REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.07[2] | -1.05[3] | -1.09[4] | -1.37[5] | -1.00[6] | -0.48[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.63[16] | -0.30[17] | -0.72[18] | -0.51[19] | -0.62[20] | -0.03[21] |
4 | NEDD8 | NEDD8 | [22] | -0.61[23] | -1.96[24] | -1.91[25] | -1.88[26] | -1.81[27] | -2.13[28] |
5 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [29] | 1.01[30] | 0.83[31] | -0.92[32] | 1.15[33] | 0.65[34] | 0.02[35] |
6 | STRAP | Serine-threonine kinase receptor-associated protein | [36] | -0.09[37] | 0.10[38] | 0.52[39] | 0.07[40] | 0.81[41] | -0.38[42] |
7 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [43] | 1.81[44] | 1.94[45] | 2.79[46] | 0.88[47] | 1.61[48] | 0.74[49] |
8 | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | [50] | -0.62[51] | -1.36[52] | -1.03[53] | -0.80[54] | 0.07[55] | -2.22[56] |
9 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [57] | 1.11[58] | 1.05[59] | 2.07[60] | 2.94[61] | 0.46[62] | 0.44[63] |
10 | FURIN | Furin | [64] | 2.76[65] | -0.77[66] | 1.20[67] | 0.14[68] | 0.52[69] | 3.05[70] |
11 | STUB1 | E3 ubiquitin-protein ligase CHIP | [71] | -0.86[72] | -0.61[73] | -1.46[74] | -1.25[75] | -1.01[76] | -0.86[77] |
12 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [78] | 0.89[79] | 1.68[80] | 1.58[81] | 2.17[82] | 1.91[83] | 1.89[84] |
13 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.80[85] | 2.81[86] | 2.84[87] | 1.65[88] | 1.67[89] | 0.31[90] | |
14 | UBE2M | NEDD8-conjugating enzyme Ubc12 | [91] | 0.47[92] | 0.42[93] | 0.90[94] | 0.95[95] | 0.77[96] | -1.30[97] |
15 | XPO1 | Exportin-1 | [98] | 2.49[99] | 3.42[100] | 3.26[101] | 3.54[102] | 3.54[103] | 2.25[104] |
16 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | [105] | 0.10[106] | 1.19[107] | 0.63[108] | 1.92[109] | 1.39[110] | 1.18[111] |
17 | TGFBR2 | TGF-beta receptor type-2 | [112] | 3.94[113] | 3.64[114] | 3.10[115] | 2.48[116] | 4.11[117] | 2.90[118] |
18 | MTMR4 | Myotubularin-related protein 4 | [119] | 1.77[120] | 2.84[121] | 3.00[122] | 0.84[123] | 1.38[124] | 3.74[125] |
19 | BAMBI | BMP and activin membrane-bound inhibitor homolog | [126] | 2.35[127] | 1.52[128] | 2.01[129] | 2.42[130] | 1.62[131] | -0.26[132] |
20 | SMAD3 | Mothers against decapentaplegic homolog 3 | [133] | 3.06[134] | 2.68[135] | 2.71[136] | 3.21[137] | 4.00[138] | 1.61[139] |
21 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | [140] | 3.66[141] | 3.80[142] | 3.42[143] | 1.48[144] | 2.31[145] | 2.13[146] |
22 | TGFBR1 | TGF-beta receptor type-1 | [147] | 1.46[148] | 1.91[149] | 1.22[150] | 1.76[151] | 2.78[152] | 2.73[153] |
23 | SMAD7 | Mothers against decapentaplegic homolog 7 | [154] | 2.98[155] | 1.32[156] | 0.12[157] | 2.00[158] | 1.61[159] | 1.39[160] |
24 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [161] | 2.57[162] | 2.23[163] | 2.96[164] | 2.62[165] | 2.43[166] | 2.78[167] |
25 | USP15 | Ubiquitin carboxyl-terminal hydrolase 15 | [168] | 1.25[169] | 3.34[170] | 2.56[171] | 3.40[172] | 3.23[173] | 4.04[174] |
26 | SMAD4 | Mothers against decapentaplegic homolog 4 | [175] | 2.52[176] | 3.37[177] | 3.15[178] | 3.32[179] | 3.60[180] | 4.18[181] |
27 | SMAD2 | Mothers against decapentaplegic homolog 2 | [182] | 3.15[183] | 3.63[184] | 2.94[185] | 3.80[186] | 3.90[187] | 3.96[188] |
28 | TGFB1 | Transforming growth factor beta-1 | [189] | 4.60[190] | 3.78[191] | 0.85[192] | 5.25[193] | 4.39[194] | 0.16[195] |
29 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [196] | 2.84[197] | 3.09[198] | 1.41[199] | 2.60[200] | 2.96[201] | 1.53[202] |
30 | ZFYVE9 | Zinc finger FYVE domain-containing protein 9 | [203] | 2.77[204] | 3.23[205] | 2.99[206] | 3.02[207] | 3.38[208] | 3.60[209] |
31 | CBL | E3 ubiquitin-protein ligase CBL | [210] | 5.57[211] | 4.74[212] | 4.77[213] | 6.55[214] | 5.94[215] | 5.15[216] |
32 | PMEPA1 | Protein TMEPAI | [217] | 4.55[218] | [219] | -3.99[220] | 5.12[221] | 5.52[222] | 3.36[223] |