REACTOME_SUMOYLATION_OF_TRANSCRIPTION_FACTORS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SUMO1 Small ubiquitin-related modifier 1 [1] -1.74[2] -1.88[3] -2.11[4] -1.48[5] -1.64[6] -1.05[7]
2 SUMO2 Small ubiquitin-related modifier 2 [8] -0.11[9] -0.20[10] -0.03[11] -0.65[12] -0.77[13] -1.09[14]
3 SUMO3 Small ubiquitin-related modifier 3 [15] -0.19[16] -0.66[17] -0.62[18] -0.58[19] -0.69[20] -0.16[21]
4 MTA1 Metastasis-associated protein MTA1 [22] 0.15[23] -0.22[24] 0.05[25] -0.11[26] -0.35[27] -1.53[28]
5 UBE2I SUMO-conjugating enzyme UBC9 [29] 1.15[30] 0.52[31] 1.04[32] 0.31[33] 0.77[34] -0.06[35]
6 MDM2 E3 ubiquitin-protein ligase Mdm2 [36] 1.97[37] 3.09[38] 0.46[39] 0.50[40] 1.27[41] 2.66[42]
7 TP53 Cellular tumor antigen p53 [43] 1.50[44] 0.76[45] 1.65[46] 1.28[47] 0.84[48] 0.45[49]
8 SP3 Transcription factor Sp3 [50] 1.29[51] 2.34[52] 2.42[53] 2.14[54] 1.81[55] 2.56[56]
9 PIAS4 E3 SUMO-protein ligase PIAS4 [57] 0.10[58] -0.68[59] 0.20[60] -0.54[61] -0.54[62] 0.08[63]
10 PIAS1 E3 SUMO-protein ligase PIAS1 [64] -0.10[65] -0.14[66] 0.90[67] 0.86[68] 0.48[69] 1.67[70]
11 MITF Microphthalmia-associated transcription factor [71] -4.48[72] -5.69[73] -7.43[74] 1.27[75] -0.58[76] -0.27[77]
12 PIAS2 E3 SUMO-protein ligase PIAS2 [78] 1.04[79] 1.19[80] 1.53[81] 1.67[82] 1.59[83] 2.90[84]
13 TP53BP1 TP53-binding protein 1 [85] 2.44[86] 1.65[87] 2.75[88] 3.92[89] 3.27[90] 2.77[91]
14 PIAS3 E3 SUMO-protein ligase PIAS3 [92] 1.16[93] 0.05[94] 1.48[95] 2.70[96] 2.30[97] 1.26[98]
15 CDKN2A Cyclin-dependent kinase inhibitor 2A [99] 3.94[100] 1.41[101] 4.95[102] 5.20[103] 6.88[104] -1.66[105]
16 HIC1 Hypermethylated in cancer 1 protein [106] 0.76[107] -3.36[108] -2.09[109] 0.98[110] 2.76[111] 3.98[112]
17 TFAP2C Transcription factor AP-2 gamma [113] [114] [115] [116] 4.01[117] 4.64[118] 1.54[119]
18 FOXL2 Forkhead box protein L2 [120] [121] [122] [123] [124] [125] [126]
19 TFAP2A Transcription factor AP-2-alpha [127] [128] [129] [130] [131] [132] [133]
20 TFAP2B Transcription factor AP-2-beta [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte SUMO1
Mean 76.3
Standard deviation 10
Values 80 74 89 61 77
[2]
HepG2 SUMO1
Mean 55.7
Standard deviation 4.2
Values 53 59
[3]
HepG2.C3A SUMO1
Mean 55.2
Standard deviation 14
Values 45 65
[4]
HuH.7 SUMO1
Mean 41.2
Standard deviation 13
Values 44 27 53
[5]
SNU475 SUMO1
Mean 50.5
Standard deviation 16
Values 62 40
[6]
THLE SUMO1
Mean 54.6
Standard deviation 7.9
Values 49 60
[7]
liver SUMO1
Mean 37.2
Standard deviation 30
Values 71 13 54 10
[8]
ref_hepatocyte SUMO2
Mean 67.7
Standard deviation 34
Values 1.2e+02 53 37 48 76
[9]
HepG2 SUMO2
Mean 153
Standard deviation 10
Values 1.5e+02 1.6e+02
[10]
HepG2.C3A SUMO2
Mean 157
Standard deviation 23
Values 1.4e+02 1.7e+02
[11]
HuH.7 SUMO2
Mean 155
Standard deviation 18
Values 1.5e+02 1.4e+02 1.8e+02
[12]
SNU475 SUMO2
Mean 80
Standard deviation 11
Values 88 72
[13]
THLE SUMO2
Mean 88.4
Standard deviation 8.1
Values 83 94
[14]
liver SUMO2
Mean 32.2
Standard deviation 23
Values 57 15 46 11
[15]
ref_hepatocyte SUMO3
Mean 29
Standard deviation 8
Values 26 26 43 27 23
[16]
HepG2 SUMO3
Mean 62.2
Standard deviation 3.4
Values 60 65
[17]
HepG2.C3A SUMO3
Mean 49.2
Standard deviation 15
Values 38 60
[18]
HuH.7 SUMO3
Mean 44.1
Standard deviation 5.5
Values 45 38 49
[19]
SNU475 SUMO3
Mean 36
Standard deviation 9.5
Values 43 29
[20]
THLE SUMO3
Mean 40.1
Standard deviation 4.9
Values 37 44
[21]
liver SUMO3
Mean 26.3
Standard deviation 15
Values 42 14 37 12
[22]
ref_hepatocyte MTA1
Mean 12.6
Standard deviation 11
Values 31 16 7.8 4.2 4.1
[23]
HepG2 MTA1
Mean 34
Standard deviation 12
Values 43 25
[24]
HepG2.C3A MTA1
Mean 28.8
Standard deviation 11
Values 36 21
[25]
HuH.7 MTA1
Mean 30.5
Standard deviation 3.7
Values 33 26 32
[26]
SNU475 MTA1
Mean 21.6
Standard deviation 3.6
Values 24 19
[27]
THLE MTA1
Mean 22
Standard deviation 0.52
Values 22 22
[28]
liver MTA1
Mean 4.42
Standard deviation 2.3
Values 2.6 6.2 2.3 6.6
[29]
ref_hepatocyte UBE2I
Mean 10.7
Standard deviation 3.4
Values 12 8.6 16 9 7.8
[30]
HepG2 UBE2I
Mean 58
Standard deviation 6.1
Values 62 54
[31]
HepG2.C3A UBE2I
Mean 41.3
Standard deviation 6.2
Values 37 46
[32]
HuH.7 UBE2I
Mean 51.7
Standard deviation 14
Values 57 36 63
[33]
SNU475 UBE2I
Mean 24.7
Standard deviation 1.6
Values 26 24
[34]
THLE UBE2I
Mean 41
Standard deviation 5.6
Values 37 45
[35]
liver UBE2I
Mean 10.4
Standard deviation 6.3
Values 16 5.3 15 4.7
[36]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 11 7.6 5 3.6 4.8
[37]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 51 70
[38]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.1e+02 1.8e+02
[39]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 21 20 20
[40]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 18 15
[41]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[42]
liver MDM2
Mean 40.5
Standard deviation 11
Values 29 54 35 45
[43]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 5.5 3.7 6.2 5.5 5.5
[44]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[45]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 23 25
[46]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 50 20 46
[47]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 28 19
[48]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[49]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 9 5 9.5 5.6
[50]
ref_hepatocyte SP3
Mean 4.63
Standard deviation 2.5
Values 8.8 3.2 3.7 2.6 4.8
[51]
HepG2 SP3
Mean 27.5
Standard deviation 11
Values 20 35
[52]
HepG2.C3A SP3
Mean 62.3
Standard deviation 18
Values 50 75
[53]
HuH.7 SP3
Mean 57.9
Standard deviation 10
Values 55 70 50
[54]
SNU475 SP3
Mean 37.8
Standard deviation 1.9
Values 39 36
[55]
THLE SP3
Mean 36.2
Standard deviation 1.8
Values 35 37
[56]
liver SP3
Mean 27.7
Standard deviation 9.3
Values 23 34 17 37
[57]
ref_hepatocyte PIAS4
Mean 3.53
Standard deviation 1
Values 4.5 2.7 3.6 4.6 2.3
[58]
HepG2 PIAS4
Mean 9.22
Standard deviation 1.8
Values 10 8
[59]
HepG2.C3A PIAS4
Mean 5.88
Standard deviation 0.98
Values 6.6 5.2
[60]
HuH.7 PIAS4
Mean 9.46
Standard deviation 0.82
Values 10 8.9 9.1
[61]
SNU475 PIAS4
Mean 4.49
Standard deviation 0.4
Values 4.2 4.8
[62]
THLE PIAS4
Mean 5.43
Standard deviation 0.61
Values 5 5.9
[63]
liver PIAS4
Mean 3.76
Standard deviation 0.52
Values 4.1 3.9 3 4.1
[64]
ref_hepatocyte PIAS1
Mean 2.96
Standard deviation 1.1
Values 2.2 2.9 4.9 2.2 2.7
[65]
HepG2 PIAS1
Mean 6.75
Standard deviation 3.6
Values 4.2 9.3
[66]
HepG2.C3A PIAS1
Mean 7.18
Standard deviation 2
Values 5.7 8.6
[67]
HuH.7 PIAS1
Mean 12.9
Standard deviation 1.7
Values 15 12 12
[68]
SNU475 PIAS1
Mean 9.97
Standard deviation 0.61
Values 10 9.5
[69]
THLE PIAS1
Mean 9.23
Standard deviation 0.13
Values 9.1 9.3
[70]
liver PIAS1
Mean 9.55
Standard deviation 5.5
Values 15 5.5 13 4.3
[71]
ref_hepatocyte MITF
Mean 2.3
Standard deviation 4.6
Values 0 10 0.41 0.3 0.34
[72]
HepG2 MITF
Mean 0.252
Standard deviation 0.017
Values 0.26 0.24
[73]
HepG2.C3A MITF
Mean 0.119
Standard deviation 0.044
Values 0.087 0.15
[74]
HuH.7 MITF
Mean 0.0312
Standard deviation 0.016
Values 0.049 0.026 0.019
[75]
SNU475 MITF
Mean 10.3
Standard deviation 2.2
Values 12 8.7
[76]
THLE MITF
Mean 3.43
Standard deviation 0.23
Values 3.6 3.3
[77]
liver MITF
Mean 1.94
Standard deviation 0.54
Values 2.5 2.2 1.9 1.2
[78]
ref_hepatocyte PIAS2
Mean 1.65
Standard deviation 0.6
Values 1.8 2.5 0.88 1.5 1.6
[79]
HepG2 PIAS2
Mean 8.25
Standard deviation 3.1
Values 6.1 10
[80]
HepG2.C3A PIAS2
Mean 10.1
Standard deviation 2.4
Values 8.4 12
[81]
HuH.7 PIAS2
Mean 11.1
Standard deviation 0.25
Values 11 11 11
[82]
SNU475 PIAS2
Mean 9.72
Standard deviation 1.6
Values 11 8.6
[83]
THLE PIAS2
Mean 11.1
Standard deviation 0.42
Values 11 11
[84]
liver PIAS2
Mean 12.5
Standard deviation 3
Values 9.8 17 11 12
[85]
ref_hepatocyte TP53BP1
Mean 1.45
Standard deviation 0.79
Values 2.6 1.9 0.55 1.2 1.1
[86]
HepG2 TP53BP1
Mean 19.2
Standard deviation 4.3
Values 16 22
[87]
HepG2.C3A TP53BP1
Mean 12.2
Standard deviation 0.33
Values 12 12
[88]
HuH.7 TP53BP1
Mean 22.8
Standard deviation 5.7
Values 29 19 20
[89]
SNU475 TP53BP1
Mean 40.8
Standard deviation 4
Values 44 38
[90]
THLE TP53BP1
Mean 31.4
Standard deviation 1.4
Values 30 32
[91]
liver TP53BP1
Mean 10
Standard deviation 6
Values 4.5 19 8 9.1
[92]
ref_hepatocyte PIAS3
Mean 1.39
Standard deviation 0.72
Values 0.36 1.1 2 2.1 1.3
[93]
HepG2 PIAS3
Mean 7.59
Standard deviation 0.22
Values 7.7 7.4
[94]
HepG2.C3A PIAS3
Mean 3.85
Standard deviation 0.47
Values 3.5 4.2
[95]
HuH.7 PIAS3
Mean 9.07
Standard deviation 2.5
Values 11 6.2 10
[96]
SNU475 PIAS3
Mean 16.8
Standard deviation 3.3
Values 19 14
[97]
THLE PIAS3
Mean 15.3
Standard deviation 1.8
Values 14 17
[98]
liver PIAS3
Mean 3.37
Standard deviation 2.5
Values 4.5 1.2 6.4 1.4
[99]
ref_hepatocyte CDKN2A
Mean 0.323
Standard deviation 0.62
Values 1.4 0 0 0.13 0.065
[100]
HepG2 CDKN2A
Mean 12.1
Standard deviation 5.5
Values 16 8.2
[101]
HepG2.C3A CDKN2A
Mean 2.29
Standard deviation 0.19
Values 2.1 2.4
[102]
HuH.7 CDKN2A
Mean 23.3
Standard deviation 9
Values 24 14 32
[103]
SNU475 CDKN2A
Mean 21.9
Standard deviation 6.8
Values 27 17
[104]
THLE CDKN2A
Mean 84.5
Standard deviation 8.9
Values 78 91
[105]
liver CDKN2A
Mean 0.103
Standard deviation 0.079
Values 0.21 0.071 0.1 0.026
[106]
ref_hepatocyte HIC1
Mean 0.0973
Standard deviation 0.1
Values 0 0.22 0.19 0.052 0.024
[107]
HepG2 HIC1
Mean 0.401
Standard deviation 0.28
Values 0.6 0.21
[108]
HepG2.C3A HIC1
Mean 0.0253
Standard deviation 0.0055
Values 0.029 0.021
[109]
HuH.7 HIC1
Mean 0.0532
Standard deviation 0.051
Values 0.041 0.11 0.0094
[110]
SNU475 HIC1
Mean 0.355
Standard deviation 0.21
Values 0.21 0.5
[111]
THLE HIC1
Mean 1.47
Standard deviation 0.12
Values 1.4 1.5
[112]
liver HIC1
Mean 1.55
Standard deviation 1.5
Values 0.38 3.5 0.39 2
[113]
ref_hepatocyte TFAP2C
Mean 0.0185
Standard deviation 0.041
Values 0 0 0.092 0 0
[114]
HepG2 TFAP2C
Mean 0
Standard deviation 0
Values 0 0
[115]
HepG2.C3A TFAP2C
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 TFAP2C
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 TFAP2C
Mean 0.552
Standard deviation 0.6
Values 0.13 0.98
[118]
THLE TFAP2C
Mean 1.03
Standard deviation 0.31
Values 1.2 0.81
[119]
liver TFAP2C
Mean 0.0543
Standard deviation 0.05
Values 0 0.086 0.026 0.11
[120]
ref_hepatocyte FOXL2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 FOXL2
Mean 0.0558
Standard deviation 0.055
Values 0.017 0.094
[122]
HepG2.C3A FOXL2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[123]
HuH.7 FOXL2
Mean 0.136
Standard deviation 0.033
Values 0.098 0.16 0.15
[124]
SNU475 FOXL2
Mean 2.71
Standard deviation 0.15
Values 2.6 2.8
[125]
THLE FOXL2
Mean 1.6
Standard deviation 0.29
Values 1.4 1.8
[126]
liver FOXL2
Mean 0
Standard deviation 0
Values 0 0 0 0
[127]
ref_hepatocyte TFAP2A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 TFAP2A
Mean 0.0229
Standard deviation 0.032
Values 0.046 0
[129]
HepG2.C3A TFAP2A
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[130]
HuH.7 TFAP2A
Mean 0.224
Standard deviation 0.043
Values 0.26 0.23 0.18
[131]
SNU475 TFAP2A
Mean 10.4
Standard deviation 1.4
Values 11 9.5
[132]
THLE TFAP2A
Mean 2.69
Standard deviation 1
Values 2 3.4
[133]
liver TFAP2A
Mean 0.0326
Standard deviation 0.047
Values 0 0.014 0.1 0.013
[134]
ref_hepatocyte TFAP2B
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 TFAP2B
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A TFAP2B
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 TFAP2B
Mean 0.0935
Standard deviation 0.061
Values 0.033 0.15 0.094
[138]
SNU475 TFAP2B
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE TFAP2B
Mean 0
Standard deviation 0
Values 0 0
[140]
liver TFAP2B
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0