REACTOME_THYROXINE_BIOSYNTHESIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 DIO1 Type I iodothyronine deiodinase [1] -0.04[2] 0.04[3] -0.09[4] -5.46[5] -4.85[6] -0.05[7]
2 IYD Iodotyrosine deiodinase 1 [8] -1.10[9] -1.18[10] 0.55[11] -0.71[12] -0.58[13] 1.22[14]
3 DIO3 Thyroxine 5-deiodinase [15] [16] [17] -0.83[18] -0.58[19] -2.55[20] -3.15[21]
4 SLC5A5 Sodium/iodide cotransporter [22] 0.10[23] 0.62[24] 2.08[25] 3.00[26] 2.30[27] -2.20[28]
5 DUOX2 Dual oxidase 2 [29] 2.86[30] -2.42[31] 0.27[32] 0.88[33] 0.39[34] -2.23[35]
6 DUOX1 Dual oxidase 1 [36] 1.21[37] 1.43[38] 1.69[39] 2.80[40] 3.41[41] 0.94[42]
7 CGA Glycoprotein hormones alpha chain [43] [44] [45] 0.46[46] 1.12[47] -0.26[48] -4.55[49]
8 DIO2 Type II iodothyronine deiodinase [50] 1.14[51] [52] 1.49[53] 10.15[54] 10.17[55] 1.71[56]
9 TPO Thyroid peroxidase [57] [58] [59] [60] [61] [62] [63]
10 TSHB Thyrotropin subunit beta [64] [65] [66] [67] [68] [69] [70]
[1]
ref_hepatocyte DIO1
Mean 29
Standard deviation 27
Values 24 2.5 3.8 53 61
[2]
HepG2 DIO1
Mean 13.4
Standard deviation 8.3
Values 7.5 19
[3]
HepG2.C3A DIO1
Mean 15.8
Standard deviation 0.073
Values 16 16
[4]
HuH.7 DIO1
Mean 7.28
Standard deviation 4.8
Values 3.8 13 5.3
[5]
SNU475 DIO1
Mean 0.0487
Standard deviation 0.0099
Values 0.042 0.056
[6]
THLE DIO1
Mean 0.0872
Standard deviation 0.011
Values 0.095 0.08
[7]
liver DIO1
Mean 54.4
Standard deviation 59
Values 1.4e+02 13 23 41
[8]
ref_hepatocyte IYD
Mean 1.19
Standard deviation 1.6
Values 0.14 0.6 0.038 1.2 4
[9]
HepG2 IYD
Mean 0.263
Standard deviation 0.11
Values 0.34 0.19
[10]
HepG2.C3A IYD
Mean 0.278
Standard deviation 0.077
Values 0.22 0.33
[11]
HuH.7 IYD
Mean 0.469
Standard deviation 0.18
Values 0.41 0.67 0.33
[12]
SNU475 IYD
Mean 0.0538
Standard deviation 0.017
Values 0.042 0.066
[13]
THLE IYD
Mean 0.0692
Standard deviation 0.023
Values 0.053 0.085
[14]
liver IYD
Mean 5.38
Standard deviation 0.69
Values 6 5.9 5 4.6
[15]
ref_hepatocyte DIO3
Mean 0.359
Standard deviation 0.52
Values 0 0 0.65 1.1 0
[16]
HepG2 DIO3
Mean 0
Standard deviation 0
Values 0 0
[17]
HepG2.C3A DIO3
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 DIO3
Mean 0.0541
Standard deviation 0.065
Values 0.025 0.13 0.0094
[19]
SNU475 DIO3
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[20]
THLE DIO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[21]
liver DIO3
Mean 0.0785
Standard deviation 0.08
Values 0.024 0.17 0 0.12
[22]
ref_hepatocyte SLC5A5
Mean 0.297
Standard deviation 0.18
Values 0.61 0.27 0.15 0.23 0.21
[23]
HepG2 SLC5A5
Mean 0.151
Standard deviation 0.011
Values 0.14 0.16
[24]
HepG2.C3A SLC5A5
Mean 0.241
Standard deviation 0.038
Values 0.21 0.27
[25]
HuH.7 SLC5A5
Mean 0.336
Standard deviation 0.081
Values 0.25 0.42 0.34
[26]
SNU475 SLC5A5
Mean 0.175
Standard deviation 0.054
Values 0.21 0.14
[27]
THLE SLC5A5
Mean 0.127
Standard deviation 0.089
Values 0.19 0.064
[28]
liver SLC5A5
Mean 0.125
Standard deviation 0.1
Values 0.047 0.27 0.051 0.13
[29]
ref_hepatocyte DUOX2
Mean 0.247
Standard deviation 0.52
Values 0 0 1.2 0.052 0
[30]
HepG2 DUOX2
Mean 0.851
Standard deviation 0.48
Values 1.2 0.51
[31]
HepG2.C3A DUOX2
Mean 0.0243
Standard deviation 0.034
Values 0.049 0
[32]
HuH.7 DUOX2
Mean 0.0795
Standard deviation 0.0089
Values 0.074 0.09 0.075
[33]
SNU475 DUOX2
Mean 0.0335
Standard deviation 0.012
Values 0.042 0.025
[34]
THLE DUOX2
Mean 0.0281
Standard deviation 0.0021
Values 0.03 0.027
[35]
liver DUOX2
Mean 0.102
Standard deviation 0.078
Values 0.024 0.11 0.21 0.066
[36]
ref_hepatocyte DUOX1
Mean 0.147
Standard deviation 0.22
Values 0.042 0 0.52 0.17 0
[37]
HepG2 DUOX1
Mean 0.161
Standard deviation 0.033
Values 0.14 0.18
[38]
HepG2.C3A DUOX1
Mean 0.209
Standard deviation 0.0073
Values 0.2 0.21
[39]
HuH.7 DUOX1
Mean 0.128
Standard deviation 0.14
Values 0.082 0.28 0.019
[40]
SNU475 DUOX1
Mean 0.0755
Standard deviation 0.015
Values 0.065 0.086
[41]
THLE DUOX1
Mean 0.136
Standard deviation 0.034
Values 0.16 0.11
[42]
liver DUOX1
Mean 0.548
Standard deviation 0.41
Values 0.33 0.56 0.18 1.1
[43]
ref_hepatocyte CGA
Mean 0.0776
Standard deviation 0.17
Values 0 0 0 0.39 0
[44]
HepG2 CGA
Mean 0
Standard deviation 0
Values 0 0
[45]
HepG2.C3A CGA
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 CGA
Mean 0.0287
Standard deviation 0.011
Values 0.016 0.032 0.037
[47]
SNU475 CGA
Mean 0.0125
Standard deviation 0.011
Values 0.0046 0.02
[48]
THLE CGA
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[49]
liver CGA
Mean 0.00642
Standard deviation 0.013
Values 0 0 0.026 0
[50]
ref_hepatocyte DIO2
Mean 0.0226
Standard deviation 0.031
Values 0.061 0 0 0.052 0
[51]
HepG2 DIO2
Mean 0.0236
Standard deviation 0.0091
Values 0.017 0.03
[52]
HepG2.C3A DIO2
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 DIO2
Mean 0.017
Standard deviation 0.011
Values 0.016 0.0064 0.028
[54]
SNU475 DIO2
Mean 1.89
Standard deviation 1.3
Values 0.99 2.8
[55]
THLE DIO2
Mean 2.25
Standard deviation 0.12
Values 2.2 2.3
[56]
liver DIO2
Mean 0.143
Standard deviation 0.12
Values 0 0.26 0.077 0.24
[57]
ref_hepatocyte TPO
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[58]
HepG2 TPO
Mean 0.00573
Standard deviation 0.0081
Values 0.011 0
[59]
HepG2.C3A TPO
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[60]
HuH.7 TPO
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 TPO
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE TPO
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[63]
liver TPO
Mean 0
Standard deviation 0
Values 0 0 0 0
[64]
ref_hepatocyte TSHB
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 TSHB
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A TSHB
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 TSHB
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 TSHB
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[69]
THLE TSHB
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[70]
liver TSHB
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0