REACTOME_TELOMERE_EXTENSION_BY_TELOMERASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NOP10 H/ACA ribonucleoprotein complex subunit 3 [1] -1.52[2] -1.68[3] -2.85[4] -2.34[5] -2.20[6] -1.20[7]
2 NHP2 H/ACA ribonucleoprotein complex subunit 2 [8] -1.30[9] -1.52[10] -1.24[11] -2.00[12] -1.58[13] -1.23[14]
3 RUVBL2 RuvB-like 2 [15] 0.14[16] -0.26[17] 0.22[18] -0.55[19] -0.04[20] -0.24[21]
4 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 [22] -0.31[23] -0.09[24] -0.35[25] -0.66[26] -0.35[27] 0.00[28]
5 DKC1 H/ACA ribonucleoprotein complex subunit 4 [29] 0.99[30] 0.85[31] 0.29[32] 0.09[33] 0.07[34] -0.22[35]
6 RUVBL1 RuvB-like 1 [36] 0.72[37] 0.22[38] 0.08[39] -0.40[40] 0.19[41] -0.59[42]
7 CDK2 Cyclin-dependent kinase 2 [43] -0.11[44] -0.07[45] 0.06[46] 0.23[47] 0.72[48] -1.30[49]
8 GAR1 H/ACA ribonucleoprotein complex subunit 1 [50] -0.84[51] -1.42[52] -1.96[53] -1.52[54] -1.28[55] -2.66[56]
9 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 [57] 1.04[58] 1.37[59] 2.45[60] 3.09[61] 1.28[62] 2.37[63]
10 TINF2 TERF1-interacting nuclear factor 2 [64] 1.07[65] -0.39[66] -0.65[67] 0.15[68] 0.05[69] 0.68[70]
11 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit [71] 1.27[72] 1.16[73] 1.35[74] 1.58[75] 1.62[76] 1.64[77]
12 TERF1 Telomeric repeat-binding factor 1 [78] -0.60[79] 0.43[80] 0.42[81] 1.48[82] 0.46[83] 0.85[84]
13 ANKRD28 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 0.44[85] 1.43[86] 1.66[87] 0.54[88] 1.52[89] 2.81[90]
14 TERF2 Telomeric repeat-binding factor 2 [91] 0.61[92] 0.50[93] 1.01[94] 0.16[95] 0.47[96] 0.44[97]
15 SHQ1 Protein SHQ1 homolog [98] 0.27[99] 0.06[100] -0.71[101] -0.28[102] 0.74[103] 1.14[104]
16 CCNA2 Cyclin-A2 [105] 2.51[106] 3.40[107] 2.49[108] 2.25[109] 3.54[110] -0.35[111]
17 POT1 Protection of telomeres protein 1 [112] 0.31[113] 1.47[114] 1.47[115] 2.02[116] 1.67[117] 1.68[118]
18 WRAP53 Telomerase Cajal body protein 1 [119] 1.25[120] 0.73[121] 1.35[122] 0.49[123] 1.26[124] -0.54[125]
19 ACD Adrenocortical dysplasia protein homolog [126] 2.00[127] 2.15[128] 1.67[129] 1.01[130] 1.63[131] 0.19[132]
20 RTEL1 Regulator of telomere elongation helicase 1 [133] -1.40[134] -0.39[135] -2.46[136] -2.04[137] -1.57[138] -0.77[139]
21 PIF1 ATP-dependent DNA helicase PIF1 [140] 2.31[141] 4.09[142] 3.89[143] 2.88[144] 3.50[145] 0.69[146]
22 TERT Telomerase reverse transcriptase [147] 3.79[148] 3.43[149] 4.11[150] 2.43[151] -3.72[152] -3.02[153]
23 CCNA1 Cyclin-A1 [154] [155] -3.21[156] [157] -0.54[158] 6.76[159] [160]
[1]
ref_hepatocyte NOP10
Mean 76
Standard deviation 53
Values 13 28 1.3e+02 1.3e+02 87
[2]
HepG2 NOP10
Mean 47.6
Standard deviation 0.51
Values 48 47
[3]
HepG2.C3A NOP10
Mean 41.1
Standard deviation 11
Values 33 49
[4]
HuH.7 NOP10
Mean 20.9
Standard deviation 8.3
Values 19 14 30
[5]
SNU475 NOP10
Mean 23.1
Standard deviation 2.4
Values 25 21
[6]
THLE NOP10
Mean 30.8
Standard deviation 0.77
Values 30 31
[7]
liver NOP10
Mean 25.5
Standard deviation 22
Values 49 8.5 38 5.8
[8]
ref_hepatocyte NHP2
Mean 49.9
Standard deviation 22
Values 28 77 37 70 38
[9]
HepG2 NHP2
Mean 36.4
Standard deviation 5.5
Values 40 32
[10]
HepG2.C3A NHP2
Mean 30.1
Standard deviation 7.3
Values 25 35
[11]
HuH.7 NHP2
Mean 42
Standard deviation 19
Values 47 21 58
[12]
SNU475 NHP2
Mean 19.3
Standard deviation 1.3
Values 20 18
[13]
THLE NHP2
Mean 31
Standard deviation 4.5
Values 28 34
[14]
liver NHP2
Mean 16.4
Standard deviation 14
Values 24 4.8 32 4.1
[15]
ref_hepatocyte RUVBL2
Mean 28.8
Standard deviation 12
Values 12 37 43 30 23
[16]
HepG2 RUVBL2
Mean 56.9
Standard deviation 17
Values 69 45
[17]
HepG2.C3A RUVBL2
Mean 41.9
Standard deviation 2
Values 41 43
[18]
HuH.7 RUVBL2
Mean 66.4
Standard deviation 27
Values 80 35 84
[19]
SNU475 RUVBL2
Mean 30.4
Standard deviation 3.9
Values 28 33
[20]
THLE RUVBL2
Mean 52
Standard deviation 2.8
Values 50 54
[21]
liver RUVBL2
Mean 18.9
Standard deviation 8.4
Values 20 15 30 10
[22]
ref_hepatocyte TERF2IP
Mean 20.1
Standard deviation 5.4
Values 22 25 25 16 13
[23]
HepG2 TERF2IP
Mean 29
Standard deviation 0.8
Values 30 28
[24]
HepG2.C3A TERF2IP
Mean 32.6
Standard deviation 7.5
Values 38 27
[25]
HuH.7 TERF2IP
Mean 31.3
Standard deviation 5
Values 27 30 37
[26]
SNU475 TERF2IP
Mean 19.6
Standard deviation 0.25
Values 19 20
[27]
THLE TERF2IP
Mean 29.2
Standard deviation 1
Values 28 30
[28]
liver TERF2IP
Mean 15.5
Standard deviation 7.4
Values 23 9.1 21 9.1
[29]
ref_hepatocyte DKC1
Mean 17.8
Standard deviation 9.7
Values 24 30 18 10 6.4
[30]
HepG2 DKC1
Mean 63.7
Standard deviation 6.2
Values 68 59
[31]
HepG2.C3A DKC1
Mean 55.7
Standard deviation 4.5
Values 53 59
[32]
HuH.7 DKC1
Mean 43.3
Standard deviation 19
Values 49 23 58
[33]
SNU475 DKC1
Mean 29.3
Standard deviation 7.8
Values 24 35
[34]
THLE DKC1
Mean 34.8
Standard deviation 4.3
Values 32 38
[35]
liver DKC1
Mean 11.8
Standard deviation 4.9
Values 14 8.4 17 7
[36]
ref_hepatocyte RUVBL1
Mean 14.6
Standard deviation 5.5
Values 14 22 18 10 8.5
[37]
HepG2 RUVBL1
Mean 43.2
Standard deviation 11
Values 51 35
[38]
HepG2.C3A RUVBL1
Mean 29.5
Standard deviation 4.5
Values 26 33
[39]
HuH.7 RUVBL1
Mean 30.5
Standard deviation 13
Values 36 15 40
[40]
SNU475 RUVBL1
Mean 17.1
Standard deviation 3.3
Values 15 19
[41]
THLE RUVBL1
Mean 30.9
Standard deviation 6.8
Values 26 36
[42]
liver RUVBL1
Mean 7.48
Standard deviation 2.4
Values 9.4 6.5 9.5 4.5
[43]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 19 28 3.3 5.7 4.6
[44]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 18 22
[45]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 14 26
[46]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 30 11 33
[47]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 20 24
[48]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[49]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 4.4 2.3 5.2 3.2
[50]
ref_hepatocyte GAR1
Mean 11
Standard deviation 6.7
Values 4.9 17 20 8.3 5.7
[51]
HepG2 GAR1
Mean 11
Standard deviation 2.3
Values 13 9.4
[52]
HepG2.C3A GAR1
Mean 7.16
Standard deviation 0.84
Values 6.6 7.8
[53]
HuH.7 GAR1
Mean 5.61
Standard deviation 2.2
Values 6.3 3.2 7.4
[54]
SNU475 GAR1
Mean 5.96
Standard deviation 0.37
Values 5.7 6.2
[55]
THLE GAR1
Mean 8.45
Standard deviation 0.75
Values 7.9 9
[56]
liver GAR1
Mean 1.35
Standard deviation 0.93
Values 2.1 0.78 2.2 0.34
[57]
ref_hepatocyte PPP6R3
Mean 9.96
Standard deviation 5.4
Values 16 15 7.6 4.3 6.5
[58]
HepG2 PPP6R3
Mean 36.6
Standard deviation 8.2
Values 31 42
[59]
HepG2.C3A PPP6R3
Mean 44.7
Standard deviation 6.4
Values 40 49
[60]
HuH.7 PPP6R3
Mean 108
Standard deviation 10
Values 1.2e+02 1e+02 1e+02
[61]
SNU475 PPP6R3
Mean 131
Standard deviation 1.3
Values 1.3e+02 1.3e+02
[62]
THLE PPP6R3
Mean 45.1
Standard deviation 0.76
Values 45 46
[63]
liver PPP6R3
Mean 39.8
Standard deviation 14
Values 31 48 25 55
[64]
ref_hepatocyte TINF2
Mean 8.21
Standard deviation 1.3
Values 10 7.4 8.3 7.2 7.7
[65]
HepG2 TINF2
Mean 30.8
Standard deviation 1.5
Values 30 32
[66]
HepG2.C3A TINF2
Mean 10.8
Standard deviation 0.3
Values 11 11
[67]
HuH.7 TINF2
Mean 10.4
Standard deviation 1.3
Values 10 9 12
[68]
SNU475 TINF2
Mean 14.1
Standard deviation 0.013
Values 14 14
[69]
THLE TINF2
Mean 15.8
Standard deviation 1.4
Values 15 17
[70]
liver TINF2
Mean 10.2
Standard deviation 2.5
Values 12 7.3 12 8.9
[71]
ref_hepatocyte PPP6C
Mean 6.47
Standard deviation 1.2
Values 8 6.3 4.6 6.6 6.7
[72]
HepG2 PPP6C
Mean 27.9
Standard deviation 5.2
Values 24 32
[73]
HepG2.C3A PPP6C
Mean 25.1
Standard deviation 2.5
Values 23 27
[74]
HuH.7 PPP6C
Mean 32.8
Standard deviation 2.8
Values 33 35 30
[75]
SNU475 PPP6C
Mean 29.9
Standard deviation 1.7
Values 31 29
[76]
THLE PPP6C
Mean 37
Standard deviation 4.1
Values 34 40
[77]
liver PPP6C
Mean 15.5
Standard deviation 7.9
Values 24 9.2 20 8.4
[78]
ref_hepatocyte TERF1
Mean 4.67
Standard deviation 2
Values 2.2 3.5 6.2 4.5 6.9
[79]
HepG2 TERF1
Mean 5.51
Standard deviation 1.4
Values 4.5 6.5
[80]
HepG2.C3A TERF1
Mean 10.9
Standard deviation 3
Values 8.8 13
[81]
HuH.7 TERF1
Mean 12.4
Standard deviation 1.1
Values 13 11 12
[82]
SNU475 TERF1
Mean 20.1
Standard deviation 0.86
Values 21 19
[83]
THLE TERF1
Mean 11.9
Standard deviation 0.88
Values 11 13
[84]
liver TERF1
Mean 6.49
Standard deviation 1.9
Values 8.7 6.1 6.9 4.2
[85]
ref_hepatocyte ANKRD28
Mean 4.42
Standard deviation 1.5
Values 4.6 6.5 3.6 2.5 4.9
[86]
HepG2 ANKRD28
Mean 10.7
Standard deviation 1.5
Values 9.7 12
[87]
HepG2.C3A ANKRD28
Mean 20.6
Standard deviation 1.1
Values 20 21
[88]
HuH.7 ANKRD28
Mean 27.6
Standard deviation 4.1
Values 32 26 24
[89]
SNU475 ANKRD28
Mean 9.89
Standard deviation 2.6
Values 8 12
[90]
THLE ANKRD28
Mean 23.6
Standard deviation 0.36
Values 23 24
[91]
liver ANKRD28
Mean 23.8
Standard deviation 12
Values 17 39 11 27
[92]
ref_hepatocyte TERF2
Mean 4.13
Standard deviation 0.67
Values 4.9 4.3 4.6 3.7 3.2
[93]
HepG2 TERF2
Mean 11.3
Standard deviation 0.25
Values 11 11
[94]
HepG2.C3A TERF2
Mean 10.1
Standard deviation 0.26
Values 9.9 10
[95]
HuH.7 TERF2
Mean 16.5
Standard deviation 2.9
Values 17 13 19
[96]
SNU475 TERF2
Mean 7.14
Standard deviation 0.058
Values 7.1 7.2
[97]
THLE TERF2
Mean 10.6
Standard deviation 0.15
Values 11 11
[98]
liver TERF2
Mean 4.32
Standard deviation 1.4
Values 6.4 3.6 3.6 3.7
[99]
ref_hepatocyte SHQ1
Mean 3.82
Standard deviation 1.8
Values 4.8 6.2 3.9 1.7 2.5
[100]
HepG2 SHQ1
Mean 8.25
Standard deviation 1.2
Values 7.4 9.1
[101]
HepG2.C3A SHQ1
Mean 6.92
Standard deviation 2.2
Values 5.4 8.5
[102]
HuH.7 SHQ1
Mean 4.62
Standard deviation 0.69
Values 5.4 4 4.5
[103]
SNU475 SHQ1
Mean 4.84
Standard deviation 1.1
Values 4 5.6
[104]
THLE SHQ1
Mean 11.8
Standard deviation 3
Values 9.7 14
[105]
liver SHQ1
Mean 6.48
Standard deviation 1.1
Values 6.8 6.4 7.8 5
[106]
ref_hepatocyte CCNA2
Mean 3.28
Standard deviation 3.7
Values 7 7.5 0.2 1.1 0.57
[107]
HepG2 CCNA2
Mean 33.4
Standard deviation 16
Values 22 44
[108]
HepG2.C3A CCNA2
Mean 60.1
Standard deviation 42
Values 30 90
[109]
HuH.7 CCNA2
Mean 36.5
Standard deviation 15
Values 47 20 43
[110]
SNU475 CCNA2
Mean 24.1
Standard deviation 0.4
Values 24 24
[111]
THLE CCNA2
Mean 71
Standard deviation 9.4
Values 64 78
[112]
liver CCNA2
Mean 1.99
Standard deviation 1.7
Values 0.85 3.4 3.5 0.21
[113]
ref_hepatocyte POT1
Mean 2.27
Standard deviation 0.82
Values 3.2 2.4 0.96 2.2 2.5
[114]
HepG2 POT1
Mean 5.04
Standard deviation 1.2
Values 4.2 5.9
[115]
HepG2.C3A POT1
Mean 10.9
Standard deviation 2
Values 9.5 12
[116]
HuH.7 POT1
Mean 12.4
Standard deviation 0.67
Values 12 13 12
[117]
SNU475 POT1
Mean 14.1
Standard deviation 0.62
Values 14 15
[118]
THLE POT1
Mean 13.4
Standard deviation 2.1
Values 15 12
[119]
liver POT1
Mean 5.58
Standard deviation 1.5
Values 4.5 7.1 6.7 4.1
[120]
ref_hepatocyte WRAP53
Mean 2.2
Standard deviation 2.1
Values 0.84 0.88 5.8 1.7 1.8
[121]
HepG2 WRAP53
Mean 9.4
Standard deviation 1
Values 8.7 10
[122]
HepG2.C3A WRAP53
Mean 6.34
Standard deviation 3.1
Values 4.2 8.5
[123]
HuH.7 WRAP53
Mean 11.1
Standard deviation 4
Values 13 6.6 14
[124]
SNU475 WRAP53
Mean 4.75
Standard deviation 0.87
Values 4.1 5.4
[125]
THLE WRAP53
Mean 9.78
Standard deviation 2.1
Values 8.3 11
[126]
liver WRAP53
Mean 1.16
Standard deviation 0.7
Values 1.8 0.41 1.7 0.73
[127]
ref_hepatocyte ACD
Mean 2.1
Standard deviation 0.79
Values 3 2.7 2.2 1.6 1
[128]
HepG2 ACD
Mean 15.1
Standard deviation 1.5
Values 16 14
[129]
HepG2.C3A ACD
Mean 16.2
Standard deviation 0.61
Values 16 17
[130]
HuH.7 ACD
Mean 13.3
Standard deviation 3.4
Values 15 9.4 15
[131]
SNU475 ACD
Mean 6.51
Standard deviation 0.88
Values 5.9 7.1
[132]
THLE ACD
Mean 12.1
Standard deviation 0.43
Values 12 12
[133]
liver ACD
Mean 1.85
Standard deviation 1.2
Values 3.2 0.64 2.5 1
[134]
ref_hepatocyte RTEL1
Mean 1.41
Standard deviation 0.26
Values 1.7 1.2 1.4 1.6 1.1
[135]
HepG2 RTEL1
Mean 0.952
Standard deviation 0.24
Values 0.79 1.1
[136]
HepG2.C3A RTEL1
Mean 1.86
Standard deviation 0.37
Values 2.1 1.6
[137]
HuH.7 RTEL1
Mean 0.508
Standard deviation 0.12
Values 0.61 0.37 0.54
[138]
SNU475 RTEL1
Mean 0.529
Standard deviation 0.019
Values 0.51 0.54
[139]
THLE RTEL1
Mean 0.883
Standard deviation 0.16
Values 0.99 0.77
[140]
liver RTEL1
Mean 0.636
Standard deviation 0.18
Values 0.87 0.47 0.51 0.69
[141]
ref_hepatocyte PIF1
Mean 0.247
Standard deviation 0.11
Values 0.27 0.4 0.26 0.1 0.21
[142]
HepG2 PIF1
Mean 2.19
Standard deviation 0.27
Values 2 2.4
[143]
HepG2.C3A PIF1
Mean 7.28
Standard deviation 1.3
Values 6.4 8.2
[144]
HuH.7 PIF1
Mean 7.23
Standard deviation 4.1
Values 6.5 3.6 12
[145]
SNU475 PIF1
Mean 2.8
Standard deviation 0.4
Values 3.1 2.5
[146]
THLE PIF1
Mean 5.17
Standard deviation 0.74
Values 4.6 5.7
[147]
liver PIF1
Mean 0.307
Standard deviation 0.13
Values 0.26 0.5 0.26 0.21
[148]
ref_hepatocyte TERT
Mean 0.123
Standard deviation 0.19
Values 0.44 0 0.18 0 0
[149]
HepG2 TERT
Mean 3.05
Standard deviation 0.27
Values 2.9 3.2
[150]
HepG2.C3A TERT
Mean 2.3
Standard deviation 0.4
Values 2 2.6
[151]
HuH.7 TERT
Mean 4.23
Standard deviation 2.5
Values 5.5 1.4 5.9
[152]
SNU475 TERT
Mean 1.03
Standard deviation 0.19
Values 0.89 1.2
[153]
THLE TERT
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[154]
liver TERT
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[155]
ref_hepatocyte CCNA1
Mean 0.0259
Standard deviation 0.058
Values 0.13 0 0 0 0
[156]
HepG2 CCNA1
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A CCNA1
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[158]
HuH.7 CCNA1
Mean 0
Standard deviation 0
Values 0 0 0
[159]
SNU475 CCNA1
Mean 0.0274
Standard deviation 0.026
Values 0.0093 0.046
[160]
THLE CCNA1
Mean 5.22
Standard deviation 2.3
Values 3.6 6.9
[161]
liver CCNA1
Mean 0
Standard deviation 0
Values 0 0 0 0