REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ACSL1 Long-chain-fatty-acid--CoA ligase 1 [1] -1.31[2] -4.67[3] -4.09[4] -3.51[5] -0.78[6] 0.81[7]
2 ELOVL5 Elongation of very long chain fatty acids protein 5 [8] -0.63[9] -1.39[10] -0.62[11] 1.17[12] 0.18[13] -2.44[14]
3 TECR Very-long-chain enoyl-CoA reductase [15] -0.12[16] -1.41[17] 0.30[18] -0.33[19] -0.04[20] -1.87[21]
4 ACSL5 Long-chain-fatty-acid--CoA ligase 5 [22] 0.96[23] -0.02[24] -3.50[25] -1.96[26] -4.94[27] -0.35[28]
5 ELOVL1 Elongation of very long chain fatty acids protein 1 [29] 0.52[30] -0.92[31] -1.27[32] 0.98[33] -0.07[34] -3.23[35]
6 HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase [36] -0.48[37] -0.13[38] 0.40[39] -0.70[40] -0.06[41] -0.45[42]
7 ACSL3 Long-chain-fatty-acid--CoA ligase 3 [43] 0.82[44] 2.06[45] 1.20[46] 1.66[47] 0.72[48] -0.73[49]
8 ELOVL6 Elongation of very long chain fatty acids protein 6 [50] -2.05[51] 0.12[52] 0.16[53] 0.34[54] 0.62[55] -1.09[56]
9 ELOVL2 Elongation of very long chain fatty acids protein 2 [57] 0.71[58] 1.63[59] 0.28[60] -0.42[61] -2.90[62] -1.28[63]
10 ACSL4 Long-chain-fatty-acid--CoA ligase 4 [64] 3.43[65] 4.27[66] 4.52[67] 2.99[68] 3.39[69] -0.49[70]
11 SLC27A3 Long-chain fatty acid transport protein 3 [71] -2.18[72] -1.15[73] -2.40[74] -2.07[75] -1.36[76] -0.89[77]
12 ACSF3 Acyl-CoA synthetase family member 3, mitochondrial [78] 1.09[79] 0.22[80] -0.87[81] 0.81[82] 1.00[83] -0.18[84]
13 ELOVL7 Elongation of very long chain fatty acids protein 7 [85] 1.57[86] 2.23[87] 2.48[88] 1.88[89] 1.08[90] -1.81[91]
14 HSD17B3 Testosterone 17-beta-dehydrogenase 3 [92] -2.48[93] -3.42[94] 1.13[95] 1.38[96] -4.96[97] -0.57[98]
15 ACSL6 Long-chain-fatty-acid--CoA ligase 6 [99] 0.65[100] 2.13[101] -0.54[102] 0.18[103] -0.82[104] 1.57[105]
16 ELOVL4 Elongation of very long chain fatty acids protein 4 [106] -0.51[107] [108] -2.57[109] 2.64[110] 5.15[111] -2.29[112]
17 ELOVL3 Elongation of very long chain fatty acids protein 3 [113] 3.86[114] 2.36[115] 2.52[116] 1.52[117] 5.05[118] [119]
18 ACSBG1 Long-chain-fatty-acid--CoA ligase ACSBG1 [120] 1.98[121] 3.87[122] -0.75[123] 1.64[124] 0.82[125] -0.36[126]
19 TECRL Trans-2,3-enoyl-CoA reductase-like [127] [128] -2.46[129] [130] -1.31[131] [132] -3.83[133]
20 ACSBG2 Long-chain-fatty-acid--CoA ligase ACSBG2 [134] 1.17[135] 1.18[136] 2.04[137] 2.61[138] 2.73[139] 0.64[140]
21 HACD4 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 [141] [142] [143] [144] [145] [146] [147]
22 HACD1 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 [148] [149] [150] [151] [152] [153] [154]
23 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 [155] [156] [157] [158] [159] [160] [161]
24 HACD2 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte ACSL1
Mean 173
Standard deviation 2.2e+02
Values 17 17 13 3.2e+02 5e+02
[2]
HepG2 ACSL1
Mean 93.9
Standard deviation 14
Values 1e+02 84
[3]
HepG2.C3A ACSL1
Mean 15.2
Standard deviation 4.9
Values 19 12
[4]
HuH.7 ACSL1
Mean 22.4
Standard deviation 13
Values 15 38 14
[5]
SNU475 ACSL1
Mean 10.3
Standard deviation 0.5
Values 9.9 11
[6]
THLE ACSL1
Mean 103
Standard deviation 35
Values 1.3e+02 78
[7]
liver ACSL1
Mean 1.18e+03
Standard deviation 2.6e+02
Values 9.5e+02 1.1e+03 1.1e+03 1.6e+03
[8]
ref_hepatocyte ELOVL5
Mean 56.8
Standard deviation 44
Values 1.2e+02 80 33 23 24
[9]
HepG2 ELOVL5
Mean 49.5
Standard deviation 3.3
Values 52 47
[10]
HepG2.C3A ELOVL5
Mean 48.2
Standard deviation 12
Values 56 40
[11]
HuH.7 ELOVL5
Mean 81.7
Standard deviation 21
Values 81 1e+02 61
[12]
SNU475 ELOVL5
Mean 86.1
Standard deviation 20
Values 1e+02 72
[13]
THLE ELOVL5
Mean 65.5
Standard deviation 8
Values 60 71
[14]
liver ELOVL5
Mean 40.8
Standard deviation 18
Values 29 37 68 30
[15]
ref_hepatocyte TECR
Mean 33.9
Standard deviation 31
Values 17 7.9 9.7 69 66
[16]
HepG2 TECR
Mean 41.9
Standard deviation 1.2
Values 43 41
[17]
HepG2.C3A TECR
Mean 28.5
Standard deviation 4.8
Values 32 25
[18]
HuH.7 TECR
Mean 92.1
Standard deviation 25
Values 1.1e+02 65 97
[19]
SNU475 TECR
Mean 18.2
Standard deviation 1.3
Values 17 19
[20]
THLE TECR
Mean 33.8
Standard deviation 0.066
Values 34 34
[21]
liver TECR
Mean 36.1
Standard deviation 38
Values 79 3.7 57 5.1
[22]
ref_hepatocyte ACSL5
Mean 28.5
Standard deviation 4.5
Values 31 30 21 32 29
[23]
HepG2 ACSL5
Mean 74.6
Standard deviation 45
Values 1.1e+02 43
[24]
HepG2.C3A ACSL5
Mean 62.5
Standard deviation 11
Values 70 55
[25]
HuH.7 ACSL5
Mean 5.57
Standard deviation 4.2
Values 3.3 10 3
[26]
SNU475 ACSL5
Mean 4.95
Standard deviation 0.24
Values 4.8 5.1
[27]
THLE ACSL5
Mean 0.948
Standard deviation 0.26
Values 0.76 1.1
[28]
liver ACSL5
Mean 86.6
Standard deviation 32
Values 46 90 84 1.3e+02
[29]
ref_hepatocyte ELOVL1
Mean 24.3
Standard deviation 16
Values 9.4 40 42 20 10
[30]
HepG2 ELOVL1
Mean 46.8
Standard deviation 3.4
Values 44 49
[31]
HepG2.C3A ELOVL1
Mean 28.6
Standard deviation 0.69
Values 28 29
[32]
HuH.7 ELOVL1
Mean 22.2
Standard deviation 4.3
Values 25 17 24
[33]
SNU475 ELOVL1
Mean 32.3
Standard deviation 1.1
Values 33 32
[34]
THLE ELOVL1
Mean 23.6
Standard deviation 3.4
Values 21 26
[35]
liver ELOVL1
Mean 10.1
Standard deviation 8.1
Values 17 2.8 17 3.2
[36]
ref_hepatocyte HSD17B12
Mean 20.5
Standard deviation 14
Values 5.1 15 13 28 42
[37]
HepG2 HSD17B12
Mean 19.8
Standard deviation 1.3
Values 19 21
[38]
HepG2.C3A HSD17B12
Mean 41.8
Standard deviation 12
Values 50 34
[39]
HuH.7 HSD17B12
Mean 59.9
Standard deviation 5.1
Values 57 66 57
[40]
SNU475 HSD17B12
Mean 8.53
Standard deviation 0.57
Values 8.1 8.9
[41]
THLE HSD17B12
Mean 20.1
Standard deviation 2.8
Values 18 22
[42]
liver HSD17B12
Mean 58.4
Standard deviation 21
Values 56 62 83 32
[43]
ref_hepatocyte ACSL3
Mean 17.7
Standard deviation 9.8
Values 33 11 21 10 12
[44]
HepG2 ACSL3
Mean 41.8
Standard deviation 11
Values 34 49
[45]
HepG2.C3A ACSL3
Mean 164
Standard deviation 67
Values 2.1e+02 1.2e+02
[46]
HuH.7 ACSL3
Mean 89.4
Standard deviation 16
Values 89 1.1e+02 74
[47]
SNU475 ACSL3
Mean 37.6
Standard deviation 1.8
Values 36 39
[48]
THLE ACSL3
Mean 29.6
Standard deviation 1.5
Values 29 31
[49]
liver ACSL3
Mean 41.4
Standard deviation 11
Values 28 50 50 37
[50]
ref_hepatocyte ELOVL6
Mean 14.4
Standard deviation 6.8
Values 3 20 15 15 19
[51]
HepG2 ELOVL6
Mean 4.69
Standard deviation 0.45
Values 4.4 5
[52]
HepG2.C3A ELOVL6
Mean 34.9
Standard deviation 11
Values 42 27
[53]
HuH.7 ELOVL6
Mean 35.5
Standard deviation 5.9
Values 34 42 30
[54]
SNU475 ELOVL6
Mean 12.3
Standard deviation 1.9
Values 14 11
[55]
THLE ELOVL6
Mean 22.7
Standard deviation 1.3
Values 22 24
[56]
liver ELOVL6
Mean 26.3
Standard deviation 2.3
Values 24 27 29 25
[57]
ref_hepatocyte ELOVL2
Mean 11.4
Standard deviation 14
Values 36 6.9 0.76 3.6 10
[58]
HepG2 ELOVL2
Mean 25.1
Standard deviation 4.4
Values 22 28
[59]
HepG2.C3A ELOVL2
Mean 78.4
Standard deviation 3.4
Values 76 81
[60]
HuH.7 ELOVL2
Mean 30.6
Standard deviation 8.3
Values 28 40 24
[61]
SNU475 ELOVL2
Mean 5.74
Standard deviation 0.25
Values 5.9 5.6
[62]
THLE ELOVL2
Mean 1.56
Standard deviation 0.62
Values 2 1.1
[63]
liver ELOVL2
Mean 18.3
Standard deviation 11
Values 32 7.1 11 24
[64]
ref_hepatocyte ACSL4
Mean 8.43
Standard deviation 12
Values 30 3.6 4.9 2.5 1.3
[65]
HepG2 ACSL4
Mean 122
Standard deviation 39
Values 95 1.5e+02
[66]
HepG2.C3A ACSL4
Mean 362
Standard deviation 36
Values 3.9e+02 3.4e+02
[67]
HuH.7 ACSL4
Mean 426
Standard deviation 72
Values 4.8e+02 4.5e+02 3.5e+02
[68]
SNU475 ACSL4
Mean 45.3
Standard deviation 4
Values 42 48
[69]
THLE ACSL4
Mean 90.2
Standard deviation 2.5
Values 92 88
[70]
liver ACSL4
Mean 23.4
Standard deviation 10
Values 11 34 20 28
[71]
ref_hepatocyte SLC27A3
Mean 5.3
Standard deviation 6.2
Values 0.68 0.047 1.8 13 11
[72]
HepG2 SLC27A3
Mean 1.58
Standard deviation 0.82
Values 2.2 1
[73]
HepG2.C3A SLC27A3
Mean 5.33
Standard deviation 1.3
Values 6.3 4.4
[74]
HuH.7 SLC27A3
Mean 2.22
Standard deviation 0.65
Values 2.5 1.5 2.7
[75]
SNU475 SLC27A3
Mean 0.848
Standard deviation 0.25
Values 0.67 1
[76]
THLE SLC27A3
Mean 2.1
Standard deviation 0.44
Values 1.8 2.4
[77]
liver SLC27A3
Mean 11.1
Standard deviation 1.5
Values 11 9.3 13 11
[78]
ref_hepatocyte ACSF3
Mean 4.02
Standard deviation 2.3
Values 1.6 3 2.6 5.7 7.1
[79]
HepG2 ACSF3
Mean 11.5
Standard deviation 2
Values 13 10
[80]
HepG2.C3A ACSF3
Mean 10.4
Standard deviation 0.96
Values 11 9.7
[81]
HuH.7 ACSF3
Mean 4.83
Standard deviation 0.71
Values 5.4 5.1 4
[82]
SNU475 ACSF3
Mean 4.74
Standard deviation 0.96
Values 5.4 4.1
[83]
THLE ACSF3
Mean 8.18
Standard deviation 0.63
Values 8.6 7.7
[84]
liver ACSF3
Mean 13.8
Standard deviation 5.7
Values 12 11 22 9.9
[85]
ref_hepatocyte ELOVL7
Mean 0.648
Standard deviation 0.69
Values 1.7 0.45 1 0.078 0.033
[86]
HepG2 ELOVL7
Mean 2.58
Standard deviation 0.35
Values 2.3 2.8
[87]
HepG2.C3A ELOVL7
Mean 6.78
Standard deviation 1.1
Values 7.6 6
[88]
HuH.7 ELOVL7
Mean 7.95
Standard deviation 4
Values 6.1 13 5.2
[89]
SNU475 ELOVL7
Mean 1.61
Standard deviation 0.26
Values 1.8 1.4
[90]
THLE ELOVL7
Mean 1.4
Standard deviation 0.25
Values 1.6 1.2
[91]
liver ELOVL7
Mean 0.716
Standard deviation 0.14
Values 0.8 0.51 0.82 0.73
[92]
ref_hepatocyte HSD17B3
Mean 0.262
Standard deviation 0.31
Values 0 0.1 0 0.63 0.58
[93]
HepG2 HSD17B3
Mean 0.063
Standard deviation 0.032
Values 0.04 0.086
[94]
HepG2.C3A HSD17B3
Mean 0.0545
Standard deviation 0.047
Values 0.087 0.021
[95]
HuH.7 HSD17B3
Mean 1.27
Standard deviation 0.54
Values 0.65 1.5 1.6
[96]
SNU475 HSD17B3
Mean 0.46
Standard deviation 0.0054
Values 0.46 0.46
[97]
THLE HSD17B3
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[98]
liver HSD17B3
Mean 0.686
Standard deviation 0.23
Values 0.89 0.54 0.44 0.87
[99]
ref_hepatocyte ACSL6
Mean 0.236
Standard deviation 0.16
Values 0.27 0.19 0.038 0.21 0.48
[100]
HepG2 ACSL6
Mean 0.499
Standard deviation 0.21
Values 0.35 0.65
[101]
HepG2.C3A ACSL6
Mean 2.3
Standard deviation 0.03
Values 2.3 2.3
[102]
HuH.7 ACSL6
Mean 0.36
Standard deviation 0.036
Values 0.4 0.34 0.34
[103]
SNU475 ACSL6
Mean 0.181
Standard deviation 0.046
Values 0.15 0.21
[104]
THLE ACSL6
Mean 0.137
Standard deviation 0.017
Values 0.12 0.15
[105]
liver ACSL6
Mean 2.73
Standard deviation 1.7
Values 4.2 1.6 0.87 4.2
[106]
ref_hepatocyte ELOVL4
Mean 0.0947
Standard deviation 0.15
Values 0 0.036 0.36 0 0.081
[107]
HepG2 ELOVL4
Mean 0.0895
Standard deviation 0.036
Values 0.11 0.064
[108]
HepG2.C3A ELOVL4
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 ELOVL4
Mean 0.0351
Standard deviation 0.018
Values 0.016 0.051 0.037
[110]
SNU475 ELOVL4
Mean 0.398
Standard deviation 0.18
Values 0.27 0.52
[111]
THLE ELOVL4
Mean 3.43
Standard deviation 0.48
Values 3.1 3.8
[112]
liver ELOVL4
Mean 0.0751
Standard deviation 0.08
Values 0.094 0 0.18 0.026
[113]
ref_hepatocyte ELOVL3
Mean 0.0431
Standard deviation 0.096
Values 0 0 0 0.22 0
[114]
HepG2 ELOVL3
Mean 0.839
Standard deviation 0.046
Values 0.87 0.81
[115]
HepG2.C3A ELOVL3
Mean 0.494
Standard deviation 0.12
Values 0.41 0.58
[116]
HuH.7 ELOVL3
Mean 0.547
Standard deviation 0.3
Values 0.49 0.28 0.87
[117]
SNU475 ELOVL3
Mean 0.0834
Standard deviation 0.033
Values 0.06 0.11
[118]
THLE ELOVL3
Mean 1.46
Standard deviation 0.1
Values 1.5 1.4
[119]
liver ELOVL3
Mean 0
Standard deviation 0
Values 0 0 0 0
[120]
ref_hepatocyte ACSBG1
Mean 0.0373
Standard deviation 0.05
Values 0.04 0 0.12 0 0.024
[121]
HepG2 ACSBG1
Mean 0.198
Standard deviation 0.0048
Values 0.19 0.2
[122]
HepG2.C3A ACSBG1
Mean 1.22
Standard deviation 0.22
Values 1.4 1.1
[123]
HuH.7 ACSBG1
Mean 0.0492
Standard deviation 0.031
Values 0.025 0.039 0.084
[124]
SNU475 ACSBG1
Mean 0.0785
Standard deviation 0.032
Values 0.056 0.1
[125]
THLE ACSBG1
Mean 0.0671
Standard deviation 0.0029
Values 0.065 0.069
[126]
liver ACSBG1
Mean 0.113
Standard deviation 0.025
Values 0.12 0.086 0.1 0.15
[127]
ref_hepatocyte TECRL
Mean 0.0372
Standard deviation 0.039
Values 0 0 0.076 0.078 0.033
[128]
HepG2 TECRL
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A TECRL
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[130]
HuH.7 TECRL
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 TECRL
Mean 0.0101
Standard deviation 0.014
Values 0 0.02
[132]
THLE TECRL
Mean 0
Standard deviation 0
Values 0 0
[133]
liver TECRL
Mean 0.0102
Standard deviation 0.013
Values 0 0.014 0 0.026
[134]
ref_hepatocyte ACSBG2
Mean 0.0114
Standard deviation 0.025
Values 0 0 0 0 0.057
[135]
HepG2 ACSBG2
Mean 0.0343
Standard deviation 0.049
Values 0 0.069
[136]
HepG2.C3A ACSBG2
Mean 0.0575
Standard deviation 0.04
Values 0.029 0.086
[137]
HuH.7 ACSBG2
Mean 0.104
Standard deviation 0.046
Values 0.16 0.071 0.084
[138]
SNU475 ACSBG2
Mean 0.0469
Standard deviation 0.027
Values 0.028 0.066
[139]
THLE ACSBG2
Mean 0.0769
Standard deviation 0.034
Values 0.1 0.053
[140]
liver ACSBG2
Mean 0.0688
Standard deviation 0.071
Values 0 0.014 0.13 0.13
[141]
ref_hepatocyte HACD4
Missing
[142]
HepG2 HACD4
Missing
[143]
HepG2.C3A HACD4
Missing
[144]
HuH.7 HACD4
Missing
[145]
SNU475 HACD4
Missing
[146]
THLE HACD4
Missing
[147]
liver HACD4
Missing
[148]
ref_hepatocyte HACD1
Missing
[149]
HepG2 HACD1
Missing
[150]
HepG2.C3A HACD1
Missing
[151]
HuH.7 HACD1
Missing
[152]
SNU475 HACD1
Missing
[153]
THLE HACD1
Missing
[154]
liver HACD1
Missing
[155]
ref_hepatocyte HACD3
Missing
[156]
HepG2 HACD3
Missing
[157]
HepG2.C3A HACD3
Missing
[158]
HuH.7 HACD3
Missing
[159]
SNU475 HACD3
Missing
[160]
THLE HACD3
Missing
[161]
liver HACD3
Missing
[162]
ref_hepatocyte HACD2
Missing
[163]
HepG2 HACD2
Missing
[164]
HepG2.C3A HACD2
Missing
[165]
HuH.7 HACD2
Missing
[166]
SNU475 HACD2
Missing
[167]
THLE HACD2
Missing
[168]
liver HACD2
Missing