REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 UBB Polyubiquitin-B [1] -0.67[2] -0.83[3] -0.82[4] -1.00[5] -0.65[6] -0.25[7]
2 RPS27A Ubiquitin-40S ribosomal protein S27a [8] [9] [10] [11] [12] [13] [14]
3 UBC Polyubiquitin-C [15] -0.23[16] -0.08[17] -0.46[18] -0.14[19] -0.28[20] 0.20[21]
4 UBA52 Ubiquitin-60S ribosomal protein L40 [22] 2.20[23] 2.16[24] 3.05[25] 1.25[26] 1.95[27] 0.97[28]
5 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 2.33[29] 2.19[30] 1.98[31] 2.99[32] 2.20[33] 1.77[34]
6 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1.80[35] 1.94[36] 1.16[37] 2.53[38] 2.52[39] 1.52[40]
7 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1.13[41] 0.84[42] 0.77[43] 1.33[44] 1.11[45] 0.64[46]
8 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [47] 1.97[48] 2.45[49] 2.26[50] 2.67[51] 3.19[52] 2.88[53]
9 GRB2 Growth factor receptor-bound protein 2 [54] 2.72[55] 2.60[56] 2.58[57] 2.34[58] 2.14[59] 1.92[60]
10 MAPK1 Mitogen-activated protein kinase 1 [61] 3.23[62] 3.42[63] 3.10[64] 3.63[65] 3.16[66] 3.40[67]
11 MAPK3 Mitogen-activated protein kinase 3 [68] 3.37[69] 3.47[70] 3.36[71] 2.21[72] 2.11[73] 0.59[74]
12 MKNK1 MAP kinase-interacting serine/threonine-protein kinase 1 [75] 1.89[76] 1.56[77] 1.93[78] 2.13[79] 1.61[80] 2.33[81]
13 SRC Proto-oncogene tyrosine-protein kinase Src [82] 4.55[83] 4.58[84] 3.43[85] 4.18[86] 3.24[87] 0.78[88]
14 SPRY2 Protein sprouty homolog 2 [89] 0.93[90] 1.12[91] 3.40[92] -0.49[93] 1.42[94] 1.80[95]
15 BRAF Serine/threonine-protein kinase B-raf [96] 1.77[97] 1.55[98] 3.43[99] 2.53[100] 2.10[101] 3.48[102]
16 CBL E3 ubiquitin-protein ligase CBL [103] 5.97[104] 4.96[105] 5.04[106] 6.92[107] 6.28[108] 5.38[109]
[1]
ref_hepatocyte UBB
Mean 764
Standard deviation 4.8e+02
Values 3.8e+02 3.5e+02 5.3e+02 1.2e+03 1.3e+03
[2]
HepG2 UBB
Mean 368
Standard deviation 39
Values 4e+02 3.4e+02
[3]
HepG2.C3A UBB
Mean 285
Standard deviation 14
Values 2.8e+02 3e+02
[4]
HuH.7 UBB
Mean 304
Standard deviation 40
Values 2.9e+02 2.7e+02 3.5e+02
[5]
SNU475 UBB
Mean 204
Standard deviation 3.3
Values 2.1e+02 2e+02
[6]
THLE UBB
Mean 315
Standard deviation 34
Values 2.9e+02 3.4e+02
[7]
liver UBB
Mean 296
Standard deviation 1.3e+02
Values 4.3e+02 2.1e+02 3.9e+02 1.5e+02
[8]
ref_hepatocyte RPS27A
Mean 499
Standard deviation 2.2e+02
Values 6.6e+02 6.1e+02 1.7e+02 6.8e+02 3.8e+02
[9]
HepG2 RPS27A
Missing
[10]
HepG2.C3A RPS27A
Missing
[11]
HuH.7 RPS27A
Missing
[12]
SNU475 RPS27A
Missing
[13]
THLE RPS27A
Missing
[14]
liver RPS27A
Missing
[15]
ref_hepatocyte UBC
Mean 480
Standard deviation 2.8e+02
Values 1.8e+02 3.5e+02 9.1e+02 5.8e+02 3.8e+02
[16]
HepG2 UBC
Mean 314
Standard deviation 38
Values 3.4e+02 2.9e+02
[17]
HepG2.C3A UBC
Mean 302
Standard deviation 41
Values 3.3e+02 2.7e+02
[18]
HuH.7 UBC
Mean 246
Standard deviation 64
Values 2.4e+02 3.1e+02 1.9e+02
[19]
SNU475 UBC
Mean 232
Standard deviation 63
Values 2.8e+02 1.9e+02
[20]
THLE UBC
Mean 257
Standard deviation 41
Values 2.3e+02 2.9e+02
[21]
liver UBC
Mean 254
Standard deviation 78
Values 2.2e+02 3.1e+02 3.3e+02 1.6e+02
[22]
ref_hepatocyte UBA52
Mean 57.3
Standard deviation 43
Values 14 23 49 1.2e+02 81
[23]
HepG2 UBA52
Mean 203
Standard deviation 20
Values 2.2e+02 1.9e+02
[24]
HepG2.C3A UBA52
Mean 169
Standard deviation 3.3
Values 1.7e+02 1.7e+02
[25]
HuH.7 UBA52
Mean 334
Standard deviation 46
Values 3.4e+02 2.8e+02 3.7e+02
[26]
SNU475 UBA52
Mean 72.9
Standard deviation 11
Values 65 81
[27]
THLE UBA52
Mean 144
Standard deviation 15
Values 1.3e+02 1.5e+02
[28]
liver UBA52
Mean 51.7
Standard deviation 26
Values 79 32 68 28
[29]
ref_hepatocyte PPP2R1A
Mean 27.9
Standard deviation 5.4
Values 23 30 23 36 28
[30]
HepG2 PPP2R1A
Mean 107
Standard deviation 6.5
Values 1.1e+02 1e+02
[31]
HepG2.C3A PPP2R1A
Mean 84.7
Standard deviation 12
Values 93 76
[32]
HuH.7 PPP2R1A
Mean 77.2
Standard deviation 6.8
Values 84 70 78
[33]
SNU475 PPP2R1A
Mean 118
Standard deviation 14
Values 1.3e+02 1.1e+02
[34]
THLE PPP2R1A
Mean 83.3
Standard deviation 16
Values 72 94
[35]
liver PPP2R1A
Mean 43.9
Standard deviation 17
Values 51 30 65 30
[36]
ref_hepatocyte PPP2CA
Mean 27.3
Standard deviation 6.4
Values 27 38 22 24 25
[37]
HepG2 PPP2CA
Mean 72.8
Standard deviation 15
Values 62 83
[38]
HepG2.C3A PPP2CA
Mean 69.2
Standard deviation 19
Values 55 83
[39]
HuH.7 PPP2CA
Mean 42.8
Standard deviation 4.9
Values 43 38 48
[40]
SNU475 PPP2CA
Mean 83.9
Standard deviation 4.1
Values 81 87
[41]
THLE PPP2CA
Mean 102
Standard deviation 13
Values 92 1.1e+02
[42]
liver PPP2CA
Mean 36.1
Standard deviation 13
Values 49 27 46 23
[43]
ref_hepatocyte PPP2CB
Mean 25.5
Standard deviation 11
Values 15 43 27 17 26
[44]
HepG2 PPP2CB
Mean 43
Standard deviation 1.5
Values 44 42
[45]
HepG2.C3A PPP2CB
Mean 30.2
Standard deviation 0.78
Values 31 30
[46]
HuH.7 PPP2CB
Mean 30.6
Standard deviation 2.8
Values 28 34 30
[47]
SNU475 PPP2CB
Mean 34.2
Standard deviation 0.1
Values 34 34
[48]
THLE PPP2CB
Mean 35.7
Standard deviation 2.6
Values 37 34
[49]
liver PPP2CB
Mean 18.3
Standard deviation 7.2
Values 28 14 19 12
[50]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[51]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[52]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[53]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[54]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[55]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[56]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[57]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[58]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[59]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[60]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[61]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[62]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[63]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[64]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[65]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[66]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[67]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[68]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[69]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[70]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[78]
ref_hepatocyte MKNK1
Mean 3.72
Standard deviation 0.64
Values 3 4.7 3.9 3.7 3.4
[79]
HepG2 MKNK1
Mean 10.6
Standard deviation 2.1
Values 9.1 12
[80]
HepG2.C3A MKNK1
Mean 7.29
Standard deviation 0.2
Values 7.4 7.2
[81]
HuH.7 MKNK1
Mean 10
Standard deviation 0.97
Values 10 8.9 11
[82]
SNU475 MKNK1
Mean 8.68
Standard deviation 2.1
Values 10 7.2
[83]
THLE MKNK1
Mean 7.38
Standard deviation 0.36
Values 7.6 7.1
[84]
liver MKNK1
Mean 8.59
Standard deviation 2.1
Values 11 6.3 10 7.3
[85]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[86]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[87]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[88]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[89]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[90]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[91]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[92]
ref_hepatocyte SPRY2
Mean 3.21
Standard deviation 2
Values 0.39 2.4 4.2 5.7 3.3
[93]
HepG2 SPRY2
Mean 4.68
Standard deviation 0.29
Values 4.9 4.5
[94]
HepG2.C3A SPRY2
Mean 4.63
Standard deviation 0.85
Values 5.2 4
[95]
HuH.7 SPRY2
Mean 23.8
Standard deviation 10
Values 27 12 32
[96]
SNU475 SPRY2
Mean 1.22
Standard deviation 0.58
Values 0.81 1.6
[97]
THLE SPRY2
Mean 5.56
Standard deviation 0.25
Values 5.4 5.7
[98]
liver SPRY2
Mean 5.14
Standard deviation 2.3
Values 4.7 5.4 2.4 8
[99]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 0.56 1.2 2.3 0.67 0.67
[100]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 2.4 3.2
[101]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 1.6 2.5
[102]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 6.4 15 3.4
[103]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.2 3.4
[104]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[105]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 3.1 8 2.9 7.9
[106]
ref_hepatocyte CBL
Mean 0.522
Standard deviation 0.26
Values 0.83 0.62 0.65 0.18 0.33
[107]
HepG2 CBL
Mean 25.2
Standard deviation 0.64
Values 26 25
[108]
HepG2.C3A CBL
Mean 10.8
Standard deviation 0.61
Values 11 10
[109]
HuH.7 CBL
Mean 12.1
Standard deviation 3
Values 15 11 9.5
[110]
SNU475 CBL
Mean 33.7
Standard deviation 5.1
Values 30 37
[111]
THLE CBL
Mean 26.4
Standard deviation 3.4
Values 24 29
[112]
liver CBL
Mean 10
Standard deviation 4.2
Values 5.8 14 7.1 14