REACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RBP4 Retinol-binding protein 4 [1] -0.12[2] -0.06[3] 0.45[4] -6.04[5] -4.63[6] 0.17[7]
2 TTR Transthyretin [8] -1.66[9] -0.47[10] -1.81[11] -8.81[12] -7.61[13] -1.09[14]
3 HSD17B6 17-beta-hydroxysteroid dehydrogenase type 6 [15] -5.04[16] -5.99[17] -5.27[18] 0.87[19] -1.90[20] 0.97[21]
4 RDH16 Retinol dehydrogenase 16 [22] -6.80[23] -5.95[24] -5.93[25] -4.42[26] -4.15[27] 0.61[28]
5 RDH11 Retinol dehydrogenase 11 [29] 3.33[30] 3.70[31] 3.48[32] 5.22[33] 6.20[34] 1.80[35]
6 RDH5 11-cis retinol dehydrogenase [36] -2.34[37] -1.50[38] -1.70[39] -1.59[40] -0.16[41] -1.51[42]
7 DHRS9 Dehydrogenase/reductase SDR family member 9 [43] -3.08[44] -4.39[45] -5.89[46] 0.90[47] 2.23[48] -4.56[49]
8 CYP4V2 Cytochrome P450 4V2 [50] 2.21[51] 2.83[52] 0.68[53] 3.02[54] 4.46[55] 3.06[56]
9 RDH10 Retinol dehydrogenase 10 [57] 5.58[58] 5.16[59] 3.88[60] 7.33[61] 6.83[62] 2.31[63]
10 RBP1 Retinol-binding protein 1 [64] 7.59[65] 1.75[66] 2.81[67] 5.71[68] 2.80[69] 2.15[70]
11 NAPEPLD N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [71] 5.02[72] 4.93[73] 5.63[74] 7.78[75] 7.04[76] 3.36[77]
12 HSD17B1 Estradiol 17-beta-dehydrogenase 1 [78] 6.25[79] 5.77[80] 4.95[81] 6.85[82] 7.49[83] 0.87[84]
13 MYO7A Unconventional myosin-VIIa [85] 6.86[86] 6.08[87] 3.91[88] 3.63[89] 2.06[90] 4.88[91]
14 RDH12 Retinol dehydrogenase 12 [92] 4.23[93] 5.25[94] -1.74[95] 2.29[96] 3.50[97] 1.65[98]
15 LRAT Lecithin retinol acyltransferase [99] 3.76[100] 3.20[101] 1.76[102] 5.45[103] 6.96[104] 6.50[105]
16 ABCA4 Retinal-specific ATP-binding cassette transporter [106] 9.37[107] 4.45[108] 5.74[109] 9.87[110] 6.18[111] 4.75[112]
17 STRA6 Receptor for retinol uptake STRA6 [113] 11.37[114] 6.19[115] 2.50[116] 15.17[117] 12.45[118] -1.68[119]
18 RBP3 Retinol-binding protein 3 [120] [121] [122] [123] [124] [125] [126]
19 RDH8 Retinol dehydrogenase 8 [127] [128] [129] [130] [131] [132] [133]
20 RPE65 Retinoid isomerohydrolase [134] [135] [136] [137] [138] [139] [140]
21 RHO Rhodopsin [141] [142] [143] [144] [145] [146] [147]
22 SDR9C7 Short-chain dehydrogenase/reductase family 9C member 7 [148] [149] [150] [151] [152] [153] [154]
23 RLBP1 Retinaldehyde-binding protein 1 [155] [156] [157] [158] [159] [160] [161]
[1]
ref_hepatocyte RBP4
Mean 3.15e+03
Standard deviation 4.2e+03
Values 2.4e+02 2.1e+02 6e+02 5e+03 9.7e+03
[2]
HepG2 RBP4
Mean 147
Standard deviation 7.2
Values 1.5e+02 1.4e+02
[3]
HepG2.C3A RBP4
Mean 297
Standard deviation 52
Values 3.3e+02 2.6e+02
[4]
HuH.7 RBP4
Mean 472
Standard deviation 54
Values 4.9e+02 4.1e+02 5.2e+02
[5]
SNU475 RBP4
Mean 0.74
Standard deviation 0.5
Values 0.38 1.1
[6]
THLE RBP4
Mean 1.18
Standard deviation 0.52
Values 1.5 0.81
[7]
liver RBP4
Mean 2.05e+03
Standard deviation 1.9e+03
Values 4.2e+03 4.1e+02 3.1e+03 4.9e+02
[8]
ref_hepatocyte TTR
Mean 2.04e+03
Standard deviation 3.1e+03
Values 80 1.8e+02 2.9e+02 2.5e+03 7.2e+03
[9]
HepG2 TTR
Mean 32.6
Standard deviation 28
Values 13 53
[10]
HepG2.C3A TTR
Mean 145
Standard deviation 36
Values 1.7e+02 1.2e+02
[11]
HuH.7 TTR
Mean 63.5
Standard deviation 11
Values 60 55 76
[12]
SNU475 TTR
Mean 0.0705
Standard deviation 0.0079
Values 0.065 0.076
[13]
THLE TTR
Mean 0.097
Standard deviation 0.047
Values 0.13 0.064
[14]
liver TTR
Mean 555
Standard deviation 6.9e+02
Values 1.5e+03 59 6e+02 53
[15]
ref_hepatocyte HSD17B6
Mean 293
Standard deviation 4.4e+02
Values 0.55 12 25 4e+02 1e+03
[16]
HepG2 HSD17B6
Mean 0.448
Standard deviation 0.28
Values 0.65 0.25
[17]
HepG2.C3A HSD17B6
Mean 0.452
Standard deviation 0.2
Values 0.59 0.31
[18]
HuH.7 HSD17B6
Mean 0.833
Standard deviation 0.2
Values 0.65 0.8 1
[19]
SNU475 HSD17B6
Mean 8.3
Standard deviation 4.2
Values 11 5.3
[20]
THLE HSD17B6
Mean 0.727
Standard deviation 0.11
Values 0.8 0.65
[21]
liver HSD17B6
Mean 332
Standard deviation 93
Values 4.3e+02 2.6e+02 3.9e+02 2.5e+02
[22]
ref_hepatocyte RDH16
Mean 193
Standard deviation 2.8e+02
Values 0 0.34 10 3.4e+02 6.1e+02
[23]
HepG2 RDH16
Mean 0.0873
Standard deviation 0.014
Values 0.097 0.077
[24]
HepG2.C3A RDH16
Mean 0.306
Standard deviation 0.16
Values 0.42 0.19
[25]
HuH.7 RDH16
Mean 0.346
Standard deviation 0.14
Values 0.24 0.3 0.51
[26]
SNU475 RDH16
Mean 0.14
Standard deviation 0.046
Values 0.11 0.17
[27]
THLE RDH16
Mean 0.101
Standard deviation 0.067
Values 0.15 0.053
[28]
liver RDH16
Mean 170
Standard deviation 54
Values 2.1e+02 91 2.1e+02 1.7e+02
[29]
ref_hepatocyte RDH11
Mean 49.5
Standard deviation 12
Values 38 60 36 54 60
[30]
HepG2 RDH11
Mean 25.2
Standard deviation 3.8
Values 23 28
[31]
HepG2.C3A RDH11
Mean 63.3
Standard deviation 21
Values 78 49
[32]
HuH.7 RDH11
Mean 60.2
Standard deviation 6.3
Values 54 67 60
[33]
SNU475 RDH11
Mean 28.5
Standard deviation 0.012
Values 28 29
[34]
THLE RDH11
Mean 33.8
Standard deviation 2.5
Values 32 36
[35]
liver RDH11
Mean 99.7
Standard deviation 22
Values 1.1e+02 89 1.3e+02 77
[36]
ref_hepatocyte RDH5
Mean 23.8
Standard deviation 26
Values 0.53 17 3.6 35 64
[37]
HepG2 RDH5
Mean 0.238
Standard deviation 0.045
Values 0.27 0.21
[38]
HepG2.C3A RDH5
Mean 0.829
Standard deviation 0.051
Values 0.87 0.79
[39]
HuH.7 RDH5
Mean 0.802
Standard deviation 0.21
Values 0.58 0.99 0.83
[40]
SNU475 RDH5
Mean 0.123
Standard deviation 0.023
Values 0.14 0.11
[41]
THLE RDH5
Mean 0.198
Standard deviation 0.021
Values 0.18 0.21
[42]
liver RDH5
Mean 4.84
Standard deviation 3.7
Values 4.5 4 9.8 1.1
[43]
ref_hepatocyte DHRS9
Mean 11.8
Standard deviation 22
Values 0 8.5 50 0.39 0.55
[44]
HepG2 DHRS9
Mean 0.0708
Standard deviation 0.052
Values 0.034 0.11
[45]
HepG2.C3A DHRS9
Mean 0.0555
Standard deviation 0.018
Values 0.068 0.043
[46]
HuH.7 DHRS9
Mean 0.0218
Standard deviation 0.015
Values 0.0082 0.039 0.019
[47]
SNU475 DHRS9
Mean 0.342
Standard deviation 0.33
Values 0.11 0.58
[48]
THLE DHRS9
Mean 0.514
Standard deviation 0.043
Values 0.54 0.48
[49]
liver DHRS9
Mean 0.291
Standard deviation 0.14
Values 0.16 0.3 0.49 0.21
[50]
ref_hepatocyte CYP4V2
Mean 11.2
Standard deviation 14
Values 1.9 3.8 1.4 13 36
[51]
HepG2 CYP4V2
Mean 2.61
Standard deviation 0.57
Values 2.2 3
[52]
HepG2.C3A CYP4V2
Mean 7.77
Standard deviation 2.1
Values 9.2 6.3
[53]
HuH.7 CYP4V2
Mean 1.95
Standard deviation 0.48
Values 1.8 2.5 1.6
[54]
SNU475 CYP4V2
Mean 1.4
Standard deviation 0.069
Values 1.5 1.4
[55]
THLE CYP4V2
Mean 2.28
Standard deviation 0.08
Values 2.3 2.2
[56]
liver CYP4V2
Mean 53.7
Standard deviation 9.2
Values 62 52 41 59
[57]
ref_hepatocyte RDH10
Mean 6.75
Standard deviation 3.6
Values 7.6 3.6 2.3 9.8 10
[58]
HepG2 RDH10
Mean 16.3
Standard deviation 4.8
Values 20 13
[59]
HepG2.C3A RDH10
Mean 23.6
Standard deviation 3.5
Values 26 21
[60]
HuH.7 RDH10
Mean 10.9
Standard deviation 1.6
Values 9.1 12 12
[61]
SNU475 RDH10
Mean 16.9
Standard deviation 5
Values 20 13
[62]
THLE RDH10
Mean 7.13
Standard deviation 1.4
Values 6.1 8.1
[63]
liver RDH10
Mean 19.3
Standard deviation 7.3
Values 22 22 8.6 25
[64]
ref_hepatocyte RBP1
Mean 4.21
Standard deviation 1.7
Values 6.5 5.6 3.2 3.4 2.4
[65]
HepG2 RBP1
Mean 41.1
Standard deviation 6.5
Values 46 36
[66]
HepG2.C3A RBP1
Mean 1.39
Standard deviation 0.9
Values 0.76 2
[67]
HuH.7 RBP1
Mean 3.24
Standard deviation 1.6
Values 3.7 1.4 4.6
[68]
SNU475 RBP1
Mean 3.41
Standard deviation 1.4
Values 4.4 2.4
[69]
THLE RBP1
Mean 0.272
Standard deviation 0.092
Values 0.34 0.21
[70]
liver RBP1
Mean 10.8
Standard deviation 10
Values 24 2 14 3.6
[71]
ref_hepatocyte NAPEPLD
Mean 1.95
Standard deviation 1.3
Values 1.1 2.6 0.44 1.7 3.8
[72]
HepG2 NAPEPLD
Mean 3.18
Standard deviation 1.3
Values 2.3 4.1
[73]
HepG2.C3A NAPEPLD
Mean 5.82
Standard deviation 0.86
Values 5.2 6.4
[74]
HuH.7 NAPEPLD
Mean 10.5
Standard deviation 0.91
Values 11 9.6 11
[75]
SNU475 NAPEPLD
Mean 6.63
Standard deviation 0.69
Values 7.1 6.1
[76]
THLE NAPEPLD
Mean 2.38
Standard deviation 0.027
Values 2.4 2.4
[77]
liver NAPEPLD
Mean 11.6
Standard deviation 3.7
Values 17 11 8.2 11
[78]
ref_hepatocyte HSD17B1
Mean 1.84
Standard deviation 1.8
Values 0 0 3.8 3.6 1.8
[79]
HepG2 HSD17B1
Mean 7.09
Standard deviation 0.31
Values 7.3 6.9
[80]
HepG2.C3A HSD17B1
Mean 9.86
Standard deviation 0.69
Values 10 9.4
[81]
HuH.7 HSD17B1
Mean 6.23
Standard deviation 0.45
Values 6 5.9 6.7
[82]
SNU475 HSD17B1
Mean 3.28
Standard deviation 0.071
Values 3.3 3.2
[83]
THLE HSD17B1
Mean 3.07
Standard deviation 0.04
Values 3.1 3
[84]
liver HSD17B1
Mean 1.94
Standard deviation 0.82
Values 2.9 0.98 2.1 1.7
[85]
ref_hepatocyte MYO7A
Mean 1.56
Standard deviation 0.95
Values 2.6 1.1 0.17 1.9 2
[86]
HepG2 MYO7A
Mean 9.16
Standard deviation 4
Values 6.3 12
[87]
HepG2.C3A MYO7A
Mean 10.3
Standard deviation 0.25
Values 11 10
[88]
HuH.7 MYO7A
Mean 2.58
Standard deviation 1.2
Values 2.4 3.9 1.4
[89]
SNU475 MYO7A
Mean 0.3
Standard deviation 0.17
Values 0.42 0.18
[90]
THLE MYO7A
Mean 0.0606
Standard deviation 0.048
Values 0.095 0.027
[91]
liver MYO7A
Mean 26.5
Standard deviation 9.8
Values 26 28 14 38
[92]
ref_hepatocyte RDH12
Mean 0.661
Standard deviation 0.71
Values 0.31 0.065 0.22 1.8 0.9
[93]
HepG2 RDH12
Mean 0.626
Standard deviation 0.27
Values 0.82 0.43
[94]
HepG2.C3A RDH12
Mean 2.47
Standard deviation 0.33
Values 2.7 2.2
[95]
HuH.7 RDH12
Mean 0.0216
Standard deviation 0.015
Values 0.0082 0.019 0.037
[96]
SNU475 RDH12
Mean 0.05
Standard deviation 0.051
Values 0.014 0.086
[97]
THLE RDH12
Mean 0.0692
Standard deviation 0.023
Values 0.053 0.085
[98]
liver RDH12
Mean 1.2
Standard deviation 1.2
Values 0.63 1 2.9 0.19
[99]
ref_hepatocyte LRAT
Mean 0.0892
Standard deviation 0.057
Values 0.14 0.12 0.052 0.12 0.0081
[100]
HepG2 LRAT
Mean 0.0608
Standard deviation 0.005
Values 0.057 0.064
[101]
HepG2.C3A LRAT
Mean 0.0803
Standard deviation 0.038
Values 0.11 0.054
[102]
HuH.7 LRAT
Mean 0.0332
Standard deviation 0.029
Values 0.0082 0.026 0.066
[103]
SNU475 LRAT
Mean 0.0606
Standard deviation 0.00038
Values 0.06 0.061
[104]
THLE LRAT
Mean 0.103
Standard deviation 0.055
Values 0.14 0.064
[105]
liver LRAT
Mean 4.65
Standard deviation 3.2
Values 9.2 2.5 4.5 2.4
[106]
ref_hepatocyte ABCA4
Mean 0.0577
Standard deviation 0.042
Values 0.096 0.065 0 0.095 0.033
[107]
HepG2 ABCA4
Mean 1.94
Standard deviation 0.43
Values 2.2 1.6
[108]
HepG2.C3A ABCA4
Mean 0.124
Standard deviation 0.11
Values 0.2 0.043
[109]
HuH.7 ABCA4
Mean 0.338
Standard deviation 0.27
Values 0.19 0.65 0.18
[110]
SNU475 ABCA4
Mean 0.839
Standard deviation 0.51
Values 0.48 1.2
[111]
THLE ABCA4
Mean 0.0387
Standard deviation 0.013
Values 0.03 0.048
[112]
liver ABCA4
Mean 0.9
Standard deviation 0.48
Values 0.47 1.2 0.51 1.4
[113]
ref_hepatocyte STRA6
Mean 0.0325
Standard deviation 0.055
Values 0.13 0 0.035 0 0
[114]
HepG2 STRA6
Mean 4.33
Standard deviation 0.93
Values 5 3.7
[115]
HepG2.C3A STRA6
Mean 0.233
Standard deviation 0.056
Values 0.27 0.19
[116]
HuH.7 STRA6
Mean 0.0201
Standard deviation 0.021
Values 0.041 0.019 0
[117]
SNU475 STRA6
Mean 18.6
Standard deviation 10
Values 11 26
[118]
THLE STRA6
Mean 1.68
Standard deviation 0.51
Values 2 1.3
[119]
liver STRA6
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[120]
ref_hepatocyte RBP3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 RBP3
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A RBP3
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 RBP3
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[124]
SNU475 RBP3
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[125]
THLE RBP3
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[126]
liver RBP3
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte RDH8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 RDH8
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A RDH8
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 RDH8
Mean 0.0138
Standard deviation 0.017
Values 0 0.032 0.0094
[131]
SNU475 RDH8
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[132]
THLE RDH8
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[133]
liver RDH8
Mean 0
Standard deviation 0
Values 0 0 0 0
[134]
ref_hepatocyte RPE65
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 RPE65
Mean 0.0258
Standard deviation 0.012
Values 0.017 0.034
[136]
HepG2.C3A RPE65
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 RPE65
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 RPE65
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE RPE65
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[140]
liver RPE65
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte RHO
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 RHO
Mean 0.122
Standard deviation 0.1
Values 0.052 0.19
[143]
HepG2.C3A RHO
Mean 0.141
Standard deviation 0.089
Values 0.078 0.2
[144]
HuH.7 RHO
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[145]
SNU475 RHO
Mean 0.0377
Standard deviation 0.032
Values 0.06 0.015
[146]
THLE RHO
Mean 0
Standard deviation 0
Values 0 0
[147]
liver RHO
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte SDR9C7
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 SDR9C7
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A SDR9C7
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 SDR9C7
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[152]
SNU475 SDR9C7
Mean 0.0361
Standard deviation 0.008
Values 0.042 0.03
[153]
THLE SDR9C7
Mean 0
Standard deviation 0
Values 0 0
[154]
liver SDR9C7
Mean 0.00918
Standard deviation 0.011
Values 0.024 0 0 0.013
[155]
ref_hepatocyte RLBP1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 RLBP1
Mean 0.519
Standard deviation 0.35
Values 0.77 0.27
[157]
HepG2.C3A RLBP1
Mean 0.0603
Standard deviation 0.025
Values 0.078 0.043
[158]
HuH.7 RLBP1
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[159]
SNU475 RLBP1
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[160]
THLE RLBP1
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[161]
liver RLBP1
Mean 0.038
Standard deviation 0.031
Values 0.071 0.029 0 0.053