REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKR1C1 Aldo-keto reductase family 1 member C1 [1] -0.29[2] -0.49[3] -1.23[4] -1.15[5] -2.21[6] -3.19[7]
2 AKR1C3 Aldo-keto reductase family 1 member C3 [8] 0.20[9] 0.94[10] -2.74[11] 2.09[12] -1.25[13] -1.15[14]
3 AKR1C2 Aldo-keto reductase family 1 member C2 [15] 1.58[16] -0.35[17] -0.01[18] 1.20[19] -1.02[20] -0.12[21]
4 CYP27A1 Sterol 26-hydroxylase, mitochondrial [22] 0.38[23] 1.29[24] 1.17[25] -2.85[26] -0.68[27] 1.13[28]
5 AKR1C4 Aldo-keto reductase family 1 member C4 [29] -6.60[30] -4.12[31] -1.74[32] -8.96[33] -10.71[34] 0.16[35]
6 SLC27A5 Bile acyl-CoA synthetase [36] -2.98[37] -1.61[38] -0.24[39] -5.78[40] -4.55[41] 1.67[42]
7 SLC27A2 Very long-chain acyl-CoA synthetase [43] -1.07[44] -0.79[45] 1.92[46] -2.37[47] -2.55[48] 2.20[49]
8 CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [50] -5.75[51] -3.09[52] -4.05[53] -8.27[54] -6.37[55] 3.49[56]
9 HSD3B7 3 beta-hydroxysteroid dehydrogenase type 7 [57] 1.23[58] 2.21[59] 2.05[60] -1.76[61] 1.57[62] 1.38[63]
10 AKR1D1 3-oxo-5-beta-steroid 4-dehydrogenase [64] -0.62[65] 0.87[66] 1.14[67] -8.41[68] -4.90[69] 0.77[70]
11 AMACR Alpha-methylacyl-CoA racemase [71] -1.39[72] -1.26[73] 3.16[74] -2.87[75] 0.44[76] -0.78[77]
12 CYP39A1 24-hydroxycholesterol 7-alpha-hydroxylase [78] -2.60[79] -2.66[80] 4.95[81] -3.23[82] 2.46[83] 1.52[84]
13 PTGIS Prostacyclin synthase [85] 0.91[86] 2.15[87] 9.09[88] 2.82[89] 12.50[90] 5.88[91]
14 CYP46A1 Cholesterol 24-hydroxylase [92] -1.32[93] 0.14[94] 2.08[95] -0.85[96] 4.08[97] 3.30[98]
[1]
ref_hepatocyte AKR1C1
Mean 1e+03
Standard deviation 4.3e+02
Values 1.4e+03 1.3e+03 9.2e+02 1e+03 3.2e+02
[2]
HepG2 AKR1C1
Mean 329
Standard deviation 2.6e+02
Values 5.1e+02 1.5e+02
[3]
HepG2.C3A AKR1C1
Mean 233
Standard deviation 65
Values 2.8e+02 1.9e+02
[4]
HuH.7 AKR1C1
Mean 17.1
Standard deviation 16
Values 7.8 35 8.5
[5]
SNU475 AKR1C1
Mean 254
Standard deviation 82
Values 2e+02 3.1e+02
[6]
THLE AKR1C1
Mean 10.3
Standard deviation 0.06
Values 10 10
[7]
liver AKR1C1
Mean 75.6
Standard deviation 54
Values 63 67 1.5e+02 21
[8]
ref_hepatocyte AKR1C3
Mean 242
Standard deviation 1.8e+02
Values 99 4.4e+02 1.1e+02 4.3e+02 1.2e+02
[9]
HepG2 AKR1C3
Mean 111
Standard deviation 53
Values 1.5e+02 74
[10]
HepG2.C3A AKR1C3
Mean 152
Standard deviation 34
Values 1.8e+02 1.3e+02
[11]
HuH.7 AKR1C3
Mean 1.46
Standard deviation 0.83
Values 1.1 2.4 0.84
[12]
SNU475 AKR1C3
Mean 580
Standard deviation 2.8e+02
Values 7.8e+02 3.9e+02
[13]
THLE AKR1C3
Mean 4.84
Standard deviation 0.00088
Values 4.8 4.8
[14]
liver AKR1C3
Mean 75.4
Standard deviation 53
Values 51 67 1.5e+02 32
[15]
ref_hepatocyte AKR1C2
Mean 167
Standard deviation 1.2e+02
Values 1.2e+02 3.4e+02 1.1e+02 2.3e+02 40
[16]
HepG2 AKR1C2
Mean 199
Standard deviation 1.3e+02
Values 2.9e+02 1e+02
[17]
HepG2.C3A AKR1C2
Mean 42.9
Standard deviation 7.5
Values 48 38
[18]
HuH.7 AKR1C2
Mean 6.67
Standard deviation 6.9
Values 3 15 2.5
[19]
SNU475 AKR1C2
Mean 215
Standard deviation 34
Values 2.4e+02 1.9e+02
[20]
THLE AKR1C2
Mean 3.9
Standard deviation 0.29
Values 4.1 3.7
[21]
liver AKR1C2
Mean 106
Standard deviation 92
Values 64 1.1e+02 2.3e+02 19
[22]
ref_hepatocyte CYP27A1
Mean 135
Standard deviation 1.6e+02
Values 62 8 18 2.1e+02 3.7e+02
[23]
HepG2 CYP27A1
Mean 70.5
Standard deviation 16
Values 59 82
[24]
HepG2.C3A CYP27A1
Mean 108
Standard deviation 25
Values 1.3e+02 90
[25]
HuH.7 CYP27A1
Mean 12.2
Standard deviation 7.3
Values 7.2 21 8.9
[26]
SNU475 CYP27A1
Mean 10.5
Standard deviation 1.6
Values 12 9.4
[27]
THLE CYP27A1
Mean 4.01
Standard deviation 0.91
Values 4.7 3.4
[28]
liver CYP27A1
Mean 204
Standard deviation 1e+02
Values 3.3e+02 1.2e+02 2.5e+02 1.1e+02
[29]
ref_hepatocyte AKR1C4
Mean 105
Standard deviation 1.4e+02
Values 0 3.6 1.7 2.3e+02 2.8e+02
[30]
HepG2 AKR1C4
Mean 0.432
Standard deviation 0.36
Values 0.69 0.18
[31]
HepG2.C3A AKR1C4
Mean 1.97
Standard deviation 0.48
Values 1.6 2.3
[32]
HuH.7 AKR1C4
Mean 1.26
Standard deviation 0.56
Values 0.75 1.9 1.2
[33]
SNU475 AKR1C4
Mean 0.118
Standard deviation 0.055
Values 0.079 0.16
[34]
THLE AKR1C4
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[35]
liver AKR1C4
Mean 80.8
Standard deviation 62
Values 56 66 1.7e+02 30
[36]
ref_hepatocyte SLC27A5
Mean 83.6
Standard deviation 1.2e+02
Values 0.8 1.2 6 1.4e+02 2.7e+02
[37]
HepG2 SLC27A5
Mean 4.25
Standard deviation 0.62
Values 4.7 3.8
[38]
HepG2.C3A SLC27A5
Mean 8.96
Standard deviation 1.1
Values 9.7 8.2
[39]
HuH.7 SLC27A5
Mean 2.84
Standard deviation 0.59
Values 2.3 2.7 3.5
[40]
SNU475 SLC27A5
Mean 0.856
Standard deviation 0.043
Values 0.83 0.89
[41]
THLE SLC27A5
Mean 0.169
Standard deviation 0.036
Values 0.2 0.14
[42]
liver SLC27A5
Mean 184
Standard deviation 60
Values 2.2e+02 1.1e+02 2.5e+02 1.6e+02
[43]
ref_hepatocyte SLC27A2
Mean 66.6
Standard deviation 61
Values 7.2 40 22 1.4e+02 1.2e+02
[44]
HepG2 SLC27A2
Mean 12.7
Standard deviation 1.5
Values 12 14
[45]
HepG2.C3A SLC27A2
Mean 12.6
Standard deviation 2.5
Values 14 11
[46]
HuH.7 SLC27A2
Mean 10.1
Standard deviation 2.6
Values 8.2 13 9.1
[47]
SNU475 SLC27A2
Mean 7.28
Standard deviation 1.4
Values 8.2 6.3
[48]
THLE SLC27A2
Mean 0.539
Standard deviation 0.043
Values 0.51 0.57
[49]
liver SLC27A2
Mean 212
Standard deviation 71
Values 1.1e+02 2.6e+02 2.6e+02 2.2e+02
[50]
ref_hepatocyte CYP8B1
Mean 34.6
Standard deviation 44
Values 1.2 0.33 6.4 79 86
[51]
HepG2 CYP8B1
Mean 0.257
Standard deviation 0.2
Values 0.11 0.4
[52]
HepG2.C3A CYP8B1
Mean 1.33
Standard deviation 0.5
Values 1.7 0.98
[53]
HuH.7 CYP8B1
Mean 0.084
Standard deviation 0.016
Values 0.09 0.096 0.066
[54]
SNU475 CYP8B1
Mean 0.0631
Standard deviation 0.004
Values 0.06 0.066
[55]
THLE CYP8B1
Mean 0.0198
Standard deviation 0.0054
Values 0.024 0.016
[56]
liver CYP8B1
Mean 269
Standard deviation 1.3e+02
Values 4.2e+02 1.3e+02 3e+02 2.2e+02
[57]
ref_hepatocyte HSD3B7
Mean 30.9
Standard deviation 9.6
Values 18 42 26 31 38
[58]
HepG2 HSD3B7
Mean 29.1
Standard deviation 6.4
Values 25 34
[59]
HepG2.C3A HSD3B7
Mean 46.7
Standard deviation 4.6
Values 43 50
[60]
HuH.7 HSD3B7
Mean 5.15
Standard deviation 1.4
Values 4.5 6.7 4.2
[61]
SNU475 HSD3B7
Mean 5.15
Standard deviation 1.7
Values 6.4 3.9
[62]
THLE HSD3B7
Mean 4.37
Standard deviation 0.17
Values 4.2 4.5
[63]
liver HSD3B7
Mean 55.4
Standard deviation 32
Values 95 26 66 35
[64]
ref_hepatocyte AKR1D1
Mean 25.3
Standard deviation 42
Values 4.5 0.35 0.37 23 99
[65]
HepG2 AKR1D1
Mean 6.61
Standard deviation 3
Values 4.5 8.7
[66]
HepG2.C3A AKR1D1
Mean 15.2
Standard deviation 0.35
Values 15 15
[67]
HuH.7 AKR1D1
Mean 2.24
Standard deviation 3.1
Values 0.38 5.8 0.5
[68]
SNU475 AKR1D1
Mean 0.042
Standard deviation 0.027
Values 0.023 0.061
[69]
THLE AKR1D1
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[70]
liver AKR1D1
Mean 29.7
Standard deviation 5.8
Values 23 35 26 34
[71]
ref_hepatocyte AMACR
Mean 11.6
Standard deviation 11
Values 5.6 4.7 2.4 17 28
[72]
HepG2 AMACR
Mean 1.76
Standard deviation 1
Values 1 2.5
[73]
HepG2.C3A AMACR
Mean 1.58
Standard deviation 0.45
Values 1.3 1.9
[74]
HuH.7 AMACR
Mean 4.17
Standard deviation 1.7
Values 3.7 6.1 2.7
[75]
SNU475 AMACR
Mean 0.891
Standard deviation 0.32
Values 1.1 0.66
[76]
THLE AMACR
Mean 0.744
Standard deviation 0.26
Values 0.56 0.93
[77]
liver AMACR
Mean 4.64
Standard deviation 1.1
Values 5.7 3.1 5.1 4.7
[78]
ref_hepatocyte CYP39A1
Mean 7.02
Standard deviation 11
Values 0.052 1.3 0.69 8.1 25
[79]
HepG2 CYP39A1
Mean 0.464
Standard deviation 0.049
Values 0.5 0.43
[80]
HepG2.C3A CYP39A1
Mean 0.363
Standard deviation 0.032
Values 0.34 0.39
[81]
HuH.7 CYP39A1
Mean 8.71
Standard deviation 0.36
Values 8.7 9.1 8.4
[82]
SNU475 CYP39A1
Mean 0.422
Standard deviation 0.11
Values 0.35 0.5
[83]
THLE CYP39A1
Mean 1.83
Standard deviation 0.14
Values 1.9 1.7
[84]
liver CYP39A1
Mean 13.9
Standard deviation 9.4
Values 28 8.3 13 7.1
[85]
ref_hepatocyte PTGIS
Mean 0.218
Standard deviation 0.14
Values 0.14 0.08 0.32 0.4 0.15
[86]
HepG2 PTGIS
Mean 0.163
Standard deviation 0.012
Values 0.17 0.15
[87]
HepG2.C3A PTGIS
Mean 0.316
Standard deviation 0.0069
Values 0.32 0.31
[88]
HuH.7 PTGIS
Mean 4.77
Standard deviation 0.64
Values 5.5 4.3 4.5
[89]
SNU475 PTGIS
Mean 0.868
Standard deviation 0.11
Values 0.79 0.94
[90]
THLE PTGIS
Mean 59.9
Standard deviation 32
Values 37 82
[91]
liver PTGIS
Mean 8.86
Standard deviation 2.8
Values 5.9 11 12 7.1
[92]
ref_hepatocyte CYP46A1
Mean 0.0447
Standard deviation 0.068
Values 0 0 0 0.069 0.15
[93]
HepG2 CYP46A1
Mean 0.00716
Standard deviation 0.002
Values 0.0057 0.0086
[94]
HepG2.C3A CYP46A1
Mean 0.0161
Standard deviation 0.023
Values 0 0.032
[95]
HuH.7 CYP46A1
Mean 0.00761
Standard deviation 0.0083
Values 0.016 0.0064 0
[96]
SNU475 CYP46A1
Mean 0.0139
Standard deviation 0.02
Values 0.028 0
[97]
THLE CYP46A1
Mean 0.0358
Standard deviation 0.017
Values 0.024 0.048
[98]
liver CYP46A1
Mean 0.303
Standard deviation 0.093
Values 0.38 0.17 0.36 0.3