REACTOME_TNFR2_NON_CANONICAL_NF_KB_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.12[2] | -1.19[3] | -0.99[4] | -1.41[5] | -1.10[6] | -0.50[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.68[16] | -0.43[17] | -0.63[18] | -0.55[19] | -0.72[20] | -0.05[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.45[23] | -2.02[24] | -1.60[25] | -1.27[26] | -1.95[27] | -1.00[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.26[30] | -1.65[31] | -1.69[32] | -1.06[33] | -1.48[34] | -0.63[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.69[37] | 0.82[38] | -0.44[39] | 0.57[40] | -0.01[41] | 0.40[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.24[44] | 0.37[45] | -0.64[46] | -0.68[47] | -0.05[48] | 0.23[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.24[51] | -1.01[52] | 0.09[53] | -0.70[54] | -0.95[55] | -0.06[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | 0.00[58] | 0.19[59] | 0.38[60] | 0.73[61] | 0.59[62] | -0.39[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.94[65] | -0.91[66] | -0.71[67] | -1.04[68] | -0.74[69] | -0.83[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.46[72] | 0.05[73] | 0.04[74] | -0.32[75] | -0.17[76] | -0.35[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.58[79] | 0.33[80] | 0.33[81] | 0.21[82] | 0.09[83] | -0.27[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.34[86] | 0.35[87] | 0.21[88] | 0.51[89] | 0.21[90] | -0.35[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | 0.10[93] | 0.63[94] | -0.20[95] | 0.87[96] | 0.94[97] | 0.68[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.38[100] | -0.42[101] | 0.27[102] | -0.69[103] | -0.62[104] | 0.12[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -0.97[107] | 0.07[108] | -0.55[109] | 0.06[110] | -0.52[111] | -0.10[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.42[114] | -0.24[115] | -0.03[116] | -0.49[117] | -0.89[118] | 0.05[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.50[121] | 0.49[122] | 0.88[123] | 0.01[124] | 0.25[125] | 0.28[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | 0.02[128] | 0.06[129] | 0.32[130] | 0.71[131] | 0.05[132] | -0.04[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.07[135] | 0.34[136] | 0.26[137] | -0.38[138] | -0.03[139] | -0.22[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | 0.10[142] | 0.37[143] | 0.57[144] | -0.10[145] | 0.53[146] | -0.19[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.63[149] | 0.84[150] | 0.98[151] | 1.01[152] | 2.18[153] | 0.84[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.04[156] | 0.05[157] | -0.54[158] | 1.19[159] | 0.59[160] | 0.00[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | 0.14[163] | 0.56[164] | 0.69[165] | 0.77[166] | 0.14[167] | 0.49[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.76[170] | 1.80[171] | 2.88[172] | 0.84[173] | 1.51[174] | 0.72[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.46[177] | 0.38[178] | 0.52[179] | 0.18[180] | 0.46[181] | 0.26[182] |
27 | TNFRSF12 | Tumor necrosis factor receptor superfamily member 12A | [183] | 0.55[184] | 0.26[185] | -1.69[186] | 0.19[187] | 0.61[188] | -1.74[189] |
28 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [190] | 0.85[191] | 0.38[192] | 1.03[193] | 0.71[194] | 0.80[195] | -0.03[196] |
29 | PSMB8 | Proteasome subunit beta type-8 | [197] | -1.54[198] | -2.10[199] | -9.25[200] | 0.68[201] | -0.75[202] | -0.72[203] |
30 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [204] | 0.03[205] | 0.67[206] | 0.99[207] | 0.57[208] | 0.48[209] | -0.17[210] |
31 | PSMC4 | 26S proteasome regulatory subunit 6B | [211] | 0.46[212] | 0.52[213] | 0.52[214] | 0.20[215] | 0.19[216] | 0.31[217] |
32 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [218] | -0.70[219] | -0.18[220] | -1.21[221] | -0.43[222] | 0.26[223] | -0.28[224] |
33 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [225] | 0.50[226] | 0.65[227] | 1.21[228] | 0.63[229] | 0.02[230] | -0.10[231] |
34 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [232] | -0.32[233] | -0.21[234] | -0.45[235] | 0.25[236] | 0.19[237] | -0.18[238] |
35 | PSMC6 | 26S proteasome regulatory subunit 10B | [239] | -0.02[240] | 1.58[241] | 0.47[242] | 0.61[243] | 0.42[244] | 0.48[245] |
36 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [246] | 0.86[247] | 0.50[248] | 1.16[249] | 1.02[250] | 1.05[251] | 1.30[252] |
37 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [253] | 0.61[254] | 0.28[255] | 0.62[256] | 1.74[257] | 1.77[258] | 1.45[259] |
38 | LTBR | Tumor necrosis factor receptor superfamily member 3 | [260] | 0.11[261] | -0.17[262] | 0.52[263] | 0.60[264] | 1.07[265] | 1.59[266] |
39 | PSMC2 | 26S proteasome regulatory subunit 7 | [267] | 0.61[268] | 1.05[269] | 0.89[270] | 1.41[271] | 1.11[272] | 1.36[273] |
40 | PSME3 | Proteasome activator complex subunit 3 | [274] | 1.84[275] | 1.59[276] | 1.34[277] | 1.44[278] | 1.58[279] | 0.92[280] |
41 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [281] | 1.60[282] | 1.95[283] | 1.89[284] | 2.24[285] | 2.13[286] | 2.11[287] |
42 | PSMB10 | Proteasome subunit beta type-10 | [288] | -1.12[289] | -0.50[290] | -2.32[291] | 0.03[292] | -1.26[293] | -0.04[294] |
43 | PSMA5 | Proteasome subunit alpha type-5 | [295] | 1.93[296] | 2.39[297] | 2.01[298] | 2.30[299] | 1.73[300] | 1.95[301] |
44 | PSMF1 | Proteasome inhibitor PI31 subunit | [302] | 2.31[303] | 2.38[304] | 1.25[305] | 1.30[306] | 0.94[307] | 1.89[308] |
45 | UBE2M | NEDD8-conjugating enzyme Ubc12 | [309] | 0.43[310] | 0.29[311] | 1.00[312] | 0.91[313] | 0.67[314] | -1.31[315] |
46 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [316] | 0.31[317] | 0.75[318] | 1.24[319] | -0.01[320] | 0.69[321] | -1.64[322] |
47 | PSMB2 | Proteasome subunit beta type-2 | [323] | 2.09[324] | 1.85[325] | 2.30[326] | 2.60[327] | 2.46[328] | 2.43[329] |
48 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [330] | -2.03[331] | -0.88[332] | -3.23[333] | -1.75[334] | 1.87[335] | -0.70[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -1.92[338] | -4.51[339] | -6.75[340] | 1.85[341] | -0.54[342] | -0.46[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | 0.47[345] | 0.99[346] | 0.07[347] | 0.48[348] | 0.79[349] | 0.76[350] |
51 | CUL1 | Cullin-1 | [351] | 0.70[352] | 1.51[353] | 1.10[354] | 1.95[355] | 1.46[356] | 2.12[357] |
52 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [358] | 1.32[359] | 2.41[360] | 1.40[361] | 1.79[362] | 2.43[363] | 2.10[364] |
53 | UBA3 | NEDD8-activating enzyme E1 catalytic subunit | [365] | 0.81[366] | 1.50[367] | 0.63[368] | 1.56[369] | 2.02[370] | 1.20[371] |
54 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [372] | 1.02[373] | 1.37[374] | 1.46[375] | 2.15[376] | 1.34[377] | 0.75[378] |
55 | TNFRSF14 | Tumor necrosis factor receptor superfamily member 14 | [379] | 0.04[380] | 0.94[381] | -6.05[382] | -2.52[383] | -2.20[384] | 0.85[385] |
56 | PSME4 | Proteasome activator complex subunit 4 | [386] | 2.55[387] | 3.49[388] | 3.56[389] | 2.71[390] | 2.54[391] | 3.02[392] |
57 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [393] | 1.44[394] | 1.02[395] | 2.65[396] | 2.53[397] | 2.49[398] | 2.20[399] |
58 | FBXW11 | F-box/WD repeat-containing protein 11 | [400] | 2.46[401] | 2.50[402] | 3.30[403] | 2.90[404] | 2.66[405] | 2.32[406] |
59 | TRAF2 | TNF receptor-associated factor 2 | [407] | 1.31[408] | 1.50[409] | 1.28[410] | 1.49[411] | 1.35[412] | 0.58[413] |
60 | CD40 | Tumor necrosis factor receptor superfamily member 5 | [414] | 0.28[415] | -0.78[416] | -8.99[417] | -1.45[418] | -0.27[419] | 0.44[420] |
61 | TNFSF14 | Tumor necrosis factor ligand superfamily member 14 | [421] | -3.44[422] | 1.04[423] | -3.77[424] | -3.93[425] | -2.47[426] | 3.36[427] |
62 | RELB | Transcription factor RelB | [428] | 0.79[429] | 0.51[430] | 0.80[431] | 0.36[432] | 1.43[433] | -1.13[434] |
63 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [435] | 1.98[436] | 3.34[437] | 3.34[438] | 2.02[439] | 2.68[440] | 2.89[441] |
64 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [442] | -1.04[443] | -5.02[444] | -5.64[445] | -2.00[446] | -0.51[447] | 2.83[448] |
65 | TNFSF13 | Tumor necrosis factor ligand superfamily member 13 | [449] | -0.84[450] | -0.61[451] | -3.58[452] | -1.87[453] | -0.46[454] | -0.78[455] |
66 | TNFSF12 | Tumor necrosis factor ligand superfamily member 12 | [456] | -0.57[457] | 1.10[458] | -3.16[459] | -0.54[460] | -0.03[461] | -0.10[462] |
67 | BTRC | F-box/WD repeat-containing protein 1A | [463] | 2.49[464] | 3.42[465] | 3.07[466] | 2.13[467] | 2.52[468] | 2.72[469] |
68 | TNFSF11 | Tumor necrosis factor ligand superfamily member 11 | [470] | [471] | [472] | [473] | -9.16[474] | -3.83[475] | -2.38[476] |
69 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [477] | 0.68[478] | 1.27[479] | 0.15[480] | 3.45[481] | 2.28[482] | 2.26[483] |
70 | TRAF3 | TNF receptor-associated factor 3 | [484] | 3.97[485] | 3.52[486] | 3.17[487] | 4.20[488] | 4.46[489] | 3.30[490] |
71 | LTB | Lymphotoxin-beta | [491] | -0.68[492] | -0.82[493] | -5.01[494] | -3.28[495] | -4.56[496] | -1.42[497] |
72 | TNFRSF11 | Tumor necrosis factor receptor superfamily member 11A | [498] | 3.13[499] | 2.03[500] | 0.23[501] | 0.74[502] | 1.92[503] | 0.13[504] |
73 | TNFSF9 | Tumor necrosis factor ligand superfamily member 9 | [505] | 0.99[506] | 0.85[507] | 1.64[508] | 1.74[509] | 0.58[510] | -4.12[511] |
74 | CD27 | CD27 antigen | [512] | -3.33[513] | -3.20[514] | -4.15[515] | -4.87[516] | -1.48[517] | -0.24[518] |
75 | TNFSF18 | Tumor necrosis factor ligand superfamily member 18 | [519] | [520] | [521] | -4.61[522] | -5.01[523] | -4.73[524] | -6.46[525] |
76 | TNFRSF6B | Tumor necrosis factor receptor superfamily member 6B | [526] | -4.22[527] | -3.33[528] | -4.03[529] | -4.50[530] | -1.31[531] | -2.90[532] |
77 | EDA | Ectodysplasin-A | [533] | 6.03[534] | 4.20[535] | -4.70[536] | -2.40[537] | 2.11[538] | 1.72[539] |
78 | EDA2R | Tumor necrosis factor receptor superfamily member 27 | [540] | 4.30[541] | 4.33[542] | -5.80[543] | -5.98[544] | 2.35[545] | -1.72[546] |
79 | TNFRSF11 | Tumor necrosis factor receptor superfamily member 11B | [547] | -2.33[548] | -2.75[549] | 3.62[550] | 3.42[551] | 3.64[552] | 4.15[553] |
80 | TNFRSF9 | Tumor necrosis factor receptor superfamily member 9 | [554] | 1.44[555] | 0.37[556] | -0.13[557] | 5.93[558] | 5.19[559] | -0.33[560] |
81 | TNFSF13B | Tumor necrosis factor ligand superfamily member 13B | [561] | -4.81[562] | -1.70[563] | -2.78[564] | 0.30[565] | 1.60[566] | 4.21[567] |
82 | TNFRSF17 | Tumor necrosis factor receptor superfamily member 17 | [568] | -5.66[569] | [570] | -4.85[571] | [572] | [573] | 1.03[574] |
83 | TNFRSF25 | Tumor necrosis factor receptor superfamily member 25 | [575] | 1.96[576] | 3.20[577] | 1.45[578] | 0.45[579] | 2.26[580] | 2.16[581] |
84 | TNF | Tumor necrosis factor | [582] | 2.18[583] | 0.18[584] | -4.38[585] | -0.85[586] | -4.22[587] | -0.52[588] |
85 | CD40LG | CD40 ligand | [589] | -3.69[590] | [591] | -5.17[592] | -2.87[593] | [594] | 0.80[595] |
86 | TNFSF8 | Tumor necrosis factor ligand superfamily member 8 | [596] | -0.06[597] | [598] | [599] | -3.08[600] | -1.56[601] | 3.59[602] |
87 | TNFSF4 | Tumor necrosis factor ligand superfamily member 4 | [603] | 4.82[604] | 7.81[605] | 6.65[606] | 3.73[607] | 6.96[608] | 3.15[609] |
88 | TNFRSF8 | Tumor necrosis factor receptor superfamily member 8 | [610] | -1.45[611] | [612] | [613] | 0.75[614] | 1.89[615] | 0.94[616] |
89 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [617] | -2.73[618] | -0.73[619] | -4.66[620] | [621] | [622] | 1.96[623] |
90 | LTA | Lymphotoxin-alpha | [624] | -2.30[625] | [626] | -1.70[627] | 0.52[628] | -1.89[629] | -0.46[630] |
91 | TNFSF15 | Tumor necrosis factor ligand superfamily member 15 | [631] | 5.95[632] | 2.93[633] | 3.99[634] | 3.88[635] | 1.56[636] | 4.33[637] |
92 | TNFRSF4 | Tumor necrosis factor receptor superfamily member 4 | [638] | 1.59[639] | 1.20[640] | -1.34[641] | [642] | 0.32[643] | 1.37[644] |
93 | EDAR | Tumor necrosis factor receptor superfamily member EDAR | [645] | -2.39[646] | -2.14[647] | 0.33[648] | -1.27[649] | 0.05[650] | 4.57[651] |
94 | TNFRSF18 | Tumor necrosis factor receptor superfamily member 18 | [652] | 1.48[653] | 0.93[654] | -2.23[655] | 1.06[656] | [657] | 1.63[658] |
95 | TNFRSF13 | Tumor necrosis factor receptor superfamily member 13B | [659] | [660] | [661] | [662] | [663] | [664] | 3.24[665] |
96 | SEM1 | Putative protein SEM1, isoform 2 | [666] | [667] | [668] | [669] | [670] | [671] | [672] |
97 | PSMA8 | Proteasome subunit alpha type-7-like | [673] | [674] | [675] | [676] | [677] | [678] | [679] |
98 | PSMB11 | Proteasome subunit beta type-11 | [680] | [681] | [682] | [683] | [684] | [685] | [686] |
99 | EDARADD | Ectodysplasin-A receptor-associated adapter protein | [687] | [688] | [689] | [690] | [691] | [692] | [693] |
100 | TNFRSF13 | Tumor necrosis factor receptor superfamily member 13C | [694] | [695] | [696] | [697] | [698] | [699] | [700] |
101 | CD70 | CD70 antigen | [701] | [702] | [703] | [704] | [705] | [706] | [707] |