REACTOME_THE_NLRP3_INFLAMMASOME Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TXN Thioredoxin [1] -2.36[2] -2.31[3] -2.30[4] -1.56[5] -1.78[6] -1.46[7]
2 HSP90AB1 Heat shock protein HSP 90-beta [8] 0.79[9] 0.87[10] 0.55[11] 0.36[12] -0.03[13] -0.30[14]
3 APP Amyloid-beta A4 protein [15] 0.94[16] 0.37[17] 1.52[18] 1.69[19] 2.32[20] 1.94[21]
4 HMOX1 Heme oxygenase 1 [22] 0.08[23] -0.86[24] -1.49[25] -0.69[26] -0.70[27] -0.28[28]
5 SUGT1 Protein SGT1 homolog [29] -1.04[30] -0.58[31] 0.05[32] -0.50[33] -0.35[34] -0.14[35]
6 NFKB2 Nuclear factor NF-kappa-B p100 subunit [36] -0.20[37] 0.08[38] 1.02[39] -0.47[40] 0.61[41] -1.22[42]
7 RELA Transcription factor p65 [43] 0.70[44] 0.18[45] 0.80[46] 0.85[47] 0.99[48] 0.92[49]
8 TXNIP Thioredoxin-interacting protein [50] 1.43[51] 2.12[52] 3.22[53] 3.25[54] 3.49[55] 4.34[56]
9 PANX1 Pannexin-1 [57] 0.19[58] -0.68[59] -1.05[60] 0.28[61] 0.89[62] 1.31[63]
10 NFKB1 Nuclear factor NF-kappa-B p105 subunit [64] 1.23[65] 0.89[66] 1.17[67] 0.66[68] 1.80[69] 2.25[70]
11 CASP1 Caspase-1 [71] -2.47[72] -5.89[73] -3.87[74] 0.99[75] 1.37[76] 1.07[77]
12 PYCARD Apoptosis-associated speck-like protein containing a CARD [78] 0.62[79] 0.79[80] -7.78[81] -7.33[82] 1.47[83] 0.97[84]
13 P2RX7 P2X purinoceptor 7 [85] -4.31[86] -1.05[87] -5.15[88] -4.46[89] 0.97[90] 2.91[91]
14 MEFV Pyrin [92] -0.38[93] 0.43[94] 0.37[95] 0.28[96] 0.46[97] 3.05[98]
15 PSTPIP1 Proline-serine-threonine phosphatase-interacting protein 1 [99] 0.80[100] 2.51[101] [102] -3.38[103] 1.50[104] 2.48[105]
16 NLRP3 NACHT, LRR and PYD domains-containing protein 3 [106] -3.07[107] -0.85[108] -2.16[109] -0.48[110] 2.23[111] 3.39[112]
[1]
ref_hepatocyte TXN
Mean 524
Standard deviation 4.3e+02
Values 6.9e+02 1.2e+03 2.7e+02 2.4e+02 2e+02
[2]
HepG2 TXN
Mean 153
Standard deviation 27
Values 1.7e+02 1.3e+02
[3]
HepG2.C3A TXN
Mean 142
Standard deviation 55
Values 1e+02 1.8e+02
[4]
HuH.7 TXN
Mean 98.2
Standard deviation 36
Values 91 67 1.4e+02
[5]
SNU475 TXN
Mean 174
Standard deviation 25
Values 1.9e+02 1.6e+02
[6]
THLE TXN
Mean 143
Standard deviation 0.49
Values 1.4e+02 1.4e+02
[7]
liver TXN
Mean 77.5
Standard deviation 77
Values 1.5e+02 16 1.3e+02 7.5
[8]
ref_hepatocyte HSP90AB1
Mean 469
Standard deviation 3.2e+02
Values 8.1e+02 7.8e+02 4e+02 2.1e+02 1.4e+02
[9]
HepG2 HSP90AB1
Mean 1.22e+03
Standard deviation 89
Values 1.2e+03 1.3e+03
[10]
HepG2.C3A HSP90AB1
Mean 1.16e+03
Standard deviation 1.2e+02
Values 1.2e+03 1.1e+03
[11]
HuH.7 HSP90AB1
Mean 634
Standard deviation 9.5
Values 6.3e+02 6.2e+02 6.4e+02
[12]
SNU475 HSP90AB1
Mean 591
Standard deviation 65
Values 5.4e+02 6.4e+02
[13]
THLE HSP90AB1
Mean 431
Standard deviation 80
Values 3.7e+02 4.9e+02
[14]
liver HSP90AB1
Mean 156
Standard deviation 26
Values 1.5e+02 1.4e+02 1.9e+02 1.3e+02
[15]
ref_hepatocyte APP
Mean 58.3
Standard deviation 28
Values 31 1e+02 46 51 59
[16]
HepG2 APP
Mean 167
Standard deviation 49
Values 2e+02 1.3e+02
[17]
HepG2.C3A APP
Mean 102
Standard deviation 27
Values 1.2e+02 83
[18]
HuH.7 APP
Mean 154
Standard deviation 13
Values 1.6e+02 1.7e+02 1.4e+02
[19]
SNU475 APP
Mean 184
Standard deviation 28
Values 2e+02 1.6e+02
[20]
THLE APP
Mean 273
Standard deviation 68
Values 2.3e+02 3.2e+02
[21]
liver APP
Mean 91
Standard deviation 73
Values 32 1.7e+02 28 1.3e+02
[22]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 19 4.5 1.2e+02 47 37
[23]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 92 52
[24]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 30 37
[25]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 10 22 12
[26]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 24 31
[27]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[28]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 16 13 18 15
[29]
ref_hepatocyte SUGT1
Mean 24.1
Standard deviation 16
Values 25 52 17 15 12
[30]
HepG2 SUGT1
Mean 17.5
Standard deviation 5.9
Values 13 22
[31]
HepG2.C3A SUGT1
Mean 21.7
Standard deviation 4.7
Values 18 25
[32]
HuH.7 SUGT1
Mean 23
Standard deviation 0.71
Values 22 23 24
[33]
SNU475 SUGT1
Mean 16.7
Standard deviation 0.19
Values 17 17
[34]
THLE SUGT1
Mean 17.8
Standard deviation 1.7
Values 17 19
[35]
liver SUGT1
Mean 8.95
Standard deviation 4
Values 13 6.1 12 5
[36]
ref_hepatocyte NFKB2
Mean 16.8
Standard deviation 20
Values 3.6 24 49 4.1 3
[37]
HepG2 NFKB2
Mean 21.8
Standard deviation 8.1
Values 28 16
[38]
HepG2.C3A NFKB2
Mean 23.9
Standard deviation 12
Values 32 16
[39]
HuH.7 NFKB2
Mean 31.3
Standard deviation 3.8
Values 29 36 29
[40]
SNU475 NFKB2
Mean 11.9
Standard deviation 3
Values 9.7 14
[41]
THLE NFKB2
Mean 24
Standard deviation 2.2
Values 22 26
[42]
liver NFKB2
Mean 2.95
Standard deviation 1.2
Values 2.1 3.3 1.8 4.5
[43]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 9.8 12 35 15 8.1
[44]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 42 35
[45]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 29 20
[46]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 29 25 23
[47]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[48]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[49]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 19 4.1 20 5.7
[50]
ref_hepatocyte TXNIP
Mean 11
Standard deviation 11
Values 6.2 1.1 4.9 29 13
[51]
HepG2 TXNIP
Mean 44
Standard deviation 36
Values 69 19
[52]
HepG2.C3A TXNIP
Mean 64.3
Standard deviation 30
Values 85 43
[53]
HuH.7 TXNIP
Mean 94.3
Standard deviation 8.4
Values 86 1e+02 94
[54]
SNU475 TXNIP
Mean 102
Standard deviation 25
Values 84 1.2e+02
[55]
THLE TXNIP
Mean 115
Standard deviation 45
Values 1.5e+02 83
[56]
liver TXNIP
Mean 90.5
Standard deviation 29
Values 1.2e+02 66 65 1.1e+02
[57]
ref_hepatocyte PANX1
Mean 7.99
Standard deviation 5.8
Values 5.7 12 16 3.7 2.6
[58]
HepG2 PANX1
Mean 13.6
Standard deviation 2.4
Values 12 15
[59]
HepG2.C3A PANX1
Mean 6.72
Standard deviation 2.2
Values 5.2 8.3
[60]
HuH.7 PANX1
Mean 3.55
Standard deviation 0.36
Values 3.8 3.7 3.1
[61]
SNU475 PANX1
Mean 9.5
Standard deviation 0.8
Values 8.9 10
[62]
THLE PANX1
Mean 13.8
Standard deviation 3.4
Values 11 16
[63]
liver PANX1
Mean 8.07
Standard deviation 2.2
Values 8.2 11 5.6 7.5
[64]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 3 6.7 12 5.3 4.7
[65]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 18 26
[66]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 15 17
[67]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 14 12 13
[68]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 9.6 10
[69]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[70]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 9.7 15 7.2 17
[71]
ref_hepatocyte CASP1
Mean 3.66
Standard deviation 3.7
Values 0.5 9.1 0.076 3.7 4.9
[72]
HepG2 CASP1
Mean 0.987
Standard deviation 0.74
Values 0.46 1.5
[73]
HepG2.C3A CASP1
Mean 0.0833
Standard deviation 0.049
Values 0.049 0.12
[74]
HuH.7 CASP1
Mean 0.231
Standard deviation 0.041
Values 0.19 0.27 0.23
[75]
SNU475 CASP1
Mean 7.12
Standard deviation 0.23
Values 7.3 6.9
[76]
THLE CASP1
Mean 8.87
Standard deviation 1.2
Values 9.7 8
[77]
liver CASP1
Mean 3.13
Standard deviation 0.99
Values 3.7 2.6 4.2 2
[78]
ref_hepatocyte PYCARD
Mean 2.47
Standard deviation 1.8
Values 0.17 2 2.3 2.7 5.2
[79]
HepG2 PYCARD
Mean 5.68
Standard deviation 3.5
Values 8.1 3.2
[80]
HepG2.C3A PYCARD
Mean 5.76
Standard deviation 0.0033
Values 5.8 5.8
[81]
HuH.7 PYCARD
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[82]
SNU475 PYCARD
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[83]
THLE PYCARD
Mean 6.42
Standard deviation 0.22
Values 6.3 6.6
[84]
liver PYCARD
Mean 1.97
Standard deviation 1.2
Values 3.3 0.9 2.7 0.99
[85]
ref_hepatocyte P2RX7
Mean 0.791
Standard deviation 1
Values 0.038 0.61 2.6 0.16 0.55
[86]
HepG2 P2RX7
Mean 0.0594
Standard deviation 0.029
Values 0.08 0.039
[87]
HepG2.C3A P2RX7
Mean 0.516
Standard deviation 0.27
Values 0.71 0.32
[88]
HuH.7 P2RX7
Mean 0.0205
Standard deviation 0.023
Values 0.0082 0.0064 0.047
[89]
SNU475 P2RX7
Mean 0.0353
Standard deviation 0.043
Values 0.0046 0.066
[90]
THLE P2RX7
Mean 1.45
Standard deviation 0.57
Values 1.9 1
[91]
liver P2RX7
Mean 2.43
Standard deviation 0.35
Values 2.6 2.6 2.6 1.9
[92]
ref_hepatocyte MEFV
Mean 0.361
Standard deviation 0.42
Values 1.1 0 0.4 0.1 0.25
[93]
HepG2 MEFV
Mean 0.414
Standard deviation 0.039
Values 0.44 0.39
[94]
HepG2.C3A MEFV
Mean 0.653
Standard deviation 0.17
Values 0.53 0.77
[95]
HuH.7 MEFV
Mean 0.43
Standard deviation 0.13
Values 0.39 0.58 0.32
[96]
SNU475 MEFV
Mean 0.429
Standard deviation 0.003
Values 0.43 0.43
[97]
THLE MEFV
Mean 0.467
Standard deviation 0.043
Values 0.5 0.44
[98]
liver MEFV
Mean 1.22
Standard deviation 1.1
Values 0.38 1.5 0.33 2.7
[99]
ref_hepatocyte PSTPIP1
Mean 0.267
Standard deviation 0.16
Values 0.32 0 0.45 0.3 0.27
[100]
HepG2 PSTPIP1
Mean 0.695
Standard deviation 0.03
Values 0.72 0.67
[101]
HepG2.C3A PSTPIP1
Mean 2.05
Standard deviation 0.68
Values 2.5 1.6
[102]
HuH.7 PSTPIP1
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 PSTPIP1
Mean 0.0251
Standard deviation 0.029
Values 0.0046 0.046
[104]
THLE PSTPIP1
Mean 0.707
Standard deviation 0.26
Values 0.53 0.89
[105]
liver PSTPIP1
Mean 0.607
Standard deviation 0.18
Values 0.52 0.47 0.57 0.87
[106]
ref_hepatocyte NLRP3
Mean 0.117
Standard deviation 0.12
Values 0 0.11 0 0.28 0.19
[107]
HepG2 NLRP3
Mean 0.0207
Standard deviation 0.013
Values 0.011 0.03
[108]
HepG2.C3A NLRP3
Mean 0.0871
Standard deviation 0.013
Values 0.078 0.097
[109]
HuH.7 NLRP3
Mean 0.024
Standard deviation 0.036
Values 0 0.0064 0.066
[110]
SNU475 NLRP3
Mean 0.0819
Standard deviation 0.063
Values 0.037 0.13
[111]
THLE NLRP3
Mean 0.513
Standard deviation 0.15
Values 0.62 0.4
[112]
liver NLRP3
Mean 0.499
Standard deviation 0.28
Values 0.19 0.84 0.39 0.58