REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKR1C1 Aldo-keto reductase family 1 member C1 [1] -0.31[2] -0.68[3] -3.31[4] -1.04[5] -3.36[6] -3.83[7]
2 AKR1C3 Aldo-keto reductase family 1 member C3 [8] 0.17[9] 0.75[10] -4.81[11] 2.20[12] -2.40[13] -1.78[14]
3 SCP2 Non-specific lipid-transfer protein [15] -1.40[16] -0.31[17] 1.03[18] -1.62[19] 0.70[20] 0.75[21]
4 AKR1C2 Aldo-keto reductase family 1 member C2 [22] 1.56[23] -0.53[24] -2.08[25] 1.31[26] -2.17[27] -0.76[28]
5 CYP27A1 Sterol 26-hydroxylase, mitochondrial [29] 0.36[30] 1.10[31] -0.90[32] -2.74[33] -1.83[34] 0.50[35]
6 AKR1C4 Aldo-keto reductase family 1 member C4 [36] -6.62[37] -4.30[38] -3.81[39] -8.85[40] -11.86[41] -0.47[42]
7 HSD17B4 Peroxisomal multifunctional enzyme type 2 [43] 1.01[44] 1.33[45] 2.14[46] -0.18[47] 2.96[48] 1.18[49]
8 SLC27A5 Bile acyl-CoA synthetase [50] -3.00[51] -1.80[52] -2.32[53] -5.67[54] -5.70[55] 1.04[56]
9 SLC27A2 Very long-chain acyl-CoA synthetase [57] -1.09[58] -0.97[59] -0.16[60] -2.26[61] -3.70[62] 1.57[63]
10 BAAT Bile acid-CoA:amino acid N-acyltransferase [64] -3.07[65] -2.50[66] -3.77[67] -6.44[68] -5.28[69] 2.16[70]
11 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [71] -5.77[72] -3.28[73] -6.12[74] -8.16[75] -7.52[76] 2.86[77]
12 HSD3B7 3 beta-hydroxysteroid dehydrogenase type 7 [78] 1.21[79] 2.02[80] -0.02[81] -1.65[82] 0.42[83] 0.74[84]
13 AKR1D1 3-oxo-5-beta-steroid 4-dehydrogenase [85] -0.64[86] 0.69[87] -0.94[88] -8.30[89] -6.05[90] 0.14[91]
14 NR1H4 Bile acid receptor [92] 0.85[93] 1.39[94] 4.26[95] -6.24[96] -3.80[97] 0.93[98]
15 ACOX2 Peroxisomal acyl-coenzyme A oxidase 2 [99] 0.03[100] 1.31[101] 2.13[102] -6.06[103] -1.26[104] 1.53[105]
16 RXRA Retinoic acid receptor RXR-alpha [106] 2.39[107] 2.15[108] 4.07[109] 1.83[110] 3.97[111] 2.56[112]
17 AMACR Alpha-methylacyl-CoA racemase [113] -1.42[114] -1.45[115] 1.09[116] -2.76[117] -0.72[118] -1.42[119]
18 ACOT8 Acyl-coenzyme A thioesterase 8 [120] 1.50[121] 1.93[122] 3.05[123] 0.86[124] 2.83[125] -0.45[126]
19 CYP7A1 Cholesterol 7-alpha-monooxygenase [127] -1.90[128] -4.27[129] -6.73[130] -8.15[131] [132] -2.55[133]
20 NCOA1 Nuclear receptor coactivator 1 [134] 2.91[135] 3.43[136] 4.71[137] 3.61[138] 5.53[139] 3.06[140]
21 ABCB11 Bile salt export pump [141] -4.35[142] [143] -2.01[144] -3.71[145] [146] 5.20[147]
22 CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase [148] -5.59[149] -4.35[150] [151] -7.21[152] -1.01[153] 2.68[154]
23 NCOA2 Nuclear receptor coactivator 2 [155] 4.02[156] 4.80[157] 7.70[158] 5.01[159] 5.78[160] 5.01[161]
24 PTGIS Prostacyclin synthase [162] 0.88[163] 1.96[164] 7.02[165] 2.93[166] 11.35[167] 5.25[168]
[1]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 1.4e+03 1.3e+03 9.2e+02 1e+03 3.2e+02
[2]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 5.1e+02 1.5e+02
[3]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 2.8e+02 1.9e+02
[4]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 7.8 35 8.5
[5]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 2e+02 3.1e+02
[6]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[7]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 63 67 1.5e+02 21
[8]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 1.1e+02 4.3e+02 1.2e+02
[9]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[10]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[11]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[12]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[13]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[14]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 51 67 1.5e+02 32
[15]
ref_hepatocyte SCP2
Mean 227
Standard deviation 2.8e+02
Values 1.4e+02 77 9.1 2e+02 7.1e+02
[16]
HepG2 SCP2
Mean 35
Standard deviation 12
Values 27 43
[17]
HepG2.C3A SCP2
Mean 68.2
Standard deviation 19
Values 55 82
[18]
HuH.7 SCP2
Mean 78.3
Standard deviation 13
Values 83 63 89
[19]
SNU475 SCP2
Mean 38.6
Standard deviation 10
Values 46 32
[20]
THLE SCP2
Mean 38.9
Standard deviation 1.4
Values 40 38
[21]
liver SCP2
Mean 407
Standard deviation 2e+02
Values 6.5e+02 2.1e+02 4.9e+02 2.8e+02
[22]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.2e+02 3.4e+02 1.1e+02 2.3e+02 40
[23]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 2.9e+02 1e+02
[24]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 48 38
[25]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 3 15 2.5
[26]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 2.4e+02 1.9e+02
[27]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[28]
liver AKR1C2
Mean 106
Standard deviation 92
Values 64 1.1e+02 2.3e+02 19
[29]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 18 2.1e+02 3.7e+02
[30]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[31]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[32]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[33]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[34]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[35]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 3.3e+02 1.2e+02 2.5e+02 1.1e+02
[36]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 1.7 2.3e+02 2.8e+02
[37]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[38]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[39]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[40]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[41]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[42]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 56 66 1.7e+02 30
[43]
ref_hepatocyte HSD17B4
Mean 85.8
Standard deviation 51
Values 1.2e+02 57 11 1.1e+02 1.3e+02
[44]
HepG2 HSD17B4
Mean 70.1
Standard deviation 24
Values 53 87
[45]
HepG2.C3A HSD17B4
Mean 80.1
Standard deviation 0.22
Values 80 80
[46]
HuH.7 HSD17B4
Mean 64.3
Standard deviation 5.5
Values 68 58 67
[47]
SNU475 HSD17B4
Mean 39.5
Standard deviation 6.9
Values 44 35
[48]
THLE HSD17B4
Mean 70.3
Standard deviation 2.4
Values 69 72
[49]
liver HSD17B4
Mean 208
Standard deviation 20
Values 1.9e+02 2.2e+02 2.3e+02 1.9e+02
[50]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 0.8 1.2 6 1.4e+02 2.7e+02
[51]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 4.7 3.8
[52]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 9.7 8.2
[53]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 2.3 2.7 3.5
[54]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.83 0.89
[55]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[56]
liver SLC27A5
Mean 184
Standard deviation 60
Values 2.2e+02 1.1e+02 2.5e+02 1.6e+02
[57]
ref_hepatocyte SLC27A2
Mean 66.6
Standard deviation 61
Values 7.2 40 22 1.4e+02 1.2e+02
[58]
HepG2 SLC27A2
Mean 12.7
Standard deviation 1.5
Values 12 14
[59]
HepG2.C3A SLC27A2
Mean 12.6
Standard deviation 2.5
Values 14 11
[60]
HuH.7 SLC27A2
Mean 10.1
Standard deviation 2.6
Values 8.2 13 9.1
[61]
SNU475 SLC27A2
Mean 7.28
Standard deviation 1.4
Values 8.2 6.3
[62]
THLE SLC27A2
Mean 0.539
Standard deviation 0.043
Values 0.51 0.57
[63]
liver SLC27A2
Mean 212
Standard deviation 71
Values 1.1e+02 2.6e+02 2.6e+02 2.2e+02
[64]
ref_hepatocyte BAAT
Mean 50.1
Standard deviation 39
Values 1.6 59 17 89 84
[65]
HepG2 BAAT
Mean 2.42
Standard deviation 0.81
Values 1.9 3
[66]
HepG2.C3A BAAT
Mean 3.29
Standard deviation 0.29
Values 3.5 3.1
[67]
HuH.7 BAAT
Mean 0.621
Standard deviation 0.84
Values 0.098 1.6 0.18
[68]
SNU475 BAAT
Mean 0.302
Standard deviation 0.27
Values 0.49 0.11
[69]
THLE BAAT
Mean 0.136
Standard deviation 0.042
Values 0.17 0.11
[70]
liver BAAT
Mean 239
Standard deviation 1.3e+02
Values 4.1e+02 1.7e+02 2.7e+02 1.1e+02
[71]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[72]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[73]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[74]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[75]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[76]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[77]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[78]
ref_hepatocyte HSD3B7
Mean 30.9
Standard deviation 9.6
Values 18 42 26 31 38
[79]
HepG2 HSD3B7
Mean 29.1
Standard deviation 6.4
Values 25 34
[80]
HepG2.C3A HSD3B7
Mean 46.7
Standard deviation 4.6
Values 43 50
[81]
HuH.7 HSD3B7
Mean 5.15
Standard deviation 1.4
Values 4.5 6.7 4.2
[82]
SNU475 HSD3B7
Mean 5.15
Standard deviation 1.7
Values 6.4 3.9
[83]
THLE HSD3B7
Mean 4.37
Standard deviation 0.17
Values 4.2 4.5
[84]
liver HSD3B7
Mean 55.4
Standard deviation 32
Values 95 26 66 35
[85]
ref_hepatocyte AKR1D1
Mean 25.3
Standard deviation 42
Values 4.5 0.35 0.37 23 99
[86]
HepG2 AKR1D1
Mean 6.61
Standard deviation 3
Values 4.5 8.7
[87]
HepG2.C3A AKR1D1
Mean 15.2
Standard deviation 0.35
Values 15 15
[88]
HuH.7 AKR1D1
Mean 2.24
Standard deviation 3.1
Values 0.38 5.8 0.5
[89]
SNU475 AKR1D1
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[90]
THLE AKR1D1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[91]
liver AKR1D1
Mean 29.7
Standard deviation 5.8
Values 23 35 26 34
[92]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 15 9.3 3.8 43 33
[93]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 11 20
[94]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 19 21
[95]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 62 82 58
[96]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.12 0.17
[97]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[98]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 59 37 35 39
[99]
ref_hepatocyte ACOX2
Mean 19.6
Standard deviation 24
Values 4.4 1.3 1.6 39 52
[100]
HepG2 ACOX2
Mean 8.11
Standard deviation 2.8
Values 6.1 10
[101]
HepG2.C3A ACOX2
Mean 18
Standard deviation 1.3
Values 17 19
[102]
HuH.7 ACOX2
Mean 14.5
Standard deviation 1.3
Values 13 15 15
[103]
SNU475 ACOX2
Mean 0.154
Standard deviation 0.11
Values 0.074 0.23
[104]
THLE ACOX2
Mean 0.86
Standard deviation 0.15
Values 0.96 0.76
[105]
liver ACOX2
Mean 60.6
Standard deviation 24
Values 91 37 69 45
[106]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[107]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[108]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[109]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[110]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[111]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[112]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[113]
ref_hepatocyte AMACR
Mean 11.6
Standard deviation 11
Values 5.6 4.7 2.4 17 28
[114]
HepG2 AMACR
Mean 1.76
Standard deviation 1
Values 1 2.5
[115]
HepG2.C3A AMACR
Mean 1.58
Standard deviation 0.45
Values 1.3 1.9
[116]
HuH.7 AMACR
Mean 4.17
Standard deviation 1.7
Values 3.7 6.1 2.7
[117]
SNU475 AMACR
Mean 0.891
Standard deviation 0.32
Values 1.1 0.66
[118]
THLE AMACR
Mean 0.744
Standard deviation 0.26
Values 0.56 0.93
[119]
liver AMACR
Mean 4.64
Standard deviation 1.1
Values 5.7 3.1 5.1 4.7
[120]
ref_hepatocyte ACOT8
Mean 9.09
Standard deviation 5.1
Values 7.6 4.2 4.6 14 15
[121]
HepG2 ACOT8
Mean 10.5
Standard deviation 0.047
Values 10 10
[122]
HepG2.C3A ACOT8
Mean 12.9
Standard deviation 0.35
Values 13 13
[123]
HuH.7 ACOT8
Mean 12.8
Standard deviation 3.6
Values 14 8.8 16
[124]
SNU475 ACOT8
Mean 8.62
Standard deviation 1.7
Values 9.8 7.4
[125]
THLE ACOT8
Mean 6.83
Standard deviation 0.25
Values 6.7 7
[126]
liver ACOT8
Mean 7.1
Standard deviation 3.2
Values 9.8 5.3 9.8 3.5
[127]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 9.8 0 0 0.69 9.7
[128]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.11 0.77
[129]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.058 0.097
[130]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[131]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[132]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[133]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 1.1 0.94 0.82 0.079
[134]
ref_hepatocyte NCOA1
Mean 2.09
Standard deviation 0.73
Values 1.8 2 1.1 2.8 2.8
[135]
HepG2 NCOA1
Mean 6.38
Standard deviation 1.4
Values 5.4 7.4
[136]
HepG2.C3A NCOA1
Mean 8.42
Standard deviation 0.79
Values 7.9 9
[137]
HuH.7 NCOA1
Mean 9.25
Standard deviation 2.7
Values 9.2 12 6.6
[138]
SNU475 NCOA1
Mean 13.3
Standard deviation 1
Values 14 13
[139]
THLE NCOA1
Mean 10.2
Standard deviation 0.47
Values 9.9 11
[140]
liver NCOA1
Mean 18.7
Standard deviation 4.8
Values 17 23 13 22
[141]
ref_hepatocyte ABCB11
Mean 1.97
Standard deviation 1.6
Values 0 1 1.8 3 4.1
[142]
HepG2 ABCB11
Mean 0.0394
Standard deviation 0.025
Values 0.057 0.021
[143]
HepG2.C3A ABCB11
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 ABCB11
Mean 0.0829
Standard deviation 0.04
Values 0.11 0.096 0.037
[145]
SNU475 ABCB11
Mean 0.0787
Standard deviation 0.039
Values 0.051 0.11
[146]
THLE ABCB11
Mean 0
Standard deviation 0
Values 0 0
[147]
liver ABCB11
Mean 77.6
Standard deviation 77
Values 17 1.9e+02 36 71
[148]
ref_hepatocyte CYP7B1
Mean 1.44
Standard deviation 1
Values 0 2.2 1.1 1.2 2.7
[149]
HepG2 CYP7B1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[150]
HepG2.C3A CYP7B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[151]
HuH.7 CYP7B1
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 CYP7B1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[153]
THLE CYP7B1
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[154]
liver CYP7B1
Mean 9.87
Standard deviation 5.4
Values 6.3 17 4.8 12
[155]
ref_hepatocyte NCOA2
Mean 1.14
Standard deviation 0.47
Values 1.5 1.7 1.2 0.47 0.91
[156]
HepG2 NCOA2
Mean 7.51
Standard deviation 4.4
Values 4.4 11
[157]
HepG2.C3A NCOA2
Mean 11.8
Standard deviation 4.3
Values 8.7 15
[158]
HuH.7 NCOA2
Mean 40.1
Standard deviation 18
Values 55 45 21
[159]
SNU475 NCOA2
Mean 19.2
Standard deviation 3.8
Values 22 17
[160]
THLE NCOA2
Mean 6.6
Standard deviation 1.4
Values 5.6 7.6
[161]
liver NCOA2
Mean 39.3
Standard deviation 20
Values 25 56 20 57
[162]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[163]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[164]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[165]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[166]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[167]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[168]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1