REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WH			Return to index
Order	Gene	Description	ref_hepatocyte	HepG2	HepG2.C3A	HuH.7	SNU475	THLE	liver
1	NPM1	Nucleophosmin	[1]	-0.80[2]	-0.51[3]	-0.40[4]	-1.17[5]	-1.12[6]	-1.90[7]
2	PLK2	Serine/threonine-protein kinase PLK2	[8]	-1.78[9]	-4.36[10]	-6.10[11]	1.59[12]	-1.42[13]	-0.58[14]
3	CNOT7	CCR4-NOT transcription complex subunit 7	[15]	0.96[16]	0.91[17]	0.75[18]	0.66[19]	0.75[20]	1.94[21]
4	TNKS1BP1	182 kDa tankyrase-1-binding protein	[22]	1.29[23]	-0.19[24]	-0.32[25]	2.54[26]	2.47[27]	2.64[28]
5	CNOT8	CCR4-NOT transcription complex subunit 8	[29]	1.43[30]	1.45[31]	1.49[32]	1.61[33]	1.86[34]	1.80[35]
6	CNOT1	CCR4-NOT transcription complex subunit 1	[36]	4.00[37]	3.54[38]	3.40[39]	3.64[40]	4.26[41]	4.62[42]
7	CNOT2	CCR4-NOT transcription complex subunit 2	[43]	1.40[44]	1.64[45]	1.00[46]	2.12[47]	2.01[48]	2.80[49]
8	CNOT3	CCR4-NOT transcription complex subunit 3	[50]	1.27[51]	0.44[52]	1.12[53]	1.89[54]	1.61[55]	0.70[56]
9	TP53	Cellular tumor antigen p53	[57]	2.73[58]	1.72[59]	1.90[60]	2.60[61]	2.28[62]	2.00[63]
10	CNOT10	CCR4-NOT transcription complex subunit 10	[64]	1.19[65]	1.33[66]	1.79[67]	1.39[68]	2.19[69]	2.39[70]
11	BTG2	Protein BTG2	[71]	2.43[72]	0.75[73]	0.43[74]	-0.55[75]	0.80[76]	1.25[77]
12	CNOT4	CCR4-NOT transcription complex subunit 4	[78]	0.42[79]	-0.17[80]	-0.09[81]	1.46[82]	1.31[83]	2.57[84]
13	PLK3	Serine/threonine-protein kinase PLK3	[85]	1.78[86]	1.09[87]	-2.53[88]	0.38[89]	1.62[90]	0.74[91]
14	CNOT6L	CCR4-NOT transcription complex subunit 6-like	[92]	2.47[93]	3.02[94]	2.09[95]	2.89[96]	3.15[97]	5.16[98]
15	CNOT6	CCR4-NOT transcription complex subunit 6	[99]	3.56[100]	3.33[101]	3.64[102]	4.34[103]	4.20[104]	3.69[105]
16	CENPJ	Centromere protein J	[106]	1.57[107]	2.77[108]	2.35[109]	4.13[110]	3.49[111]	2.85[112]
17	CDC25C	M-phase inducer phosphatase 3	[113]	3.02[114]	3.61[115]	3.06[116]	3.23[117]	4.10[118]	0.63[119]
18	RGCC	Regulator of cell cycle RGCC	[120]	0.57[121]	-0.84[122]	-0.76[123]	-5.35[124]	-3.31[125]	0.87[126]
19	PLAGL1	Zinc finger protein PLAGL1	[127]	2.53[128]	1.58[129]	3.28[130]	-3.85[131]	6.06[132]	3.99[133]
20	CNOT9	CCR4-NOT transcription complex subunit 9	[134]	[135]	[136]	[137]	[138]	[139]	[140]
21	CNOT11	CCR4-NOT transcription complex subunit 11	[141]	[142]	[143]	[144]	[145]	[146]	[147]

ref_hepatocyte NPM1
Mean 751
Standard deviation 7.3e+02
Values 1.1e+03 1.9e+03 4.5e+02 2.1e+02 1.2e+02

HepG2 NPM1
Mean 448
Standard deviation 23
Values 4.3e+02 4.6e+02

HepG2.C3A NPM1
Mean 727
Standard deviation 15
Values 7.2e+02 7.4e+02

HuH.7 NPM1
Mean 1.12e+03
Standard deviation 1e+02
Values 1e+03 1.2e+03 1.2e+03

SNU475 NPM1
Mean 248
Standard deviation 24
Values 2.3e+02 2.6e+02

THLE NPM1
Mean 283
Standard deviation 68
Values 2.3e+02 3.3e+02

liver NPM1
Mean 69.2
Standard deviation 20
Values 69 85 81 41

ref_hepatocyte PLK2
Mean 34.3
Standard deviation 52
Values 3.3 1.3e+02 34 7.4 1.6

HepG2 PLK2
Mean 10.3
Standard deviation 2.5
Values 12 8.6

HepG2.C3A PLK2
Mean 2.29
Standard deviation 0.33
Values 2.1 2.5

HuH.7 PLK2
Mean 0.986
Standard deviation 0.06
Values 1 1 0.92

SNU475 PLK2
Mean 76.6
Standard deviation 8.6
Values 83 70

THLE PLK2
Mean 10.5
Standard deviation 1.4
Values 9.5 12

liver PLK2
Mean 7.9
Standard deviation 1.8
Values 10 6.1 8.5 6.9

ref_hepatocyte CNOT7
Mean 22.4
Standard deviation 8.4
Values 30 32 21 13 16

HepG2 CNOT7
Mean 45.3
Standard deviation 9.7
Values 38 52

HepG2.C3A CNOT7
Mean 57.8
Standard deviation 6.7
Values 53 62

HuH.7 CNOT7
Mean 74.2
Standard deviation 2.9
Values 77 71 75

SNU475 CNOT7
Mean 26.3
Standard deviation 0.76
Values 26 27

THLE CNOT7
Mean 30.9
Standard deviation 1.5
Values 32 30

liver CNOT7
Mean 29.6
Standard deviation 13
Values 44 22 37 16

ref_hepatocyte TNKS1BP1
Mean 11.8
Standard deviation 4.3
Values 5.1 9.8 15 15 14

HepG2 TNKS1BP1
Mean 30
Standard deviation 1.9
Values 31 29

HepG2.C3A TNKS1BP1
Mean 14.2
Standard deviation 3.8
Values 17 11

HuH.7 TNKS1BP1
Mean 18.5
Standard deviation 3.7
Values 22 15 19

SNU475 TNKS1BP1
Mean 50.8
Standard deviation 10
Values 58 44

THLE TNKS1BP1
Mean 53.6
Standard deviation 7.1
Values 49 59

liver TNKS1BP1
Mean 25.3
Standard deviation 14
Values 17 36 10 38

ref_hepatocyte CNOT8
Mean 9.07
Standard deviation 2.5
Values 12 8.6 5.7 10 8.2

HepG2 CNOT8
Mean 25.4
Standard deviation 5.2
Values 22 29

HepG2.C3A CNOT8
Mean 34.1
Standard deviation 5.1
Values 38 30

HuH.7 CNOT8
Mean 50.1
Standard deviation 8.4
Values 47 44 60

SNU475 CNOT8
Mean 20.5
Standard deviation 1.9
Values 22 19

THLE CNOT8
Mean 27
Standard deviation 3.2
Values 25 29

liver CNOT8
Mean 10.9
Standard deviation 2.6
Values 14 8.3 12 9.3

ref_hepatocyte CNOT1
Mean 8.47
Standard deviation 4.2
Values 16 7.4 8.4 5.5 5.4

HepG2 CNOT1
Mean 140
Standard deviation 43
Values 1.1e+02 1.7e+02

HepG2.C3A CNOT1
Mean 135
Standard deviation 8.6
Values 1.3e+02 1.4e+02

HuH.7 CNOT1
Mean 176
Standard deviation 52
Values 2.3e+02 1.6e+02 1.3e+02

SNU475 CNOT1
Mean 78.7
Standard deviation 1.2
Values 79 78

THLE CNOT1
Mean 133
Standard deviation 7.1
Values 1.3e+02 1.4e+02

liver CNOT1
Mean 71.6
Standard deviation 40
Values 36 1e+02 38 1.1e+02

ref_hepatocyte CNOT2
Mean 7.04
Standard deviation 1.3
Values 6.3 8.2 8.7 6.2 5.7

HepG2 CNOT2
Mean 19.3
Standard deviation 6.8
Values 14 24

HepG2.C3A CNOT2
Mean 30
Standard deviation 5
Values 27 34

HuH.7 CNOT2
Mean 27.6
Standard deviation 1.4
Values 29 28 26

SNU475 CNOT2
Mean 22.7
Standard deviation 1.9
Values 24 21

THLE CNOT2
Mean 23.2
Standard deviation 1.4
Values 22 24

liver CNOT2
Mean 16.8
Standard deviation 2.6
Values 20 17 16 14

ref_hepatocyte CNOT3
Mean 6.59
Standard deviation 6.4
Values 3.1 1.7 17 7.4 3.3

HepG2 CNOT3
Mean 16.6
Standard deviation 1.3
Values 17 16

HepG2.C3A CNOT3
Mean 12.3
Standard deviation 1.5
Values 13 11

HuH.7 CNOT3
Mean 28.1
Standard deviation 3
Values 30 25 29

SNU475 CNOT3
Mean 18.2
Standard deviation 0.65
Values 19 18

THLE CNOT3
Mean 16.5
Standard deviation 1.8
Values 15 18

liver CNOT3
Mean 3.7
Standard deviation 0.74
Values 4.1 2.6 4 4.1

ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5

HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36

HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25

HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46

SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19

THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26

liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6

ref_hepatocyte CNOT10
Mean 4.56
Standard deviation 0.49
Values 4.7 5.2 4.5 4.5 3.8

HepG2 CNOT10
Mean 10.8
Standard deviation 2.1
Values 9.4 12

HepG2.C3A CNOT10
Mean 15.7
Standard deviation 0.95
Values 15 16

HuH.7 CNOT10
Mean 31.1
Standard deviation 1.2
Values 31 32 30

SNU475 CNOT10
Mean 8.9
Standard deviation 1.9
Values 7.6 10

THLE CNOT10
Mean 17
Standard deviation 1.1
Values 16 18

liver CNOT10
Mean 8.23
Standard deviation 1.8
Values 8.3 7.8 11 6.2

ref_hepatocyte BTG2
Mean 3.73
Standard deviation 1.8
Values 6 4.7 1.1 3.4 3.4

HepG2 BTG2
Mean 20.9
Standard deviation 1.3
Values 22 20

HepG2.C3A BTG2
Mean 8.6
Standard deviation 3.5
Values 6.1 11

HuH.7 BTG2
Mean 9.87
Standard deviation 2.6
Values 8.6 13 8.2

SNU475 BTG2
Mean 1.89
Standard deviation 0.18
Values 1.8 2

THLE BTG2
Mean 5.34
Standard deviation 0.43
Values 5.6 5

liver BTG2
Mean 3.06
Standard deviation 1.9
Values 5.7 1.3 3.1 2.1

ref_hepatocyte CNOT4
Mean 3.66
Standard deviation 1.4
Values 3.2 4.1 5.8 2.2 3.1

HepG2 CNOT4
Mean 5.09
Standard deviation 1.1
Values 4.3 5.9

HepG2.C3A CNOT4
Mean 4.45
Standard deviation 0.073
Values 4.5 4.4

HuH.7 CNOT4
Mean 6.77
Standard deviation 0.65
Values 7.4 6.8 6.1

SNU475 CNOT4
Mean 7.48
Standard deviation 0.28
Values 7.3 7.7

THLE CNOT4
Mean 7.42
Standard deviation 0.36
Values 7.2 7.7

liver CNOT4
Mean 7.49
Standard deviation 2.9
Values 10 5.1 9.9 4.8

ref_hepatocyte PLK3
Mean 2.39
Standard deviation 2.2
Values 0.3 2 5.7 3.3 0.58

HepG2 PLK3
Mean 8.55
Standard deviation 3
Values 11 6.5

HepG2.C3A PLK3
Mean 7
Standard deviation 2
Values 8.4 5.6

HuH.7 PLK3
Mean 0.812
Standard deviation 0.22
Values 1 0.56 0.87

SNU475 PLK3
Mean 2.31
Standard deviation 1.5
Values 1.2 3.4

THLE PLK3
Mean 6.03
Standard deviation 0.48
Values 5.7 6.4

liver PLK3
Mean 1.37
Standard deviation 0.46
Values 1.3 1 1.2 2

ref_hepatocyte CNOT6L
Mean 1.65
Standard deviation 0.86
Values 3.1 1.5 1.1 0.91 1.7

HepG2 CNOT6L
Mean 9.5
Standard deviation 3.7
Values 6.9 12

HepG2.C3A CNOT6L
Mean 18.4
Standard deviation 2.2
Values 20 17

HuH.7 CNOT6L
Mean 13.8
Standard deviation 4.3
Values 14 18 9.7

SNU475 CNOT6L
Mean 9.1
Standard deviation 0.058
Values 9.1 9.1

THLE CNOT6L
Mean 12
Standard deviation 2
Values 11 13

liver CNOT6L
Mean 20.4
Standard deviation 4.6
Values 19 27 16 20

ref_hepatocyte CNOT6
Mean 1.39
Standard deviation 0.83
Values 2.8 1.4 1.3 0.75 0.78

HepG2 CNOT6
Mean 17
Standard deviation 4
Values 14 20

HepG2.C3A CNOT6
Mean 19.2
Standard deviation 2.8
Values 17 21

HuH.7 CNOT6
Mean 34
Standard deviation 8.1
Values 43 27 32

SNU475 CNOT6
Mean 20.9
Standard deviation 1.8
Values 22 20

THLE CNOT6
Mean 21
Standard deviation 2.7
Values 19 23

liver CNOT6
Mean 6.17
Standard deviation 2.1
Values 4.3 8.7 4.5 7.1

ref_hepatocyte CENPJ
Mean 0.807
Standard deviation 0.53
Values 1.3 0.99 1.2 0.24 0.24

HepG2 CENPJ
Mean 2.48
Standard deviation 1.1
Values 1.7 3.2

HepG2.C3A CENPJ
Mean 7.53
Standard deviation 3.6
Values 5 10

HuH.7 CENPJ
Mean 8.07
Standard deviation 1.6
Values 9.4 6.3 8.5

SNU475 CENPJ
Mean 10.5
Standard deviation 1.1
Values 9.7 11

THLE CENPJ
Mean 7.42
Standard deviation 0.1
Values 7.3 7.5

liver CENPJ
Mean 2
Standard deviation 0.45
Values 1.8 2.7 1.7 1.8

ref_hepatocyte CDC25C
Mean 0.731
Standard deviation 0.89
Values 2 1.3 0.11 0.078 0.13

HepG2 CDC25C
Mean 6.16
Standard deviation 0.58
Values 5.7 6.6

HepG2.C3A CDC25C
Mean 12.2
Standard deviation 6.2
Values 7.8 17

HuH.7 CDC25C
Mean 12
Standard deviation 5.4
Values 14 5.9 16

SNU475 CDC25C
Mean 5.11
Standard deviation 0.28
Values 5.3 4.9

THLE CDC25C
Mean 10.3
Standard deviation 1.8
Values 9 12

liver CDC25C
Mean 0.389
Standard deviation 0.27
Values 0.45 0.43 0.67 0.013

ref_hepatocyte RGCC
Mean 0.685
Standard deviation 0.78
Values 0 0 1.9 0.78 0.74

HepG2 RGCC
Mean 1.05
Standard deviation 1
Values 1.8 0.34

HepG2.C3A RGCC
Mean 0.526
Standard deviation 0.42
Values 0.83 0.23

HuH.7 RGCC
Mean 0.794
Standard deviation 0.32
Values 0.59 0.63 1.2

SNU475 RGCC
Mean 0.0125
Standard deviation 0.011
Values 0.0046 0.02

THLE RGCC
Mean 0.0565
Standard deviation 0.012
Values 0.065 0.048

liver RGCC
Mean 0.431
Standard deviation 0.27
Values 0.49 0.31 0.77 0.15

ref_hepatocyte PLAGL1
Mean 0.188
Standard deviation 0.12
Values 0.39 0.085 0.17 0.21 0.089

HepG2 PLAGL1
Mean 1.13
Standard deviation 0.63
Values 1.6 0.68

HepG2.C3A PLAGL1
Mean 0.772
Standard deviation 0.076
Values 0.83 0.72

HuH.7 PLAGL1
Mean 3.59
Standard deviation 0.98
Values 2.7 4.7 3.4

SNU475 PLAGL1
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01

THLE PLAGL1
Mean 10.3
Standard deviation 0.048
Values 10 10

liver PLAGL1
Mean 1.03
Standard deviation 0.44
Values 1.4 0.64 1.4 0.66

ref_hepatocyte CNOT9
Missing

HepG2 CNOT9
Missing

HepG2.C3A CNOT9
Missing

HuH.7 CNOT9
Missing

SNU475 CNOT9
Missing

THLE CNOT9
Missing

liver CNOT9
Missing

ref_hepatocyte CNOT11
Missing

HepG2 CNOT11
Mean 55.3
Standard deviation 3.3
Values 53 58

HepG2.C3A CNOT11
Mean 71.5
Standard deviation 0.066
Values 72 71

HuH.7 CNOT11
Mean 69.4
Standard deviation 10
Values 76 58 75

SNU475 CNOT11
Mean 19
Standard deviation 2
Values 20 18

THLE CNOT11
Mean 22.8
Standard deviation 2.8
Values 21 25

liver CNOT11
Mean 8.79
Standard deviation 2.2
Values 12 7 9.8 6.9