REACTOME_STAT5_ACTIVATION_DOWNSTREAM_OF_FLT3_ITD_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] -0.36[2] -1.27[3] -4.29[4] -1.99[5] -0.03[6] -1.83[7]
2 BCL2L1 Bcl-2-like protein 1 [8] 0.94[9] 0.81[10] 1.44[11] -0.62[12] -0.82[13] -0.82[14]
3 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [15] -0.76[16] 0.16[17] -0.22[18] 0.89[19] 0.93[20] 1.26[21]
4 GRB2 Growth factor receptor-bound protein 2 [22] -0.01[23] 0.31[24] 0.10[25] 0.55[26] -0.13[27] 0.30[28]
5 PIM1 Serine/threonine-protein kinase pim-1 [29] -1.01[30] -0.76[31] -1.72[32] 0.38[33] -1.23[34] -1.12[35]
6 STAT5B Signal transducer and activator of transcription 5B [36] 0.15[37] 0.26[38] 0.64[39] 1.55[40] 0.10[41] 1.62[42]
7 STAT5A Signal transducer and activator of transcription 5A [43] -3.15[44] -1.49[45] -2.75[46] -0.85[47] -0.68[48] 0.24[49]
8 GAB2 GRB2-associated-binding protein 2 [50] 0.36[51] 0.63[52] 0.55[53] 0.92[54] 0.41[55] 0.54[56]
9 NOX4 NADPH oxidase 4 [57] -4.44[58] -1.18[59] -1.31[60] -2.59[61] -1.95[62] 2.10[63]
10 FLT3 Receptor-type tyrosine-protein kinase FLT3 [64] [65] [66] -4.55[67] -2.79[68] [69] 2.92[70]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 19 48 76 52 5.7
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.9e+02 1.2e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 51 57
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 6.5 10 7.3
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 13 24
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 26 16
[8]
ref_hepatocyte BCL2L1
Mean 26.8
Standard deviation 12
Values 16 44 34 23 16
[9]
HepG2 BCL2L1
Mean 260
Standard deviation 56
Values 3e+02 2.2e+02
[10]
HepG2.C3A BCL2L1
Mean 152
Standard deviation 4.3
Values 1.5e+02 1.5e+02
[11]
HuH.7 BCL2L1
Mean 283
Standard deviation 60
Values 3.1e+02 2.1e+02 3.2e+02
[12]
SNU475 BCL2L1
Mean 32.1
Standard deviation 4.1
Values 29 35
[13]
THLE BCL2L1
Mean 47
Standard deviation 4.7
Values 44 50
[14]
liver BCL2L1
Mean 21.6
Standard deviation 11
Values 31 9.8 31 14
[15]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[16]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[17]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[18]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[19]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[20]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[21]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[22]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[23]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[24]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[25]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[26]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[27]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[28]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[29]
ref_hepatocyte PIM1
Mean 9.92
Standard deviation 7.8
Values 6.1 2 13 22 6.7
[30]
HepG2 PIM1
Mean 25
Standard deviation 18
Values 38 12
[31]
HepG2.C3A PIM1
Mean 19
Standard deviation 15
Values 29 8.7
[32]
HuH.7 PIM1
Mean 11.7
Standard deviation 6.4
Values 8.2 19 7.9
[33]
SNU475 PIM1
Mean 23.8
Standard deviation 9.3
Values 30 17
[34]
THLE PIM1
Mean 13.2
Standard deviation 2.3
Values 12 15
[35]
liver PIM1
Mean 6.47
Standard deviation 0.83
Values 6.6 5.4 6.4 7.5
[36]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 4.1 3.3 2.3 4.6 5.6
[37]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 27 18
[38]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 18 13
[39]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 25 22 26
[40]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 24 19
[41]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[42]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 13 21 14 22
[43]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 1.8 2.7 5 1.5 0.95
[44]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.4 1.3
[45]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.6 2.9
[46]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.1 1.8 1.2
[47]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.5 2.3
[48]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[49]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 3 3.5 3.3 6.2
[50]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[51]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[52]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[53]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[54]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[55]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[56]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[57]
ref_hepatocyte NOX4
Mean 0.125
Standard deviation 0.15
Values 0.38 0.091 0.079 0.043 0.033
[58]
HepG2 NOX4
Mean 0.0293
Standard deviation 0.025
Values 0.011 0.047
[59]
HepG2.C3A NOX4
Mean 0.179
Standard deviation 0.02
Values 0.17 0.19
[60]
HuH.7 NOX4
Mean 0.197
Standard deviation 0.076
Values 0.14 0.28 0.17
[61]
SNU475 NOX4
Mean 0.0382
Standard deviation 0.018
Values 0.051 0.025
[62]
THLE NOX4
Mean 0.101
Standard deviation 0.0083
Values 0.095 0.11
[63]
liver NOX4
Mean 0.762
Standard deviation 0.18
Values 0.52 0.76 0.85 0.93
[64]
ref_hepatocyte FLT3
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[65]
HepG2 FLT3
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A FLT3
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 FLT3
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[68]
SNU475 FLT3
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[69]
THLE FLT3
Mean 0
Standard deviation 0
Values 0 0
[70]
liver FLT3
Mean 0.402
Standard deviation 0.15
Values 0.21 0.44 0.39 0.57