 3.67[52] 3.44[53] 3.46[54] 3.24[55] 4.16[56]
9 TP73 Tumor protein p73 [57] 0.38[58] 2.31[59] 1.28[60] -0.02[61] 1.41[62] -0.18[63]
10 NLRC4 NLR family CARD domain-containing protein 4 [64] -1.20[65] 1.00[66] 0.38[67] 0.24[68] -0.49[69] 2.21[70]
11 TP63 Tumor protein 63 [71] [72] [73] -2.98[74] -2.07[75] -5.35[76] -2.31[77]
12 PIDD1 p53-induced death domain-containing protein 1 [78] [79] [80] [81] [82] [83] [84]
[1]
ref_hepatocyte CRADD
Mean 11.8
Standard deviation 4
Values 12 13 5.7 17 12
[2]
HepG2 CRADD
Mean 5.95
Standard deviation 0.72
Values 6.5 5.4
[3]
HepG2.C3A CRADD
Mean 13.1
Standard deviation 1.3
Values 12 14
[4]
HuH.7 CRADD
Mean 2.34
Standard deviation 0.43
Values 1.9 2.8 2.4
[5]
SNU475 CRADD
Mean 3.61
Standard deviation 1.6
Values 4.7 2.5
[6]
THLE CRADD
Mean 2.57
Standard deviation 0.15
Values 2.5 2.7
[7]
liver CRADD
Mean 9.42
Standard deviation 3.6
Values 13 5.6 12 7.1
[8]
ref_hepatocyte CASP6
Mean 8.44
Standard deviation 1.3
Values 8.6 10 7.9 7 8.2
[9]
HepG2 CASP6
Mean 7.74
Standard deviation 2.2
Values 6.2 9.3
[10]
HepG2.C3A CASP6
Mean 7.97
Standard deviation 4.4
Values 4.9 11
[11]
HuH.7 CASP6
Mean 9.83
Standard deviation 3.2
Values 10 6.4 13
[12]
SNU475 CASP6
Mean 8.02
Standard deviation 2.2
Values 9.5 6.5
[13]
THLE CASP6
Mean 7.17
Standard deviation 0.61
Values 6.7 7.6
[14]
liver CASP6
Mean 6.51
Standard deviation 3
Values 9.1 4 9.2 3.8
[15]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[16]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[17]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[18]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[19]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[20]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[21]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[22]
ref_hepatocyte CASP1
Mean 3.66
Standard deviation 3.7
Values 0.5 9.1 0.076 3.7 4.9
[23]
HepG2 CASP1
Mean 0.987
Standard deviation 0.74
Values 0.46 1.5
[24]
HepG2.C3A CASP1
Mean 0.0833
Standard deviation 0.049
Values 0.049 0.12
[25]
HuH.7 CASP1
Mean 0.231
Standard deviation 0.041
Values 0.19 0.27 0.23
[26]
SNU475 CASP1
Mean 7.12
Standard deviation 0.23
Values 7.3 6.9
[27]
THLE CASP1
Mean 8.87
Standard deviation 1.2
Values 9.7 8
[28]
liver CASP1
Mean 3.13
Standard deviation 0.99
Values 3.7 2.6 4.2 2
[29]
ref_hepatocyte CASP10
Mean 1.74
Standard deviation 0.76
Values 3 1 1.8 1.3 1.6
[30]
HepG2 CASP10
Mean 8.95
Standard deviation 0.044
Values 9 8.9
[31]
HepG2.C3A CASP10
Mean 19.5
Standard deviation 6.6
Values 24 15
[32]
HuH.7 CASP10
Mean 9.07
Standard deviation 0.43
Values 9 9.5 8.7
[33]
SNU475 CASP10
Mean 4.29
Standard deviation 1.6
Values 5.5 3.1
[34]
THLE CASP10
Mean 5
Standard deviation 0.38
Values 5.3 4.7
[35]
liver CASP10
Mean 5.18
Standard deviation 1.9
Values 3.7 7.8 3.9 5.3
[36]
ref_hepatocyte CASP2
Mean 1.49
Standard deviation 0.81
Values 2.9 1 1.5 0.94 1.1
[37]
HepG2 CASP2
Mean 10.7
Standard deviation 1.9
Values 9.4 12
[38]
HepG2.C3A CASP2
Mean 7.41
Standard deviation 0.75
Values 6.9 7.9
[39]
HuH.7 CASP2
Mean 12.4
Standard deviation 4.7
Values 15 6.9 15
[40]
SNU475 CASP2
Mean 10
Standard deviation 0.13
Values 9.9 10
[41]
THLE CASP2
Mean 15.2
Standard deviation 2.5
Values 13 17
[42]
liver CASP2
Mean 6.36
Standard deviation 2.4
Values 7.2 5.2 9.2 3.8
[43]
ref_hepatocyte APAF1
Mean 1.36
Standard deviation 0.48
Values 1.9 1.8 1.2 0.79 1.1
[44]
HepG2 APAF1
Mean 9.46
Standard deviation 4.9
Values 6 13
[45]
HepG2.C3A APAF1
Mean 11.3
Standard deviation 2.5
Values 9.5 13
[46]
HuH.7 APAF1
Mean 12.9
Standard deviation 2.1
Values 15 12 12
[47]
SNU475 APAF1
Mean 15.4
Standard deviation 1.9
Values 17 14
[48]
THLE APAF1
Mean 9.25
Standard deviation 1.4
Values 8.2 10
[49]
liver APAF1
Mean 5.4
Standard deviation 3.4
Values 2.4 8.5 2.5 8.2
[50]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 2.1 0.69 0.27 0.7 1.1
[51]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 12 23
[52]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 44 51
[53]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 41 44 27
[54]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 38 26
[55]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[56]
liver ATM
Mean 43.7
Standard deviation 31
Values 17 76 17 64
[57]
ref_hepatocyte TP73
Mean 0.183
Standard deviation 0.15
Values 0.4 0 0.19 0.23 0.098
[58]
HepG2 TP73
Mean 0.666
Standard deviation 0.13
Values 0.57 0.76
[59]
HepG2.C3A TP73
Mean 3.48
Standard deviation 0.49
Values 3.1 3.8
[60]
HuH.7 TP73
Mean 1.58
Standard deviation 0.41
Values 2.1 1.4 1.3
[61]
SNU475 TP73
Mean 0.537
Standard deviation 0.035
Values 0.56 0.51
[62]
THLE TP73
Mean 1.32
Standard deviation 0.075
Values 1.3 1.4
[63]
liver TP73
Mean 0.407
Standard deviation 0.19
Values 0.19 0.47 0.33 0.64
[64]
ref_hepatocyte NLRC4
Mean 0.121
Standard deviation 0.1
Values 0.073 0 0.18 0.086 0.27
[65]
HepG2 NLRC4
Mean 0.147
Standard deviation 0.044
Values 0.18 0.12
[66]
HepG2.C3A NLRC4
Mean 0.925
Standard deviation 0.25
Values 1.1 0.75
[67]
HuH.7 NLRC4
Mean 0.559
Standard deviation 0.068
Values 0.52 0.51 0.64
[68]
SNU475 NLRC4
Mean 0.426
Standard deviation 0.21
Values 0.28 0.57
[69]
THLE NLRC4
Mean 0.233
Standard deviation 0.097
Values 0.3 0.16
[70]
liver NLRC4
Mean 1.41
Standard deviation 0.51
Values 1.1 1.9 0.85 1.8
[71]
ref_hepatocyte TP63
Mean 0.0845
Standard deviation 0.17
Values 0 0.026 0.4 0 0
[72]
HepG2 TP63
Mean 0
Standard deviation 0
Values 0 0
[73]
HepG2.C3A TP63
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 TP63
Mean 0.038
Standard deviation 0.033
Values 0 0.058 0.056
[75]
SNU475 TP63
Mean 0.06
Standard deviation 0.059
Values 0.019 0.1
[76]
THLE TP63
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[77]
liver TP63
Mean 0.0431
Standard deviation 0.045
Values 0.024 0.043 0 0.11
[78]
ref_hepatocyte PIDD1
Missing
[79]
HepG2 PIDD1
Missing
[80]
HepG2.C3A PIDD1
Missing
[81]
HuH.7 PIDD1
Missing
[82]
SNU475 PIDD1
Missing
[83]
THLE PIDD1
Missing
[84]
liver PIDD1
Missing