REACTOME_TNFR1_INDUCED_NFKAPPAB_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -0.52[2] | -0.84[3] | -0.69[4] | -0.83[5] | -0.66[6] | -0.27[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.08[16] | -0.09[17] | -0.32[18] | 0.03[19] | -0.28[20] | 0.18[21] |
4 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [22] | 2.36[23] | 2.14[24] | 3.19[25] | 1.42[26] | 1.95[27] | 0.95[28] |
5 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [29] | 1.21[30] | 0.62[31] | 0.93[32] | 2.32[33] | 2.21[34] | 1.69[35] |
6 | IKBKG | NF-kappa-B essential modulator | [36] | 0.79[37] | 0.81[38] | -1.43[39] | 1.10[40] | -0.40[41] | 1.00[42] |
7 | RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | [43] | 2.60[44] | 3.13[45] | 1.27[46] | 1.73[47] | 0.82[48] | 1.14[49] |
8 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [50] | -1.44[51] | -0.54[52] | -2.93[53] | -1.17[54] | 2.31[55] | -0.47[56] |
9 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [57] | 2.31[58] | 2.89[59] | -0.37[60] | 0.74[61] | 2.42[62] | 0.58[63] |
10 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [64] | 1.92[65] | 2.76[66] | 1.71[67] | 2.37[68] | 2.87[69] | 2.33[70] |
11 | SHARPIN | Sharpin | [71] | 1.41[72] | 1.14[73] | 1.17[74] | 2.04[75] | 1.22[76] | 1.31[77] |
12 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [78] | 2.05[79] | 2.09[80] | 2.36[81] | 3.65[82] | 2.82[83] | 1.85[84] |
13 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [85] | 1.58[86] | 2.53[87] | 2.40[88] | 2.44[89] | 2.33[90] | 1.86[91] |
14 | TRAF1 | TNF receptor-associated factor 1 | [92] | -2.74[93] | -2.99[94] | -2.15[95] | -1.59[96] | -1.31[97] | -1.29[98] |
15 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [99] | 1.74[100] | 3.56[101] | 3.66[102] | 2.30[103] | 3.21[104] | 2.44[105] |
16 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | 1.42[106] | 1.14[107] | -0.03[108] | 0.97[109] | 0.53[110] | 1.02[111] | |
17 | USP4 | Ubiquitin carboxyl-terminal hydrolase 4 | [112] | 1.86[113] | 2.22[114] | 1.48[115] | 1.96[116] | 2.65[117] | 2.43[118] |
18 | TRAF2 | TNF receptor-associated factor 2 | [119] | 1.91[120] | 1.85[121] | 1.59[122] | 2.07[123] | 1.79[124] | 0.81[125] |
19 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [126] | 1.97[127] | 2.01[128] | 1.69[129] | 3.03[130] | 2.26[131] | 3.09[132] |
20 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | [133] | 1.58[134] | 1.59[135] | 0.40[136] | 2.90[137] | 3.84[138] | 3.55[139] |
21 | RNF31 | E3 ubiquitin-protein ligase RNF31 | [140] | 4.12[141] | 2.22[142] | 3.01[143] | 3.07[144] | 2.37[145] | 2.69[146] |
22 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [147] | 2.58[148] | 3.68[149] | 3.65[150] | 2.60[151] | 3.12[152] | 3.12[153] |
23 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [154] | 2.33[155] | 2.85[156] | 2.93[157] | 1.96[158] | 2.01[159] | 1.83[160] |
24 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [161] | 2.20[162] | 2.14[163] | 2.25[164] | 2.21[165] | 2.01[166] | 2.79[167] |
25 | OTUD7B | OTU domain-containing protein 7B | [168] | 2.75[169] | 2.20[170] | 2.62[171] | 4.04[172] | 3.20[173] | 3.03[174] |
26 | XIAP | E3 ubiquitin-protein ligase XIAP | [175] | 3.20[176] | 3.66[177] | 4.12[178] | 4.54[179] | 3.67[180] | 4.29[181] |
27 | USP21 | Ubiquitin carboxyl-terminal hydrolase 21 | [182] | 2.75[183] | 2.77[184] | 2.69[185] | 3.47[186] | 2.89[187] | 1.65[188] |
28 | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | [189] | 2.89[190] | 2.44[191] | 1.47[192] | 1.66[193] | -0.13[194] | 1.74[195] |
29 | TNF | Tumor necrosis factor | [196] | 2.78[197] | 0.52[198] | -4.07[199] | -0.27[200] | -3.78[201] | -0.28[202] |
30 | RACK1 | Receptor of activated protein C kinase 1 | [203] | [204] | [205] | [206] | [207] | [208] | [209] |