REACTOME_TP53_REGULATES_METABOLIC_GENES |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
TXN |
Thioredoxin |
[1] |
-1.81[2] |
-1.76[3] |
-2.22[4] |
-1.68[5] |
-1.60[6] |
-2.05[7] |
2 |
PRDX1 |
Peroxiredoxin-1 |
[8] |
-0.39[9] |
-1.07[10] |
-0.62[11] |
-0.97[12] |
-0.99[13] |
-0.92[14] |
3 |
COX4I1 |
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
[15] |
-1.12[16] |
-0.90[17] |
-0.57[18] |
-2.13[19] |
-1.19[20] |
-0.97[21] |
4 |
COX7C |
Cytochrome c oxidase subunit 7C, mitochondrial |
[22] |
-1.72[23] |
-1.12[24] |
-0.58[25] |
-2.29[26] |
-1.70[27] |
-0.89[28] |
5 |
GPX2 |
Glutathione peroxidase 2 |
[29] |
0.25[30] |
-0.43[31] |
-2.56[32] |
-10.38[33] |
-10.02[34] |
0.67[35] |
6 |
COX6A1 |
Cytochrome c oxidase subunit 6A1, mitochondrial |
[36] |
-1.48[37] |
-0.65[38] |
-0.94[39] |
-2.45[40] |
-1.58[41] |
-0.38[42] |
7 |
YWHAE |
14-3-3 protein epsilon |
[43] |
-0.13[44] |
-0.03[45] |
0.34[46] |
-0.08[47] |
0.50[48] |
-0.34[49] |
8 |
COX5B |
Cytochrome c oxidase subunit 5B, mitochondrial |
[50] |
-1.37[51] |
-1.09[52] |
-1.01[53] |
-2.61[54] |
-1.65[55] |
-0.85[56] |
9 |
TXNRD1 |
Thioredoxin reductase 1, cytoplasmic |
[57] |
0.51[58] |
-0.31[59] |
-0.44[60] |
2.25[61] |
1.49[62] |
-0.84[63] |
10 |
YWHAZ |
14-3-3 protein zeta/delta |
[64] |
0.54[65] |
0.37[66] |
0.71[67] |
1.69[68] |
0.80[69] |
-0.43[70] |
11 |
PRDX5 |
Peroxiredoxin-5, mitochondrial |
[71] |
-0.87[72] |
-0.76[73] |
-0.38[74] |
-1.21[75] |
-1.67[76] |
-1.20[77] |
12 |
COX7B |
Cytochrome c oxidase subunit 7B, mitochondrial |
[78] |
-2.16[79] |
-1.73[80] |
-1.71[81] |
-1.87[82] |
-1.59[83] |
-0.55[84] |
13 |
COX6B1 |
Cytochrome c oxidase subunit 6B1 |
[85] |
-1.24[86] |
-1.08[87] |
-0.46[88] |
-1.89[89] |
-1.28[90] |
-0.64[91] |
14 |
COX8A |
Cytochrome c oxidase subunit 8A, mitochondrial |
[92] |
-0.92[93] |
-1.20[94] |
-0.97[95] |
-1.65[96] |
-0.60[97] |
-0.79[98] |
15 |
COX7A2L |
Cytochrome c oxidase subunit 7A-related protein, mitochondrial |
[99] |
-0.54[100] |
-0.04[101] |
-0.68[102] |
-1.91[103] |
-1.56[104] |
-1.19[105] |
16 |
PRDX2 |
Peroxiredoxin-2 |
[106] |
0.14[107] |
0.23[108] |
0.21[109] |
-2.00[110] |
-0.31[111] |
0.31[112] |
17 |
COX6C |
Cytochrome c oxidase subunit 6C |
[113] |
-1.50[114] |
-1.12[115] |
-1.22[116] |
-1.34[117] |
-1.27[118] |
0.09[119] |
18 |
COX5A |
Cytochrome c oxidase subunit 5A, mitochondrial |
[120] |
-0.57[121] |
-0.77[122] |
-0.09[123] |
-1.38[124] |
-0.63[125] |
0.05[126] |
19 |
RHEB |
GTP-binding protein Rheb |
[127] |
-0.84[128] |
-0.27[129] |
-0.33[130] |
-0.32[131] |
0.33[132] |
0.13[133] |
20 |
YWHAH |
14-3-3 protein eta |
[134] |
-0.26[135] |
-0.68[136] |
-0.69[137] |
-0.41[138] |
-0.28[139] |
-0.74[140] |
21 |
YWHAQ |
14-3-3 protein theta |
[141] |
1.37[142] |
1.17[143] |
0.90[144] |
2.14[145] |
2.00[146] |
0.62[147] |
22 |
LAMTOR2 |
Ragulator complex protein LAMTOR2 |
[148] |
-2.31[149] |
-2.29[150] |
-2.49[151] |
-2.75[152] |
-2.02[153] |
-0.96[154] |
23 |
SFN |
14-3-3 protein sigma |
[155] |
-1.25[156] |
-1.62[157] |
-1.21[158] |
-7.05[159] |
-7.44[160] |
-8.88[161] |
24 |
NDUFA4 |
Cytochrome c oxidase subunit NDUFA4 |
[162] |
0.22[163] |
0.94[164] |
1.21[165] |
-0.28[166] |
0.70[167] |
1.44[168] |
25 |
YWHAG |
14-3-3 protein gamma |
[169] |
1.31[170] |
0.76[171] |
0.84[172] |
1.50[173] |
1.34[174] |
-0.12[175] |
26 |
YWHAB |
14-3-3 protein beta/alpha |
[176] |
2.15[177] |
1.85[178] |
1.15[179] |
2.08[180] |
2.05[181] |
1.12[182] |
27 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[183] |
1.19[184] |
0.94[185] |
-0.12[186] |
0.73[187] |
1.29[188] |
0.97[189] |
28 |
LAMTOR1 |
Ragulator complex protein LAMTOR1 |
[190] |
0.48[191] |
-0.27[192] |
-0.34[193] |
-0.30[194] |
0.20[195] |
-0.08[196] |
29 |
COX14 |
Cytochrome c oxidase assembly protein COX14 |
[197] |
-0.98[198] |
-0.85[199] |
-1.08[200] |
-1.68[201] |
-1.56[202] |
0.01[203] |
30 |
DDIT4 |
DNA damage-inducible transcript 4 protein |
[204] |
1.96[205] |
2.62[206] |
1.16[207] |
-1.30[208] |
2.20[209] |
0.48[210] |
31 |
GSR |
Glutathione reductase, mitochondrial |
[211] |
1.63[212] |
1.23[213] |
1.72[214] |
1.58[215] |
0.53[216] |
0.36[217] |
32 |
TACO1 |
Translational activator of cytochrome c oxidase 1 |
[218] |
-0.41[219] |
-0.27[220] |
-0.56[221] |
-1.87[222] |
-1.15[223] |
0.20[224] |
33 |
RRAGA |
Ras-related GTP-binding protein A |
[225] |
1.42[226] |
0.65[227] |
-0.60[228] |
-0.25[229] |
0.88[230] |
0.38[231] |
34 |
GPI |
Glucose-6-phosphate isomerase |
[232] |
2.88[233] |
2.12[234] |
2.94[235] |
2.48[236] |
2.71[237] |
3.05[238] |
35 |
SURF1 |
Surfeit locus protein 1 |
[239] |
-0.74[240] |
-0.49[241] |
-0.28[242] |
-1.13[243] |
-0.81[244] |
0.62[245] |
36 |
COX11 |
Cytochrome c oxidase assembly protein COX11, mitochondrial |
[246] |
0.51[247] |
1.42[248] |
0.79[249] |
-1.71[250] |
-0.05[251] |
-0.11[252] |
37 |
SCO1 |
Protein SCO1 homolog, mitochondrial |
[253] |
-0.10[254] |
-0.47[255] |
-0.48[256] |
-0.81[257] |
-0.12[258] |
-0.10[259] |
38 |
COX16 |
Cytochrome c oxidase assembly
protein COX16 homolog, mitochondrial |
-1.79[260] |
-1.28[261] |
-2.04[262] |
-2.14[263] |
-1.66[264] |
-1.32[265] |
39 |
LRPPRC |
Leucine-rich PPR motif-containing protein, mitochondrial |
[266] |
2.52[267] |
3.75[268] |
3.05[269] |
2.06[270] |
2.13[271] |
2.28[272] |
40 |
PRKAG1 |
5'-AMP-activated protein kinase subunit gamma-1 |
[273] |
-0.31[274] |
0.21[275] |
0.35[276] |
0.44[277] |
0.68[278] |
-0.43[279] |
41 |
GLS2 |
Glutaminase liver isoform, mitochondrial |
[280] |
-1.38[281] |
-0.80[282] |
-5.12[283] |
-6.31[284] |
-5.26[285] |
1.70[286] |
42 |
COX20 |
Cytochrome c oxidase protein 20 homolog |
[287] |
-2.82[288] |
-2.09[289] |
-2.93[290] |
-2.96[291] |
-3.80[292] |
-3.33[293] |
43 |
CYCS |
Cytochrome c |
[294] |
2.44[295] |
2.63[296] |
2.72[297] |
2.12[298] |
3.05[299] |
2.54[300] |
44 |
PRKAG2 |
5'-AMP-activated protein kinase subunit gamma-2 |
[301] |
-2.95[302] |
-8.06[303] |
-1.61[304] |
-0.96[305] |
-0.28[306] |
0.75[307] |
45 |
SCO2 |
Protein SCO2 homolog, mitochondrial |
[308] |
-3.10[309] |
-2.94[310] |
-2.29[311] |
-4.40[312] |
-4.51[313] |
-3.17[314] |
46 |
AKT2 |
RAC-beta serine/threonine-protein kinase |
[315] |
2.07[316] |
2.33[317] |
2.48[318] |
1.64[319] |
1.97[320] |
2.35[321] |
47 |
MLST8 |
Target of rapamycin complex subunit LST8 |
[322] |
0.94[323] |
1.25[324] |
1.64[325] |
-0.19[326] |
0.69[327] |
0.66[328] |
48 |
GLS |
Glutaminase kidney isoform, mitochondrial |
[329] |
2.39[330] |
3.22[331] |
2.15[332] |
3.75[333] |
2.68[334] |
0.67[335] |
49 |
PRKAA1 |
5'-AMP-activated protein kinase catalytic subunit alpha-1 |
[336] |
1.02[337] |
2.30[338] |
3.83[339] |
2.25[340] |
3.05[341] |
3.28[342] |
50 |
PRKAB2 |
5'-AMP-activated protein kinase subunit beta-2 |
[343] |
1.99[344] |
3.17[345] |
3.30[346] |
1.81[347] |
1.31[348] |
2.63[349] |
51 |
RRAGC |
Ras-related GTP-binding protein C |
[350] |
0.55[351] |
-0.29[352] |
0.12[353] |
1.15[354] |
1.38[355] |
0.26[356] |
52 |
MOV10 |
Putative helicase MOV-10 |
[357] |
2.09[358] |
2.30[359] |
2.30[360] |
1.86[361] |
2.24[362] |
2.30[363] |
53 |
SLC38A9 |
Sodium-coupled neutral amino acid transporter 9 |
[364] |
0.43[365] |
0.66[366] |
-0.20[367] |
-0.14[368] |
0.31[369] |
0.99[370] |
54 |
SESN2 |
Sestrin-2 |
[371] |
1.90[372] |
1.25[373] |
1.87[374] |
-0.24[375] |
1.08[376] |
1.47[377] |
55 |
G6PD |
Glucose-6-phosphate 1-dehydrogenase |
[378] |
3.80[379] |
1.81[380] |
1.57[381] |
5.29[382] |
2.79[383] |
-1.31[384] |
56 |
PTEN |
Phosphatidylinositol
3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
0.57[385] |
1.95[386] |
2.17[387] |
0.22[388] |
2.00[389] |
3.70[390] |
57 |
TP53 |
Cellular tumor antigen p53 |
[391] |
2.74[392] |
2.30[393] |
3.07[394] |
2.08[395] |
2.27[396] |
1.18[397] |
58 |
RRM2B |
Ribonucleoside-diphosphate reductase subunit M2 B |
[398] |
2.34[399] |
2.50[400] |
1.34[401] |
1.79[402] |
2.12[403] |
1.67[404] |
59 |
PRKAB1 |
5'-AMP-activated protein kinase subunit beta-1 |
[405] |
1.82[406] |
2.34[407] |
1.51[408] |
0.72[409] |
1.36[410] |
1.22[411] |
60 |
LAMTOR3 |
Ragulator complex protein LAMTOR3 |
[412] |
2.09[413] |
2.67[414] |
1.80[415] |
1.26[416] |
2.31[417] |
2.11[418] |
61 |
MTOR |
Serine/threonine-protein kinase mTOR |
[419] |
3.64[420] |
4.64[421] |
4.23[422] |
3.47[423] |
4.08[424] |
4.67[425] |
62 |
TSC2 |
Tuberin |
[426] |
2.92[427] |
2.44[428] |
3.14[429] |
1.98[430] |
3.04[431] |
3.30[432] |
63 |
SESN1 |
Sestrin-1 |
[433] |
2.39[434] |
2.71[435] |
0.21[436] |
-0.10[437] |
1.65[438] |
1.92[439] |
64 |
COX19 |
Cytochrome c oxidase assembly protein COX19 |
[440] |
1.48[441] |
2.57[442] |
2.91[443] |
0.78[444] |
1.70[445] |
1.52[446] |
65 |
TNRC6A |
Trinucleotide repeat-containing gene 6A protein |
[447] |
3.36[448] |
3.99[449] |
3.19[450] |
3.07[451] |
3.64[452] |
4.21[453] |
66 |
COX18 |
Mitochondrial inner membrane protein COX18 |
[454] |
1.43[455] |
2.04[456] |
1.83[457] |
0.45[458] |
1.57[459] |
2.28[460] |
67 |
RPTOR |
Regulatory-associated protein of mTOR |
[461] |
4.19[462] |
3.42[463] |
3.54[464] |
2.63[465] |
3.40[466] |
3.56[467] |
68 |
RRAGD |
Ras-related GTP-binding protein D |
[468] |
0.09[469] |
-3.62[470] |
4.29[471] |
1.90[472] |
0.71[473] |
2.40[474] |
69 |
TSC1 |
Hamartin |
[475] |
3.00[476] |
3.65[477] |
3.81[478] |
2.84[479] |
3.59[480] |
3.98[481] |
70 |
RRAGB |
Ras-related GTP-binding protein B |
[482] |
0.83[483] |
1.38[484] |
-8.06[485] |
1.23[486] |
1.59[487] |
1.81[488] |
71 |
TNRC6B |
Trinucleotide repeat-containing gene 6B protein |
[489] |
3.33[490] |
3.53[491] |
5.23[492] |
3.50[493] |
4.01[494] |
6.56[495] |
72 |
PRKAA2 |
5'-AMP-activated protein kinase catalytic subunit alpha-2 |
[496] |
4.14[497] |
4.58[498] |
4.62[499] |
3.83[500] |
2.40[501] |
3.07[502] |
73 |
SESN3 |
Sestrin-3 |
[503] |
2.53[504] |
-1.02[505] |
6.13[506] |
3.26[507] |
3.68[508] |
4.57[509] |
74 |
TNRC6C |
Trinucleotide repeat-containing gene 6C protein |
[510] |
3.19[511] |
3.13[512] |
3.43[513] |
1.55[514] |
2.06[515] |
4.52[516] |
75 |
AKT3 |
RAC-gamma serine/threonine-protein kinase |
[517] |
-0.73[518] |
-3.30[519] |
-2.60[520] |
6.63[521] |
6.11[522] |
4.83[523] |
76 |
TP63 |
Tumor protein 63 |
[524] |
[525] |
[526] |
-0.95[527] |
-0.59[528] |
-3.64[529] |
-0.26[530] |
77 |
PRKAG3 |
5'-AMP-activated protein kinase subunit gamma-3 |
[531] |
-0.63[532] |
[533] |
-0.95[534] |
-0.23[535] |
[536] |
4.34[537] |
78 |
AGO3 |
Protein argonaute-3 |
[538] |
[539] |
[540] |
[541] |
[542] |
[543] |
[544] |
79 |
MT-CO3 |
Cytochrome c oxidase subunit 3 |
[545] |
[546] |
[547] |
[548] |
[549] |
[550] |
[551] |
80 |
LAMTOR5 |
Ragulator complex protein LAMTOR5 |
[552] |
[553] |
[554] |
[555] |
[556] |
[557] |
[558] |
81 |
AGO4 |
Protein argonaute-4 |
[559] |
[560] |
[561] |
[562] |
[563] |
[564] |
[565] |
82 |
TIGAR |
Fructose-2,6-bisphosphatase TIGAR |
[566] |
[567] |
[568] |
[569] |
[570] |
[571] |
[572] |
83 |
AGO2 |
Protein argonaute-2 |
[573] |
[574] |
[575] |
[576] |
[577] |
[578] |
[579] |
84 |
MT-CO2 |
Cytochrome c oxidase subunit 2 |
[580] |
[581] |
[582] |
[583] |
[584] |
[585] |
[586] |
85 |
MT-CO1 |
Cytochrome c oxidase subunit 1 |
[587] |
[588] |
[589] |
[590] |
[591] |
[592] |
[593] |
86 |
LAMTOR4 |
Ragulator complex protein LAMTOR4 |
[594] |
[595] |
[596] |
[597] |
[598] |
[599] |
[600] |
87 |
AGO1 |
Protein argonaute-1 |
[601] |
[602] |
[603] |
[604] |
[605] |
[606] |
[607] |
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