REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SUMO1 | Small ubiquitin-related modifier 1 | [1] | -1.92[2] | -2.04[3] | -2.71[4] | -2.01[5] | -2.13[6] | -1.67[7] |
2 | SUMO2 | Small ubiquitin-related modifier 2 | [8] | -0.29[9] | -0.36[10] | -0.63[11] | -1.18[12] | -1.26[13] | -1.71[14] |
3 | SEC13 | Protein SEC13 homolog | [15] | -1.27[16] | -1.18[17] | -1.30[18] | -2.27[19] | -2.18[20] | -1.69[21] |
4 | CETN2 | Centrin-2 | [22] | -2.93[23] | -2.83[24] | -4.31[25] | -3.21[26] | -3.69[27] | -3.62[28] |
5 | PARP1 | Poly [ADP-ribose] polymerase 1 | [29] | -0.19[30] | -0.72[31] | -0.29[32] | -0.02[33] | -0.56[34] | -0.54[35] |
6 | SUMO3 | Small ubiquitin-related modifier 3 | [36] | -0.37[37] | -0.82[38] | -1.22[39] | -1.11[40] | -1.18[41] | -0.78[42] |
7 | NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog | [43] | -1.66[44] | -2.02[45] | -2.20[46] | -3.63[47] | -3.00[48] | -2.04[49] |
8 | PHC2 | Polyhomeotic-like protein 2 | [50] | 0.14[51] | -0.30[52] | -1.00[53] | -0.78[54] | 0.35[55] | -0.81[56] |
9 | SP100 | Nuclear autoantigen Sp-100 | [57] | -2.08[58] | -3.48[59] | -4.66[60] | -1.34[61] | -1.08[62] | -0.39[63] |
10 | RAD21 | Double-strand-break repair protein rad21 homolog | [64] | 0.11[65] | 1.22[66] | 1.01[67] | 1.52[68] | 1.08[69] | 0.25[70] |
11 | RAE1 | mRNA export factor | [71] | 0.25[72] | -0.31[73] | -1.74[74] | 0.03[75] | -0.72[76] | -1.15[77] |
12 | UBE2I | SUMO-conjugating enzyme UBC9 | [78] | 0.97[79] | 0.36[80] | 0.44[81] | -0.22[82] | 0.28[83] | -0.68[84] |
13 | SMC3 | Structural maintenance of chromosomes protein 3 | [85] | -1.49[86] | 0.88[87] | 1.04[88] | -0.13[89] | 0.23[90] | -0.07[91] |
14 | RING1 | E3 ubiquitin-protein ligase RING1 | [92] | -0.25[93] | -0.82[94] | -1.88[95] | -0.23[96] | -0.87[97] | -2.30[98] |
15 | NUP88 | Nuclear pore complex protein Nup88 | [99] | -0.38[100] | -0.13[101] | -0.33[102] | -0.87[103] | -0.44[104] | 0.99[105] |
16 | NSMCE4A | Non-structural maintenance of chromosomes element 4 homolog A | [106] | -0.77[107] | 0.35[108] | -0.84[109] | -1.99[110] | -1.82[111] | -0.64[112] |
17 | SEH1L | Nucleoporin SEH1 | [113] | -0.10[114] | 0.11[115] | 0.26[116] | 0.03[117] | -0.81[118] | 0.05[119] |
18 | NUP35 | Nucleoporin NUP53 | [120] | -1.41[121] | -1.10[122] | -1.43[123] | -1.64[124] | -1.91[125] | -1.35[126] |
19 | RPA1 | Replication protein A 70 kDa DNA-binding subunit | [127] | 0.99[128] | 0.45[129] | 0.41[130] | 1.31[131] | 1.26[132] | -0.13[133] |
20 | NUP62 | Nuclear pore glycoprotein p62 | [134] | 0.85[135] | 0.18[136] | 0.93[137] | 0.66[138] | 0.69[139] | 0.29[140] |
21 | NSMCE2 | E3 SUMO-protein ligase NSE2 | [141] | -1.37[142] | -1.36[143] | -1.27[144] | -0.88[145] | -1.77[146] | -2.12[147] |
22 | NUP85 | Nuclear pore complex protein Nup85 | [148] | 0.42[149] | 0.50[150] | 0.43[151] | 0.03[152] | 0.17[153] | 0.09[154] |
23 | AAAS | Aladin | [155] | -0.06[156] | -0.02[157] | -0.73[158] | -0.33[159] | -0.35[160] | -0.31[161] |
24 | CBX4 | E3 SUMO-protein ligase CBX4 | [162] | 0.81[163] | 0.39[164] | -0.06[165] | -0.22[166] | -1.00[167] | -1.53[168] |
25 | NUP50 | Nuclear pore complex protein Nup50 | [169] | 0.45[170] | 0.85[171] | 0.95[172] | 0.44[173] | 0.87[174] | 1.43[175] |
26 | RANBP2 | E3 SUMO-protein ligase RanBP2 | [176] | 0.15[177] | 1.56[178] | 0.99[179] | 0.99[180] | 1.08[181] | 2.82[182] |
27 | NUP93 | Nuclear pore complex protein Nup93 | [183] | 1.35[184] | 0.60[185] | 0.27[186] | 0.39[187] | 0.63[188] | -0.64[189] |
28 | NUP98 | Nuclear pore complex protein Nup98-Nup96 | [190] | 1.85[191] | 1.26[192] | 1.21[193] | 1.68[194] | 1.18[195] | 1.73[196] |
29 | NUP54 | Nucleoporin p54 | [197] | -0.22[198] | 0.15[199] | -0.16[200] | -0.21[201] | 0.20[202] | -0.12[203] |
30 | NUP107 | Nuclear pore complex protein Nup107 | [204] | 0.18[205] | 1.01[206] | 0.69[207] | 0.75[208] | 0.61[209] | -0.13[210] |
31 | TDG | G/T mismatch-specific thymine DNA glycosylase | [211] | -0.65[212] | 0.11[213] | -0.46[214] | 0.97[215] | 0.28[216] | -0.21[217] |
32 | NUP37 | Nucleoporin Nup37 | [218] | 0.34[219] | 0.34[220] | 0.13[221] | -0.09[222] | -0.16[223] | -1.55[224] |
33 | TPR | Nucleoprotein TPR | [225] | 0.31[226] | 1.89[227] | 1.90[228] | 2.00[229] | 2.17[230] | 2.46[231] |
34 | STAG2 | Cohesin subunit SA-2 | [232] | -0.04[233] | 1.69[234] | 2.40[235] | 1.99[236] | 1.41[237] | 1.82[238] |
35 | XPC | DNA repair protein complementing XP-C cells | [239] | 0.58[240] | 0.07[241] | 0.65[242] | -0.10[243] | 0.09[244] | 1.11[245] |
36 | NUP160 | Nuclear pore complex protein Nup160 | [246] | 1.53[247] | 1.40[248] | 1.70[249] | 0.63[250] | 0.87[251] | 1.34[252] |
37 | SMC1A | Structural maintenance of chromosomes protein 1A | [253] | 1.77[254] | 1.36[255] | 2.06[256] | 2.47[257] | 3.25[258] | 2.31[259] |
38 | POM121 | Nuclear envelope pore membrane protein POM 121 | [260] | 1.12[261] | 1.20[262] | 0.73[263] | 1.00[264] | 0.38[265] | 1.17[266] |
39 | NUP133 | Nuclear pore complex protein Nup133 | [267] | 0.86[268] | 0.93[269] | 1.58[270] | 1.67[271] | 0.95[272] | 0.92[273] |
40 | PML | Protein PML | [274] | -0.09[275] | -1.38[276] | 0.02[277] | 1.34[278] | 0.77[279] | 0.11[280] |
41 | NUP153 | Nuclear pore complex protein Nup153 | [281] | 2.07[282] | 1.99[283] | 1.32[284] | 2.71[285] | 1.81[286] | 1.81[287] |
42 | NUP43 | Nucleoporin Nup43 | [288] | 1.59[289] | 1.49[290] | 0.93[291] | 1.54[292] | 1.21[293] | 0.18[294] |
43 | SMC6 | Structural maintenance of chromosomes protein 6 | [295] | -0.06[296] | 1.74[297] | 0.25[298] | 0.59[299] | 0.73[300] | 0.89[301] |
44 | PIAS4 | E3 SUMO-protein ligase PIAS4 | [302] | -0.08[303] | -0.84[304] | -0.40[305] | -1.07[306] | -1.03[307] | -0.54[308] |
45 | NUP205 | Nuclear pore complex protein Nup205 | [309] | 1.86[310] | 1.50[311] | 2.36[312] | 2.24[313] | 2.35[314] | 1.38[315] |
46 | SMC5 | Structural maintenance of chromosomes protein 5 | [316] | -0.53[317] | 1.27[318] | 1.06[319] | 1.08[320] | 1.31[321] | 1.89[322] |
47 | POM121C | Nuclear envelope pore membrane protein POM 121C | [323] | 0.96[324] | -0.06[325] | -0.69[326] | 0.86[327] | 0.22[328] | 0.30[329] |
48 | PIAS1 | E3 SUMO-protein ligase PIAS1 | [330] | -0.28[331] | -0.30[332] | 0.30[333] | 0.33[334] | -0.01[335] | 1.05[336] |
49 | NUP214 | Nuclear pore complex protein Nup214 | [337] | 1.70[338] | 0.73[339] | 1.55[340] | 1.64[341] | 1.50[342] | 1.63[343] |
50 | STAG1 | Cohesin subunit SA-1 | [344] | 0.13[345] | 1.13[346] | 0.02[347] | 1.03[348] | 1.07[349] | 2.05[350] |
51 | PCGF2 | Polycomb group RING finger protein 2 | [351] | 1.06[352] | 0.17[353] | 0.45[354] | 0.18[355] | -0.18[356] | -3.74[357] |
52 | NUP188 | Nucleoporin NUP188 homolog | [358] | 2.94[359] | 2.04[360] | 2.37[361] | 1.97[362] | 3.08[363] | 1.70[364] |
53 | NUP210 | Nuclear pore membrane glycoprotein 210 | [365] | 3.38[366] | 2.91[367] | 3.71[368] | 1.56[369] | -0.11[370] | 2.86[371] |
54 | CBX8 | Chromobox protein homolog 8 | [372] | -0.08[373] | 0.22[374] | -0.29[375] | -0.49[376] | -1.69[377] | -2.22[378] |
55 | RNF168 | E3 ubiquitin-protein ligase RNF168 | [379] | 0.07[380] | 0.44[381] | 1.12[382] | -0.47[383] | 0.63[384] | 1.96[385] |
56 | RNF2 | E3 ubiquitin-protein ligase RING2 | [386] | 0.45[387] | 1.06[388] | 0.19[389] | 1.55[390] | -0.05[391] | 0.22[392] |
57 | BMI1 | Polycomb complex protein BMI-1 | [393] | -3.02[394] | -1.54[395] | -2.81[396] | -1.51[397] | -1.76[398] | -1.62[399] |
58 | SCMH1 | Polycomb protein SCMH1 | [400] | 1.27[401] | -1.58[402] | 0.10[403] | 0.69[404] | 0.77[405] | 0.97[406] |
59 | MDC1 | Mediator of DNA damage checkpoint protein 1 | [407] | 2.16[408] | 2.29[409] | 2.32[410] | 2.35[411] | 2.21[412] | 1.32[413] |
60 | NUP155 | Nuclear pore complex protein Nup155 | [414] | 1.79[415] | 1.12[416] | 1.80[417] | 1.93[418] | 2.74[419] | 1.61[420] |
61 | XRCC4 | DNA repair protein XRCC4 | [421] | -0.91[422] | 0.41[423] | -0.11[424] | -0.35[425] | -0.43[426] | -0.88[427] |
62 | BRCA1 | Breast cancer type 1 susceptibility protein | [428] | 1.35[429] | 2.32[430] | 2.40[431] | 1.60[432] | 2.06[433] | 1.55[434] |
63 | HERC2 | E3 ubiquitin-protein ligase HERC2 | [435] | 2.13[436] | 1.55[437] | 1.80[438] | 2.54[439] | 2.55[440] | 4.04[441] |
64 | PHC1 | Polyhomeotic-like protein 1 | [442] | 1.20[443] | 0.04[444] | -0.11[445] | 0.21[446] | 1.15[447] | 0.06[448] |
65 | PIAS2 | E3 SUMO-protein ligase PIAS2 | [449] | 0.86[450] | 1.03[451] | 0.93[452] | 1.14[453] | 1.10[454] | 2.29[455] |
66 | HDAC7 | Histone deacetylase 7 | [456] | 2.06[457] | 1.14[458] | 0.52[459] | 2.56[460] | 2.82[461] | 0.85[462] |
67 | WRN | Werner syndrome ATP-dependent helicase | [463] | 0.28[464] | 1.47[465] | 3.10[466] | 1.15[467] | 0.91[468] | 1.84[469] |
68 | RAD52 | DNA repair protein RAD52 homolog | [470] | 0.05[471] | 0.54[472] | 0.35[473] | -0.96[474] | -0.57[475] | 0.62[476] |
69 | PHC3 | Polyhomeotic-like protein 3 | [477] | 1.39[478] | 2.33[479] | 3.21[480] | 2.08[481] | 2.52[482] | 4.14[483] |
70 | CBX2 | Chromobox protein homolog 2 | [484] | 3.01[485] | 2.66[486] | 3.32[487] | 2.16[488] | 1.07[489] | -0.99[490] |
71 | EID3 | EP300-interacting inhibitor of differentiation 3 | [491] | -3.91[492] | -4.45[493] | -4.51[494] | 0.48[495] | 0.16[496] | 1.19[497] |
72 | BLM | Bloom syndrome protein | [498] | 1.22[499] | 2.29[500] | 2.80[501] | 2.35[502] | 2.37[503] | -0.51[504] |
73 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [505] | 3.76[506] | 1.25[507] | 4.35[508] | 4.66[509] | 6.39[510] | -2.28[511] |
74 | NDC1 | Nucleoporin NDC1 | [512] | [513] | [514] | [515] | [516] | [517] | [518] |
75 | NUP42 | [519] | [520] | [521] | [522] | [523] | [524] | [525] | |
76 | NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog | [526] | [527] | [528] | [529] | [530] | [531] | [532] |
77 | NUP58 | Nucleoporin p58/p45 | [533] | [534] | [535] | [536] | [537] | [538] | [539] |