REACTOME_SYNTHESIS_OF_DNA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.37[2] | -1.54[3] | -1.50[4] | -1.72[5] | -1.46[6] | -0.57[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.92[16] | -0.78[17] | -1.14[18] | -0.87[19] | -1.08[20] | -0.12[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.69[23] | -2.37[24] | -2.11[25] | -1.59[26] | -2.30[27] | -1.07[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.51[30] | -2.00[31] | -2.20[32] | -1.37[33] | -1.84[34] | -0.69[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.45[37] | 0.47[38] | -0.95[39] | 0.25[40] | -0.36[41] | 0.33[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | -0.01[44] | 0.02[45] | -1.14[46] | -0.99[47] | -0.40[48] | 0.17[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.49[51] | -1.36[52] | -0.42[53] | -1.01[54] | -1.31[55] | -0.13[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.25[58] | -0.16[59] | -0.12[60] | 0.42[61] | 0.23[62] | -0.46[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.19[65] | -1.26[66] | -1.22[67] | -1.36[68] | -1.09[69] | -0.89[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.21[72] | -0.30[73] | -0.46[74] | -0.64[75] | -0.53[76] | -0.42[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.34[79] | -0.02[80] | -0.18[81] | -0.11[82] | -0.27[83] | -0.34[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.59[86] | 0.00[87] | -0.30[88] | 0.19[89] | -0.15[90] | -0.42[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.15[93] | 0.28[94] | -0.71[95] | 0.55[96] | 0.58[97] | 0.62[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.63[100] | -0.77[101] | -0.24[102] | -1.00[103] | -0.98[104] | 0.05[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.21[107] | -0.28[108] | -1.05[109] | -0.26[110] | -0.88[111] | -0.17[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.66[114] | -0.59[115] | -0.54[116] | -0.81[117] | -1.24[118] | -0.01[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.75[121] | 0.14[122] | 0.38[123] | -0.31[124] | -0.11[125] | 0.21[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.23[128] | -0.29[129] | -0.18[130] | 0.39[131] | -0.31[132] | -0.11[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.31[135] | -0.01[136] | -0.25[137] | -0.69[138] | -0.39[139] | -0.29[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.15[142] | 0.02[143] | 0.07[144] | -0.42[145] | 0.17[146] | -0.26[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.38[149] | 0.49[150] | 0.47[151] | 0.69[152] | 1.82[153] | 0.77[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.29[156] | -0.30[157] | -1.04[158] | 0.88[159] | 0.23[160] | -0.07[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | -0.11[163] | 0.21[164] | 0.18[165] | 0.45[166] | -0.21[167] | 0.42[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.51[170] | 1.45[171] | 2.38[172] | 0.53[173] | 1.15[174] | 0.65[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.21[177] | 0.03[178] | 0.02[179] | -0.14[180] | 0.11[181] | 0.19[182] |
27 | ANAPC11 | Anaphase-promoting complex subunit 11 | [183] | -1.00[184] | -0.53[185] | -1.06[186] | -1.26[187] | -1.07[188] | -0.09[189] |
28 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [190] | -1.22[191] | -0.76[192] | -0.99[193] | -1.65[194] | -1.42[195] | -0.79[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.61[198] | 0.03[199] | 0.53[200] | 0.39[201] | 0.45[202] | -0.10[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.79[205] | -2.45[206] | -9.76[207] | 0.36[208] | -1.11[209] | -0.78[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.22[212] | 0.32[213] | 0.48[214] | 0.25[215] | 0.12[216] | -0.24[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.21[219] | 0.17[220] | 0.01[221] | -0.12[222] | -0.17[223] | 0.24[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.94[226] | -0.53[227] | -1.72[228] | -0.74[229] | -0.10[230] | -0.35[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.25[233] | 0.29[234] | 0.70[235] | 0.32[236] | -0.34[237] | -0.16[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.57[240] | -0.56[241] | -0.96[242] | -0.06[243] | -0.16[244] | -0.24[245] |
36 | PCNA | Proliferating cell nuclear antigen | [246] | 1.72[247] | 1.74[248] | 0.21[249] | 0.84[250] | 0.93[251] | -1.76[252] |
37 | PSMC6 | 26S proteasome regulatory subunit 10B | [253] | -0.27[254] | 1.23[255] | -0.04[256] | 0.29[257] | 0.06[258] | 0.41[259] |
38 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [260] | 0.61[261] | 0.15[262] | 0.65[263] | 0.70[264] | 0.69[265] | 1.24[266] |
39 | POLD2 | DNA polymerase delta subunit 2 | [267] | 0.23[268] | 0.44[269] | 0.83[270] | 0.19[271] | 0.37[272] | 1.19[273] |
40 | POLD4 | DNA polymerase delta subunit 4 | [274] | -1.30[275] | -1.61[276] | 0.35[277] | 2.50[278] | -1.28[279] | 0.83[280] |
41 | PSMC2 | 26S proteasome regulatory subunit 7 | [281] | 0.37[282] | 0.70[283] | 0.38[284] | 1.10[285] | 0.76[286] | 1.29[287] |
42 | CDC26 | Anaphase-promoting complex subunit CDC26 | [288] | -1.95[289] | -1.44[290] | -1.58[291] | -1.97[292] | -1.27[293] | -0.90[294] |
43 | POLE3 | DNA polymerase epsilon subunit 3 | [295] | 0.05[296] | -0.06[297] | 0.11[298] | 0.00[299] | 0.84[300] | -0.26[301] |
44 | PSME3 | Proteasome activator complex subunit 3 | [302] | 1.59[303] | 1.24[304] | 0.83[305] | 1.12[306] | 1.22[307] | 0.86[308] |
45 | POLE4 | DNA polymerase epsilon subunit 4 | [309] | -0.21[310] | 0.55[311] | -3.01[312] | -0.57[313] | -1.23[314] | -0.50[315] |
46 | UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 | [316] | -0.12[317] | 0.15[318] | 0.75[319] | 0.57[320] | 0.64[321] | -1.50[322] |
47 | RPA2 | Replication protein A 32 kDa subunit | [323] | -0.62[324] | -0.52[325] | -0.07[326] | 0.31[327] | 0.20[328] | -1.09[329] |
48 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [330] | 1.35[331] | 1.60[332] | 1.39[333] | 1.93[334] | 1.77[335] | 2.04[336] |
49 | PSMB10 | Proteasome subunit beta type-10 | [337] | -1.37[338] | -0.85[339] | -2.83[340] | -0.28[341] | -1.61[342] | -0.11[343] |
50 | PSMA5 | Proteasome subunit alpha type-5 | [344] | 1.68[345] | 2.04[346] | 1.51[347] | 1.98[348] | 1.37[349] | 1.88[350] |
51 | PSMF1 | Proteasome inhibitor PI31 subunit | [351] | 2.06[352] | 2.03[353] | 0.75[354] | 0.99[355] | 0.58[356] | 1.82[357] |
52 | ANAPC16 | Anaphase-promoting complex subunit 16 | [358] | 1.02[359] | 1.76[360] | 0.48[361] | 0.63[362] | 0.67[363] | 1.85[364] |
53 | ANAPC5 | Anaphase-promoting complex subunit 5 | [365] | 1.71[366] | 2.40[367] | 2.45[368] | 1.39[369] | 1.66[370] | 2.02[371] |
54 | PSMB2 | Proteasome subunit beta type-2 | [372] | 1.84[373] | 1.50[374] | 1.80[375] | 2.28[376] | 2.10[377] | 2.37[378] |
55 | PSMB9 | Proteasome subunit beta type-9 | [379] | -2.16[380] | -4.86[381] | -7.26[382] | 1.54[383] | -0.90[384] | -0.53[385] |
56 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [386] | 0.22[387] | 0.64[388] | -0.44[389] | 0.16[390] | 0.43[391] | 0.70[392] |
57 | CUL1 | Cullin-1 | [393] | 0.45[394] | 1.16[395] | 0.59[396] | 1.64[397] | 1.10[398] | 2.06[399] |
58 | CDC27 | Cell division cycle protein 27 homolog | [400] | 1.05[401] | 1.92[402] | 1.15[403] | 2.24[404] | 1.59[405] | 1.46[406] |
59 | MCM7 | DNA replication licensing factor MCM7 | [407] | 2.75[408] | 2.57[409] | 3.68[410] | 2.34[411] | 2.70[412] | 0.51[413] |
60 | MCM3 | DNA replication licensing factor MCM3 | [414] | 3.13[415] | 3.01[416] | 3.01[417] | 2.04[418] | 2.93[419] | 0.62[420] |
61 | CDC16 | Cell division cycle protein 16 homolog | [421] | 0.34[422] | 0.60[423] | -0.17[424] | 0.63[425] | 0.89[426] | 1.18[427] |
62 | CDK2 | Cyclin-dependent kinase 2 | [428] | 0.42[429] | 0.62[430] | 0.88[431] | 1.04[432] | 1.43[433] | -0.88[434] |
63 | UBE2C | Ubiquitin-conjugating enzyme E2 C | [435] | 0.60[436] | 1.01[437] | 1.66[438] | 1.18[439] | 1.88[440] | -2.49[441] |
64 | RFC4 | Replication factor C subunit 4 | [442] | -0.14[443] | 0.52[444] | 0.99[445] | 0.09[446] | 1.23[447] | -1.44[448] |
65 | UBE2S | Ubiquitin-conjugating enzyme E2 S | [449] | 1.28[450] | 0.88[451] | 2.95[452] | 2.02[453] | 3.19[454] | -1.28[455] |
66 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [456] | 0.77[457] | 1.02[458] | 0.95[459] | 1.83[460] | 0.98[461] | 0.68[462] |
67 | RFC1 | Replication factor C subunit 1 | [463] | 0.97[464] | 2.29[465] | 2.56[466] | 1.38[467] | 2.03[468] | 2.09[469] |
68 | MCM4 | DNA replication licensing factor MCM4 | [470] | 2.90[471] | 2.81[472] | 3.42[473] | 3.05[474] | 3.50[475] | 0.33[476] |
69 | RFC2 | Replication factor C subunit 2 | [477] | 0.57[478] | 0.46[479] | 0.38[480] | 1.23[481] | 1.50[482] | 0.54[483] |
70 | FEN1 | Flap endonuclease 1 | [484] | 1.86[485] | 1.68[486] | 2.43[487] | 1.73[488] | 2.44[489] | 0.21[490] |
71 | MCM5 | DNA replication licensing factor MCM5 | [491] | 2.05[492] | 1.94[493] | 2.46[494] | 1.57[495] | 2.31[496] | 0.39[497] |
72 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [498] | 2.15[499] | 1.91[500] | 2.07[501] | 2.91[502] | 2.73[503] | 1.31[504] |
73 | RPA3 | Replication protein A 14 kDa subunit | [505] | 0.47[506] | 1.30[507] | 1.90[508] | 0.15[509] | 0.24[510] | 0.62[511] |
74 | PSME4 | Proteasome activator complex subunit 4 | [512] | 2.30[513] | 3.14[514] | 3.05[515] | 2.39[516] | 2.18[517] | 2.95[518] |
75 | ORC4 | Origin recognition complex subunit 4 | [519] | 0.89[520] | 2.10[521] | 1.71[522] | 2.43[523] | 1.49[524] | 4.28[525] |
76 | CDC23 | Cell division cycle protein 23 homolog | [526] | 1.21[527] | 1.44[528] | 1.58[529] | 2.09[530] | 1.60[531] | 1.51[532] |
77 | ORC5 | Origin recognition complex subunit 5 | [533] | -0.15[534] | 0.23[535] | 0.69[536] | 0.91[537] | 0.48[538] | 1.13[539] |
78 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [540] | 1.19[541] | 0.67[542] | 2.14[543] | 2.22[544] | 2.13[545] | 2.13[546] |
79 | FZR1 | Fizzy-related protein homolog | [547] | 1.58[548] | 1.26[549] | 1.23[550] | 1.09[551] | 1.49[552] | 1.93[553] |
80 | ANAPC7 | Anaphase-promoting complex subunit 7 | [554] | 1.83[555] | 2.26[556] | 1.62[557] | 1.96[558] | 2.02[559] | 1.50[560] |
81 | ANAPC2 | Anaphase-promoting complex subunit 2 | [561] | 1.44[562] | 0.91[563] | 1.41[564] | 1.09[565] | 0.86[566] | 1.36[567] |
82 | RFC5 | Replication factor C subunit 5 | [568] | 0.96[569] | 1.45[570] | 1.53[571] | 1.32[572] | 1.66[573] | 0.43[574] |
83 | GINS2 | DNA replication complex GINS protein PSF2 | [575] | 1.44[576] | 1.76[577] | 1.38[578] | 0.53[579] | 1.33[580] | -1.99[581] |
84 | ORC2 | Origin recognition complex subunit 2 | [582] | 1.29[583] | 2.28[584] | 1.90[585] | 1.36[586] | 1.46[587] | 0.88[588] |
85 | CDC6 | Cell division control protein 6 homolog | [589] | 2.69[590] | 2.29[591] | 2.78[592] | 2.62[593] | 2.70[594] | -0.76[595] |
86 | ORC6 | Origin recognition complex subunit 6 | [596] | 1.59[597] | 2.18[598] | 1.29[599] | 1.84[600] | 1.90[601] | -2.39[602] |
87 | MCM6 | DNA replication licensing factor MCM6 | [603] | 2.03[604] | 1.77[605] | 3.68[606] | 3.48[607] | 4.08[608] | 0.02[609] |
88 | MCM2 | DNA replication licensing factor MCM2 | [610] | 3.76[611] | 3.24[612] | 4.42[613] | 3.18[614] | 4.00[615] | -0.31[616] |
89 | ORC3 | Origin recognition complex subunit 3 | [617] | 0.92[618] | 2.15[619] | 2.18[620] | 1.60[621] | 2.38[622] | 1.57[623] |
90 | ANAPC1 | Anaphase-promoting complex subunit 1 | [624] | 3.24[625] | 3.45[626] | 3.22[627] | 2.98[628] | 2.81[629] | 2.76[630] |
91 | SKP2 | S-phase kinase-associated protein 2 | [631] | 2.15[632] | 2.64[633] | 3.66[634] | 2.32[635] | 2.21[636] | 2.39[637] |
92 | CCNE1 | G1/S-specific cyclin-E1 | [638] | 2.07[639] | 2.21[640] | 0.28[641] | 0.65[642] | 1.06[643] | -3.32[644] |
93 | CCNA2 | Cyclin-A2 | [645] | 3.04[646] | 4.08[647] | 3.31[648] | 3.06[649] | 4.26[650] | 0.08[651] |
94 | RFC3 | Replication factor C subunit 3 | [652] | 2.01[653] | 2.90[654] | 2.93[655] | 2.31[656] | 2.71[657] | 0.44[658] |
95 | LIG1 | DNA ligase 1 | [659] | 2.46[660] | 2.51[661] | 3.03[662] | 1.56[663] | 2.11[664] | 0.94[665] |
96 | ANAPC4 | Anaphase-promoting complex subunit 4 | [666] | 1.03[667] | 1.98[668] | 2.20[669] | 2.24[670] | 1.53[671] | 2.29[672] |
97 | CDC45 | Cell division control protein 45 homolog | [673] | 2.03[674] | 2.01[675] | 2.56[676] | 2.31[677] | 2.46[678] | -1.60[679] |
98 | POLA2 | DNA polymerase alpha subunit B | [680] | 1.48[681] | 1.14[682] | 1.59[683] | 2.57[684] | 2.68[685] | 0.47[686] |
99 | PRIM1 | DNA primase small subunit | [687] | 1.50[688] | 2.86[689] | 3.08[690] | 2.21[691] | 2.61[692] | 0.40[693] |
100 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [694] | 1.63[695] | 2.52[696] | 2.75[697] | 2.57[698] | 2.15[699] | 1.81[700] |
101 | POLD1 | DNA polymerase delta catalytic subunit | [701] | 2.69[702] | 2.95[703] | 3.65[704] | 2.88[705] | 3.45[706] | 1.98[707] |
102 | GINS1 | DNA replication complex GINS protein PSF1 | [708] | 3.04[709] | 2.97[710] | 3.04[711] | 3.36[712] | 2.47[713] | -1.32[714] |
103 | PRIM2 | DNA primase large subunit | [715] | 2.11[716] | 1.95[717] | 1.45[718] | 2.24[719] | 2.29[720] | -0.28[721] |
104 | ANAPC10 | Anaphase-promoting complex subunit 10 | [722] | 0.60[723] | 1.52[724] | 0.79[725] | 0.83[726] | 1.42[727] | 1.43[728] |
105 | GINS3 | DNA replication complex GINS protein PSF3 | [729] | 1.99[730] | 1.21[731] | 0.89[732] | 1.79[733] | 2.81[734] | -0.76[735] |
106 | MCM8 | DNA helicase MCM8 | [736] | 3.03[737] | 3.77[738] | 2.94[739] | 3.66[740] | 3.02[741] | 0.94[742] |
107 | ORC1 | Origin recognition complex subunit 1 | [743] | 2.38[744] | 2.45[745] | 3.83[746] | 2.33[747] | 2.71[748] | -0.80[749] |
108 | POLD3 | DNA polymerase delta subunit 3 | [750] | 2.01[751] | 1.91[752] | 2.77[753] | 3.17[754] | 3.46[755] | 2.29[756] |
109 | POLE | DNA polymerase epsilon catalytic subunit A | [757] | 3.88[758] | 4.53[759] | 4.47[760] | 3.79[761] | 4.61[762] | 4.24[763] |
110 | POLE2 | DNA polymerase epsilon subunit 2 | [764] | 1.54[765] | 2.36[766] | 3.24[767] | 2.21[768] | 2.56[769] | 0.15[770] |
111 | CDT1 | DNA replication factor Cdt1 | [771] | 4.07[772] | 4.39[773] | 5.75[774] | 3.59[775] | 3.99[776] | -0.52[777] |
112 | POLA1 | DNA polymerase alpha catalytic subunit | [778] | 2.84[779] | 2.98[780] | 3.42[781] | 4.04[782] | 3.82[783] | 2.98[784] |
113 | CCNE2 | G1/S-specific cyclin-E2 | [785] | 1.26[786] | 1.68[787] | 1.10[788] | 4.09[789] | 3.80[790] | 0.96[791] |
114 | GINS4 | DNA replication complex GINS protein SLD5 | [792] | 3.32[793] | 3.24[794] | 3.97[795] | 2.84[796] | 3.22[797] | 0.36[798] |
115 | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2 | [799] | 2.59[800] | 4.39[801] | 3.48[802] | 3.70[803] | 3.17[804] | 2.87[805] |
116 | CCNA1 | Cyclin-A1 | [806] | [807] | -2.53[808] | [809] | 0.26[810] | 7.48[811] | [812] |
117 | ANAPC15 | Anaphase-promoting complex subunit 15 | [813] | [814] | [815] | [816] | [817] | [818] | [819] |
118 | SEM1 | Putative protein SEM1, isoform 2 | [820] | [821] | [822] | [823] | [824] | [825] | [826] |
119 | PSMA8 | Proteasome subunit alpha type-7-like | [827] | [828] | [829] | [830] | [831] | [832] | [833] |
120 | PSMB11 | Proteasome subunit beta type-11 | [834] | [835] | [836] | [837] | [838] | [839] | [840] |