REACTOME_STABILIZATION_OF_P53 | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.10[2] | -1.18[3] | -1.01[4] | -1.34[5] | -1.00[6] | -0.45[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -0.66[16] | -0.43[17] | -0.64[18] | -0.49[19] | -0.62[20] | 0.00[21] |
4 | PSME1 | Proteasome activator complex subunit 1 | [22] | -0.43[23] | -2.01[24] | -1.61[25] | -1.21[26] | -1.84[27] | -0.95[28] |
5 | PSME2 | Proteasome activator complex subunit 2 | [29] | -0.24[30] | -1.64[31] | -1.70[32] | -0.99[33] | -1.38[34] | -0.58[35] |
6 | PSMA7 | Proteasome subunit alpha type-7 | [36] | 0.71[37] | 0.83[38] | -0.46[39] | 0.63[40] | 0.10[41] | 0.44[42] |
7 | PSMB1 | Proteasome subunit beta type-1 | [43] | 0.26[44] | 0.38[45] | -0.65[46] | -0.61[47] | 0.06[48] | 0.28[49] |
8 | PSMB3 | Proteasome subunit beta type-3 | [50] | -0.22[51] | -1.00[52] | 0.07[53] | -0.63[54] | -0.85[55] | -0.02[56] |
9 | PSMB4 | Proteasome subunit beta type-4 | [57] | 0.02[58] | 0.20[59] | 0.37[60] | 0.80[61] | 0.70[62] | -0.34[63] |
10 | PSMB7 | Proteasome subunit beta type-7 | [64] | -0.92[65] | -0.90[66] | -0.73[67] | -0.98[68] | -0.63[69] | -0.78[70] |
11 | PSMB5 | Proteasome subunit beta type-5 | [71] | 1.48[72] | 0.06[73] | 0.03[74] | -0.26[75] | -0.07[76] | -0.31[77] |
12 | PSMA6 | Proteasome subunit alpha type-6 | [78] | 1.60[79] | 0.34[80] | 0.31[81] | 0.27[82] | 0.20[83] | -0.22[84] |
13 | PSMA4 | Proteasome subunit alpha type-4 | [85] | -0.32[86] | 0.35[87] | 0.19[88] | 0.58[89] | 0.31[90] | -0.30[91] |
14 | PSMC3 | 26S proteasome regulatory subunit 6A | [92] | -0.36[93] | -0.41[94] | 0.25[95] | -0.62[96] | -0.52[97] | 0.17[98] |
15 | PSMA3 | Proteasome subunit alpha type-3 | [99] | -0.95[100] | 0.07[101] | -0.56[102] | 0.12[103] | -0.42[104] | -0.06[105] |
16 | PSMB6 | Proteasome subunit beta type-6 | [106] | -0.40[107] | -0.23[108] | -0.04[109] | -0.42[110] | -0.78[111] | 0.10[112] |
17 | PSMA2 | Proteasome subunit alpha type-2 | [113] | -0.48[114] | 0.50[115] | 0.87[116] | 0.07[117] | 0.36[118] | 0.32[119] |
18 | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 | [120] | 0.04[121] | 0.07[122] | 0.31[123] | 0.77[124] | 0.15[125] | 0.00[126] |
19 | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7 | [127] | -0.05[128] | 0.34[129] | 0.24[130] | -0.31[131] | 0.07[132] | -0.17[133] |
20 | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8 | [134] | 0.12[135] | 0.38[136] | 0.56[137] | -0.04[138] | 0.64[139] | -0.15[140] |
21 | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2 | [141] | 1.65[142] | 0.85[143] | 0.96[144] | 1.07[145] | 2.28[146] | 0.89[147] |
22 | PSMC1 | 26S proteasome regulatory subunit 4 | [148] | -0.02[149] | 0.06[150] | -0.55[151] | 1.26[152] | 0.69[153] | 0.05[154] |
23 | PSMA1 | Proteasome subunit alpha type-1 | [155] | 0.16[156] | 0.57[157] | 0.67[158] | 0.83[159] | 0.25[160] | 0.54[161] |
24 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [162] | 1.78[163] | 1.81[164] | 2.87[165] | 0.91[166] | 1.61[167] | 0.77[168] |
25 | PSMC5 | 26S proteasome regulatory subunit 8 | [169] | 0.48[170] | 0.39[171] | 0.51[172] | 0.24[173] | 0.57[174] | 0.30[175] |
26 | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | [176] | 0.87[177] | 0.39[178] | 1.02[179] | 0.77[180] | 0.91[181] | 0.02[182] |
27 | PSMB8 | Proteasome subunit beta type-8 | [183] | -1.52[184] | -2.10[185] | -9.27[186] | 0.75[187] | -0.65[188] | -0.67[189] |
28 | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14 | [190] | 0.05[191] | 0.68[192] | 0.97[193] | 0.64[194] | 0.58[195] | -0.13[196] |
29 | PSMC4 | 26S proteasome regulatory subunit 6B | [197] | 0.48[198] | 0.53[199] | 0.50[200] | 0.27[201] | 0.29[202] | 0.35[203] |
30 | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6 | [204] | -0.68[205] | -0.17[206] | -1.22[207] | -0.36[208] | 0.36[209] | -0.24[210] |
31 | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13 | [211] | 0.52[212] | 0.65[213] | 1.19[214] | 0.70[215] | 0.12[216] | -0.05[217] |
32 | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12 | [218] | -0.30[219] | -0.20[220] | -0.47[221] | 0.32[222] | 0.30[223] | -0.13[224] |
33 | PSMC6 | 26S proteasome regulatory subunit 10B | [225] | 0.00[226] | 1.59[227] | 0.45[228] | 0.68[229] | 0.52[230] | 0.53[231] |
34 | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11 | [232] | 0.88[233] | 0.51[234] | 1.14[235] | 1.08[236] | 1.15[237] | 1.35[238] |
35 | PSMC2 | 26S proteasome regulatory subunit 7 | [239] | 0.63[240] | 1.05[241] | 0.87[242] | 1.48[243] | 1.22[244] | 1.40[245] |
36 | PSME3 | Proteasome activator complex subunit 3 | [246] | 1.86[247] | 1.60[248] | 1.32[249] | 1.50[250] | 1.68[251] | 0.97[252] |
37 | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1 | [253] | 1.62[254] | 1.96[255] | 1.88[256] | 2.31[257] | 2.23[258] | 2.16[259] |
38 | PSMB10 | Proteasome subunit beta type-10 | [260] | -1.10[261] | -0.49[262] | -2.34[263] | 0.10[264] | -1.15[265] | 0.01[266] |
39 | PSMA5 | Proteasome subunit alpha type-5 | [267] | 1.95[268] | 2.39[269] | 2.00[270] | 2.36[271] | 1.84[272] | 2.00[273] |
40 | PSMF1 | Proteasome inhibitor PI31 subunit | [274] | 2.33[275] | 2.39[276] | 1.24[277] | 1.37[278] | 1.04[279] | 1.94[280] |
41 | PSMB2 | Proteasome subunit beta type-2 | [281] | 2.11[282] | 1.86[283] | 2.29[284] | 2.67[285] | 2.56[286] | 2.48[287] |
42 | PSMB9 | Proteasome subunit beta type-9 | [288] | -1.90[289] | -4.50[290] | -6.77[291] | 1.92[292] | -0.44[293] | -0.41[294] |
43 | PSMD9 | 26S proteasome non-ATPase regulatory subunit 9 | [295] | 0.49[296] | 1.00[297] | 0.05[298] | 0.54[299] | 0.89[300] | 0.81[301] |
44 | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10 | [302] | 1.04[303] | 1.38[304] | 1.44[305] | 2.21[306] | 1.45[307] | 0.80[308] |
45 | PSME4 | Proteasome activator complex subunit 4 | [309] | 2.57[310] | 3.50[311] | 3.54[312] | 2.77[313] | 2.64[314] | 3.06[315] |
46 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [316] | 3.21[317] | 4.75[318] | 2.01[319] | 1.95[320] | 2.71[321] | 3.59[322] |
47 | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5 | [323] | 1.46[324] | 1.03[325] | 2.63[326] | 2.60[327] | 2.59[328] | 2.24[329] |
48 | CHEK2 | Serine/threonine-protein kinase Chk2 | [330] | 1.20[331] | 1.76[332] | 2.18[333] | 1.19[334] | 0.70[335] | -1.86[336] |
49 | TP53 | Cellular tumor antigen p53 | [337] | 2.74[338] | 2.42[339] | 3.20[340] | 2.73[341] | 2.28[342] | 1.38[343] |
50 | PHF20 | PHD finger protein 20 | [344] | 3.23[345] | 3.14[346] | 3.71[347] | 4.64[348] | 3.55[349] | 3.18[350] |
51 | ATM | Serine-protein kinase ATM | [351] | 4.13[352] | 5.86[353] | 5.60[354] | 5.59[355] | 4.96[356] | 6.41[357] |
52 | MDM4 | Protein Mdm4 | [358] | 2.74[359] | 3.87[360] | 4.33[361] | 3.73[362] | 3.50[363] | 5.98[364] |
53 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [365] | 5.18[366] | 3.07[367] | 6.50[368] | 6.65[369] | 8.32[370] | -0.73[371] |
54 | COP1 | [372] | [373] | [374] | [375] | [376] | [377] | [378] | |
55 | SEM1 | Putative protein SEM1, isoform 2 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |
56 | PSMA8 | Proteasome subunit alpha type-7-like | [386] | [387] | [388] | [389] | [390] | [391] | [392] |
57 | PSMB11 | Proteasome subunit beta type-11 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |