REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALB Serum albumin [1] -0.21[2] 0.15[3] 0.03[4] -7.59[5] -5.53[6] 0.01[7]
2 AKR1C1 Aldo-keto reductase family 1 member C1 [8] 0.32[9] -2.27[10] -4.16[11] 1.61[12] -1.29[13] -4.10[14]
3 AKR1C3 Aldo-keto reductase family 1 member C3 [15] 0.81[16] -0.84[17] -5.66[18] 4.85[19] -0.33[20] -2.05[21]
4 SCP2 Non-specific lipid-transfer protein [22] -0.76[23] -1.89[24] 0.18[25] 1.04[26] 2.77[27] 0.48[28]
5 AKR1C2 Aldo-keto reductase family 1 member C2 [29] 2.19[30] -2.12[31] -2.94[32] 3.96[33] -0.10[34] -1.03[35]
6 CYP27A1 Sterol 26-hydroxylase, mitochondrial [36] 1.00[37] -0.48[38] -1.75[39] -0.09[40] 0.24[41] 0.23[42]
7 AKR1C4 Aldo-keto reductase family 1 member C4 [43] -5.99[44] -5.89[45] -4.66[46] -6.20[47] -9.79[48] -0.74[49]
8 HSD17B4 Peroxisomal multifunctional enzyme type 2 [50] 1.64[51] -0.26[52] 1.29[53] 2.47[54] 5.03[55] 0.91[56]
9 SLC27A5 Bile acyl-CoA synthetase [57] -2.36[58] -3.38[59] -3.17[60] -3.02[61] -3.63[62] 0.77[63]
10 SLC27A2 Very long-chain acyl-CoA synthetase [64] -0.46[65] -2.56[66] -1.01[67] 0.40[68] -1.64[69] 1.30[70]
11 BAAT Bile acid-CoA:amino acid N-acyltransferase [71] -2.44[72] -4.09[73] -4.62[74] -3.79[75] -3.21[76] 1.89[77]
12 SLC10A1 Sodium/bile acid cotransporter [78] -6.73[79] -9.38[80] -9.04[81] -7.51[82] -6.98[83] -0.26[84]
13 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [85] -12.10[86] -10.58[87] -3.53[88] -7.88[89] [90] 1.71[91]
14 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [92] -5.14[93] -4.87[94] -6.98[95] -5.51[96] -5.46[97] 2.59[98]
15 HSD3B7 3 beta-hydroxysteroid dehydrogenase type 7 [99] 1.84[100] 0.43[101] -0.87[102] 1.01[103] 2.49[104] 0.47[105]
16 AKR1D1 3-oxo-5-beta-steroid 4-dehydrogenase [106] 0.00[107] -0.90[108] -1.79[109] -5.64[110] -3.98[111] -0.13[112]
17 OSBPL9 Oxysterol-binding protein-related protein 9 [113] 3.08[114] 1.24[115] 3.10[116] 5.10[117] 6.59[118] 0.93[119]
18 NR1H4 Bile acid receptor [120] 1.48[121] -0.20[122] 3.41[123] -3.58[124] -1.73[125] 0.66[126]
19 ACOX2 Peroxisomal acyl-coenzyme A oxidase 2 [127] 0.66[128] -0.28[129] 1.28[130] -3.40[131] 0.81[132] 1.26[133]
20 SLCO1B3 Solute carrier organic anion transporter family member 1B3 [134] -4.63[135] -5.49[136] 1.19[137] -6.13[138] -4.38[139] 2.08[140]
21 RXRA Retinoic acid receptor RXR-alpha [141] 3.02[142] 0.56[143] 3.22[144] 4.48[145] 6.04[146] 2.29[147]
22 ABCC3 Canalicular multispecific organic anion transporter 2 [148] 4.16[149] 1.21[150] 1.39[151] 4.73[152] 6.03[153] 2.78[154]
23 STARD5 StAR-related lipid transfer protein 5 [155] -2.92[156] -4.20[157] -5.32[158] -0.64[159] 0.90[160] -0.15[161]
24 OSBP Oxysterol-binding protein 1 [162] 3.27[163] 1.19[164] 4.54[165] 4.94[166] 6.68[167] 1.97[168]
25 AMACR Alpha-methylacyl-CoA racemase [169] -0.78[170] -3.04[171] 0.24[172] -0.11[173] 1.35[174] -1.69[175]
26 ACOT8 Acyl-coenzyme A thioesterase 8 [176] 2.13[177] 0.34[178] 2.20[179] 3.51[180] 4.90[181] -0.72[182]
27 CYP39A1 24-hydroxycholesterol 7-alpha-hydroxylase [183] -1.99[184] -4.43[185] 2.02[186] -0.46[187] 3.37[188] 0.61[189]
28 OSBPL2 Oxysterol-binding protein-related protein 2 [190] 4.28[191] 1.80[192] 3.00[193] 5.19[194] 6.20[195] 0.60[196]
29 CYP7A1 Cholesterol 7-alpha-monooxygenase [197] -1.27[198] -5.86[199] -7.58[200] -5.50[201] [202] -2.82[203]
30 NCOA1 Nuclear receptor coactivator 1 [204] 3.54[205] 1.85[206] 3.86[207] 6.26[208] 7.60[209] 2.79[210]
31 OSBPL1A Oxysterol-binding protein-related protein 1 [211] -2.30[212] -5.77[213] 3.29[214] 6.36[215] 7.96[216] 1.80[217]
32 ABCB11 Bile salt export pump [218] -3.71[219] [220] -2.86[221] -1.06[222] [223] 4.93[224]
33 CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase [225] -4.95[226] -5.94[227] [228] -4.56[229] 1.05[230] 2.41[231]
34 NCOA2 Nuclear receptor coactivator 2 [232] 4.65[233] 3.21[234] 6.85[235] 7.67[236] 7.85[237] 4.74[238]
35 OSBPL3 Oxysterol-binding protein-related protein 3 [239] 6.72[240] 4.71[241] 6.26[242] 7.11[243] 9.42[244] 0.07[245]
36 OSBPL6 Oxysterol-binding protein-related protein 6 [246] 0.24[247] -2.53[248] 5.78[249] 4.06[250] 10.44[251] 2.44[252]
37 OSBPL7 Oxysterol-binding protein-related protein 7 [253] 5.37[254] 3.82[255] -0.23[256] 7.41[257] 9.54[258] 1.03[259]
38 PTGIS Prostacyclin synthase [260] 1.52[261] 0.38[262] 6.16[263] 5.59[264] 13.42[265] 4.98[266]
39 SLCO1A2 Solute carrier organic anion transporter family member 1A2 [267] 1.62[268] -0.30[269] 9.43[270] 7.89[271] 4.47[272] 4.64[273]
40 CYP46A1 Cholesterol 24-hydroxylase [274] -0.71[275] -1.64[276] -0.84[277] 1.91[278] 4.99[279] 2.39[280]
41 CH25H Cholesterol 25-hydroxylase [281] -0.06[282] [283] -0.15[284] 12.69[285] 8.06[286] 3.24[287]
42 SLC51B Organic solute transporter subunit beta [288] [289] [290] [291] [292] [293] [294]
43 SLC10A2 Ileal sodium/bile acid cotransporter [295] [296] [297] [298] [299] [300] [301]
44 FABP6 Gastrotropin [302] [303] [304] [305] [306] [307] [308]
45 SLC51A Organic solute transporter subunit alpha [309] [310] [311] [312] [313] [314] [315]
[1]
ref_hepatocyte ALB
Mean 1.45e+04
Standard deviation 2e+04
Values 3e+03 3.5e+02 7.4e+02 2.1e+04 4.8e+04
[2]
HepG2 ALB
Mean 3.29e+03
Standard deviation 9.9e+02
Values 2.6e+03 4e+03
[3]
HepG2.C3A ALB
Mean 1.8e+04
Standard deviation 4.3e+03
Values 2.1e+04 1.5e+04
[4]
HuH.7 ALB
Mean 4.54e+03
Standard deviation 1.4e+03
Values 3.4e+03 6.1e+03 4.1e+03
[5]
SNU475 ALB
Mean 6.25
Standard deviation 1.4
Values 5.3 7.2
[6]
THLE ALB
Mean 7.91
Standard deviation 4.5
Values 11 4.7
[7]
liver ALB
Mean 1.88e+04
Standard deviation 4.8e+03
Values 2.2e+04 2.3e+04 1.8e+04 1.3e+04
[8]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 1.4e+03 1.3e+03 9.2e+02 1e+03 3.2e+02
[9]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 5.1e+02 1.5e+02
[10]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 2.8e+02 1.9e+02
[11]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 7.8 35 8.5
[12]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 2e+02 3.1e+02
[13]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[14]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 63 67 1.5e+02 21
[15]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 1.1e+02 4.3e+02 1.2e+02
[16]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[17]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[18]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[19]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[20]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[21]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 51 67 1.5e+02 32
[22]
ref_hepatocyte SCP2
Mean 227
Standard deviation 2.8e+02
Values 1.4e+02 77 9.1 2e+02 7.1e+02
[23]
HepG2 SCP2
Mean 35
Standard deviation 12
Values 27 43
[24]
HepG2.C3A SCP2
Mean 68.2
Standard deviation 19
Values 55 82
[25]
HuH.7 SCP2
Mean 78.3
Standard deviation 13
Values 83 63 89
[26]
SNU475 SCP2
Mean 38.6
Standard deviation 10
Values 46 32
[27]
THLE SCP2
Mean 38.9
Standard deviation 1.4
Values 40 38
[28]
liver SCP2
Mean 407
Standard deviation 2e+02
Values 6.5e+02 2.1e+02 4.9e+02 2.8e+02
[29]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.2e+02 3.4e+02 1.1e+02 2.3e+02 40
[30]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 2.9e+02 1e+02
[31]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 48 38
[32]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 3 15 2.5
[33]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 2.4e+02 1.9e+02
[34]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[35]
liver AKR1C2
Mean 106
Standard deviation 92
Values 64 1.1e+02 2.3e+02 19
[36]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 18 2.1e+02 3.7e+02
[37]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[38]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[39]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[40]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[41]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[42]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 3.3e+02 1.2e+02 2.5e+02 1.1e+02
[43]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 1.7 2.3e+02 2.8e+02
[44]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[45]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[46]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[47]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[48]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[49]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 56 66 1.7e+02 30
[50]
ref_hepatocyte HSD17B4
Mean 85.8
Standard deviation 51
Values 1.2e+02 57 11 1.1e+02 1.3e+02
[51]
HepG2 HSD17B4
Mean 70.1
Standard deviation 24
Values 53 87
[52]
HepG2.C3A HSD17B4
Mean 80.1
Standard deviation 0.22
Values 80 80
[53]
HuH.7 HSD17B4
Mean 64.3
Standard deviation 5.5
Values 68 58 67
[54]
SNU475 HSD17B4
Mean 39.5
Standard deviation 6.9
Values 44 35
[55]
THLE HSD17B4
Mean 70.3
Standard deviation 2.4
Values 69 72
[56]
liver HSD17B4
Mean 208
Standard deviation 20
Values 1.9e+02 2.2e+02 2.3e+02 1.9e+02
[57]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 0.8 1.2 6 1.4e+02 2.7e+02
[58]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 4.7 3.8
[59]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 9.7 8.2
[60]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 2.3 2.7 3.5
[61]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.83 0.89
[62]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[63]
liver SLC27A5
Mean 184
Standard deviation 60
Values 2.2e+02 1.1e+02 2.5e+02 1.6e+02
[64]
ref_hepatocyte SLC27A2
Mean 66.6
Standard deviation 61
Values 7.2 40 22 1.4e+02 1.2e+02
[65]
HepG2 SLC27A2
Mean 12.7
Standard deviation 1.5
Values 12 14
[66]
HepG2.C3A SLC27A2
Mean 12.6
Standard deviation 2.5
Values 14 11
[67]
HuH.7 SLC27A2
Mean 10.1
Standard deviation 2.6
Values 8.2 13 9.1
[68]
SNU475 SLC27A2
Mean 7.28
Standard deviation 1.4
Values 8.2 6.3
[69]
THLE SLC27A2
Mean 0.539
Standard deviation 0.043
Values 0.51 0.57
[70]
liver SLC27A2
Mean 212
Standard deviation 71
Values 1.1e+02 2.6e+02 2.6e+02 2.2e+02
[71]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 1.6 59 17 89 84
[72]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 1.9 3
[73]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.5 3.1
[74]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.098 1.6 0.18
[75]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.49 0.11
[76]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[77]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 4.1e+02 1.7e+02 2.7e+02 1.1e+02
[78]
ref_hepatocyte SLC10A1
Mean 41.6
Standard deviation 64
Values 0 0 1.5 60 1.5e+02
[79]
HepG2 SLC10A1
Mean 0.102
Standard deviation 0.08
Values 0.046 0.16
[80]
HepG2.C3A SLC10A1
Mean 0.0701
Standard deviation 0.038
Values 0.097 0.043
[81]
HuH.7 SLC10A1
Mean 0.0242
Standard deviation 0.015
Values 0.041 0.013 0.019
[82]
SNU475 SLC10A1
Mean 0.019
Standard deviation 0.013
Values 0.028 0.01
[83]
THLE SLC10A1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[84]
liver SLC10A1
Mean 44.8
Standard deviation 22
Values 64 22 63 29
[85]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 0 40 1.4 37 1e+02
[86]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[87]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[88]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.074 2.6 0.22
[89]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[90]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[91]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 1.8e+02 1.8e+02 1.5e+02 95
[92]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[93]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[94]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[95]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[96]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[97]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[98]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[99]
ref_hepatocyte HSD3B7
Mean 30.9
Standard deviation 9.6
Values 18 42 26 31 38
[100]
HepG2 HSD3B7
Mean 29.1
Standard deviation 6.4
Values 25 34
[101]
HepG2.C3A HSD3B7
Mean 46.7
Standard deviation 4.6
Values 43 50
[102]
HuH.7 HSD3B7
Mean 5.15
Standard deviation 1.4
Values 4.5 6.7 4.2
[103]
SNU475 HSD3B7
Mean 5.15
Standard deviation 1.7
Values 6.4 3.9
[104]
THLE HSD3B7
Mean 4.37
Standard deviation 0.17
Values 4.2 4.5
[105]
liver HSD3B7
Mean 55.4
Standard deviation 32
Values 95 26 66 35
[106]
ref_hepatocyte AKR1D1
Mean 25.3
Standard deviation 42
Values 4.5 0.35 0.37 23 99
[107]
HepG2 AKR1D1
Mean 6.61
Standard deviation 3
Values 4.5 8.7
[108]
HepG2.C3A AKR1D1
Mean 15.2
Standard deviation 0.35
Values 15 15
[109]
HuH.7 AKR1D1
Mean 2.24
Standard deviation 3.1
Values 0.38 5.8 0.5
[110]
SNU475 AKR1D1
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[111]
THLE AKR1D1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[112]
liver AKR1D1
Mean 29.7
Standard deviation 5.8
Values 23 35 26 34
[113]
ref_hepatocyte OSBPL9
Mean 22.1
Standard deviation 9
Values 28 33 11 17 21
[114]
HepG2 OSBPL9
Mean 49
Standard deviation 15
Values 39 60
[115]
HepG2.C3A OSBPL9
Mean 58.7
Standard deviation 11
Values 51 67
[116]
HuH.7 OSBPL9
Mean 58.1
Standard deviation 3.3
Values 57 62 55
[117]
SNU475 OSBPL9
Mean 62.8
Standard deviation 14
Values 73 53
[118]
THLE OSBPL9
Mean 53.6
Standard deviation 0.54
Values 54 53
[119]
liver OSBPL9
Mean 54.5
Standard deviation 4.6
Values 57 56 48 57
[120]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 15 9.3 3.8 43 33
[121]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 11 20
[122]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 19 21
[123]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 62 82 58
[124]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.12 0.17
[125]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[126]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 59 37 35 39
[127]
ref_hepatocyte ACOX2
Mean 19.6
Standard deviation 24
Values 4.4 1.3 1.6 39 52
[128]
HepG2 ACOX2
Mean 8.11
Standard deviation 2.8
Values 6.1 10
[129]
HepG2.C3A ACOX2
Mean 18
Standard deviation 1.3
Values 17 19
[130]
HuH.7 ACOX2
Mean 14.5
Standard deviation 1.3
Values 13 15 15
[131]
SNU475 ACOX2
Mean 0.154
Standard deviation 0.11
Values 0.074 0.23
[132]
THLE ACOX2
Mean 0.86
Standard deviation 0.15
Values 0.96 0.76
[133]
liver ACOX2
Mean 60.6
Standard deviation 24
Values 91 37 69 45
[134]
ref_hepatocyte SLCO1B3
Mean 16.4
Standard deviation 25
Values 0 3.8 0.31 18 60
[135]
HepG2 SLCO1B3
Mean 0.173
Standard deviation 0.087
Values 0.23 0.11
[136]
HepG2.C3A SLCO1B3
Mean 0.409
Standard deviation 0.26
Values 0.59 0.23
[137]
HuH.7 SLCO1B3
Mean 11.4
Standard deviation 8.7
Values 5.7 21 7.1
[138]
SNU475 SLCO1B3
Mean 0.0194
Standard deviation 0.0012
Values 0.019 0.02
[139]
THLE SLCO1B3
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[140]
liver SLCO1B3
Mean 89.3
Standard deviation 67
Values 1.9e+02 52 44 75
[141]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[142]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[143]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[144]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[145]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[146]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[147]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[148]
ref_hepatocyte ABCC3
Mean 14.4
Standard deviation 9.9
Values 14 12 5 31 9.7
[149]
HepG2 ABCC3
Mean 67.6
Standard deviation 20
Values 81 54
[150]
HepG2.C3A ABCC3
Mean 37.4
Standard deviation 7.2
Values 42 32
[151]
HuH.7 ABCC3
Mean 11.6
Standard deviation 4.6
Values 7.9 17 10
[152]
SNU475 ABCC3
Mean 31.8
Standard deviation 16
Values 43 21
[153]
THLE ABCC3
Mean 23.7
Standard deviation 5.8
Values 28 20
[154]
liver ABCC3
Mean 128
Standard deviation 23
Values 93 1.4e+02 1.5e+02 1.3e+02
[155]
ref_hepatocyte STARD5
Mean 12.5
Standard deviation 16
Values 0.18 1.9 0.6 27 33
[156]
HepG2 STARD5
Mean 0.434
Standard deviation 0.03
Values 0.41 0.45
[157]
HepG2.C3A STARD5
Mean 0.76
Standard deviation 0.15
Values 0.87 0.65
[158]
HuH.7 STARD5
Mean 0.0956
Standard deviation 0.039
Values 0.12 0.051 0.11
[159]
SNU475 STARD5
Mean 0.667
Standard deviation 0.038
Values 0.64 0.69
[160]
THLE STARD5
Mean 0.587
Standard deviation 0.048
Values 0.62 0.55
[161]
liver STARD5
Mean 14.5
Standard deviation 8.7
Values 26 6.4 15 9.9
[162]
ref_hepatocyte OSBP
Mean 12.2
Standard deviation 4.2
Values 8.9 8.9 10 19 14
[163]
HepG2 OSBP
Mean 30.7
Standard deviation 3.1
Values 29 33
[164]
HepG2.C3A OSBP
Mean 31.2
Standard deviation 8.1
Values 37 25
[165]
HuH.7 OSBP
Mean 86.5
Standard deviation 8
Values 88 93 78
[166]
SNU475 OSBP
Mean 31
Standard deviation 1
Values 32 30
[167]
THLE OSBP
Mean 31.5
Standard deviation 3.5
Values 29 34
[168]
liver OSBP
Mean 61.7
Standard deviation 29
Values 38 88 36 85
[169]
ref_hepatocyte AMACR
Mean 11.6
Standard deviation 11
Values 5.6 4.7 2.4 17 28
[170]
HepG2 AMACR
Mean 1.76
Standard deviation 1
Values 1 2.5
[171]
HepG2.C3A AMACR
Mean 1.58
Standard deviation 0.45
Values 1.3 1.9
[172]
HuH.7 AMACR
Mean 4.17
Standard deviation 1.7
Values 3.7 6.1 2.7
[173]
SNU475 AMACR
Mean 0.891
Standard deviation 0.32
Values 1.1 0.66
[174]
THLE AMACR
Mean 0.744
Standard deviation 0.26
Values 0.56 0.93
[175]
liver AMACR
Mean 4.64
Standard deviation 1.1
Values 5.7 3.1 5.1 4.7
[176]
ref_hepatocyte ACOT8
Mean 9.09
Standard deviation 5.1
Values 7.6 4.2 4.6 14 15
[177]
HepG2 ACOT8
Mean 10.5
Standard deviation 0.047
Values 10 10
[178]
HepG2.C3A ACOT8
Mean 12.9
Standard deviation 0.35
Values 13 13
[179]
HuH.7 ACOT8
Mean 12.8
Standard deviation 3.6
Values 14 8.8 16
[180]
SNU475 ACOT8
Mean 8.62
Standard deviation 1.7
Values 9.8 7.4
[181]
THLE ACOT8
Mean 6.83
Standard deviation 0.25
Values 6.7 7
[182]
liver ACOT8
Mean 7.1
Standard deviation 3.2
Values 9.8 5.3 9.8 3.5
[183]
ref_hepatocyte CYP39A1
Mean 7.02
Standard deviation 11
Values 0.052 1.3 0.69 8.1 25
[184]
HepG2 CYP39A1
Mean 0.464
Standard deviation 0.049
Values 0.5 0.43
[185]
HepG2.C3A CYP39A1
Mean 0.363
Standard deviation 0.032
Values 0.34 0.39
[186]
HuH.7 CYP39A1
Mean 8.71
Standard deviation 0.36
Values 8.7 9.1 8.4
[187]
SNU475 CYP39A1
Mean 0.422
Standard deviation 0.11
Values 0.35 0.5
[188]
THLE CYP39A1
Mean 1.83
Standard deviation 0.14
Values 1.9 1.7
[189]
liver CYP39A1
Mean 13.9
Standard deviation 9.4
Values 28 8.3 13 7.1
[190]
ref_hepatocyte OSBPL2
Mean 6.69
Standard deviation 3.3
Values 12 4.8 6.9 5.2 4.3
[191]
HepG2 OSBPL2
Mean 33.9
Standard deviation 0.64
Values 34 33
[192]
HepG2.C3A OSBPL2
Mean 26.1
Standard deviation 9
Values 32 20
[193]
HuH.7 OSBPL2
Mean 16.3
Standard deviation 1.8
Values 15 18 16
[194]
SNU475 OSBPL2
Mean 20.3
Standard deviation 6.6
Values 25 16
[195]
THLE OSBPL2
Mean 12.4
Standard deviation 0.81
Values 12 13
[196]
liver OSBPL2
Mean 13.1
Standard deviation 2.8
Values 16 10 15 11
[197]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 9.8 0 0 0.69 9.7
[198]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.11 0.77
[199]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.058 0.097
[200]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[201]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[202]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[203]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 1.1 0.94 0.82 0.079
[204]
ref_hepatocyte NCOA1
Mean 2.09
Standard deviation 0.73
Values 1.8 2 1.1 2.8 2.8
[205]
HepG2 NCOA1
Mean 6.38
Standard deviation 1.4
Values 5.4 7.4
[206]
HepG2.C3A NCOA1
Mean 8.42
Standard deviation 0.79
Values 7.9 9
[207]
HuH.7 NCOA1
Mean 9.25
Standard deviation 2.7
Values 9.2 12 6.6
[208]
SNU475 NCOA1
Mean 13.3
Standard deviation 1
Values 14 13
[209]
THLE NCOA1
Mean 10.2
Standard deviation 0.47
Values 9.9 11
[210]
liver NCOA1
Mean 18.7
Standard deviation 4.8
Values 17 23 13 22
[211]
ref_hepatocyte OSBPL1A
Mean 1.99
Standard deviation 1.5
Values 0 1.7 1.5 3 3.8
[212]
HepG2 OSBPL1A
Mean 0.106
Standard deviation 0.0042
Values 0.11 0.1
[213]
HepG2.C3A OSBPL1A
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[214]
HuH.7 OSBPL1A
Mean 5.95
Standard deviation 0.96
Values 7 5.3 5.5
[215]
SNU475 OSBPL1A
Mean 13.6
Standard deviation 4.9
Values 17 10
[216]
THLE OSBPL1A
Mean 12.5
Standard deviation 1
Values 12 13
[217]
liver OSBPL1A
Mean 8.93
Standard deviation 4.5
Values 16 6.7 6.7 6.6
[218]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 0 1 1.8 3 4.1
[219]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.057 0.021
[220]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[221]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.11 0.096 0.037
[222]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.051 0.11
[223]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[224]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 17 1.9e+02 36 71
[225]
ref_hepatocyte CYP7B1
Mean 1.44
Standard deviation 1
Values 0 2.2 1.1 1.2 2.7
[226]
HepG2 CYP7B1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[227]
HepG2.C3A CYP7B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[228]
HuH.7 CYP7B1
Mean 0
Standard deviation 0
Values 0 0 0
[229]
SNU475 CYP7B1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[230]
THLE CYP7B1
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[231]
liver CYP7B1
Mean 9.87
Standard deviation 5.4
Values 6.3 17 4.8 12
[232]
ref_hepatocyte NCOA2
Mean 1.14
Standard deviation 0.47
Values 1.5 1.7 1.2 0.47 0.91
[233]
HepG2 NCOA2
Mean 7.51
Standard deviation 4.4
Values 4.4 11
[234]
HepG2.C3A NCOA2
Mean 11.8
Standard deviation 4.3
Values 8.7 15
[235]
HuH.7 NCOA2
Mean 40.1
Standard deviation 18
Values 55 45 21
[236]
SNU475 NCOA2
Mean 19.2
Standard deviation 3.8
Values 22 17
[237]
THLE NCOA2
Mean 6.6
Standard deviation 1.4
Values 5.6 7.6
[238]
liver NCOA2
Mean 39.3
Standard deviation 20
Values 25 56 20 57
[239]
ref_hepatocyte OSBPL3
Mean 0.787
Standard deviation 0.96
Values 2.3 1.2 0.24 0.069 0.15
[240]
HepG2 OSBPL3
Mean 21.7
Standard deviation 2.5
Values 20 23
[241]
HepG2.C3A OSBPL3
Mean 23
Standard deviation 4.5
Values 20 26
[242]
HuH.7 OSBPL3
Mean 18.4
Standard deviation 4.7
Values 23 14 18
[243]
SNU475 OSBPL3
Mean 9.02
Standard deviation 2.2
Values 7.5 11
[244]
THLE OSBPL3
Mean 13.5
Standard deviation 1.2
Values 13 14
[245]
liver OSBPL3
Mean 1.07
Standard deviation 0.32
Values 1.5 0.98 0.69 1.1
[246]
ref_hepatocyte OSBPL6
Mean 0.506
Standard deviation 0.35
Values 0 0.81 0.82 0.59 0.31
[247]
HepG2 OSBPL6
Mean 0.156
Standard deviation 0.039
Values 0.18 0.13
[248]
HepG2.C3A OSBPL6
Mean 0.0984
Standard deviation 0.043
Values 0.068 0.13
[249]
HuH.7 OSBPL6
Mean 8.49
Standard deviation 1.9
Values 8.5 10 6.6
[250]
SNU475 OSBPL6
Mean 0.7
Standard deviation 0.62
Values 0.26 1.1
[251]
THLE OSBPL6
Mean 17.7
Standard deviation 0.86
Values 17 18
[252]
liver OSBPL6
Mean 3.54
Standard deviation 0.68
Values 4.5 3.4 3 3.2
[253]
ref_hepatocyte OSBPL7
Mean 0.278
Standard deviation 0.42
Values 1 0.065 0.14 0.12 0.041
[254]
HepG2 OSBPL7
Mean 3
Standard deviation 0.61
Values 2.6 3.4
[255]
HepG2.C3A OSBPL7
Mean 4.39
Standard deviation 1
Values 5.1 3.7
[256]
HuH.7 OSBPL7
Mean 0.0722
Standard deviation 0.066
Values 0.041 0.15 0.028
[257]
SNU475 OSBPL7
Mean 3.92
Standard deviation 1.8
Values 5.2 2.7
[258]
THLE OSBPL7
Mean 5.2
Standard deviation 0.95
Values 5.9 4.5
[259]
liver OSBPL7
Mean 0.732
Standard deviation 0.11
Values 0.68 0.76 0.62 0.87
[260]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[261]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[262]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[263]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[264]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[265]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[266]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1
[267]
ref_hepatocyte SLCO1A2
Mean 0.102
Standard deviation 0.15
Values 0 0 0.09 0.06 0.36
[268]
HepG2 SLCO1A2
Mean 0.0816
Standard deviation 0.018
Values 0.069 0.094
[269]
HepG2.C3A SLCO1A2
Mean 0.0925
Standard deviation 0.021
Values 0.078 0.11
[270]
HuH.7 SLCO1A2
Mean 21.5
Standard deviation 7.6
Values 18 30 16
[271]
SNU475 SLCO1A2
Mean 2
Standard deviation 0.3
Values 1.8 2.2
[272]
THLE SLCO1A2
Mean 0.0565
Standard deviation 0.012
Values 0.065 0.048
[273]
liver SLCO1A2
Mean 3.26
Standard deviation 2.6
Values 1.3 5 0.82 5.9
[274]
ref_hepatocyte CYP46A1
Mean 0.0447
Standard deviation 0.068
Values 0 0 0 0.069 0.15
[275]
HepG2 CYP46A1
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[276]
HepG2.C3A CYP46A1
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[277]
HuH.7 CYP46A1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[278]
SNU475 CYP46A1
Mean 0.0139
Standard deviation 0.02
Values 0.028 0
[279]
THLE CYP46A1
Mean 0.0358
Standard deviation 0.017
Values 0.024 0.048
[280]
liver CYP46A1
Mean 0.303
Standard deviation 0.093
Values 0.38 0.17 0.36 0.3
[281]
ref_hepatocyte CH25H
Mean 0.0114
Standard deviation 0.025
Values 0 0 0 0 0.057
[282]
HepG2 CH25H
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[283]
HepG2.C3A CH25H
Mean 0
Standard deviation 0
Values 0 0
[284]
HuH.7 CH25H
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[285]
SNU475 CH25H
Mean 6.24
Standard deviation 0.89
Values 5.6 6.9
[286]
THLE CH25H
Mean 0.0766
Standard deviation 0.05
Values 0.041 0.11
[287]
liver CH25H
Mean 0.138
Standard deviation 0.14
Values 0.28 0.014 0.23 0.026
[288]
ref_hepatocyte SLC51B
Missing
[289]
HepG2 SLC51B
Mean 5.2
Standard deviation 0.49
Values 5.5 4.9
[290]
HepG2.C3A SLC51B
Mean 6.12
Standard deviation 2.1
Values 4.6 7.6
[291]
HuH.7 SLC51B
Mean 13.2
Standard deviation 4
Values 9.5 13 17
[292]
SNU475 SLC51B
Mean 0.158
Standard deviation 0.18
Values 0.032 0.28
[293]
THLE SLC51B
Mean 0.0316
Standard deviation 0.022
Values 0.047 0.016
[294]
liver SLC51B
Mean 0.29
Standard deviation 0.29
Values 0.16 0.19 0.72 0.093
[295]
ref_hepatocyte SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[296]
HepG2 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[297]
HepG2.C3A SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[298]
HuH.7 SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0
[299]
SNU475 SLC10A2
Mean 0
Standard deviation 0
Values 0 0
[300]
THLE SLC10A2
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[301]
liver SLC10A2
Mean 0
Standard deviation 0
Values 0 0 0 0
[302]
ref_hepatocyte FABP6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[303]
HepG2 FABP6
Mean 0.127
Standard deviation 0.095
Values 0.19 0.06
[304]
HepG2.C3A FABP6
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[305]
HuH.7 FABP6
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[306]
SNU475 FABP6
Mean 0.146
Standard deviation 0.0091
Values 0.14 0.15
[307]
THLE FABP6
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[308]
liver FABP6
Mean 0
Standard deviation 0
Values 0 0 0 0
[309]
ref_hepatocyte SLC51A
Missing
[310]
HepG2 SLC51A
Mean 2.9
Standard deviation 0.024
Values 2.9 2.9
[311]
HepG2.C3A SLC51A
Mean 10.5
Standard deviation 3.2
Values 13 8.2
[312]
HuH.7 SLC51A
Mean 4.67
Standard deviation 0.7
Values 4 5.3 4.7
[313]
SNU475 SLC51A
Mean 0.0895
Standard deviation 0.0047
Values 0.093 0.086
[314]
THLE SLC51A
Mean 0.0943
Standard deviation 0.025
Values 0.077 0.11
[315]
liver SLC51A
Mean 12.1
Standard deviation 5.5
Values 19 5.5 14 11