REACTOME_TIE2_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.19[2] -0.04[3] -0.40[4] -0.38[5] 0.50[6] 0.26[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.57[9] 0.12[10] -0.07[11] -0.71[12] -0.55[13] -0.71[14]
3 SHC1 SHC-transforming protein 1 [15] 0.53[16] 0.47[17] 0.23[18] 1.39[19] 1.12[20] -0.22[21]
4 NRAS GTPase NRas [22] 0.00[23] 0.15[24] 0.25[25] -0.27[26] -0.45[27] -1.25[28]
5 HRAS GTPase HRas [29] -1.64[30] -2.63[31] -3.73[32] -2.21[33] -2.18[34] -3.66[35]
6 KRAS GTPase KRas [36] -1.15[37] -1.45[38] -0.16[39] -0.46[40] -0.56[41] -0.33[42]
7 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [43] -1.10[44] -1.27[45] -0.49[46] 0.80[47] 0.55[48] 2.00[49]
8 GRB14 Growth factor receptor-bound protein 14 [50] -4.44[51] -2.33[52] 0.83[53] -4.75[54] -5.70[55] 0.52[56]
9 SOS1 Son of sevenless homolog 1 [57] -0.73[58] 0.52[59] -0.29[60] -0.42[61] -0.94[62] -0.46[63]
10 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [64] 1.24[65] 1.18[66] 1.48[67] -0.56[68] 0.25[69] -1.29[70]
11 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.58[71] 0.80[72] 0.65[73] -0.21[74] 0.19[75] 0.15[76]
12 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -1.01[77] 0.34[78] 0.22[79] -0.14[80] 0.31[81] 0.91[82]
13 GRB7 Growth factor receptor-bound protein 7 [83] 1.78[84] 1.81[85] -1.33[86] -3.91[87] -2.94[88] -1.32[89]
14 DOK2 Docking protein 2 [90] -5.48[91] -6.37[92] -7.51[93] -8.73[94] -9.52[95] 0.63[96]
15 TEK Angiopoietin-1 receptor [97] -5.18[98] -6.97[99] -6.25[100] 3.05[101] 0.91[102] 4.43[103]
16 ANGPT2 Angiopoietin-2 [104] -2.36[105] -1.40[106] -1.15[107] -1.77[108] -1.50[109] 3.99[110]
17 ANGPT1 Angiopoietin-1 [111] -0.34[112] [113] 6.00[114] 9.15[115] 4.95[116] 5.67[117]
18 ANGPT4 Angiopoietin-4 [118] [119] [120] [121] [122] [123] [124]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[16]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[17]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[18]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[19]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[20]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[21]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[22]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[23]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[24]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[25]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[26]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[27]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[28]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[29]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[30]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[31]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[32]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[33]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[34]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[35]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[36]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[37]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[38]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[39]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[40]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[41]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[42]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[43]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[44]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[45]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[46]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[47]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[48]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[49]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[50]
ref_hepatocyte GRB14
Mean 6.95
Standard deviation 4.8
Values 0.24 7.4 4.4 10 12
[51]
HepG2 GRB14
Mean 1.09
Standard deviation 0.33
Values 1.3 0.86
[52]
HepG2.C3A GRB14
Mean 5.12
Standard deviation 1.2
Values 6 4.3
[53]
HuH.7 GRB14
Mean 54.5
Standard deviation 9.2
Values 44 58 62
[54]
SNU475 GRB14
Mean 1.14
Standard deviation 0.41
Values 1.4 0.85
[55]
THLE GRB14
Mean 0.557
Standard deviation 0.066
Values 0.6 0.51
[56]
liver GRB14
Mean 28.3
Standard deviation 21
Values 60 14 20 19
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[64]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[65]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[66]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[67]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[68]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[69]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[70]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[71]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[72]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[73]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[74]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[75]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[76]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[77]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[78]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[79]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[80]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[81]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[82]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[83]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[84]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[85]
ref_hepatocyte GRB7
Mean 1.79
Standard deviation 1
Values 1.9 0.17 2.4 1.8 2.8
[86]
HepG2 GRB7
Mean 21
Standard deviation 1.2
Values 20 22
[87]
HepG2.C3A GRB7
Mean 23.3
Standard deviation 14
Values 34 13
[88]
HuH.7 GRB7
Mean 3.15
Standard deviation 1.7
Values 3.5 1.4 4.6
[89]
SNU475 GRB7
Mean 0.525
Standard deviation 0.097
Values 0.59 0.46
[90]
THLE GRB7
Mean 0.975
Standard deviation 0.065
Values 0.93 1
[91]
liver GRB7
Mean 2.04
Standard deviation 1.6
Values 4 0.68 2.5 0.89
[92]
ref_hepatocyte DOK2
Mean 0.469
Standard deviation 0.67
Values 0 0 0 0.88 1.5
[93]
HepG2 DOK2
Mean 0.0358
Standard deviation 0.039
Values 0.063 0.0086
[94]
HepG2.C3A DOK2
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[95]
HuH.7 DOK2
Mean 0.0113
Standard deviation 0.012
Values 0.025 0 0.0094
[96]
SNU475 DOK2
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[97]
THLE DOK2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[98]
liver DOK2
Mean 2.07
Standard deviation 0.54
Values 2.1 1.8 2.8 1.5
[99]
ref_hepatocyte TEK
Mean 0.182
Standard deviation 0.14
Values 0 0.075 0.32 0.26 0.25
[100]
HepG2 TEK
Mean 0.0172
Standard deviation 0.024
Values 0.034 0
[101]
HepG2.C3A TEK
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[102]
HuH.7 TEK
Mean 0.0105
Standard deviation 0.0096
Values 0 0.013 0.019
[103]
SNU475 TEK
Mean 6.66
Standard deviation 0.4
Values 6.9 6.4
[104]
THLE TEK
Mean 1.42
Standard deviation 0.52
Values 1.1 1.8
[105]
liver TEK
Mean 11.1
Standard deviation 5.3
Values 6.5 18 7.4 12
[106]
ref_hepatocyte ANGPT2
Mean 0.0772
Standard deviation 0.055
Values 0.024 0.12 0.019 0.14 0.081
[107]
HepG2 ANGPT2
Mean 0.0515
Standard deviation 6.9e-05
Values 0.052 0.051
[108]
HepG2.C3A ANGPT2
Mean 0.109
Standard deviation 0.044
Values 0.078 0.14
[109]
HuH.7 ANGPT2
Mean 0.154
Standard deviation 0.071
Values 0.09 0.23 0.14
[110]
SNU475 ANGPT2
Mean 0.0996
Standard deviation 0.0097
Values 0.093 0.11
[111]
THLE ANGPT2
Mean 0.114
Standard deviation 0.12
Values 0.2 0.032
[112]
liver ANGPT2
Mean 3.49
Standard deviation 1.7
Values 1.6 5.7 3.1 3.6
[113]
ref_hepatocyte ANGPT1
Mean 0.0114
Standard deviation 0.025
Values 0 0 0 0 0.057
[114]
HepG2 ANGPT1
Mean 0.0308
Standard deviation 0.011
Values 0.023 0.039
[115]
HepG2.C3A ANGPT1
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 ANGPT1
Mean 3.22
Standard deviation 0.24
Values 3.2 3.5 3
[117]
SNU475 ANGPT1
Mean 28.5
Standard deviation 5.2
Values 25 32
[118]
THLE ANGPT1
Mean 1.46
Standard deviation 0.3
Values 1.7 1.3
[119]
liver ANGPT1
Mean 1.66
Standard deviation 0.92
Values 0.85 2.7 2.2 0.9
[120]
ref_hepatocyte ANGPT4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 ANGPT4
Mean 0.0186
Standard deviation 0.014
Values 0.029 0.0086
[122]
HepG2.C3A ANGPT4
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 ANGPT4
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 ANGPT4
Mean 0.0162
Standard deviation 0.023
Values 0.032 0
[125]
THLE ANGPT4
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[126]
liver ANGPT4
Mean 0.0518
Standard deviation 0.036
Values 0.071 0.057 0 0.079