REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.32[2] -0.61[3] -0.55[4] -0.53[5] -0.42[6] -0.11[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] 0.12[16] 0.14[17] -0.18[18] 0.32[19] -0.04[20] 0.34[21]
4 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 [22] 1.05[23] 1.29[24] 1.44[25] 1.50[26] 1.63[27] 1.62[28]
5 UBA52 Ubiquitin-60S ribosomal protein L40 [29] 2.55[30] 2.38[31] 3.33[32] 1.72[33] 2.18[34] 1.11[35]
6 UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 [36] -2.00[37] -2.27[38] -2.22[39] -1.64[40] -2.64[41] -3.25[42]
7 IKBKG NF-kappa-B essential modulator [43] 0.99[44] 1.05[45] -1.29[46] 1.40[47] -0.16[48] 1.16[49]
8 UBE2N Ubiquitin-conjugating enzyme E2 N [50] 2.56[51] 2.96[52] 1.69[53] 2.56[54] 2.11[55] 1.04[56]
9 BIRC3 Baculoviral IAP repeat-containing protein 3 [57] -1.24[58] -0.30[59] -2.79[60] -0.87[61] 2.54[62] -0.32[63]
10 UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [64] 2.87[65] 2.84[66] 2.03[67] 3.04[68] 2.89[69] 1.73[70]
11 BIRC2 Baculoviral IAP repeat-containing protein 2 [71] 2.12[72] 2.99[73] 1.85[74] 2.66[75] 3.10[76] 2.49[77]
12 TICAM1 TIR domain-containing adapter molecule 1 [78] 1.16[79] -0.02[80] 0.82[81] 1.02[82] 1.72[83] 1.26[84]
13 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 [85] 2.16[86] 2.24[87] 1.83[88] 3.32[89] 2.50[90] 3.25[91]
14 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha [92] 2.78[93] 3.91[94] 3.79[95] 2.90[96] 3.36[97] 3.28[98]
15 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta [99] 2.39[100] 2.37[101] 2.39[102] 2.50[103] 2.25[104] 2.94[105]
16 UBE2D1 Ubiquitin-conjugating enzyme E2 D1 [106] 2.67[107] 3.45[108] 3.71[109] 3.77[110] 3.18[111] 2.26[112]
17 TLR3 Toll-like receptor 3 [113] -1.97[114] -2.51[115] -2.92[116] 1.88[117] 2.62[118] 2.81[119]
18 TRAF6 TNF receptor-associated factor 6 [120] 2.96[121] 2.77[122] 3.25[123] 3.91[124] 3.02[125] 4.67[126]
19 RIPK3 Receptor-interacting serine/threonine-protein kinase 3 [127] -4.77[128] [129] -3.62[130] [131] -3.48[132] 2.32[133]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBE2D3
Mean 65.1
Standard deviation 16
Values 40 57 79 77 72
[23]
HepG2 UBE2D3
Mean 81.2
Standard deviation 7.1
Values 76 86
[24]
HepG2.C3A UBE2D3
Mean 90.2
Standard deviation 5
Values 87 94
[25]
HuH.7 UBE2D3
Mean 102
Standard deviation 3.4
Values 99 1.1e+02 1e+02
[26]
SNU475 UBE2D3
Mean 71.5
Standard deviation 4.7
Values 75 68
[27]
THLE UBE2D3
Mean 111
Standard deviation 12
Values 1e+02 1.2e+02
[28]
liver UBE2D3
Mean 83.8
Standard deviation 35
Values 1.1e+02 56 1.1e+02 51
[29]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[30]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[31]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[32]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[33]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[34]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[35]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[36]
ref_hepatocyte UBE2V1
Mean 30.9
Standard deviation 6.6
Values 41 25 33 29 27
[37]
HepG2 UBE2V1
Mean 4.65
Standard deviation 0.14
Values 4.6 4.7
[38]
HepG2.C3A UBE2V1
Mean 3.63
Standard deviation 0.17
Values 3.8 3.5
[39]
HuH.7 UBE2V1
Mean 3.85
Standard deviation 0.39
Values 4.3 3.8 3.5
[40]
SNU475 UBE2V1
Mean 3.83
Standard deviation 0.48
Values 4.2 3.5
[41]
THLE UBE2V1
Mean 2.74
Standard deviation 0.61
Values 2.3 3.2
[42]
liver UBE2V1
Mean 1.36
Standard deviation 0.64
Values 1.9 0.84 2 0.78
[43]
ref_hepatocyte IKBKG
Mean 22.7
Standard deviation 14
Values 7.4 36 37 24 10
[44]
HepG2 IKBKG
Mean 27.1
Standard deviation 5.7
Values 31 23
[45]
HepG2.C3A IKBKG
Mean 26.7
Standard deviation 4
Values 30 24
[46]
HuH.7 IKBKG
Mean 5.4
Standard deviation 1.3
Values 5.4 4.1 6.7
[47]
SNU475 IKBKG
Mean 23.2
Standard deviation 3.5
Values 21 26
[48]
THLE IKBKG
Mean 11.2
Standard deviation 1
Values 10 12
[49]
liver IKBKG
Mean 21.3
Standard deviation 6.6
Values 20 22 29 13
[50]
ref_hepatocyte UBE2N
Mean 19.2
Standard deviation 7.8
Values 19 28 25 11 12
[51]
HepG2 UBE2N
Mean 68.4
Standard deviation 19
Values 55 82
[52]
HepG2.C3A UBE2N
Mean 84.8
Standard deviation 36
Values 60 1.1e+02
[53]
HuH.7 UBE2N
Mean 36
Standard deviation 8.3
Values 38 27 43
[54]
SNU475 UBE2N
Mean 44
Standard deviation 3.7
Values 47 41
[55]
THLE UBE2N
Mean 45.7
Standard deviation 8
Values 40 51
[56]
liver UBE2N
Mean 16.6
Standard deviation 11
Values 25 8.3 27 5.9
[57]
ref_hepatocyte BIRC3
Mean 15.6
Standard deviation 19
Values 1.2 29 43 1.5 3.2
[58]
HepG2 BIRC3
Mean 3.98
Standard deviation 0.49
Values 4.3 3.6
[59]
HepG2.C3A BIRC3
Mean 7.2
Standard deviation 0.46
Values 6.9 7.5
[60]
HuH.7 BIRC3
Mean 1.31
Standard deviation 1.3
Values 0.65 2.8 0.49
[61]
SNU475 BIRC3
Mean 3.3
Standard deviation 0.79
Values 2.7 3.9
[62]
THLE BIRC3
Mean 50.3
Standard deviation 18
Values 63 37
[63]
liver BIRC3
Mean 5.25
Standard deviation 1.9
Values 5.1 5 3.2 7.7
[64]
ref_hepatocyte UBE2D2
Mean 10.8
Standard deviation 1.4
Values 9.1 10 13 11 11
[65]
HepG2 UBE2D2
Mean 47.6
Standard deviation 2.2
Values 49 46
[66]
HepG2.C3A UBE2D2
Mean 43.8
Standard deviation 3.3
Values 41 46
[67]
HuH.7 UBE2D2
Mean 25.5
Standard deviation 2.4
Values 26 23 27
[68]
SNU475 UBE2D2
Mean 34.3
Standard deviation 1.1
Values 35 34
[69]
THLE UBE2D2
Mean 44.2
Standard deviation 1.7
Values 43 45
[70]
liver UBE2D2
Mean 14.9
Standard deviation 8
Values 22 8.8 21 7.3
[71]
ref_hepatocyte BIRC2
Mean 10
Standard deviation 3.6
Values 13 14 11 6.4 5.8
[72]
HepG2 BIRC2
Mean 26.2
Standard deviation 3.4
Values 24 29
[73]
HepG2.C3A BIRC2
Mean 45.2
Standard deviation 3.6
Values 43 48
[74]
HuH.7 BIRC2
Mean 21
Standard deviation 4
Values 18 25 20
[75]
SNU475 BIRC2
Mean 24.6
Standard deviation 0.14
Values 24 25
[76]
THLE BIRC2
Mean 47.5
Standard deviation 12
Values 56 39
[77]
liver BIRC2
Mean 23.6
Standard deviation 3.9
Values 25 25 27 18
[78]
ref_hepatocyte TICAM1
Mean 4.75
Standard deviation 6.4
Values 0 1.4 16 3.4 3
[79]
HepG2 TICAM1
Mean 6.41
Standard deviation 2.9
Values 8.5 4.3
[80]
HepG2.C3A TICAM1
Mean 2.66
Standard deviation 0.59
Values 3.1 2.2
[81]
HuH.7 TICAM1
Mean 4.87
Standard deviation 0.33
Values 5.2 4.5 4.9
[82]
SNU475 TICAM1
Mean 3.73
Standard deviation 0.28
Values 3.5 3.9
[83]
THLE TICAM1
Mean 8.64
Standard deviation 1.3
Values 7.7 9.5
[84]
liver TICAM1
Mean 4.77
Standard deviation 3.4
Values 7.9 1.4 7.4 2.3
[85]
ref_hepatocyte RIPK1
Mean 4.28
Standard deviation 0.89
Values 3.7 4.4 3.1 5.4 4.8
[86]
HepG2 RIPK1
Mean 11.5
Standard deviation 4
Values 8.7 14
[87]
HepG2.C3A RIPK1
Mean 11.5
Standard deviation 0.53
Values 11 12
[88]
HuH.7 RIPK1
Mean 8.85
Standard deviation 0.42
Values 8.4 9.3 8.8
[89]
SNU475 RIPK1
Mean 16.6
Standard deviation 2.9
Values 19 15
[90]
THLE RIPK1
Mean 13.4
Standard deviation 1
Values 13 14
[91]
liver RIPK1
Mean 17
Standard deviation 5.1
Values 12 21 13 22
[92]
ref_hepatocyte CHUK
Mean 3.93
Standard deviation 1.2
Values 4.2 5.7 2.3 3.4 4.1
[93]
HepG2 CHUK
Mean 16.2
Standard deviation 6.4
Values 12 21
[94]
HepG2.C3A CHUK
Mean 33.6
Standard deviation 13
Values 25 43
[95]
HuH.7 CHUK
Mean 31.4
Standard deviation 3.3
Values 34 28 32
[96]
SNU475 CHUK
Mean 11.3
Standard deviation 1.1
Values 11 12
[97]
THLE CHUK
Mean 22.3
Standard deviation 0.15
Values 22 22
[98]
liver CHUK
Mean 16
Standard deviation 3.3
Values 13 21 15 15
[99]
ref_hepatocyte IKBKB
Mean 3.48
Standard deviation 0.8
Values 2.9 4.3 4.2 3.5 2.5
[100]
HepG2 IKBKB
Mean 11
Standard deviation 0.46
Values 11 11
[101]
HepG2.C3A IKBKB
Mean 10.2
Standard deviation 1
Values 11 9.5
[102]
HuH.7 IKBKB
Mean 10.6
Standard deviation 1.9
Values 11 8.4 12
[103]
SNU475 IKBKB
Mean 7.65
Standard deviation 1.8
Values 8.9 6.4
[104]
THLE IKBKB
Mean 9.14
Standard deviation 0.21
Values 9.3 9
[105]
liver IKBKB
Mean 11.2
Standard deviation 0.34
Values 11 11 11 12
[106]
ref_hepatocyte UBE2D1
Mean 2.43
Standard deviation 1.1
Values 2.2 1.2 4.1 1.7 2.8
[107]
HepG2 UBE2D1
Mean 9.29
Standard deviation 2.7
Values 7.4 11
[108]
HepG2.C3A UBE2D1
Mean 15.1
Standard deviation 2.9
Values 13 17
[109]
HuH.7 UBE2D1
Mean 18.4
Standard deviation 3.8
Values 21 14 20
[110]
SNU475 UBE2D1
Mean 12.8
Standard deviation 0.14
Values 13 13
[111]
THLE UBE2D1
Mean 12.2
Standard deviation 0.065
Values 12 12
[112]
liver UBE2D1
Mean 4.88
Standard deviation 2.6
Values 6.8 2.9 7.4 2.4
[113]
ref_hepatocyte TLR3
Mean 1.04
Standard deviation 0.74
Values 0 2 0.89 0.97 1.3
[114]
HepG2 TLR3
Mean 0.16
Standard deviation 0.0012
Values 0.16 0.16
[115]
HepG2.C3A TLR3
Mean 0.103
Standard deviation 0.036
Values 0.078 0.13
[116]
HuH.7 TLR3
Mean 0.0792
Standard deviation 0.093
Values 0.033 0.19 0.019
[117]
SNU475 TLR3
Mean 1.48
Standard deviation 0.068
Values 1.5 1.4
[118]
THLE TLR3
Mean 3.51
Standard deviation 0.81
Values 4.1 2.9
[119]
liver TLR3
Mean 3.05
Standard deviation 0.49
Values 2.5 3.4 2.8 3.5
[120]
ref_hepatocyte TRAF6
Mean 0.965
Standard deviation 0.32
Values 0.82 1 1.5 0.7 0.8
[121]
HepG2 TRAF6
Mean 4.54
Standard deviation 0.72
Values 4 5
[122]
HepG2.C3A TRAF6
Mean 3.74
Standard deviation 0.086
Values 3.8 3.7
[123]
HuH.7 TRAF6
Mean 5.32
Standard deviation 1
Values 5 6.4 4.5
[124]
SNU475 TRAF6
Mean 5.61
Standard deviation 0.46
Values 5.9 5.3
[125]
THLE TRAF6
Mean 4.31
Standard deviation 0.54
Values 3.9 4.7
[126]
liver TRAF6
Mean 10.3
Standard deviation 0.99
Values 9.7 12 9.8 10
[127]
ref_hepatocyte RIPK3
Mean 0.227
Standard deviation 0.15
Values 0 0.37 0.33 0.15 0.29
[128]
HepG2 RIPK3
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[129]
HepG2.C3A RIPK3
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 RIPK3
Mean 0.0107
Standard deviation 0.019
Values 0 0.032 0
[131]
SNU475 RIPK3
Mean 0
Standard deviation 0
Values 0 0
[132]
THLE RIPK3
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[133]
liver RIPK3
Mean 0.474
Standard deviation 0.21
Values 0.78 0.43 0.36 0.33