REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKR1C1 Aldo-keto reductase family 1 member C1 [1] -0.46[2] -0.68[3] -2.77[4] -1.31[5] -2.81[6] -3.04[7]
2 AKR1C3 Aldo-keto reductase family 1 member C3 [8] 0.02[9] 0.75[10] -4.28[11] 1.93[12] -1.85[13] -0.99[14]
3 AKR1C2 Aldo-keto reductase family 1 member C2 [15] 1.40[16] -0.54[17] -1.55[18] 1.03[19] -1.62[20] 0.03[21]
4 CYP27A1 Sterol 26-hydroxylase, mitochondrial [22] 0.21[23] 1.10[24] -0.37[25] -3.01[26] -1.27[27] 1.28[28]
5 AKR1C4 Aldo-keto reductase family 1 member C4 [29] -6.77[30] -4.31[31] -3.28[32] -9.13[33] -11.31[34] 0.32[35]
6 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [36] -5.93[37] -3.28[38] -5.59[39] -8.43[40] -6.97[41] 3.65[42]
7 HSD3B7 3 beta-hydroxysteroid dehydrogenase type 7 [43] 1.06[44] 2.02[45] 0.51[46] -1.92[47] 0.98[48] 1.53[49]
8 AKR1D1 3-oxo-5-beta-steroid 4-dehydrogenase [50] -0.79[51] 0.69[52] -0.40[53] -8.57[54] -5.50[55] 0.92[56]
9 NR1H4 Bile acid receptor [57] 0.70[58] 1.39[59] 4.79[60] -6.51[61] -3.24[62] 1.72[63]
10 RXRA Retinoic acid receptor RXR-alpha [64] 2.24[65] 2.15[66] 4.60[67] 1.56[68] 4.52[69] 3.35[70]
11 CYP7A1 Cholesterol 7-alpha-monooxygenase [71] -2.05[72] -4.28[73] -6.20[74] -8.42[75] [76] -1.76[77]
12 NCOA1 Nuclear receptor coactivator 1 [78] 2.76[79] 3.43[80] 5.24[81] 3.34[82] 6.08[83] 3.85[84]
13 CYP7B1 25-hydroxycholesterol 7-alpha-hydroxylase [85] -5.74[86] -4.35[87] [88] -7.48[89] -0.46[90] 3.47[91]
14 NCOA2 Nuclear receptor coactivator 2 [92] 3.87[93] 4.79[94] 8.23[95] 4.74[96] 6.33[97] 5.80[98]
15 PTGIS Prostacyclin synthase [99] 0.73[100] 1.96[101] 7.55[102] 2.66[103] 11.90[104] 6.04[105]
[1]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 1.4e+03 1.3e+03 9.2e+02 1e+03 3.2e+02
[2]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 5.1e+02 1.5e+02
[3]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 2.8e+02 1.9e+02
[4]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 7.8 35 8.5
[5]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 2e+02 3.1e+02
[6]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[7]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 63 67 1.5e+02 21
[8]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 1.1e+02 4.3e+02 1.2e+02
[9]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[10]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[11]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[12]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[13]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[14]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 51 67 1.5e+02 32
[15]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.2e+02 3.4e+02 1.1e+02 2.3e+02 40
[16]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 2.9e+02 1e+02
[17]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 48 38
[18]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 3 15 2.5
[19]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 2.4e+02 1.9e+02
[20]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[21]
liver AKR1C2
Mean 106
Standard deviation 92
Values 64 1.1e+02 2.3e+02 19
[22]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 18 2.1e+02 3.7e+02
[23]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[24]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[25]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[26]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[27]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[28]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 3.3e+02 1.2e+02 2.5e+02 1.1e+02
[29]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 1.7 2.3e+02 2.8e+02
[30]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[31]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[32]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[33]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[34]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[35]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 56 66 1.7e+02 30
[36]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[37]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[38]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[39]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[40]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[41]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[42]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[43]
ref_hepatocyte HSD3B7
Mean 30.9
Standard deviation 9.6
Values 18 42 26 31 38
[44]
HepG2 HSD3B7
Mean 29.1
Standard deviation 6.4
Values 25 34
[45]
HepG2.C3A HSD3B7
Mean 46.7
Standard deviation 4.6
Values 43 50
[46]
HuH.7 HSD3B7
Mean 5.15
Standard deviation 1.4
Values 4.5 6.7 4.2
[47]
SNU475 HSD3B7
Mean 5.15
Standard deviation 1.7
Values 6.4 3.9
[48]
THLE HSD3B7
Mean 4.37
Standard deviation 0.17
Values 4.2 4.5
[49]
liver HSD3B7
Mean 55.4
Standard deviation 32
Values 95 26 66 35
[50]
ref_hepatocyte AKR1D1
Mean 25.3
Standard deviation 42
Values 4.5 0.35 0.37 23 99
[51]
HepG2 AKR1D1
Mean 6.61
Standard deviation 3
Values 4.5 8.7
[52]
HepG2.C3A AKR1D1
Mean 15.2
Standard deviation 0.35
Values 15 15
[53]
HuH.7 AKR1D1
Mean 2.24
Standard deviation 3.1
Values 0.38 5.8 0.5
[54]
SNU475 AKR1D1
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[55]
THLE AKR1D1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[56]
liver AKR1D1
Mean 29.7
Standard deviation 5.8
Values 23 35 26 34
[57]
ref_hepatocyte NR1H4
Mean 20.8
Standard deviation 17
Values 15 9.3 3.8 43 33
[58]
HepG2 NR1H4
Mean 15.2
Standard deviation 6.4
Values 11 20
[59]
HepG2.C3A NR1H4
Mean 20.3
Standard deviation 1.1
Values 19 21
[60]
HuH.7 NR1H4
Mean 67.4
Standard deviation 13
Values 62 82 58
[61]
SNU475 NR1H4
Mean 0.144
Standard deviation 0.04
Values 0.12 0.17
[62]
THLE NR1H4
Mean 0.158
Standard deviation 0.028
Values 0.18 0.14
[63]
liver NR1H4
Mean 42.4
Standard deviation 11
Values 59 37 35 39
[64]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 15 7.5 9.4 22 18
[65]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 33 29
[66]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 28 20
[67]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 42 51 30
[68]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 33 21
[69]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[70]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.3e+02 72 49 1.2e+02
[71]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 9.8 0 0 0.69 9.7
[72]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.11 0.77
[73]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.058 0.097
[74]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[75]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[76]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[77]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 1.1 0.94 0.82 0.079
[78]
ref_hepatocyte NCOA1
Mean 2.09
Standard deviation 0.73
Values 1.8 2 1.1 2.8 2.8
[79]
HepG2 NCOA1
Mean 6.38
Standard deviation 1.4
Values 5.4 7.4
[80]
HepG2.C3A NCOA1
Mean 8.42
Standard deviation 0.79
Values 7.9 9
[81]
HuH.7 NCOA1
Mean 9.25
Standard deviation 2.7
Values 9.2 12 6.6
[82]
SNU475 NCOA1
Mean 13.3
Standard deviation 1
Values 14 13
[83]
THLE NCOA1
Mean 10.2
Standard deviation 0.47
Values 9.9 11
[84]
liver NCOA1
Mean 18.7
Standard deviation 4.8
Values 17 23 13 22
[85]
ref_hepatocyte CYP7B1
Mean 1.44
Standard deviation 1
Values 0 2.2 1.1 1.2 2.7
[86]
HepG2 CYP7B1
Mean 0.0122
Standard deviation 0.001
Values 0.011 0.013
[87]
HepG2.C3A CYP7B1
Mean 0.0263
Standard deviation 0.023
Values 0.0097 0.043
[88]
HuH.7 CYP7B1
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 CYP7B1
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[90]
THLE CYP7B1
Mean 0.0751
Standard deviation 0.014
Values 0.065 0.085
[91]
liver CYP7B1
Mean 9.87
Standard deviation 5.4
Values 6.3 17 4.8 12
[92]
ref_hepatocyte NCOA2
Mean 1.14
Standard deviation 0.47
Values 1.5 1.7 1.2 0.47 0.91
[93]
HepG2 NCOA2
Mean 7.51
Standard deviation 4.4
Values 4.4 11
[94]
HepG2.C3A NCOA2
Mean 11.8
Standard deviation 4.3
Values 8.7 15
[95]
HuH.7 NCOA2
Mean 40.1
Standard deviation 18
Values 55 45 21
[96]
SNU475 NCOA2
Mean 19.2
Standard deviation 3.8
Values 22 17
[97]
THLE NCOA2
Mean 6.6
Standard deviation 1.4
Values 5.6 7.6
[98]
liver NCOA2
Mean 39.3
Standard deviation 20
Values 25 56 20 57
[99]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[100]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[101]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[102]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[103]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[104]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[105]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1