REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 XRCC6 X-ray repair cross-complementing protein 6 [1] -0.51[2] -0.75[3] -1.03[4] -1.39[5] -1.23[6] -1.38[7]
2 XRCC5 X-ray repair cross-complementing protein 5 [8] 0.56[9] 0.78[10] 0.18[11] 0.29[12] 0.43[13] 0.23[14]
3 DDX41 Probable ATP-dependent RNA helicase DDX41 [15] -0.49[16] -0.52[17] -0.28[18] -0.89[19] -1.11[20] -0.87[21]
4 STAT6 Signal transducer and activator of transcription 6 [22] -0.16[23] 0.21[24] -1.36[25] 0.32[26] 0.13[27] 0.78[28]
5 TRIM21 E3 ubiquitin-protein ligase TRIM21 [29] -2.60[30] -4.31[31] -5.33[32] -2.38[33] -3.44[34] -1.36[35]
6 IRF3 Interferon regulatory factor 3 [36] -0.21[37] 0.08[38] 0.34[39] -0.18[40] -0.67[41] -1.10[42]
7 TBK1 Serine/threonine-protein kinase TBK1 [43] -1.14[44] 0.66[45] -0.67[46] -0.04[47] -0.04[48] 0.56[49]
8 PRKDC DNA-dependent protein kinase catalytic subunit [50] 3.71[51] 3.29[52] 4.71[53] 4.36[54] 4.36[55] 4.32[56]
9 DTX4 E3 ubiquitin-protein ligase DTX4 [57] 0.38[58] 0.52[59] 1.26[60] 0.25[61] -3.31[62] 2.47[63]
10 TREX1 Three-prime repair exonuclease 1 [64] -4.06[65] -2.65[66] -2.18[67] -2.26[68] 0.09[69] -0.74[70]
11 IFI16 Gamma-interferon-inducible protein 16 [71] -5.95[72] -7.11[73] -6.44[74] 3.58[75] 3.28[76] 1.00[77]
12 NLRC3 NLR family CARD domain-containing protein 3 [78] -0.48[79] 0.56[80] 0.00[81] 0.09[82] 0.17[83] 3.55[84]
13 STING1 [85] [86] [87] [88] [89] [90] [91]
14 NLRP4 NACHT, LRR and PYD domains-containing protein 4 [92] [93] [94] [95] [96] [97] [98]
15 CGAS [99] [100] [101] [102] [103] [104] [105]
16 MRE11 Double-strand break repair protein MRE11 [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte XRCC6
Mean 131
Standard deviation 74
Values 1.7e+02 2.4e+02 1.2e+02 73 58
[2]
HepG2 XRCC6
Mean 289
Standard deviation 39
Values 2.6e+02 3.2e+02
[3]
HepG2.C3A XRCC6
Mean 200
Standard deviation 42
Values 1.7e+02 2.3e+02
[4]
HuH.7 XRCC6
Mean 220
Standard deviation 54
Values 2.6e+02 1.6e+02 2.4e+02
[5]
SNU475 XRCC6
Mean 132
Standard deviation 1.1
Values 1.3e+02 1.3e+02
[6]
THLE XRCC6
Mean 176
Standard deviation 61
Values 1.3e+02 2.2e+02
[7]
liver XRCC6
Mean 67.3
Standard deviation 21
Values 80 58 89 42
[8]
ref_hepatocyte XRCC5
Mean 49.2
Standard deviation 25
Values 80 72 28 35 31
[9]
HepG2 XRCC5
Mean 227
Standard deviation 47
Values 1.9e+02 2.6e+02
[10]
HepG2.C3A XRCC5
Mean 218
Standard deviation 87
Values 1.6e+02 2.8e+02
[11]
HuH.7 XRCC5
Mean 192
Standard deviation 57
Values 2.4e+02 1.3e+02 2.1e+02
[12]
SNU475 XRCC5
Mean 160
Standard deviation 1.4
Values 1.6e+02 1.6e+02
[13]
THLE XRCC5
Mean 209
Standard deviation 38
Values 1.8e+02 2.4e+02
[14]
liver XRCC5
Mean 77.5
Standard deviation 10
Values 78 81 87 63
[15]
ref_hepatocyte DDX41
Mean 15.7
Standard deviation 5.8
Values 13 26 15 15 10
[16]
HepG2 DDX41
Mean 35.1
Standard deviation 6.6
Values 30 40
[17]
HepG2.C3A DDX41
Mean 28.2
Standard deviation 3.5
Values 26 31
[18]
HuH.7 DDX41
Mean 44.4
Standard deviation 14
Values 51 28 54
[19]
SNU475 DDX41
Mean 22.5
Standard deviation 3.1
Values 25 20
[20]
THLE DDX41
Mean 23.1
Standard deviation 1.2
Values 22 24
[21]
liver DDX41
Mean 11.5
Standard deviation 2.3
Values 12 9.7 14 9.6
[22]
ref_hepatocyte STAT6
Mean 15.2
Standard deviation 7.1
Values 5.4 18 25 13 15
[23]
HepG2 STAT6
Mean 42.8
Standard deviation 1.1
Values 44 42
[24]
HepG2.C3A STAT6
Mean 45.1
Standard deviation 1.7
Values 44 46
[25]
HuH.7 STAT6
Mean 20.3
Standard deviation 2.6
Values 21 17 22
[26]
SNU475 STAT6
Mean 50.2
Standard deviation 13
Values 59 41
[27]
THLE STAT6
Mean 52.3
Standard deviation 6.6
Values 48 57
[28]
liver STAT6
Mean 35
Standard deviation 8.5
Values 41 32 43 25
[29]
ref_hepatocyte TRIM21
Mean 12
Standard deviation 9.3
Values 1.2 24 19 8.5 7.5
[30]
HepG2 TRIM21
Mean 6.22
Standard deviation 0.36
Values 6.5 6
[31]
HepG2.C3A TRIM21
Mean 1.56
Standard deviation 0.47
Values 1.2 1.9
[32]
HuH.7 TRIM21
Mean 1.02
Standard deviation 0.14
Values 0.88 1 1.2
[33]
SNU475 TRIM21
Mean 6.15
Standard deviation 1.6
Values 7.3 5
[34]
THLE TRIM21
Mean 3.51
Standard deviation 0.59
Values 3.1 3.9
[35]
liver TRIM21
Mean 6.26
Standard deviation 2.6
Values 9.5 4.4 7.1 3.9
[36]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 7.1 4.7 13 15 10
[37]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 32 23
[38]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 28 26
[39]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 47 28 54
[40]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 20 27
[41]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[42]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 8.8 3.7 8.7 4
[43]
ref_hepatocyte TBK1
Mean 6.94
Standard deviation 1.7
Values 7.8 8.4 8.4 5 5.2
[44]
HepG2 TBK1
Mean 9.87
Standard deviation 3.8
Values 7.2 13
[45]
HepG2.C3A TBK1
Mean 28.1
Standard deviation 7.6
Values 23 33
[46]
HuH.7 TBK1
Mean 14.9
Standard deviation 0.71
Values 14 16 15
[47]
SNU475 TBK1
Mean 17.9
Standard deviation 1.5
Values 19 17
[48]
THLE TBK1
Mean 21.3
Standard deviation 2.3
Values 23 20
[49]
liver TBK1
Mean 13.7
Standard deviation 2.9
Values 13 15 17 10
[50]
ref_hepatocyte PRKDC
Mean 3.34
Standard deviation 1.6
Values 5.3 5 1.9 2.2 2.4
[51]
HepG2 PRKDC
Mean 137
Standard deviation 25
Values 1.2e+02 1.5e+02
[52]
HepG2.C3A PRKDC
Mean 84.1
Standard deviation 23
Values 68 1e+02
[53]
HuH.7 PRKDC
Mean 299
Standard deviation 1.8e+02
Values 5e+02 1.6e+02 2.4e+02
[54]
SNU475 PRKDC
Mean 182
Standard deviation 16
Values 1.7e+02 1.9e+02
[55]
THLE PRKDC
Mean 216
Standard deviation 37
Values 1.9e+02 2.4e+02
[56]
liver PRKDC
Mean 89.5
Standard deviation 54
Values 43 1.5e+02 47 1.1e+02
[57]
ref_hepatocyte DTX4
Mean 2.52
Standard deviation 1.8
Values 0.67 1.7 1.6 4.9 3.8
[58]
HepG2 DTX4
Mean 10.3
Standard deviation 1.7
Values 9.1 12
[59]
HepG2.C3A DTX4
Mean 9.29
Standard deviation 0.13
Values 9.2 9.4
[60]
HuH.7 DTX4
Mean 20.7
Standard deviation 3.3
Values 23 22 17
[61]
SNU475 DTX4
Mean 7.93
Standard deviation 2.6
Values 9.8 6.1
[62]
THLE DTX4
Mean 0.804
Standard deviation 0.22
Values 0.64 0.96
[63]
liver DTX4
Mean 18.7
Standard deviation 4.9
Values 17 25 14 19
[64]
ref_hepatocyte TREX1
Mean 2.46
Standard deviation 2.5
Values 0 0.24 6.1 3.3 2.6
[65]
HepG2 TREX1
Mean 0.463
Standard deviation 0.066
Values 0.51 0.42
[66]
HepG2.C3A TREX1
Mean 1.01
Standard deviation 0.32
Values 1.2 0.78
[67]
HuH.7 TREX1
Mean 1.86
Standard deviation 0.62
Values 1.9 1.2 2.5
[68]
SNU475 TREX1
Mean 1.36
Standard deviation 0.25
Values 1.2 1.5
[69]
THLE TREX1
Mean 8.25
Standard deviation 0.64
Values 8.7 7.8
[70]
liver TREX1
Mean 1.98
Standard deviation 1.2
Values 2.6 0.88 3.3 1.1
[71]
ref_hepatocyte IFI16
Mean 1.91
Standard deviation 1.6
Values 0 0.6 3.7 2.4 2.8
[72]
HepG2 IFI16
Mean 0.0974
Standard deviation 0.089
Values 0.16 0.034
[73]
HepG2.C3A IFI16
Mean 0.0355
Standard deviation 0.0047
Values 0.039 0.032
[74]
HuH.7 IFI16
Mean 0.0756
Standard deviation 0.025
Values 0.09 0.09 0.047
[75]
SNU475 IFI16
Mean 60.5
Standard deviation 9.4
Values 54 67
[76]
THLE IFI16
Mean 58.4
Standard deviation 2.9
Values 56 60
[77]
liver IFI16
Mean 5.12
Standard deviation 1.4
Values 5.6 5 6.6 3.2
[78]
ref_hepatocyte NLRC3
Mean 0.13
Standard deviation 0.18
Values 0.019 0.018 0.17 0.0086 0.43
[79]
HepG2 NLRC3
Mean 0.293
Standard deviation 0.063
Values 0.34 0.25
[80]
HepG2.C3A NLRC3
Mean 0.492
Standard deviation 0.23
Values 0.65 0.33
[81]
HuH.7 NLRC3
Mean 0.447
Standard deviation 0.13
Values 0.33 0.59 0.42
[82]
SNU475 NLRC3
Mean 0.368
Standard deviation 0.074
Values 0.32 0.42
[83]
THLE NLRC3
Mean 0.462
Standard deviation 0.082
Values 0.52 0.4
[84]
liver NLRC3
Mean 2.04
Standard deviation 1.2
Values 1 2.6 1.1 3.5
[85]
ref_hepatocyte STING1
Missing
[86]
HepG2 STING1
Missing
[87]
HepG2.C3A STING1
Missing
[88]
HuH.7 STING1
Missing
[89]
SNU475 STING1
Missing
[90]
THLE STING1
Missing
[91]
liver STING1
Missing
[92]
ref_hepatocyte NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 NLRP4
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A NLRP4
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 NLRP4
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[96]
SNU475 NLRP4
Mean 0.0327
Standard deviation 0.04
Values 0.0046 0.061
[97]
THLE NLRP4
Mean 0
Standard deviation 0
Values 0 0
[98]
liver NLRP4
Mean 0
Standard deviation 0
Values 0 0 0 0
[99]
ref_hepatocyte CGAS
Missing
[100]
HepG2 CGAS
Missing
[101]
HepG2.C3A CGAS
Missing
[102]
HuH.7 CGAS
Missing
[103]
SNU475 CGAS
Missing
[104]
THLE CGAS
Missing
[105]
liver CGAS
Missing
[106]
ref_hepatocyte MRE11
Missing
[107]
HepG2 MRE11
Missing
[108]
HepG2.C3A MRE11
Missing
[109]
HuH.7 MRE11
Missing
[110]
SNU475 MRE11
Missing
[111]
THLE MRE11
Missing
[112]
liver MRE11
Missing