REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A [1] -0.57[2] -1.13[3] -0.26[4] -0.24[5] -0.02[6] -0.05[7]
2 TNFAIP3 Tumor necrosis factor alpha-induced protein 3 [8] 0.53[9] 1.13[10] -1.56[11] -1.82[12] 0.19[13] -1.16[14]
3 FADD FAS-associated death domain protein [15] -0.06[16] -0.87[17] 0.43[18] 1.33[19] -0.82[20] -1.90[21]
4 CASP8 Caspase-8 [22] -0.08[23] 0.39[24] 0.14[25] -0.68[26] -1.39[27] -1.55[28]
5 TRADD Tumor necrosis factor receptor type 1-associated DEATH domain protein -0.36[29] -0.62[30] -1.21[31] -1.59[32] -1.70[33] -0.72[34]
6 USP4 Ubiquitin carboxyl-terminal hydrolase 4 [35] 0.08[36] 0.47[37] 0.29[38] -0.60[39] 0.43[40] 0.69[41]
7 TRAF2 TNF receptor-associated factor 2 [42] 0.13[43] 0.09[44] 0.40[45] -0.48[46] -0.43[47] -0.93[48]
8 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [49] 0.19[50] 0.25[51] 0.51[52] 0.47[53] 0.04[54] 1.35[55]
9 CYLD Ubiquitin carboxyl-terminal hydrolase CYLD [56] -0.20[57] -0.17[58] -0.78[59] 0.34[60] 1.61[61] 1.81[62]
10 OTUD7B OTU domain-containing protein 7B [63] 0.97[64] 0.45[65] 1.43[66] 1.48[67] 0.97[68] 1.29[69]
11 USP21 Ubiquitin carboxyl-terminal hydrolase 21 [70] 0.96[71] 1.02[72] 1.50[73] 0.91[74] 0.66[75] -0.09[76]
12 USP2 Ubiquitin carboxyl-terminal hydrolase 2 [77] 1.11[78] 0.69[79] 0.28[80] -0.89[81] -2.35[82] 0.00[83]
13 TNF Tumor necrosis factor [84] 1.00[85] -1.23[86] -5.26[87] -2.82[88] -6.01[89] -2.02[90]
[1]
ref_hepatocyte TNFRSF1A
Mean 30.7
Standard deviation 20
Values 11 15 24 55 48
[2]
HepG2 TNFRSF1A
Mean 49
Standard deviation 6
Values 53 45
[3]
HepG2.C3A TNFRSF1A
Mean 31.7
Standard deviation 8.2
Values 37 26
[4]
HuH.7 TNFRSF1A
Mean 37.3
Standard deviation 0.38
Values 38 37 37
[5]
SNU475 TNFRSF1A
Mean 72.7
Standard deviation 0.99
Values 73 72
[6]
THLE TNFRSF1A
Mean 92.5
Standard deviation 20
Values 78 1.1e+02
[7]
liver TNFRSF1A
Mean 46.1
Standard deviation 22
Values 51 26 74 33
[8]
ref_hepatocyte TNFAIP3
Mean 11.3
Standard deviation 19
Values 4.3 2.5 44 3.7 1.5
[9]
HepG2 TNFAIP3
Mean 38.7
Standard deviation 5.9
Values 43 34
[10]
HepG2.C3A TNFAIP3
Mean 55.9
Standard deviation 5.4
Values 60 52
[11]
HuH.7 TNFAIP3
Mean 5.6
Standard deviation 2.8
Values 4.2 8.9 3.7
[12]
SNU475 TNFAIP3
Mean 8.95
Standard deviation 6.4
Values 4.4 13
[13]
THLE TNFAIP3
Mean 39.3
Standard deviation 6.8
Values 34 44
[14]
liver TNFAIP3
Mean 7.87
Standard deviation 2
Values 11 5.9 7.6 7.5
[15]
ref_hepatocyte FADD
Mean 9.28
Standard deviation 6.6
Values 3.8 12 20 6.3 5.1
[16]
HepG2 FADD
Mean 21.1
Standard deviation 4.6
Values 24 18
[17]
HepG2.C3A FADD
Mean 11.5
Standard deviation 1.6
Values 10 13
[18]
HuH.7 FADD
Mean 18.2
Standard deviation 3.2
Values 16 16 22
[19]
SNU475 FADD
Mean 65.1
Standard deviation 11
Values 73 58
[20]
THLE FADD
Mean 16
Standard deviation 3.5
Values 14 19
[21]
liver FADD
Mean 3.86
Standard deviation 1.3
Values 2.5 4.9 3 5.1
[22]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 18 13 8.9 1.9 2.8
[23]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 22 18
[24]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 17 35
[25]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 14 11 18
[26]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 16 15
[27]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[28]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 3.4 5.2 5.3 5
[29]
ref_hepatocyte TRADD
Mean 5.53
Standard deviation 1.5
Values 3.6 4.8 5.3 7.4 6.5
[30]
HepG2 TRADD
Mean 10.2
Standard deviation 3.2
Values 12 8
[31]
HepG2.C3A TRADD
Mean 8.12
Standard deviation 2.3
Values 9.8 6.5
[32]
HuH.7 TRADD
Mean 3.47
Standard deviation 1.2
Values 2.9 2.7 4.9
[33]
SNU475 TRADD
Mean 5.13
Standard deviation 1
Values 5.8 4.4
[34]
THLE TRADD
Mean 5.18
Standard deviation 0.33
Values 4.9 5.4
[35]
liver TRADD
Mean 5.22
Standard deviation 3
Values 9.2 2.7 6 3
[36]
ref_hepatocyte USP4
Mean 5.41
Standard deviation 1.7
Values 4.6 8.4 4.1 5.1 4.8
[37]
HepG2 USP4
Mean 13.6
Standard deviation 2.2
Values 12 15
[38]
HepG2.C3A USP4
Mean 16.9
Standard deviation 2.6
Values 15 19
[39]
HuH.7 USP4
Mean 9.64
Standard deviation 1.7
Values 12 8.3 9.1
[40]
SNU475 USP4
Mean 9.98
Standard deviation 1.4
Values 11 9
[41]
THLE USP4
Mean 22.1
Standard deviation 2.8
Values 20 24
[42]
liver USP4
Mean 13.6
Standard deviation 6.3
Values 14 11 22 6.9
[43]
ref_hepatocyte TRAF2
Mean 5.07
Standard deviation 4.4
Values 1.1 5.1 12 4.2 2.5
[44]
HepG2 TRAF2
Mean 13.1
Standard deviation 2.2
Values 15 12
[45]
HepG2.C3A TRAF2
Mean 12.2
Standard deviation 1.2
Values 13 11
[46]
HuH.7 TRAF2
Mean 9.75
Standard deviation 2.3
Values 9.4 7.6 12
[47]
SNU475 TRAF2
Mean 10.1
Standard deviation 0.75
Values 9.6 11
[48]
THLE TRAF2
Mean 11.4
Standard deviation 2.7
Values 9.5 13
[49]
liver TRAF2
Mean 4.15
Standard deviation 1.4
Values 4 2.6 6 4.1
[50]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[51]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[52]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[53]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[54]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[55]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[56]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[57]
ref_hepatocyte CYLD
Mean 4.19
Standard deviation 3.9
Values 1.9 11 5.5 1.5 1.6
[58]
HepG2 CYLD
Mean 8.62
Standard deviation 3.8
Values 5.9 11
[59]
HepG2.C3A CYLD
Mean 8.42
Standard deviation 0.26
Values 8.6 8.2
[60]
HuH.7 CYLD
Mean 3.55
Standard deviation 1.5
Values 2.9 5.2 2.6
[61]
SNU475 CYLD
Mean 14.8
Standard deviation 2.6
Values 17 13
[62]
THLE CYLD
Mean 38.9
Standard deviation 5.8
Values 43 35
[63]
liver CYLD
Mean 22.8
Standard deviation 4.7
Values 22 26 17 27
[64]
ref_hepatocyte OTUD7B
Mean 2.95
Standard deviation 1.5
Values 3.2 4.9 3.8 1.2 1.7
[65]
HepG2 OTUD7B
Mean 13.7
Standard deviation 0.66
Values 13 14
[66]
HepG2.C3A OTUD7B
Mean 9.08
Standard deviation 0.14
Values 9 9.2
[67]
HuH.7 OTUD7B
Mean 11.6
Standard deviation 2.9
Values 12 14 8.4
[68]
SNU475 OTUD7B
Mean 23
Standard deviation 2.1
Values 24 21
[69]
THLE OTUD7B
Mean 17.6
Standard deviation 2.7
Values 16 20
[70]
liver OTUD7B
Mean 11.2
Standard deviation 8.3
Values 4.3 19 3.7 18
[71]
ref_hepatocyte USP21
Mean 1.92
Standard deviation 0.82
Values 2.6 0.48 2.2 2.2 2.1
[72]
HepG2 USP21
Mean 8.86
Standard deviation 0.64
Values 9.3 8.4
[73]
HepG2.C3A USP21
Mean 8.76
Standard deviation 1.2
Values 9.6 7.9
[74]
HuH.7 USP21
Mean 7.91
Standard deviation 1.1
Values 8.5 6.6 8.5
[75]
SNU475 USP21
Mean 10
Standard deviation 1.7
Values 11 8.9
[76]
THLE USP21
Mean 9.23
Standard deviation 1
Values 8.5 10
[77]
liver USP21
Mean 2.8
Standard deviation 0.83
Values 3.2 2.1 3.8 2.1
[78]
ref_hepatocyte USP2
Mean 1.28
Standard deviation 0.47
Values 1.7 1.4 1.2 1.6 0.52
[79]
HepG2 USP2
Mean 6.54
Standard deviation 0.021
Values 6.5 6.6
[80]
HepG2.C3A USP2
Mean 4.63
Standard deviation 0.13
Values 4.7 4.5
[81]
HuH.7 USP2
Mean 2.26
Standard deviation 0.065
Values 2.2 2.2 2.3
[82]
SNU475 USP2
Mean 1.92
Standard deviation 0.082
Values 2 1.9
[83]
THLE USP2
Mean 0.761
Standard deviation 0.26
Values 0.58 0.94
[84]
liver USP2
Mean 1.98
Standard deviation 0.74
Values 2.7 0.96 2.3 2
[85]
ref_hepatocyte TNF
Mean 0.113
Standard deviation 0.17
Values 0 0 0 0.17 0.39
[86]
HepG2 TNF
Mean 0.533
Standard deviation 0.44
Values 0.84 0.22
[87]
HepG2.C3A TNF
Mean 0.108
Standard deviation 0.029
Values 0.087 0.13
[88]
HuH.7 TNF
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[89]
SNU475 TNF
Mean 0.0443
Standard deviation 0.023
Values 0.028 0.061
[90]
THLE TNF
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[91]
liver TNF
Mean 0.0431
Standard deviation 0.06
Values 0 0.014 0.026 0.13