REACTOME_TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAA1 | Serum amyloid A-1 protein | [1] | -14.81[2] | -14.92[3] | -10.20[4] | -13.16[5] | -4.48[6] | -0.36[7] |
2 | UBB | Polyubiquitin-B | [8] | 2.14[9] | 1.87[10] | 1.99[11] | 1.62[12] | 1.93[13] | 0.60[14] |
3 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [15] | [16] | [17] | [18] | [19] | [20] | [21] |
4 | UBC | Polyubiquitin-C | [22] | 2.58[23] | 2.62[24] | 2.36[25] | 2.47[26] | 2.31[27] | 1.06[28] |
5 | CD14 | Monocyte differentiation antigen CD14 | [29] | -4.00[30] | -4.14[31] | -1.36[32] | -0.40[33] | -1.74[34] | 1.97[35] |
6 | HMGB1 | High mobility group protein B1 | [36] | 4.04[37] | 4.71[38] | 4.42[39] | 4.86[40] | 4.19[41] | 1.93[42] |
7 | NFKBIA | NF-kappa-B inhibitor alpha | [43] | 3.28[44] | 1.42[45] | 1.01[46] | 0.88[47] | 2.61[48] | 1.34[49] |
8 | SKP1 | S-phase kinase-associated protein 1 | [50] | 3.36[51] | 3.68[52] | 2.78[53] | 3.89[54] | 3.97[55] | 1.79[56] |
9 | APP | Amyloid-beta A4 protein | [57] | 4.72[58] | 4.10[59] | 4.72[60] | 5.18[61] | 5.44[62] | 2.62[63] |
10 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [64] | 5.02[65] | 4.85[66] | 5.87[67] | 3.87[68] | 4.54[69] | 1.82[70] |
11 | JUN | Transcription factor AP-1 | [71] | 3.85[72] | 2.24[73] | 2.48[74] | 2.70[75] | 3.12[76] | 0.67[77] |
12 | FOS | Proto-oncogene c-Fos | [78] | -1.67[79] | -0.48[80] | -1.18[81] | -1.77[82] | -0.85[83] | 1.18[84] |
13 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [85] | 3.12[86] | 3.35[87] | 2.22[88] | 2.57[89] | 2.29[90] | 1.04[91] |
14 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [92] | 0.46[93] | 0.20[94] | 0.32[95] | 0.51[96] | -0.29[97] | -2.53[98] |
15 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [99] | 3.41[100] | 3.01[101] | 3.56[102] | 3.86[103] | 4.22[104] | 1.29[105] |
16 | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isofor | 5.14[106] | 4.89[107] | 4.79[108] | 5.61[109] | 4.79[110] | 2.63[111] | |
17 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 4.61[112] | 4.63[113] | 3.97[114] | 5.14[115] | 5.11[116] | 2.38[117] | |
18 | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform | 3.95[118] | 3.53[119] | 3.58[120] | 3.94[121] | 3.69[122] | 1.49[123] | |
19 | DUSP3 | Dual specificity protein phosphatase 3 | [124] | 5.11[125] | 4.44[126] | 4.95[127] | 3.72[128] | 3.58[129] | 3.88[130] |
20 | IKBKG | NF-kappa-B essential modulator | [131] | 3.45[132] | 3.53[133] | 1.25[134] | 3.55[135] | 2.19[136] | 1.88[137] |
21 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [138] | 5.75[139] | 5.08[140] | 4.03[141] | 5.20[142] | 5.41[143] | 1.79[144] |
22 | ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | 2.82[145] | 3.46[146] | 3.93[147] | 1.47[148] | 1.63[149] | 1.40[150] | |
23 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [151] | 5.03[152] | 5.43[153] | 4.23[154] | 4.72[155] | 4.46[156] | 1.76[157] |
24 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [158] | 3.57[159] | 3.80[160] | 4.22[161] | 3.02[162] | 3.72[163] | -0.54[164] |
25 | RELA | Transcription factor p65 | [165] | 4.47[166] | 3.90[167] | 4.00[168] | 4.34[169] | 4.10[170] | 1.60[171] |
26 | TNIP2 | TNFAIP3-interacting protein 2 | [172] | 3.65[173] | 3.65[174] | 3.33[175] | 3.74[176] | 2.95[177] | 1.02[178] |
27 | DUSP6 | Dual specificity protein phosphatase 6 | [179] | 3.85[180] | 5.86[181] | 5.11[182] | 0.49[183] | 4.13[184] | 2.73[185] |
28 | CUL1 | Cullin-1 | [186] | 3.95[187] | 4.56[188] | 4.08[189] | 4.98[190] | 4.49[191] | 3.23[192] |
29 | NFKBIB | NF-kappa-B inhibitor beta | [193] | 3.18[194] | 2.93[195] | 3.23[196] | 2.59[197] | 2.78[198] | 0.75[199] |
30 | MAPKAPK | MAP kinase-activated protein kinase 2 | [200] | 4.80[201] | 3.76[202] | 4.15[203] | 5.80[204] | 4.86[205] | 1.54[206] |
31 | MYD88 | Myeloid differentiation primary response protein MyD88 | [207] | 4.15[208] | 4.14[209] | 3.54[210] | 3.36[211] | 3.51[212] | 3.28[213] |
32 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 4.79[214] | 4.20[215] | 4.58[216] | 4.67[217] | 4.30[218] | 5.41[219] | |
33 | IRF7 | Interferon regulatory factor 7 | [220] | -4.90[221] | -3.97[222] | -2.89[223] | 1.25[224] | 0.84[225] | 2.41[226] |
34 | MAPK1 | Mitogen-activated protein kinase 1 | [227] | 6.05[228] | 6.12[229] | 5.91[230] | 6.25[231] | 5.75[232] | 4.26[233] |
35 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [234] | [235] | [236] | [237] | [238] | [239] | [240] |
36 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [241] | 4.70[242] | 4.80[243] | 5.03[244] | 6.10[245] | 5.41[246] | 2.72[247] |
37 | VRK3 | Inactive serine/threonine-protein kinase VRK3 | [248] | 3.58[249] | 3.68[250] | 3.92[251] | 3.25[252] | 2.72[253] | 1.99[254] |
38 | MAPK14 | Mitogen-activated protein kinase 14 | [255] | 5.81[256] | 5.81[257] | 5.36[258] | 6.08[259] | 5.41[260] | 3.76[261] |
39 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [262] | 4.24[263] | 5.24[264] | 5.08[265] | 4.89[266] | 4.92[267] | 2.73[268] |
40 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [269] | 4.26[270] | 4.29[271] | 4.05[272] | 1.97[273] | 3.37[274] | 1.46[275] |
41 | MAPKAPK | MAP kinase-activated protein kinase 3 | [276] | 5.35[277] | 5.22[278] | 4.29[279] | 2.92[280] | 4.49[281] | 2.24[282] |
42 | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform | 5.59[283] | 5.28[284] | 4.81[285] | 5.69[286] | 5.42[287] | 2.21[288] | |
43 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [289] | 4.98[290] | 5.95[291] | 6.15[292] | 5.18[293] | 4.81[294] | 3.50[295] |
44 | NKIRAS2 | NF-kappa-B inhibitor-interacting Ras-like protein 2 | [296] | 5.09[297] | 3.77[298] | 4.80[299] | 4.98[300] | 4.63[301] | 2.68[302] |
45 | MAPK8 | Mitogen-activated protein kinase 8 | [303] | 2.89[304] | 4.23[305] | 3.08[306] | 3.50[307] | 3.21[308] | 1.97[309] |
46 | ELK1 | ETS domain-containing protein Elk-1 | [310] | 4.02[311] | 1.82[312] | 4.21[313] | 4.67[314] | 5.11[315] | 2.31[316] |
47 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [317] | 4.39[318] | 6.27[319] | 6.34[320] | 4.75[321] | 5.80[322] | 3.31[323] |
48 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [324] | 5.01[325] | 4.61[326] | 4.37[327] | 4.15[328] | 4.91[329] | 2.93[330] |
49 | FBXW11 | F-box/WD repeat-containing protein 11 | [331] | 5.71[332] | 5.55[333] | 6.28[334] | 5.92[335] | 5.69[336] | 3.43[337] |
50 | NKIRAS1 | NF-kappa-B inhibitor-interacting Ras-like protein 1 | [338] | 2.97[339] | 2.69[340] | 3.88[341] | 3.86[342] | 3.99[343] | 2.26[344] |
51 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [345] | 5.04[346] | 5.60[347] | 4.78[348] | 5.61[349] | 4.85[350] | 3.55[351] |
52 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [352] | [353] | [354] | [355] | [356] | [357] | [358] |
53 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [359] | 3.71[360] | 4.90[361] | 4.59[362] | 4.56[363] | 4.28[364] | 2.00[365] |
54 | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2 | [366] | 3.77[367] | 4.29[368] | 4.28[369] | 4.20[370] | 4.02[371] | 1.35[372] |
55 | TICAM1 | TIR domain-containing adapter molecule 1 | [373] | 3.63[374] | 2.45[375] | 3.36[376] | 3.18[377] | 4.07[378] | 1.98[379] |
56 | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | [380] | 4.72[381] | 5.28[382] | 4.33[383] | 5.21[384] | 5.27[385] | 3.11[386] |
57 | MAPK9 | Mitogen-activated protein kinase 9 | [387] | 5.57[388] | 5.72[389] | 5.75[390] | 6.11[391] | 5.42[392] | 2.99[393] |
58 | MAPK3 | Mitogen-activated protein kinase 3 | [394] | 6.19[395] | 6.16[396] | 6.17[397] | 4.82[398] | 4.69[399] | 1.44[400] |
59 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [401] | 5.24[402] | 6.39[403] | 6.32[404] | 5.05[405] | 5.71[406] | 4.00[407] |
60 | MEF2A | Myocyte-specific enhancer factor 2A | [408] | 4.31[409] | 5.02[410] | 5.67[411] | 5.57[412] | 5.51[413] | 4.64[414] |
61 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [415] | 5.30[416] | 5.38[417] | 5.92[418] | 4.68[419] | 5.09[420] | 1.72[421] |
62 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [422] | 4.99[423] | 5.56[424] | 5.61[425] | 4.41[426] | 4.60[427] | 2.70[428] |
63 | EEA1 | Early endosome antigen 1 | [429] | 4.26[430] | 6.46[431] | 6.03[432] | 5.74[433] | 4.56[434] | 4.48[435] |
64 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [436] | 4.86[437] | 4.85[438] | 4.92[439] | 4.66[440] | 4.60[441] | 3.66[442] |
65 | LY96 | Lymphocyte antigen 96 | [443] | 1.69[444] | 1.23[445] | -5.22[446] | 3.04[447] | -0.73[448] | 1.12[449] |
66 | PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | [450] | 4.49[451] | 5.33[452] | 5.81[453] | 4.14[454] | 4.09[455] | 3.88[456] |
67 | BTRC | F-box/WD repeat-containing protein 1A | [457] | 5.75[458] | 6.47[459] | 6.06[460] | 5.16[461] | 5.55[462] | 3.83[463] |
68 | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | [464] | 5.50[465] | 5.49[466] | 6.43[467] | 6.07[468] | 6.39[469] | 5.35[470] |
69 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [471] | 6.06[472] | 7.15[473] | 7.61[474] | 6.94[475] | 6.73[476] | 4.82[477] |
70 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [478] | 6.08[479] | 6.02[480] | 5.18[481] | 4.50[482] | 5.68[483] | 2.97[484] |
71 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [485] | 4.63[486] | 1.34[487] | 6.17[488] | 5.41[489] | 1.23[490] | 0.86[491] |
72 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [492] | 4.60[493] | 5.89[494] | 6.14[495] | 5.82[496] | 5.43[497] | 4.26[498] |
73 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | [499] | [500] | [501] | [502] | [503] | [504] | [505] |
74 | DUSP7 | Dual specificity protein phosphatase 7 | [506] | 5.89[507] | 4.91[508] | 6.13[509] | 3.97[510] | 6.21[511] | 2.51[512] |
75 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [513] | 6.99[514] | 6.63[515] | 6.33[516] | 6.72[517] | 5.45[518] | 5.28[519] |
76 | MAPK7 | Mitogen-activated protein kinase 7 | [520] | 5.77[521] | 5.00[522] | 4.97[523] | 6.20[524] | 6.15[525] | 2.82[526] |
77 | TRAF6 | TNF receptor-associated factor 6 | [527] | 5.43[528] | 5.25[529] | 5.78[530] | 6.06[531] | 5.37[532] | 5.39[533] |
78 | PELI3 | E3 ubiquitin-protein ligase pellino homolog 3 | [534] | 5.71[535] | 4.69[536] | 6.20[537] | 6.88[538] | 6.44[539] | 3.45[540] |
79 | NOD2 | Nucleotide-binding oligomerization domain-containing protein 2 | [541] | 2.43[542] | 0.39[543] | [544] | 0.79[545] | 4.19[546] | 1.95[547] |
80 | TLR4 | Toll-like receptor 4 | [548] | 4.61[549] | -0.61[550] | -1.53[551] | -0.70[552] | 9.57[553] | 6.95[554] |
81 | S100A12 | Protein S100-A12 | [555] | [556] | [557] | [558] | [559] | [560] | 2.76[561] |
82 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | [562] | 5.36[563] | 4.96[564] | 5.74[565] | 6.64[566] | 6.11[567] | 4.56[568] |
83 | TICAM2 | TIR domain-containing adapter molecule 2 | [569] | -3.54[570] | [571] | -3.06[572] | 2.91[573] | 3.10[574] | 0.50[575] |
84 | AGER | Advanced glycosylation end product-specific receptor | [576] | 3.29[577] | 6.40[578] | 5.30[579] | 5.04[580] | 4.66[581] | 2.37[582] |
85 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | [583] | [584] | [585] | [586] | [587] | [588] | [589] |
86 | MAPK11 | Mitogen-activated protein kinase 11 | [590] | 4.17[591] | 3.99[592] | 3.07[593] | 4.76[594] | 6.60[595] | 2.64[596] |
87 | PELI2 | E3 ubiquitin-protein ligase pellino homolog 2 | [597] | 1.49[598] | 0.52[599] | -0.05[600] | 8.37[601] | 6.96[602] | 5.96[603] |
88 | MEF2C | Myocyte-specific enhancer factor 2C | [604] | 1.23[605] | 2.29[606] | 7.22[607] | 10.01[608] | 5.85[609] | 7.77[610] |
89 | TLR7 | Toll-like receptor 7 | [611] | 3.50[612] | 4.23[613] | 4.50[614] | 3.82[615] | 3.24[616] | 3.75[617] |
90 | S100B | Protein S100-B | [618] | 0.48[619] | -0.57[620] | [621] | 2.65[622] | -1.52[623] | 3.63[624] |
91 | DUSP4 | Dual specificity protein phosphatase 4 | [625] | 9.85[626] | 6.76[627] | 12.63[628] | 12.13[629] | 9.92[630] | 6.31[631] |
92 | MAPK10 | Mitogen-activated protein kinase 10 | [632] | 2.85[633] | [634] | [635] | 13.31[636] | 8.90[637] | 9.73[638] |
93 | TLR9 | Toll-like receptor 9 | [639] | [640] | [641] | [642] | [643] | [644] | [645] |
94 | RBSN | Rabenosyn-5 | [646] | [647] | [648] | [649] | [650] | [651] | [652] |