REACTOME_TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -14.23[2] | -14.45[3] | -9.91[4] | -12.39[5] | -3.71[6] | -1.98[7] |
2 | FGG | Fibrinogen gamma chain | [8] | -1.68[9] | -0.89[10] | -0.84[11] | -8.11[12] | -10.15[13] | 0.30[14] |
3 | FGA | Fibrinogen alpha chain | [15] | -1.35[16] | -1.13[17] | -0.73[18] | -7.33[19] | -10.17[20] | 0.97[21] |
4 | FGB | Fibrinogen beta chain | [22] | -2.55[23] | -1.91[24] | 0.26[25] | -5.45[26] | -8.80[27] | 1.75[28] |
5 | UBB | Polyubiquitin-B | [29] | 2.71[30] | 2.34[31] | 2.28[32] | 2.39[33] | 2.70[34] | -1.02[35] |
6 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [36] | [37] | [38] | [39] | [40] | [41] | [42] |
7 | UBC | Polyubiquitin-C | [43] | 3.15[44] | 3.09[45] | 2.64[46] | 3.24[47] | 3.08[48] | -0.57[49] |
8 | CD14 | Monocyte differentiation antigen CD14 | [50] | -3.43[51] | -3.67[52] | -1.07[53] | 0.37[54] | -0.97[55] | 0.35[56] |
9 | HMGB1 | High mobility group protein B1 | [57] | 4.61[58] | 5.18[59] | 4.71[60] | 5.63[61] | 4.96[62] | 0.30[63] |
10 | NFKBIA | NF-kappa-B inhibitor alpha | [64] | 3.86[65] | 1.89[66] | 1.30[67] | 1.65[68] | 3.38[69] | -0.28[70] |
11 | SKP1 | S-phase kinase-associated protein 1 | [71] | 3.93[72] | 4.15[73] | 3.07[74] | 4.66[75] | 4.74[76] | 0.17[77] |
12 | APP | Amyloid-beta A4 protein | [78] | 5.29[79] | 4.57[80] | 5.01[81] | 5.95[82] | 6.21[83] | 1.00[84] |
13 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [85] | 5.59[86] | 5.32[87] | 6.16[88] | 4.64[89] | 5.31[90] | 0.20[91] |
14 | S100A1 | Protein S100-A1 | [92] | 2.97[93] | 4.04[94] | -2.06[95] | -3.09[96] | -4.41[97] | -9.41[98] |
15 | JUN | Transcription factor AP-1 | [99] | 4.42[100] | 2.70[101] | 2.77[102] | 3.47[103] | 3.89[104] | -0.95[105] |
16 | FOS | Proto-oncogene c-Fos | [106] | -1.10[107] | -0.01[108] | -0.89[109] | -1.00[110] | -0.08[111] | -0.44[112] |
17 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [113] | 3.69[114] | 3.82[115] | 2.51[116] | 3.34[117] | 3.06[118] | -0.58[119] |
18 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [120] | 1.03[121] | 0.67[122] | 0.61[123] | 1.28[124] | 0.48[125] | -4.15[126] |
19 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [127] | 3.98[128] | 3.48[129] | 3.85[130] | 4.63[131] | 4.99[132] | -0.33[133] |
20 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 5.71[134] | 5.36[135] | 5.08[136] | 6.38[137] | 5.56[138] | 1.00[139] | |
21 | S100A9 | Protein S100-A9 | [140] | -1.27[141] | -3.91[142] | -2.16[143] | -3.55[144] | -4.22[145] | -1.09[146] |
22 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 5.18[147] | 5.10[148] | 4.26[149] | 5.91[150] | 5.88[151] | 0.76[152] | |
23 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 4.52[153] | 4.00[154] | 3.87[155] | 4.71[156] | 4.46[157] | -0.13[158] | |
24 | DUSP3 | Dual specificity protein phosphatase 3 | [159] | 5.68[160] | 4.91[161] | 5.24[162] | 4.49[163] | 4.35[164] | 2.26[165] |
25 | IKBKG | NF-kappa-B essential modulator | [166] | 4.02[167] | 4.00[168] | 1.54[169] | 4.32[170] | 2.96[171] | 0.26[172] |
26 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [173] | 6.33[174] | 5.55[175] | 4.32[176] | 5.97[177] | 6.19[178] | 0.17[179] |
27 | ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | 3.39[180] | 3.93[181] | 4.22[182] | 2.24[183] | 2.40[184] | -0.22[185] | |
28 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [186] | 5.60[187] | 5.90[188] | 4.52[189] | 5.49[190] | 5.23[191] | 0.14[192] |
29 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [193] | 4.14[194] | 4.27[195] | 4.51[196] | 3.79[197] | 4.49[198] | -2.16[199] |
30 | RELA | Transcription factor p65 | [200] | 5.04[201] | 4.37[202] | 4.29[203] | 5.11[204] | 4.87[205] | -0.02[206] |
31 | SIGIRR | Single Ig IL-1-related receptor | [207] | -1.49[208] | -0.03[209] | 1.41[210] | 1.86[211] | 0.20[212] | 0.27[213] |
32 | TNIP2 | TNFAIP3-interacting protein 2 | [214] | 4.23[215] | 4.12[216] | 3.62[217] | 4.51[218] | 3.72[219] | -0.60[220] |
33 | DUSP6 | Dual specificity protein phosphatase 6 | [221] | 4.43[222] | 6.33[223] | 5.40[224] | 1.26[225] | 4.90[226] | 1.11[227] |
34 | CUL1 | Cullin-1 | [228] | 4.53[229] | 5.03[230] | 4.37[231] | 5.75[232] | 5.26[233] | 1.61[234] |
35 | NFKBIB | NF-kappa-B inhibitor beta | [235] | 3.75[236] | 3.40[237] | 3.52[238] | 3.35[239] | 3.55[240] | -0.87[241] |
36 | MAPKAPK | MAP kinase-activated protein kinase 2 | [242] | 5.37[243] | 4.23[244] | 4.44[245] | 6.57[246] | 5.63[247] | -0.08[248] |
37 | MYD88 | Myeloid differentiation primary response protein MyD88 | [249] | 4.72[250] | 4.61[251] | 3.83[252] | 4.13[253] | 4.28[254] | 1.66[255] |
38 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 5.36[256] | 4.66[257] | 4.87[258] | 5.44[259] | 5.07[260] | 3.79[261] | |
39 | MAPK1 | Mitogen-activated protein kinase 1 | [262] | 6.62[263] | 6.58[264] | 6.20[265] | 7.02[266] | 6.52[267] | 2.64[268] |
40 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [269] | [270] | [271] | [272] | [273] | [274] | [275] |
41 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [276] | 5.28[277] | 5.27[278] | 5.32[279] | 6.87[280] | 6.18[281] | 1.10[282] |
42 | VRK3 | Inactive serine/threonine-protein kinase VRK3 | [283] | 4.15[284] | 4.15[285] | 4.21[286] | 4.02[287] | 3.49[288] | 0.37[289] |
43 | MAPK14 | Mitogen-activated protein kinase 14 | [290] | 6.38[291] | 6.28[292] | 5.65[293] | 6.85[294] | 6.18[295] | 2.14[296] |
44 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [297] | 4.81[298] | 5.71[299] | 5.37[300] | 5.66[301] | 5.69[302] | 1.11[303] |
45 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [304] | 4.83[305] | 4.76[306] | 4.33[307] | 2.74[308] | 4.14[309] | -0.16[310] |
46 | MAPKAPK | MAP kinase-activated protein kinase 3 | [311] | 5.92[312] | 5.69[313] | 4.58[314] | 3.69[315] | 5.26[316] | 0.62[317] |
47 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 6.16[318] | 5.75[319] | 5.10[320] | 6.46[321] | 6.20[322] | 0.59[323] | |
48 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [324] | 5.55[325] | 6.42[326] | 6.44[327] | 5.95[328] | 5.58[329] | 1.88[330] |
49 | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 | [331] | 5.66[332] | 4.24[333] | 5.09[334] | 5.75[335] | 5.40[336] | 1.06[337] |
50 | MAPK8 | Mitogen-activated protein kinase 8 | [338] | 3.47[339] | 4.70[340] | 3.36[341] | 4.27[342] | 3.98[343] | 0.35[344] |
51 | ELK1 | ETS domain-containing protein Elk-1 | [345] | 4.60[346] | 2.29[347] | 4.50[348] | 5.44[349] | 5.88[350] | 0.69[351] |
52 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [352] | 4.97[353] | 6.74[354] | 6.63[355] | 5.52[356] | 6.57[357] | 1.69[358] |
53 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [359] | 5.58[360] | 5.08[361] | 4.66[362] | 4.92[363] | 5.68[364] | 1.31[365] |
54 | FBXW11 | F-box/WD repeat-containing protein 11 | [366] | 6.29[367] | 6.02[368] | 6.57[369] | 6.69[370] | 6.46[371] | 1.81[372] |
55 | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 | [373] | 3.54[374] | 3.16[375] | 4.17[376] | 4.63[377] | 4.76[378] | 0.64[379] |
56 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [380] | 5.62[381] | 6.07[382] | 5.06[383] | 6.38[384] | 5.63[385] | 1.92[386] |
57 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [387] | [388] | [389] | [390] | [391] | [392] | [393] |
58 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [394] | 4.29[395] | 5.37[396] | 4.88[397] | 5.32[398] | 5.06[399] | 0.38[400] |
59 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [401] | 4.34[402] | 4.76[403] | 4.56[404] | 4.97[405] | 4.79[406] | -0.27[407] |
60 | MAPK9 | Mitogen-activated protein kinase 9 | [408] | 6.14[409] | 6.19[410] | 6.04[411] | 6.88[412] | 6.19[413] | 1.37[414] |
61 | MAPK3 | Mitogen-activated protein kinase 3 | [415] | 6.76[416] | 6.63[417] | 6.46[418] | 5.59[419] | 5.47[420] | -0.18[421] |
62 | S100A8 | Protein S100-A8 | [422] | [423] | [424] | [425] | -4.31[426] | [427] | 0.91[428] |
63 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [429] | 5.81[430] | 6.86[431] | 6.61[432] | 5.82[433] | 6.48[434] | 2.38[435] |
64 | MEF2A | Myocyte-specific enhancer factor 2A | [436] | 4.88[437] | 5.49[438] | 5.96[439] | 6.34[440] | 6.28[441] | 3.02[442] |
65 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [443] | 5.87[444] | 5.85[445] | 6.21[446] | 5.45[447] | 5.86[448] | 0.10[449] |
66 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [450] | 5.56[451] | 6.03[452] | 5.90[453] | 5.18[454] | 5.37[455] | 1.08[456] |
67 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [457] | 5.43[458] | 5.32[459] | 5.21[460] | 5.43[461] | 5.37[462] | 2.04[463] |
68 | LY96 | Lymphocyte antigen 96 | [464] | 2.26[465] | 1.69[466] | -4.93[467] | 3.81[468] | 0.04[469] | -0.50[470] |
69 | PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | [471] | 5.06[472] | 5.80[473] | 6.10[474] | 4.91[475] | 4.86[476] | 2.26[477] |
70 | TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein | [478] | 4.77[479] | 4.57[480] | 4.46[481] | 5.45[482] | 4.13[483] | 1.13[484] |
71 | SOCS1 | Suppressor of cytokine signaling 1 | [485] | 3.46[486] | 4.16[487] | 4.21[488] | 3.38[489] | 1.85[490] | -0.60[491] |
72 | BTRC | F-box/WD repeat-containing protein 1A | [492] | 6.32[493] | 6.94[494] | 6.35[495] | 5.93[496] | 6.32[497] | 2.21[498] |
73 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [499] | 6.63[500] | 7.62[501] | 7.90[502] | 7.71[503] | 7.50[504] | 3.20[505] |
74 | CD36 | Platelet glycoprotein 4 | [506] | 6.25[507] | 5.39[508] | 0.10[509] | 8.35[510] | -0.80[511] | 3.94[512] |
75 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [513] | 6.66[514] | 6.49[515] | 5.47[516] | 5.27[517] | 6.45[518] | 1.35[519] |
76 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [520] | 5.20[521] | 1.81[522] | 6.46[523] | 6.18[524] | 2.00[525] | -0.76[526] |
77 | TLR2 | Toll-like receptor 2 | [527] | 1.37[528] | 2.61[529] | -4.60[530] | 0.20[531] | 6.81[532] | 2.10[533] |
78 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [534] | 5.17[535] | 6.36[536] | 6.43[537] | 6.59[538] | 6.20[539] | 2.64[540] |
79 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [541] | [542] | [543] | [544] | [545] | [546] | [547] |
80 | DUSP7 | Dual specificity protein phosphatase 7 | [548] | 6.46[549] | 5.38[550] | 6.42[551] | 4.74[552] | 6.98[553] | 0.89[554] |
81 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [555] | 7.56[556] | 7.10[557] | 6.62[558] | 7.49[559] | 6.23[560] | 3.66[561] |
82 | MAPK7 | Mitogen-activated protein kinase 7 | [562] | 6.35[563] | 5.47[564] | 5.26[565] | 6.97[566] | 6.92[567] | 1.19[568] |
83 | TRAF6 | TNF receptor-associated factor 6 | [569] | 6.00[570] | 5.71[571] | 6.07[572] | 6.83[573] | 6.14[574] | 3.77[575] |
84 | PELI3 | E3 ubiquitin-protein ligase pellino homolog 3 | [576] | 6.28[577] | 5.16[578] | 6.49[579] | 7.65[580] | 7.21[581] | 1.83[582] |
85 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [583] | 3.00[584] | 0.86[585] | [586] | 1.56[587] | 4.96[588] | 0.33[589] |
86 | TLR4 | Toll-like receptor 4 | [590] | 5.18[591] | -0.14[592] | -1.24[593] | 0.07[594] | 10.34[595] | 5.33[596] |
87 | S100A12 | Protein S100-A12 | [597] | [598] | [599] | [600] | [601] | [602] | 1.14[603] |
88 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [604] | 5.93[605] | 5.43[606] | 6.03[607] | 7.41[608] | 6.89[609] | 2.94[610] |
89 | TLR1 | Toll-like receptor 1 | [611] | 1.54[612] | [613] | -2.49[614] | 4.78[615] | 5.81[616] | 2.93[617] |
90 | AGER | Advanced glycosylation end product-specific receptor | [618] | 3.86[619] | 6.87[620] | 5.59[621] | 5.81[622] | 5.43[623] | 0.75[624] |
91 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [625] | [626] | [627] | [628] | [629] | [630] | [631] |
92 | MAPK11 | Mitogen-activated protein kinase 11 | [632] | 4.74[633] | 4.46[634] | 3.36[635] | 5.52[636] | 7.37[637] | 1.02[638] |
93 | SFTPD | Pulmonary surfactant-associated protein D | [639] | -1.98[640] | [641] | [642] | 0.89[643] | 1.11[644] | 0.19[645] |
94 | BTK | Tyrosine-protein kinase BTK | [646] | -2.47[647] | [648] | 3.99[649] | 2.16[650] | -0.21[651] | 2.69[652] |
95 | PELI2 | E3 ubiquitin-protein ligase pellino homolog 2 | [653] | 2.06[654] | 0.99[655] | 0.24[656] | 9.14[657] | 7.73[658] | 4.34[659] |
96 | TLR6 | Toll-like receptor 6 | [660] | 5.69[661] | 5.63[662] | 4.66[663] | 7.47[664] | 7.41[665] | 3.60[666] |
97 | MEF2C | Myocyte-specific enhancer factor 2C | [667] | 1.80[668] | 2.76[669] | 7.51[670] | 10.78[671] | 6.62[672] | 6.15[673] |
98 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | [674] | 3.46[675] | 4.28[676] | 5.93[677] | 11.21[678] | 13.31[679] | 6.75[680] |
99 | S100B | Protein S100-B | [681] | 1.05[682] | -0.10[683] | [684] | 3.42[685] | -0.75[686] | 2.01[687] |
100 | DUSP4 | Dual specificity protein phosphatase 4 | [688] | 10.42[689] | 7.23[690] | 12.92[691] | 12.90[692] | 10.69[693] | 4.69[694] |
101 | MAPK10 | Mitogen-activated protein kinase 10 | [695] | 3.43[696] | [697] | [698] | 14.08[699] | 9.67[700] | 8.11[701] |
102 | SFTPA2 | Pulmonary surfactant-associated protein A2 | [702] | [703] | [704] | [705] | [706] | [707] | [708] |
103 | SFTPA1 | Pulmonary surfactant-associated protein A1 | [709] | [710] | [711] | [712] | [713] | [714] | [715] |