REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTGR1 Prostaglandin reductase 1 [1] -2.44[2] -7.01[3] -1.41[4] -0.57[5] -1.08[6] -1.01[7]
2 CYP4A11 Cytochrome P450 4A11 [8] -12.26[9] -8.61[10] -10.65[11] -10.28[12] -10.14[13] 1.16[14]
3 CYP4F2 Phylloquinone omega-hydroxylase CYP4F2 [15] -4.22[16] 0.43[17] -11.45[18] -11.50[19] -8.45[20] 1.10[21]
4 LTA4H Leukotriene A-4 hydrolase [22] 2.43[23] 4.08[24] 3.70[25] 1.43[26] 3.08[27] -1.24[28]
5 GGT1 Glutathione hydrolase 1 proenzyme [29] 1.73[30] 2.49[31] 2.08[32] -0.14[33] -3.51[34] 1.00[35]
6 CYP4F11 Phylloquinone omega-hydroxylase CYP4F11 [36] -0.13[37] 0.48[38] -7.00[39] 0.94[40] -7.95[41] 1.03[42]
7 CYP4F3 Docosahexaenoic acid omega-hydroxylase CYP4F3 [43] -1.05[44] 0.88[45] 1.97[46] -2.46[47] -7.45[48] 2.47[49]
8 MAPKAPK2 MAP kinase-activated protein kinase 2 [50] 2.86[51] 2.93[52] 3.16[53] 3.45[54] 3.82[55] -0.66[56]
9 CYP4A22 Cytochrome P450 4A22 [57] [58] [59] [60] [61] [62] 2.55[63]
10 CYP4F22 Cytochrome P450 4F22 [64] -3.47[65] [66] -7.64[67] -7.91[68] -4.94[69] -0.69[70]
11 ABCC1 Multidrug resistance-associated protein 1 [71] 7.65[72] 5.87[73] 4.77[74] 6.46[75] 6.07[76] 1.06[77]
12 DPEP1 Dipeptidase 1 [78] 4.28[79] 3.60[80] -3.28[81] -5.00[82] -6.03[83] -3.85[84]
13 ALOX5AP Arachidonate 5-lipoxygenase-activating protein [85] 0.39[86] -0.43[87] 0.79[88] 1.90[89] 2.52[90] -0.05[91]
14 ALOX5 Arachidonate 5-lipoxygenase [92] 1.53[93] -2.78[94] -2.89[95] -5.08[96] -2.66[97] 3.10[98]
15 LTC4S Leukotriene C4 synthase [99] -0.51[100] 2.01[101] 0.45[102] -3.77[103] 0.73[104] 0.82[105]
16 DPEP2 Dipeptidase 2 [106] -0.79[107] 1.35[108] -0.85[109] [110] [111] 1.31[112]
17 GGT5 Glutathione hydrolase 5 proenzyme [113] 6.98[114] 5.39[115] 0.33[116] 5.96[117] 7.26[118] 5.91[119]
18 DPEP3 Dipeptidase 3 [120] [121] [122] -2.96[123] -3.88[124] [125] -0.58[126]
19 ALOX15 Arachidonate 15-lipoxygenase [127] 4.02[128] 0.98[129] 5.38[130] 0.29[131] 1.90[132] -0.66[133]
20 CYP4F8 Cytochrome P450 4F8 [134] [135] [136] [137] [138] [139] [140]
21 CYP4B1 Cytochrome P450 4B1 [141] [142] [143] [144] [145] [146] [147]
[1]
ref_hepatocyte PTGR1
Mean 540
Standard deviation 7.3e+02
Values 73 1.8e+03 1.5e+02 4.2e+02 2.3e+02
[2]
HepG2 PTGR1
Mean 41.5
Standard deviation 32
Values 64 19
[3]
HepG2.C3A PTGR1
Mean 0.764
Standard deviation 0.27
Values 0.57 0.95
[4]
HuH.7 PTGR1
Mean 40.3
Standard deviation 6.4
Values 35 47 39
[5]
SNU475 PTGR1
Mean 161
Standard deviation 14
Values 1.5e+02 1.7e+02
[6]
THLE PTGR1
Mean 56.8
Standard deviation 6.8
Values 62 52
[7]
liver PTGR1
Mean 313
Standard deviation 2.3e+02
Values 3.1e+02 2.6e+02 6.2e+02 56
[8]
ref_hepatocyte CYP4A11
Mean 109
Standard deviation 1.6e+02
Values 0 0 4 2e+02 3.4e+02
[9]
HepG2 CYP4A11
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[10]
HepG2.C3A CYP4A11
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[11]
HuH.7 CYP4A11
Mean 0.0135
Standard deviation 0.0098
Values 0.025 0.0064 0.0094
[12]
SNU475 CYP4A11
Mean 0.039
Standard deviation 0.0093
Values 0.032 0.046
[13]
THLE CYP4A11
Mean 0.0216
Standard deviation 0.022
Values 0.0059 0.037
[14]
liver CYP4A11
Mean 286
Standard deviation 2.2e+02
Values 5.7e+02 87 3.6e+02 1.3e+02
[15]
ref_hepatocyte CYP4F2
Mean 30.2
Standard deviation 38
Values 1.2 0.054 11 51 87
[16]
HepG2 CYP4F2
Mean 0.677
Standard deviation 0.5
Values 1 0.32
[17]
HepG2.C3A CYP4F2
Mean 7.41
Standard deviation 4.8
Values 11 4
[18]
HuH.7 CYP4F2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[19]
SNU475 CYP4F2
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[20]
THLE CYP4F2
Mean 0.0192
Standard deviation 0.01
Values 0.012 0.027
[21]
liver CYP4F2
Mean 75.6
Standard deviation 42
Values 86 50 1.3e+02 36
[22]
ref_hepatocyte LTA4H
Mean 21.8
Standard deviation 17
Values 50 24 8.9 13 13
[23]
HepG2 LTA4H
Mean 48.8
Standard deviation 6.4
Values 53 44
[24]
HepG2.C3A LTA4H
Mean 67.1
Standard deviation 27
Values 86 48
[25]
HuH.7 LTA4H
Mean 55.9
Standard deviation 9.7
Values 48 67 53
[26]
SNU475 LTA4H
Mean 26
Standard deviation 1.8
Values 27 25
[27]
THLE LTA4H
Mean 40.9
Standard deviation 1.6
Values 40 42
[28]
liver LTA4H
Mean 10.7
Standard deviation 1.4
Values 11 11 13 9
[29]
ref_hepatocyte GGT1
Mean 15.1
Standard deviation 12
Values 0.7 20 4.1 29 22
[30]
HepG2 GGT1
Mean 20.9
Standard deviation 6.9
Values 26 16
[31]
HepG2.C3A GGT1
Mean 15.5
Standard deviation 4.3
Values 19 12
[32]
HuH.7 GGT1
Mean 12.7
Standard deviation 3.6
Values 11 17 9.9
[33]
SNU475 GGT1
Mean 6.1
Standard deviation 1.7
Values 7.3 4.9
[34]
THLE GGT1
Mean 0.294
Standard deviation 0.0057
Values 0.29 0.3
[35]
liver GGT1
Mean 35.2
Standard deviation 23
Values 65 15 40 21
[36]
ref_hepatocyte CYP4F11
Mean 14.8
Standard deviation 11
Values 1.7 6.9 14 28 23
[37]
HepG2 CYP4F11
Mean 5.67
Standard deviation 2.2
Values 7.3 4.1
[38]
HepG2.C3A CYP4F11
Mean 3.76
Standard deviation 0.42
Values 4.1 3.5
[39]
HuH.7 CYP4F11
Mean 0.023
Standard deviation 0.029
Values 0 0.013 0.056
[40]
SNU475 CYP4F11
Mean 12.6
Standard deviation 0.65
Values 12 13
[41]
THLE CYP4F11
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[42]
liver CYP4F11
Mean 35.3
Standard deviation 12
Values 20 46 34 42
[43]
ref_hepatocyte CYP4F3
Mean 13.8
Standard deviation 15
Values 3.1 2 2.4 29 33
[44]
HepG2 CYP4F3
Mean 2.77
Standard deviation 0.38
Values 3 2.5
[45]
HepG2.C3A CYP4F3
Mean 4.62
Standard deviation 0.54
Values 5 4.2
[46]
HuH.7 CYP4F3
Mean 10.7
Standard deviation 7.3
Values 7.3 19 5.8
[47]
SNU475 CYP4F3
Mean 1.11
Standard deviation 0.19
Values 1.2 0.97
[48]
THLE CYP4F3
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[49]
liver CYP4F3
Mean 88.9
Standard deviation 26
Values 68 1.2e+02 95 70
[50]
ref_hepatocyte MAPKAPK2
Mean 13.1
Standard deviation 7.6
Values 5.2 10 24 17 8.7
[51]
HepG2 MAPKAPK2
Mean 39.7
Standard deviation 1.4
Values 41 39
[52]
HepG2.C3A MAPKAPK2
Mean 18.1
Standard deviation 4.5
Values 21 15
[53]
HuH.7 MAPKAPK2
Mean 23.2
Standard deviation 2.9
Values 25 20 25
[54]
SNU475 MAPKAPK2
Mean 63.2
Standard deviation 4
Values 66 60
[55]
THLE MAPKAPK2
Mean 40.9
Standard deviation 0.33
Values 41 41
[56]
liver MAPKAPK2
Mean 9.67
Standard deviation 2.5
Values 10 11 6 11
[57]
ref_hepatocyte CYP4A22
Mean 3.13
Standard deviation 4
Values 0 0.14 0.49 7.2 7.8
[58]
HepG2 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[59]
HepG2.C3A CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 CYP4A22
Mean 0
Standard deviation 0
Values 0 0 0
[61]
SNU475 CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[62]
THLE CYP4A22
Mean 0
Standard deviation 0
Values 0 0
[63]
liver CYP4A22
Mean 21.4
Standard deviation 17
Values 46 6.3 15 18
[64]
ref_hepatocyte CYP4F22
Mean 2.74
Standard deviation 3.4
Values 0 0.23 8.2 3.5 1.8
[65]
HepG2 CYP4F22
Mean 0.103
Standard deviation 0.15
Values 0.21 0
[66]
HepG2.C3A CYP4F22
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 CYP4F22
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[68]
SNU475 CYP4F22
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[69]
THLE CYP4F22
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[70]
liver CYP4F22
Mean 1.99
Standard deviation 1.8
Values 4.7 0.59 1.6 1.1
[71]
ref_hepatocyte ABCC1
Mean 1.64
Standard deviation 2.8
Values 6.7 0.55 0.55 0.18 0.21
[72]
HepG2 ABCC1
Mean 138
Standard deviation 32
Values 1.6e+02 1.2e+02
[73]
HepG2.C3A ABCC1
Mean 17.5
Standard deviation 0.7
Values 18 17
[74]
HuH.7 ABCC1
Mean 8.92
Standard deviation 1.5
Values 11 8.1 8.1
[75]
SNU475 ABCC1
Mean 64.4
Standard deviation 27
Values 83 45
[76]
THLE ABCC1
Mean 24.5
Standard deviation 8.1
Values 19 30
[77]
liver ABCC1
Mean 4
Standard deviation 2.2
Values 2.8 4.5 1.8 6.8
[78]
ref_hepatocyte DPEP1
Mean 1.57
Standard deviation 3.4
Values 7.6 0 0 0.17 0.098
[79]
HepG2 DPEP1
Mean 12.8
Standard deviation 5.1
Values 9.2 16
[80]
HepG2.C3A DPEP1
Mean 3.47
Standard deviation 0.61
Values 3.9 3
[81]
HuH.7 DPEP1
Mean 0.032
Standard deviation 0.0059
Values 0.033 0.026 0.037
[82]
SNU475 DPEP1
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[83]
THLE DPEP1
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[84]
liver DPEP1
Mean 0.127
Standard deviation 0.17
Values 0.38 0.029 0.026 0.079
[85]
ref_hepatocyte ALOX5AP
Mean 0.929
Standard deviation 0.85
Values 0.13 0 1.2 1.3 2
[86]
HepG2 ALOX5AP
Mean 0.507
Standard deviation 0.0044
Values 0.5 0.51
[87]
HepG2.C3A ALOX5AP
Mean 0.126
Standard deviation 0.095
Values 0.058 0.19
[88]
HuH.7 ALOX5AP
Mean 0.318
Standard deviation 0.44
Values 0.049 0.82 0.084
[89]
SNU475 ALOX5AP
Mean 1.54
Standard deviation 0.32
Values 1.8 1.3
[90]
THLE ALOX5AP
Mean 1.18
Standard deviation 0.56
Values 0.79 1.6
[91]
liver ALOX5AP
Mean 1.05
Standard deviation 0.72
Values 1.5 0.46 1.8 0.41
[92]
ref_hepatocyte ALOX5
Mean 0.387
Standard deviation 0.51
Values 0 0.18 0 0.53 1.2
[93]
HepG2 ALOX5
Mean 0.467
Standard deviation 0.66
Values 0.93 0
[94]
HepG2.C3A ALOX5
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[95]
HuH.7 ALOX5
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[96]
SNU475 ALOX5
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[97]
THLE ALOX5
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[98]
liver ALOX5
Mean 3.87
Standard deviation 1.4
Values 2.2 4.4 3.4 5.5
[99]
ref_hepatocyte LTC4S
Mean 0.22
Standard deviation 0.38
Values 0 0 0 0.22 0.88
[100]
HepG2 LTC4S
Mean 0.0644
Standard deviation 0.055
Values 0.1 0.026
[101]
HepG2.C3A LTC4S
Mean 0.162
Standard deviation 0.046
Values 0.19 0.13
[102]
HuH.7 LTC4S
Mean 0.0599
Standard deviation 0.031
Values 0.025 0.071 0.084
[103]
SNU475 LTC4S
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[104]
THLE LTC4S
Mean 0.081
Standard deviation 0.0058
Values 0.077 0.085
[105]
liver LTC4S
Mean 0.455
Standard deviation 0.39
Values 0.89 0.13 0.67 0.13
[106]
ref_hepatocyte DPEP2
Mean 0.216
Standard deviation 0.31
Values 0 0 0 0.41 0.67
[107]
HepG2 DPEP2
Mean 0.0522
Standard deviation 0.0072
Values 0.057 0.047
[108]
HepG2.C3A DPEP2
Mean 0.1
Standard deviation 0.051
Values 0.14 0.064
[109]
HuH.7 DPEP2
Mean 0.0238
Standard deviation 0.015
Values 0.0082 0.026 0.037
[110]
SNU475 DPEP2
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE DPEP2
Mean 0
Standard deviation 0
Values 0 0
[112]
liver DPEP2
Mean 0.626
Standard deviation 0.12
Values 0.59 0.5 0.8 0.62
[113]
ref_hepatocyte GGT5
Mean 0.17
Standard deviation 0.18
Values 0.15 0 0 0.41 0.3
[114]
HepG2 GGT5
Mean 8.97
Standard deviation 6.7
Values 14 4.3
[115]
HepG2.C3A GGT5
Mean 1.3
Standard deviation 0.47
Values 0.97 1.6
[116]
HuH.7 GGT5
Mean 0.0424
Standard deviation 0.034
Values 0.074 0.0064 0.047
[117]
SNU475 GGT5
Mean 4.71
Standard deviation 2.8
Values 2.7 6.7
[118]
THLE GGT5
Mean 5.79
Standard deviation 1.9
Values 4.5 7.1
[119]
liver GGT5
Mean 12
Standard deviation 7.3
Values 13 4.2 21 9.1
[120]
ref_hepatocyte DPEP3
Mean 0.084
Standard deviation 0.13
Values 0 0 0.3 0.078 0.041
[121]
HepG2 DPEP3
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A DPEP3
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 DPEP3
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[124]
SNU475 DPEP3
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[125]
THLE DPEP3
Mean 0
Standard deviation 0
Values 0 0
[126]
liver DPEP3
Mean 0.0656
Standard deviation 0.079
Values 0 0.043 0.18 0.04
[127]
ref_hepatocyte ALOX15
Mean 0.0272
Standard deviation 0.03
Values 0 0 0.019 0.052 0.065
[128]
HepG2 ALOX15
Mean 0.183
Standard deviation 0.19
Values 0.32 0.051
[129]
HepG2.C3A ALOX15
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[130]
HuH.7 ALOX15
Mean 0.223
Standard deviation 0.099
Values 0.27 0.11 0.29
[131]
SNU475 ALOX15
Mean 0.0148
Standard deviation 0.0078
Values 0.0093 0.02
[132]
THLE ALOX15
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[133]
liver ALOX15
Mean 0.0201
Standard deviation 0.031
Values 0 0.014 0 0.066
[134]
ref_hepatocyte CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 CYP4F8
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[136]
HepG2.C3A CYP4F8
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 CYP4F8
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[138]
SNU475 CYP4F8
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[139]
THLE CYP4F8
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[140]
liver CYP4F8
Mean 0
Standard deviation 0
Values 0 0 0 0
[141]
ref_hepatocyte CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 CYP4B1
Mean 0.00501
Standard deviation 0.001
Values 0.0057 0.0043
[143]
HepG2.C3A CYP4B1
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 CYP4B1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 CYP4B1
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[146]
THLE CYP4B1
Mean 0.129
Standard deviation 0.077
Values 0.18 0.074
[147]
liver CYP4B1
Mean 0.0575
Standard deviation 0.045
Values 0.047 0 0.077 0.11