REACTOME_SWITCHING_OF_ORIGINS_TO_A_POST_REPLICATIVE_STATE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.28[2] | -1.42[3] | -1.38[4] | -1.58[5] | -1.33[6] | -0.53[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.84[16] | -0.67[17] | -1.01[18] | -0.73[19] | -0.95[20] | -0.08[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.61[23] | -2.26[24] | -1.98[25] | -1.45[26] | -2.18[27] | -1.03[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.43[30] | -1.88[31] | -2.07[32] | -1.23[33] | -1.71[34] | -0.66[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.53[37] | 0.59[38] | -0.82[39] | 0.40[40] | -0.24[41] | 0.37[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.08[44] | 0.14[45] | -1.02[46] | -0.85[47] | -0.28[48] | 0.20[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.41[51] | -1.24[52] | -0.29[53] | -0.87[54] | -1.18[55] | -0.09[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | -0.16[58] | -0.04[59] | 0.00[60] | 0.56[61] | 0.36[62] | -0.42[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -1.11[65] | -1.14[66] | -1.09[67] | -1.22[68] | -0.97[69] | -0.86[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.29[72] | -0.18[73] | -0.34[74] | -0.49[75] | -0.40[76] | -0.39[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.42[79] | 0.10[80] | -0.06[81] | 0.04[82] | -0.14[83] | -0.30[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.51[86] | 0.11[87] | -0.18[88] | 0.34[89] | -0.02[90] | -0.38[91] |
14 | SKP1 | S-phase kinase-associated protein 1 | [92] | -0.06[93] | 0.39[94] | -0.59[95] | 0.70[96] | 0.71[97] | 0.65[98] |
15 | PSMC3 | 26S proteasome regulatory subunit 6A | [99] | -0.54[100] | -0.65[101] | -0.12[102] | -0.86[103] | -0.85[104] | 0.09[105] |
16 | PSMA3 | Proteasome subunit alpha type-3 | [106] | -1.13[107] | -0.17[108] | -0.93[109] | -0.12[110] | -0.75[111] | -0.14[112] |
17 | PSMB6 | Proteasome subunit beta type-6 | [113] | -0.58[114] | -0.47[115] | -0.41[116] | -0.66[117] | -1.12[118] | 0.02[119] |
18 | PSMA2 | Proteasome subunit alpha type-2 | [120] | -0.66[121] | 0.25[122] | 0.50[123] | -0.17[124] | 0.02[125] | 0.25[126] |
19 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [127] | -0.15[128] | -0.17[129] | -0.06[130] | 0.54[131] | -0.18[132] | -0.08[133] |
20 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [134] | -0.23[135] | 0.10[136] | -0.12[137] | -0.55[138] | -0.26[139] | -0.25[140] |
21 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [141] | -0.06[142] | 0.14[143] | 0.19[144] | -0.27[145] | 0.30[146] | -0.23[147] |
22 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [148] | 1.47[149] | 0.61[150] | 0.60[151] | 0.84[152] | 1.95[153] | 0.81[154] |
23 | PSMC1 | 26S proteasome regulatory subunit 4 | [155] | -0.21[156] | -0.18[157] | -0.92[158] | 1.02[159] | 0.36[160] | -0.03[161] |
24 | PSMA1 | Proteasome subunit alpha type-1 | [162] | -0.03[163] | 0.33[164] | 0.30[165] | 0.59[166] | -0.09[167] | 0.46[168] |
25 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [169] | 1.60[170] | 1.57[171] | 2.50[172] | 0.67[173] | 1.28[174] | 0.69[175] |
26 | PSMC5 | 26S proteasome regulatory subunit 8 | [176] | 0.29[177] | 0.15[178] | 0.14[179] | 0.00[180] | 0.23[181] | 0.22[182] |
27 | ANAPC11 | Anaphase-promoting complex subunit 11 | [183] | -0.92[184] | -0.41[185] | -0.94[186] | -1.12[187] | -0.95[188] | -0.05[189] |
28 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [190] | -1.14[191] | -0.65[192] | -0.87[193] | -1.50[194] | -1.29[195] | -0.76[196] |
29 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [197] | 0.69[198] | 0.14[199] | 0.65[200] | 0.54[201] | 0.57[202] | -0.06[203] |
30 | PSMB8 | Proteasome subunit beta type-8 | [204] | -1.71[205] | -2.34[206] | -9.64[207] | 0.51[208] | -0.98[209] | -0.75[210] |
31 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [211] | -0.13[212] | 0.44[213] | 0.60[214] | 0.40[215] | 0.25[216] | -0.20[217] |
32 | PSMC4 | 26S proteasome regulatory subunit 6B | [218] | 0.29[219] | 0.29[220] | 0.13[221] | 0.03[222] | -0.04[223] | 0.27[224] |
33 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [225] | -0.86[226] | -0.42[227] | -1.59[228] | -0.60[229] | 0.03[230] | -0.32[231] |
34 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [232] | 0.34[233] | 0.41[234] | 0.82[235] | 0.46[236] | -0.21[237] | -0.13[238] |
35 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [239] | -0.48[240] | -0.44[241] | -0.84[242] | 0.08[243] | -0.04[244] | -0.21[245] |
36 | PSMC6 | 26S proteasome regulatory subunit 10B | [246] | -0.19[247] | 1.35[248] | 0.08[249] | 0.44[250] | 0.19[251] | 0.45[252] |
37 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [253] | 0.70[254] | 0.27[255] | 0.78[256] | 0.85[257] | 0.82[258] | 1.27[259] |
38 | PSMC2 | 26S proteasome regulatory subunit 7 | [260] | 0.45[261] | 0.81[262] | 0.50[263] | 1.24[264] | 0.88[265] | 1.32[266] |
39 | CDC26 | Anaphase-promoting complex subunit CDC26 | [267] | -1.86[268] | -1.32[269] | -1.46[270] | -1.83[271] | -1.14[272] | -0.86[273] |
40 | PSME3 | Proteasome activator complex subunit 3 | [274] | 1.68[275] | 1.36[276] | 0.95[277] | 1.27[278] | 1.35[279] | 0.89[280] |
41 | UBE2E1 | Ubiquitin-conjugating enzyme E2 E1 | [281] | -0.04[282] | 0.26[283] | 0.87[284] | 0.72[285] | 0.77[286] | -1.47[287] |
42 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [288] | 1.44[289] | 1.72[290] | 1.51[291] | 2.07[292] | 1.90[293] | 2.08[294] |
43 | PSMB10 | Proteasome subunit beta type-10 | [295] | -1.29[296] | -0.73[297] | -2.70[298] | -0.14[299] | -1.49[300] | -0.07[301] |
44 | PSMA5 | Proteasome subunit alpha type-5 | [302] | 1.77[303] | 2.15[304] | 1.63[305] | 2.12[306] | 1.50[307] | 1.92[308] |
45 | PSMF1 | Proteasome inhibitor PI31 subunit | [309] | 2.15[310] | 2.15[311] | 0.87[312] | 1.13[313] | 0.71[314] | 1.86[315] |
46 | ANAPC16 | Anaphase-promoting complex subunit 16 | [316] | 1.10[317] | 1.88[318] | 0.61[319] | 0.77[320] | 0.80[321] | 1.89[322] |
47 | ANAPC5 | Anaphase-promoting complex subunit 5 | [323] | 1.79[324] | 2.52[325] | 2.57[326] | 1.54[327] | 1.79[328] | 2.05[329] |
48 | PSMB2 | Proteasome subunit beta type-2 | [330] | 1.93[331] | 1.62[332] | 1.92[333] | 2.43[334] | 2.23[335] | 2.40[336] |
49 | PSMB9 | Proteasome subunit beta type-9 | [337] | -2.08[338] | -4.74[339] | -7.13[340] | 1.68[341] | -0.77[342] | -0.49[343] |
50 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [344] | 0.30[345] | 0.75[346] | -0.32[347] | 0.30[348] | 0.56[349] | 0.73[350] |
51 | CUL1 | Cullin-1 | [351] | 0.53[352] | 1.27[353] | 0.72[354] | 1.78[355] | 1.23[356] | 2.09[357] |
52 | CDC27 | Cell division cycle protein 27 homolog | [358] | 1.13[359] | 2.03[360] | 1.27[361] | 2.38[362] | 1.71[363] | 1.49[364] |
53 | MCM7 | DNA replication licensing factor MCM7 | [365] | 2.83[366] | 2.69[367] | 3.81[368] | 2.49[369] | 2.83[370] | 0.54[371] |
54 | MCM3 | DNA replication licensing factor MCM3 | [372] | 3.22[373] | 3.13[374] | 3.14[375] | 2.18[376] | 3.06[377] | 0.66[378] |
55 | CDC16 | Cell division cycle protein 16 homolog | [379] | 0.42[380] | 0.71[381] | -0.05[382] | 0.78[383] | 1.01[384] | 1.21[385] |
56 | CDK2 | Cyclin-dependent kinase 2 | [386] | 0.50[387] | 0.73[388] | 1.00[389] | 1.18[390] | 1.56[391] | -0.84[392] |
57 | UBE2C | Ubiquitin-conjugating enzyme E2 C | [393] | 0.68[394] | 1.13[395] | 1.78[396] | 1.33[397] | 2.01[398] | -2.46[399] |
58 | UBE2S | Ubiquitin-conjugating enzyme E2 S | [400] | 1.36[401] | 1.00[402] | 3.08[403] | 2.16[404] | 3.31[405] | -1.25[406] |
59 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [407] | 0.86[408] | 1.14[409] | 1.08[410] | 1.98[411] | 1.11[412] | 0.72[413] |
60 | MCM4 | DNA replication licensing factor MCM4 | [414] | 2.98[415] | 2.93[416] | 3.54[417] | 3.20[418] | 3.63[419] | 0.36[420] |
61 | MCM5 | DNA replication licensing factor MCM5 | [421] | 2.13[422] | 2.06[423] | 2.59[424] | 1.72[425] | 2.43[426] | 0.43[427] |
62 | PSME4 | Proteasome activator complex subunit 4 | [428] | 2.39[429] | 3.26[430] | 3.17[431] | 2.53[432] | 2.31[433] | 2.98[434] |
63 | ORC4 | Origin recognition complex subunit 4 | [435] | 0.97[436] | 2.22[437] | 1.83[438] | 2.57[439] | 1.61[440] | 4.31[441] |
64 | CDC23 | Cell division cycle protein 23 homolog | [442] | 1.29[443] | 1.56[444] | 1.71[445] | 2.23[446] | 1.73[447] | 1.54[448] |
65 | ORC5 | Origin recognition complex subunit 5 | [449] | -0.06[450] | 0.34[451] | 0.82[452] | 1.05[453] | 0.61[454] | 1.17[455] |
66 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [456] | 1.28[457] | 0.79[458] | 2.27[459] | 2.36[460] | 2.26[461] | 2.16[462] |
67 | FZR1 | Fizzy-related protein homolog | [463] | 1.67[464] | 1.37[465] | 1.35[466] | 1.23[467] | 1.62[468] | 1.97[469] |
68 | ANAPC7 | Anaphase-promoting complex subunit 7 | [470] | 1.92[471] | 2.38[472] | 1.75[473] | 2.10[474] | 2.15[475] | 1.53[476] |
69 | ANAPC2 | Anaphase-promoting complex subunit 2 | [477] | 1.52[478] | 1.02[479] | 1.53[480] | 1.24[481] | 0.99[482] | 1.39[483] |
70 | ORC2 | Origin recognition complex subunit 2 | [484] | 1.38[485] | 2.40[486] | 2.02[487] | 1.51[488] | 1.59[489] | 0.91[490] |
71 | CDC6 | Cell division control protein 6 homolog | [491] | 2.78[492] | 2.41[493] | 2.90[494] | 2.76[495] | 2.83[496] | -0.72[497] |
72 | ORC6 | Origin recognition complex subunit 6 | [498] | 1.67[499] | 2.30[500] | 1.42[501] | 1.99[502] | 2.03[503] | -2.36[504] |
73 | MCM6 | DNA replication licensing factor MCM6 | [505] | 2.12[506] | 1.89[507] | 3.80[508] | 3.62[509] | 4.20[510] | 0.05[511] |
74 | MCM2 | DNA replication licensing factor MCM2 | [512] | 3.84[513] | 3.35[514] | 4.54[515] | 3.33[516] | 4.13[517] | -0.28[518] |
75 | ORC3 | Origin recognition complex subunit 3 | [519] | 1.00[520] | 2.27[521] | 2.30[522] | 1.74[523] | 2.50[524] | 1.60[525] |
76 | ANAPC1 | Anaphase-promoting complex subunit 1 | [526] | 3.33[527] | 3.57[528] | 3.35[529] | 3.12[530] | 2.93[531] | 2.80[532] |
77 | SKP2 | S-phase kinase-associated protein 2 | [533] | 2.23[534] | 2.75[535] | 3.78[536] | 2.46[537] | 2.34[538] | 2.42[539] |
78 | CCNE1 | G1/S-specific cyclin-E1 | [540] | 2.15[541] | 2.33[542] | 0.41[543] | 0.80[544] | 1.18[545] | -3.29[546] |
79 | CCNA2 | Cyclin-A2 | [547] | 3.12[548] | 4.20[549] | 3.43[550] | 3.20[551] | 4.38[552] | 0.11[553] |
80 | ANAPC4 | Anaphase-promoting complex subunit 4 | [554] | 1.11[555] | 2.10[556] | 2.32[557] | 2.39[558] | 1.65[559] | 2.32[560] |
81 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [561] | 1.71[562] | 2.64[563] | 2.88[564] | 2.72[565] | 2.27[566] | 1.84[567] |
82 | ANAPC10 | Anaphase-promoting complex subunit 10 | [568] | 0.68[569] | 1.63[570] | 0.91[571] | 0.98[572] | 1.55[573] | 1.46[574] |
83 | MCM8 | DNA helicase MCM8 | [575] | 3.11[576] | 3.89[577] | 3.06[578] | 3.80[579] | 3.14[580] | 0.97[581] |
84 | ORC1 | Origin recognition complex subunit 1 | [582] | 2.46[583] | 2.56[584] | 3.96[585] | 2.47[586] | 2.83[587] | -0.76[588] |
85 | CDT1 | DNA replication factor Cdt1 | [589] | 4.16[590] | 4.51[591] | 5.88[592] | 3.74[593] | 4.12[594] | -0.49[595] |
86 | CCNE2 | G1/S-specific cyclin-E2 | [596] | 1.34[597] | 1.80[598] | 1.23[599] | 4.24[600] | 3.93[601] | 0.99[602] |
87 | CCNA1 | Cyclin-A1 | [603] | [604] | -2.41[605] | [606] | 0.41[607] | 7.61[608] | [609] |
88 | PSMB11 | Proteasome subunit beta type-11 | [610] | [611] | [612] | [613] | [614] | [615] | [616] |
89 | PSMA8 | Proteasome subunit alpha type-7-like | [617] | [618] | [619] | [620] | [621] | [622] | [623] |
90 | SEM1 | Putative protein SEM1, isoform 2 | [624] | [625] | [626] | [627] | [628] | [629] | [630] |
91 | ANAPC15 | Anaphase-promoting complex subunit 15 | [631] | [632] | [633] | [634] | [635] | [636] | [637] |