REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SEC11C Signal peptidase complex catalytic subunit SEC11C [1] -2.22[2] -0.69[3] -2.88[4] -2.44[5] -3.64[6] -1.09[7]
2 SEC11A Signal peptidase complex catalytic subunit SEC11A [8] 0.19[9] 0.12[10] 0.31[11] 0.08[12] -0.33[13] -1.82[14]
3 SPCS1 Signal peptidase complex subunit 1 [15] -0.33[16] -0.97[17] -1.72[18] -1.14[19] -0.57[20] -0.46[21]
4 SPCS2 Signal peptidase complex subunit 2 [22] 2.25[23] 1.59[24] 1.06[25] 1.76[26] 1.61[27] 1.30[28]
5 SPCS3 Signal peptidase complex subunit 3 [29] 1.78[30] 2.12[31] 2.81[32] 2.39[33] 2.57[34] 2.01[35]
6 IGF1 Insulin-like growth factor I [36] -6.53[37] -8.08[38] -6.14[39] 0.34[40] -7.64[41] 1.85[42]
7 BCHE Cholinesterase [43] -10.44[44] -9.93[45] -8.23[46] 0.03[47] 1.14[48] 1.28[49]
8 KLF4 Krueppel-like factor 4 [50] -0.31[51] -4.67[52] -1.83[53] -2.28[54] 1.95[55] -1.01[56]
9 ACHE Acetylcholinesterase [57] -0.19[58] -3.13[59] 0.04[60] -3.27[61] -2.79[62] -3.52[63]
10 PLA2G7 Platelet-activating factor acetylhydrolase [64] -4.25[65] -3.09[66] 4.55[67] -2.89[68] -2.76[69] 0.86[70]
11 UCN Urocortin [71] -0.09[72] 0.89[73] 0.28[74] -0.07[75] -1.08[76] -1.10[77]
12 MBOAT4 Ghrelin O-acyltransferase [78] 5.17[79] 4.81[80] 6.88[81] 2.58[82] 0.98[83] 3.17[84]
13 PCSK1 Neuroendocrine convertase 1 [85] -1.48[86] 1.53[87] 1.88[88] 6.20[89] 7.84[90] 6.13[91]
14 LEP Leptin [92] 0.57[93] 0.93[94] 0.54[95] 1.03[96] -0.44[97] 3.23[98]
15 CRHR2 Corticotropin-releasing factor receptor 2 [99] -1.24[100] [101] 1.54[102] -0.22[103] 1.98[104] 1.00[105]
16 GCG Glucagon [106] [107] [108] [109] [110] [111] [112]
17 GH1 Somatotropin [113] [114] [115] [116] [117] [118] [119]
18 INS Insulin [120] [121] [122] [123] [124] [125] [126]
19 GHRL Appetite-regulating hormone [127] [128] [129] [130] [131] [132] [133]
[1]
ref_hepatocyte SEC11C
Mean 123
Standard deviation 68
Values 1.8e+02 82 36 2e+02 1.1e+02
[2]
HepG2 SEC11C
Mean 15.7
Standard deviation 7
Values 11 21
[3]
HepG2.C3A SEC11C
Mean 61.9
Standard deviation 9.3
Values 55 69
[4]
HuH.7 SEC11C
Mean 11.7
Standard deviation 0.95
Values 11 12 12
[5]
SNU475 SEC11C
Mean 11.3
Standard deviation 0.13
Values 11 11
[6]
THLE SEC11C
Mean 6.07
Standard deviation 1.5
Values 5 7.1
[7]
liver SEC11C
Mean 43
Standard deviation 37
Values 57 12 88 15
[8]
ref_hepatocyte SEC11A
Mean 93.2
Standard deviation 63
Values 1.8e+02 1.4e+02 33 63 51
[9]
HepG2 SEC11A
Mean 63
Standard deviation 4.4
Values 60 66
[10]
HepG2.C3A SEC11A
Mean 82.3
Standard deviation 6.8
Values 87 77
[11]
HuH.7 SEC11A
Mean 81
Standard deviation 11
Values 69 90 84
[12]
SNU475 SEC11A
Mean 48.9
Standard deviation 4.9
Values 52 45
[13]
THLE SEC11A
Mean 45.9
Standard deviation 8.2
Values 40 52
[14]
liver SEC11A
Mean 19.7
Standard deviation 6.9
Values 27 15 24 13
[15]
ref_hepatocyte SPCS1
Mean 80.6
Standard deviation 34
Values 1.1e+02 1.1e+02 27 67 92
[16]
HepG2 SPCS1
Mean 38
Standard deviation 2.5
Values 36 40
[17]
HepG2.C3A SPCS1
Mean 33.4
Standard deviation 3.4
Values 31 36
[18]
HuH.7 SPCS1
Mean 17.2
Standard deviation 3.4
Values 17 14 20
[19]
SNU475 SPCS1
Mean 18.1
Standard deviation 0.47
Values 18 18
[20]
THLE SPCS1
Mean 33.7
Standard deviation 6.1
Values 29 38
[21]
liver SPCS1
Mean 43.7
Standard deviation 42
Values 81 8.3 79 7.2
[22]
ref_hepatocyte SPCS2
Mean 21
Standard deviation 13
Values 15 9.9 9.3 33 38
[23]
HepG2 SPCS2
Mean 59.3
Standard deviation 8.6
Values 53 65
[24]
HepG2.C3A SPCS2
Mean 51.1
Standard deviation 0.48
Values 51 51
[25]
HuH.7 SPCS2
Mean 30.6
Standard deviation 2
Values 29 30 33
[26]
SNU475 SPCS2
Mean 35.4
Standard deviation 6
Values 40 31
[27]
THLE SPCS2
Mean 39.6
Standard deviation 3.9
Values 37 42
[28]
liver SPCS2
Mean 38.6
Standard deviation 36
Values 56 9.1 81 8.2
[29]
ref_hepatocyte SPCS3
Mean 20.8
Standard deviation 14
Values 37 34 5.4 12 15
[30]
HepG2 SPCS3
Mean 42.3
Standard deviation 7
Values 37 47
[31]
HepG2.C3A SPCS3
Mean 73.6
Standard deviation 12
Values 65 82
[32]
HuH.7 SPCS3
Mean 102
Standard deviation 15
Values 1.1e+02 85 1.1e+02
[33]
SNU475 SPCS3
Mean 54.2
Standard deviation 18
Values 67 41
[34]
THLE SPCS3
Mean 76.2
Standard deviation 2.2
Values 75 78
[35]
liver SPCS3
Mean 62.6
Standard deviation 25
Values 35 95 53 67
[36]
ref_hepatocyte IGF1
Mean 17.2
Standard deviation 16
Values 0 18 5 24 39
[37]
HepG2 IGF1
Mean 0.111
Standard deviation 0.0052
Values 0.11 0.11
[38]
HepG2.C3A IGF1
Mean 0.0516
Standard deviation 0.018
Values 0.039 0.064
[39]
HuH.7 IGF1
Mean 0.171
Standard deviation 0.058
Values 0.11 0.22 0.19
[40]
SNU475 IGF1
Mean 10.9
Standard deviation 5.6
Values 15 6.9
[41]
THLE IGF1
Mean 0.0535
Standard deviation 0.008
Values 0.059 0.048
[42]
liver IGF1
Mean 46.3
Standard deviation 31
Values 92 24 31 39
[43]
ref_hepatocyte BCHE
Mean 11.7
Standard deviation 16
Values 0 5.4 1.6 12 39
[44]
HepG2 BCHE
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[45]
HepG2.C3A BCHE
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[46]
HuH.7 BCHE
Mean 0.0273
Standard deviation 0.032
Values 0.0082 0.064 0.0094
[47]
SNU475 BCHE
Mean 5.94
Standard deviation 0.44
Values 6.3 5.6
[48]
THLE BCHE
Mean 15.9
Standard deviation 2.8
Values 18 14
[49]
liver BCHE
Mean 21.2
Standard deviation 9.3
Values 35 17 17 16
[50]
ref_hepatocyte KLF4
Mean 4.48
Standard deviation 4.2
Values 0 4.3 11 5.9 1.4
[51]
HepG2 KLF4
Mean 2.15
Standard deviation 2.2
Values 3.7 0.62
[52]
HepG2.C3A KLF4
Mean 0.143
Standard deviation 0.14
Values 0.24 0.043
[53]
HuH.7 KLF4
Mean 0.885
Standard deviation 0.91
Values 0.38 1.9 0.35
[54]
SNU475 KLF4
Mean 0.46
Standard deviation 0.23
Values 0.3 0.62
[55]
THLE KLF4
Mean 10.7
Standard deviation 1.6
Values 9.6 12
[56]
liver KLF4
Mean 1.67
Standard deviation 1.4
Values 1.1 1.1 0.77 3.7
[57]
ref_hepatocyte ACHE
Mean 1.58
Standard deviation 1.8
Values 0.21 2.1 4.5 0.71 0.4
[58]
HepG2 ACHE
Mean 0.818
Standard deviation 0.67
Values 1.3 0.35
[59]
HepG2.C3A ACHE
Mean 0.146
Standard deviation 0.055
Values 0.18 0.11
[60]
HuH.7 ACHE
Mean 1.14
Standard deviation 0.67
Values 0.74 1.9 0.76
[61]
SNU475 ACHE
Mean 0.0812
Standard deviation 0.036
Values 0.11 0.056
[62]
THLE ACHE
Mean 0.14
Standard deviation 0.065
Values 0.095 0.19
[63]
liver ACHE
Mean 0.102
Standard deviation 0.031
Values 0.14 0.1 0.1 0.066
[64]
ref_hepatocyte PLA2G7
Mean 0.869
Standard deviation 0.49
Values 1.6 0.54 1.1 0.41 0.71
[65]
HepG2 PLA2G7
Mean 0.0272
Standard deviation 0.0021
Values 0.029 0.026
[66]
HepG2.C3A PLA2G7
Mean 0.0828
Standard deviation 0.035
Values 0.058 0.11
[67]
HuH.7 PLA2G7
Mean 14.3
Standard deviation 2
Values 16 12 14
[68]
SNU475 PLA2G7
Mean 0.0585
Standard deviation 0.011
Values 0.051 0.066
[69]
THLE PLA2G7
Mean 0.0792
Standard deviation 0.022
Values 0.095 0.064
[70]
liver PLA2G7
Mean 1.18
Standard deviation 0.76
Values 0.31 2.1 1.5 0.89
[71]
ref_hepatocyte UCN
Mean 0.494
Standard deviation 0.51
Values 0.59 0 0 1.2 0.69
[72]
HepG2 UCN
Mean 0.276
Standard deviation 0.21
Values 0.42 0.13
[73]
HepG2.C3A UCN
Mean 0.744
Standard deviation 0.61
Values 1.2 0.31
[74]
HuH.7 UCN
Mean 0.422
Standard deviation 0.17
Values 0.23 0.52 0.52
[75]
SNU475 UCN
Mean 0.234
Standard deviation 0.042
Values 0.2 0.26
[76]
THLE UCN
Mean 0.144
Standard deviation 0.11
Values 0.22 0.069
[77]
liver UCN
Mean 0.172
Standard deviation 0.13
Values 0.094 0.14 0.36 0.093
[78]
ref_hepatocyte MBOAT4
Mean 0.0314
Standard deviation 0.043
Values 0.071 0 0 0.086 0
[79]
HepG2 MBOAT4
Mean 0.672
Standard deviation 0.22
Values 0.52 0.83
[80]
HepG2.C3A MBOAT4
Mean 0.716
Standard deviation 0.064
Values 0.67 0.76
[81]
HuH.7 MBOAT4
Mean 2.59
Standard deviation 0.91
Values 3.5 2.5 1.7
[82]
SNU475 MBOAT4
Mean 0.0933
Standard deviation 0.04
Values 0.065 0.12
[83]
THLE MBOAT4
Mean 0.0381
Standard deviation 0.029
Values 0.018 0.059
[84]
liver MBOAT4
Mean 0.211
Standard deviation 0.062
Values 0.16 0.29 0.15 0.24
[85]
ref_hepatocyte PCSK1
Mean 0.0201
Standard deviation 0.045
Values 0 0 0.1 0 0
[86]
HepG2 PCSK1
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[87]
HepG2.C3A PCSK1
Mean 0.0473
Standard deviation 0.039
Values 0.019 0.075
[88]
HuH.7 PCSK1
Mean 0.0518
Standard deviation 0.022
Values 0.041 0.077 0.037
[89]
SNU475 PCSK1
Mean 0.734
Standard deviation 0.56
Values 0.34 1.1
[90]
THLE PCSK1
Mean 2.86
Standard deviation 0.33
Values 3.1 2.6
[91]
liver PCSK1
Mean 1.05
Standard deviation 1
Values 0.24 2.2 0.1 1.7
[92]
ref_hepatocyte LEP
Mean 0.0195
Standard deviation 0.035
Values 0 0 0.016 0 0.081
[93]
HepG2 LEP
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[94]
HepG2.C3A LEP
Mean 0.0302
Standard deviation 0.012
Values 0.039 0.021
[95]
HuH.7 LEP
Mean 0.0199
Standard deviation 0.0091
Values 0.025 0.026 0.0094
[96]
SNU475 LEP
Mean 0.0198
Standard deviation 0.015
Values 0.0093 0.03
[97]
THLE LEP
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[98]
liver LEP
Mean 0.137
Standard deviation 0.14
Values 0 0.27 0.026 0.25
[99]
ref_hepatocyte CRHR2
Mean 0.0114
Standard deviation 0.025
Values 0 0 0 0 0.057
[100]
HepG2 CRHR2
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[101]
HepG2.C3A CRHR2
Mean 0
Standard deviation 0
Values 0 0
[102]
HuH.7 CRHR2
Mean 0.0232
Standard deviation 0.016
Values 0.041 0.019 0.0094
[103]
SNU475 CRHR2
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[104]
THLE CRHR2
Mean 0.0278
Standard deviation 0.0058
Values 0.024 0.032
[105]
liver CRHR2
Mean 0.0171
Standard deviation 0.02
Values 0 0.029 0 0.04
[106]
ref_hepatocyte GCG
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 GCG
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A GCG
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 GCG
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 GCG
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[111]
THLE GCG
Mean 0.00592
Standard deviation 0.0084
Values 0.012 0
[112]
liver GCG
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte GH1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 GH1
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A GH1
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 GH1
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 GH1
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[118]
THLE GH1
Mean 0
Standard deviation 0
Values 0 0
[119]
liver GH1
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[122]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[124]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[125]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[126]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0 0.057 0 0.28
[127]
ref_hepatocyte GHRL
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 GHRL
Mean 0.0336
Standard deviation 0.007
Values 0.029 0.039
[129]
HepG2.C3A GHRL
Mean 0.0603
Standard deviation 0.025
Values 0.078 0.043
[130]
HuH.7 GHRL
Mean 0.105
Standard deviation 0.026
Values 0.12 0.12 0.075
[131]
SNU475 GHRL
Mean 0.0175
Standard deviation 0.018
Values 0.0046 0.03
[132]
THLE GHRL
Mean 0.0405
Standard deviation 0.035
Values 0.065 0.016
[133]
liver GHRL
Mean 0.289
Standard deviation 0.31
Values 0.071 0.37 0.026 0.69