REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 HSP90AA1 Heat shock protein HSP 90-alpha [1] -0.01[2] 0.22[3] 0.06[4] 0.13[5] 0.10[6] -0.65[7]
2 GCHFR GTP cyclohydrolase 1 feedback regulatory protein [8] -2.44[9] -1.99[10] -2.45[11] -5.46[12] -4.79[13] -0.55[14]
3 AKT1 RAC-alpha serine/threonine-protein kinase [15] 0.72[16] -0.26[17] -0.72[18] -0.01[19] 0.29[20] 0.36[21]
4 SPR Sepiapterin reductase [22] -0.73[23] -0.76[24] -1.67[25] -2.01[26] -2.67[27] -0.22[28]
5 CALM1 Calmodulin-1 [29] 0.72[30] 0.00[31] 1.08[32] 1.63[33] 1.18[34] 2.22[35]
6 PTS 6-pyruvoyl tetrahydrobiopterin synthase [36] -0.85[37] -1.48[38] -2.97[39] -1.63[40] -1.17[41] 0.27[42]
7 GCH1 GTP cyclohydrolase 1 [43] -1.07[44] -0.88[45] -0.17[46] -2.60[47] -1.05[48] 1.38[49]
8 DHFR Dihydrofolate reductase [50] 2.18[51] 2.14[52] 3.10[53] 1.30[54] 2.44[55] 0.73[56]
9 NOS3 Nitric oxide synthase, endothelial [57] 5.41[58] 1.76[59] 1.84[60] 0.10[61] 1.71[62] 3.37[63]
10 PRKG2 cGMP-dependent protein kinase 2 [64] 3.54[65] [66] [67] 6.83[68] 1.40[69] 2.64[70]
[1]
ref_hepatocyte HSP90AA1
Mean 356
Standard deviation 2.5e+02
Values 5.4e+02 6.9e+02 1.3e+02 2.5e+02 1.7e+02
[2]
HepG2 HSP90AA1
Mean 503
Standard deviation 2.6e+02
Values 3.2e+02 6.9e+02
[3]
HepG2.C3A HSP90AA1
Mean 878
Standard deviation 5.2e+02
Values 5.1e+02 1.2e+03
[4]
HuH.7 HSP90AA1
Mean 494
Standard deviation 76
Values 5.4e+02 4.1e+02 5.4e+02
[5]
SNU475 HSP90AA1
Mean 696
Standard deviation 1.5e+02
Values 5.9e+02 8e+02
[6]
THLE HSP90AA1
Mean 627
Standard deviation 16
Values 6.4e+02 6.2e+02
[7]
liver HSP90AA1
Mean 212
Standard deviation 50
Values 2.7e+02 1.9e+02 2.4e+02 1.6e+02
[8]
ref_hepatocyte GCHFR
Mean 58.5
Standard deviation 74
Values 8.9 0.84 8.4 1.1e+02 1.6e+02
[9]
HepG2 GCHFR
Mean 15.3
Standard deviation 6.8
Values 10 20
[10]
HepG2.C3A GCHFR
Mean 31.2
Standard deviation 10
Values 24 38
[11]
HuH.7 GCHFR
Mean 14.2
Standard deviation 5.9
Values 13 9.3 21
[12]
SNU475 GCHFR
Mean 2.37
Standard deviation 0.69
Values 2.9 1.9
[13]
THLE GCHFR
Mean 3.48
Standard deviation 0.0078
Values 3.5 3.5
[14]
liver GCHFR
Mean 37.5
Standard deviation 37
Values 74 5.6 65 5.1
[15]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 55 50 19 31 32
[16]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 89 86
[17]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 65 68
[18]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 33 23 35
[19]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 76 57
[20]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[21]
liver AKT1
Mean 45.1
Standard deviation 25
Values 34 48 20 79
[22]
ref_hepatocyte SPR
Mean 32.1
Standard deviation 17
Values 11 25 26 54 44
[23]
HepG2 SPR
Mean 27.6
Standard deviation 12
Values 19 36
[24]
HepG2.C3A SPR
Mean 40.1
Standard deviation 7.9
Values 35 46
[25]
HuH.7 SPR
Mean 13.4
Standard deviation 3.9
Values 13 9.4 17
[26]
SNU475 SPR
Mean 14.2
Standard deviation 2.4
Values 16 12
[27]
THLE SPR
Mean 8.29
Standard deviation 1.3
Values 7.4 9.2
[28]
liver SPR
Mean 25.9
Standard deviation 13
Values 40 15 34 15
[29]
ref_hepatocyte CALM1
Mean 29.2
Standard deviation 11
Values 17 40 21 28 40
[30]
HepG2 CALM1
Mean 67.9
Standard deviation 4.3
Values 65 71
[31]
HepG2.C3A CALM1
Mean 62
Standard deviation 16
Values 51 73
[32]
HuH.7 CALM1
Mean 81.9
Standard deviation 15
Values 90 64 92
[33]
SNU475 CALM1
Mean 160
Standard deviation 24
Values 1.8e+02 1.4e+02
[34]
THLE CALM1
Mean 109
Standard deviation 13
Values 1e+02 1.2e+02
[35]
liver CALM1
Mean 127
Standard deviation 70
Values 2.1e+02 80 1.7e+02 57
[36]
ref_hepatocyte PTS
Mean 17.2
Standard deviation 9.6
Values 8.7 15 7.7 28 26
[37]
HepG2 PTS
Mean 13.5
Standard deviation 2.8
Values 12 15
[38]
HepG2.C3A PTS
Mean 13
Standard deviation 2.8
Values 11 15
[39]
HuH.7 PTS
Mean 2.92
Standard deviation 0.83
Values 2.3 2.5 3.9
[40]
SNU475 PTS
Mean 9.89
Standard deviation 0.52
Values 10 9.5
[41]
THLE PTS
Mean 12.6
Standard deviation 0.8
Values 12 13
[42]
liver PTS
Mean 19.4
Standard deviation 15
Values 33 6.8 32 6.1
[43]
ref_hepatocyte GCH1
Mean 15.7
Standard deviation 4.4
Values 16 11 12 21 19
[44]
HepG2 GCH1
Mean 10.6
Standard deviation 1.9
Values 9.3 12
[45]
HepG2.C3A GCH1
Mean 18.2
Standard deviation 3.9
Values 15 21
[46]
HuH.7 GCH1
Mean 18.5
Standard deviation 5
Values 20 13 23
[47]
SNU475 GCH1
Mean 4.64
Standard deviation 1.2
Values 3.8 5.5
[48]
THLE GCH1
Mean 12.6
Standard deviation 0.17
Values 13 12
[49]
liver GCH1
Mean 38.4
Standard deviation 10
Values 28 47 47 30
[50]
ref_hepatocyte DHFR
Mean 6.89
Standard deviation 3.8
Values 10 7.9 0.65 6.3 9.3
[51]
HepG2 DHFR
Mean 44.3
Standard deviation 17
Values 32 56
[52]
HepG2.C3A DHFR
Mean 64.7
Standard deviation 42
Values 35 95
[53]
HuH.7 DHFR
Mean 78.4
Standard deviation 42
Values 1.1e+02 31 96
[54]
SNU475 DHFR
Mean 30.2
Standard deviation 0.92
Values 31 30
[55]
THLE DHFR
Mean 61.5
Standard deviation 17
Values 50 73
[56]
liver DHFR
Mean 10.7
Standard deviation 3.8
Values 15 9.2 6.4 12
[57]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.58 0.37 0.014 0.12 0.18
[58]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 14 16
[59]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.8 1.9
[60]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.4 1 1.2
[61]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.68 0.28
[62]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[63]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 1.5 2.3 1.6 4.3
[64]
ref_hepatocyte PRKG2
Mean 0.00924
Standard deviation 0.021
Values 0 0 0.046 0 0
[65]
HepG2 PRKG2
Mean 0.153
Standard deviation 0.12
Values 0.24 0.064
[66]
HepG2.C3A PRKG2
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 PRKG2
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 PRKG2
Mean 1.87
Standard deviation 0.4
Values 2.2 1.6
[69]
THLE PRKG2
Mean 0.0402
Standard deviation 0.048
Values 0.0059 0.074
[70]
liver PRKG2
Mean 0.054
Standard deviation 0.05
Values 0.024 0.1 0 0.093