REACTOME_SPHINGOLIPID_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PSAP | Prosaposin | [1] | -0.05[2] | -0.24[3] | -0.06[4] | 0.40[5] | 0.22[6] | 0.00[7] |
2 | CERS2 | Ceramide synthase 2 | [8] | -1.20[9] | -1.35[10] | -0.35[11] | -1.14[12] | -1.54[13] | -0.62[14] |
3 | ORMDL3 | ORM1-like protein 3 | [15] | -1.34[16] | -0.97[17] | -1.55[18] | -3.09[19] | -2.25[20] | -1.39[21] |
4 | ALDH3A2 | Fatty aldehyde dehydrogenase | [22] | -0.43[23] | -0.35[24] | -0.85[25] | -1.00[26] | -1.65[27] | 0.20[28] |
5 | CTSA | Lysosomal protective protein | [29] | 0.94[30] | -0.24[31] | -0.82[32] | 0.28[33] | -0.51[34] | -0.19[35] |
6 | NEU1 | Sialidase-1 | [36] | 0.49[37] | 0.05[38] | -1.25[39] | -1.74[40] | -1.65[41] | -1.82[42] |
7 | HEXB | Beta-hexosaminidase subunit beta | [43] | -0.65[44] | -0.87[45] | -0.27[46] | -1.02[47] | -0.06[48] | -0.52[49] |
8 | ASAH1 | Acid ceramidase | [50] | -0.32[51] | -0.31[52] | -0.02[53] | -1.04[54] | -0.95[55] | -0.63[56] |
9 | SUMF2 | Sulfatase-modifying factor 2 | [57] | -0.63[58] | -0.06[59] | -0.62[60] | -0.45[61] | -0.41[62] | -0.45[63] |
10 | ESYT1 | Extended synaptotagmin-1 | [64] | 0.72[65] | 0.27[66] | 0.21[67] | 0.44[68] | 0.82[69] | 0.85[70] |
11 | CERS4 | Ceramide synthase 4 | [71] | -1.26[72] | -0.27[73] | -0.51[74] | -3.66[75] | -3.51[76] | -0.45[77] |
12 | SMPD1 | Sphingomyelin phosphodiesterase | [78] | -2.54[79] | -3.00[80] | -3.15[81] | -1.75[82] | -1.06[83] | 0.27[84] |
13 | DEGS1 | Sphingolipid delta(4)-desaturase DES1 | [85] | -1.11[86] | -1.46[87] | -1.30[88] | 0.97[89] | 0.58[90] | -0.68[91] |
14 | GLB1 | Beta-galactosidase | [92] | 0.23[93] | 0.03[94] | 1.11[95] | -0.80[96] | 0.19[97] | -0.10[98] |
15 | HEXA | Beta-hexosaminidase subunit alpha | [99] | 1.02[100] | 0.52[101] | 0.25[102] | 0.58[103] | 0.70[104] | 0.03[105] |
16 | ORMDL2 | ORM1-like protein 2 | [106] | -1.46[107] | -1.77[108] | -2.03[109] | -1.52[110] | -1.44[111] | -1.13[112] |
17 | SPTSSA | Serine palmitoyltransferase small subunit A | [113] | 0.64[114] | 0.98[115] | 0.54[116] | -0.47[117] | -0.44[118] | -0.83[119] |
18 | SPTLC1 | Serine palmitoyltransferase 1 | [120] | -0.26[121] | 0.59[122] | -0.06[123] | 0.06[124] | 0.90[125] | -1.04[126] |
19 | OSBP | Oxysterol-binding protein 1 | [127] | -0.24[128] | 0.12[129] | 1.70[130] | 0.18[131] | 0.24[132] | 1.62[133] |
20 | SPHK1 | Sphingosine kinase 1 | [134] | 1.15[135] | 2.01[136] | -0.44[137] | -2.49[138] | -0.02[139] | -5.22[140] |
21 | VAPA | Vesicle-associated membrane protein-associated protein A | [141] | 1.45[142] | 1.59[143] | 1.94[144] | 2.16[145] | 1.58[146] | 1.40[147] |
22 | GLTP | Glycolipid transfer protein | [148] | -0.98[149] | -0.56[150] | -1.77[151] | -0.98[152] | -0.49[153] | -0.71[154] |
23 | SMPD4 | Sphingomyelin phosphodiesterase 4 | [155] | 0.86[156] | 0.88[157] | 0.40[158] | 0.27[159] | 0.66[160] | -0.77[161] |
24 | NEU4 | Sialidase-4 | [162] | 0.38[163] | 1.49[164] | -8.11[165] | -5.94[166] | -8.52[167] | -0.37[168] |
25 | GLA | Alpha-galactosidase A | [169] | -0.49[170] | -0.98[171] | 0.22[172] | -0.09[173] | -0.08[174] | -1.77[175] |
26 | GBA | Glucosylceramidase | [176] | -0.32[177] | -1.67[178] | 0.16[179] | 0.55[180] | 0.91[181] | -1.12[182] |
27 | SUMF1 | Sulfatase-modifying factor 1 | [183] | -0.43[184] | -0.39[185] | -0.45[186] | -1.24[187] | -0.15[188] | -0.10[189] |
28 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | [190] | -1.31[191] | -1.00[192] | -2.04[193] | -0.79[194] | -0.38[195] | 0.49[196] |
29 | KDSR | 3-ketodihydrosphingosine reductase | [197] | -0.99[198] | -0.50[199] | -1.04[200] | -0.50[201] | 0.65[202] | 1.34[203] |
30 | CSNK1G2 | Casein kinase I isoform gamma-2 | [204] | 0.97[205] | 1.09[206] | 1.05[207] | -0.28[208] | 0.63[209] | -1.05[210] |
31 | GM2A | Ganglioside GM2 activator | [211] | 0.63[212] | -0.05[213] | 0.08[214] | -0.30[215] | 0.56[216] | -0.47[217] |
32 | VAPB | Vesicle-associated membrane protein-associated protein B/C | [218] | 1.29[219] | 1.59[220] | 1.15[221] | 1.83[222] | 1.33[223] | 1.14[224] |
33 | ORMDL1 | ORM1-like protein 1 | [225] | -0.66[226] | 1.25[227] | 0.51[228] | 0.16[229] | 0.74[230] | 0.68[231] |
34 | CERS5 | Ceramide synthase 5 | [232] | 0.15[233] | -0.26[234] | -0.61[235] | 0.01[236] | 0.19[237] | -1.28[238] |
35 | GBA2 | Non-lysosomal glucosylceramidase | [239] | 0.50[240] | 1.57[241] | 1.23[242] | -0.39[243] | 0.33[244] | 1.43[245] |
36 | UGCG | Ceramide glucosyltransferase | [246] | -2.88[247] | -1.62[248] | -0.92[249] | -0.59[250] | 1.05[251] | -0.77[252] |
37 | SPTLC3 | Serine palmitoyltransferase 3 | [253] | -0.90[254] | 0.39[255] | 1.83[256] | -3.78[257] | -1.38[258] | 0.55[259] |
38 | SGPL1 | Sphingosine-1-phosphate lyase 1 | [260] | 1.61[261] | 1.22[262] | 0.49[263] | 1.33[264] | 0.96[265] | 2.04[266] |
39 | ESYT2 | Extended synaptotagmin-2 | [267] | 1.56[268] | 1.66[269] | 1.19[270] | 2.32[271] | 1.93[272] | 1.17[273] |
40 | CERK | Ceramide kinase | [274] | 1.69[275] | 2.47[276] | 1.90[277] | 1.18[278] | 1.41[279] | 0.96[280] |
41 | ARSD | Arylsulfatase D | [281] | -0.62[282] | -1.16[283] | 0.50[284] | 0.08[285] | -1.74[286] | 1.87[287] |
42 | ARSA | Arylsulfatase A | [288] | 0.43[289] | 0.02[290] | 0.46[291] | -0.16[292] | -0.43[293] | 0.51[294] |
43 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | [295] | -0.99[296] | 0.16[297] | -0.83[298] | 0.75[299] | 0.89[300] | 0.87[301] |
44 | CERS6 | Ceramide synthase 6 | [302] | 0.11[303] | 0.23[304] | 2.15[305] | 0.93[306] | 0.61[307] | 1.15[308] |
45 | SPHK2 | Sphingosine kinase 2 | [309] | -0.59[310] | -0.23[311] | -0.47[312] | -0.12[313] | -0.50[314] | 0.19[315] |
46 | PRKD2 | Serine/threonine-protein kinase D2 | [316] | 0.46[317] | 0.16[318] | 1.27[319] | 0.91[320] | 1.00[321] | -0.32[322] |
47 | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2 | [323] | -2.46[324] | -1.92[325] | -5.95[326] | 0.62[327] | 2.07[328] | 1.61[329] |
48 | SMPD2 | Sphingomyelin phosphodiesterase 2 | [330] | -1.38[331] | -0.87[332] | -1.44[333] | -2.06[334] | -0.74[335] | -1.82[336] |
49 | SAMD8 | Sphingomyelin synthase-related protein 1 | [337] | 0.65[338] | 1.80[339] | 0.90[340] | 2.08[341] | 2.16[342] | 1.64[343] |
50 | PRKD3 | Serine/threonine-protein kinase D3 | [344] | 1.37[345] | 2.07[346] | 1.95[347] | 2.90[348] | 2.78[349] | 2.02[350] |
51 | ARSB | Arylsulfatase B | [351] | 3.21[352] | 1.98[353] | 1.39[354] | 1.23[355] | 1.92[356] | 1.93[357] |
52 | ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | -2.99[358] | 0.82[359] | -3.64[360] | -10.62[361] | [362] | -0.14[363] | |
53 | SPTLC2 | Serine palmitoyltransferase 2 | [364] | 2.17[365] | 2.18[366] | 1.32[367] | 2.48[368] | 2.35[369] | 2.62[370] |
54 | GALC | Galactocerebrosidase | [371] | -6.48[372] | -5.74[373] | 2.93[374] | 2.32[375] | 1.77[376] | 2.38[377] |
55 | SPNS2 | Protein spinster homolog 2 | [378] | -2.21[379] | -3.96[380] | -6.01[381] | -3.77[382] | -4.11[383] | 0.54[384] |
56 | ACER3 | Alkaline ceramidase 3 | [385] | 0.64[386] | 0.21[387] | 0.11[388] | 1.89[389] | 2.01[390] | 1.37[391] |
57 | ALDH3B1 | Aldehyde dehydrogenase family 3 member B1 | [392] | 1.45[393] | 1.70[394] | 1.29[395] | 4.47[396] | 2.79[397] | -0.30[398] |
58 | ARSJ | Arylsulfatase J | [399] | -6.98[400] | -9.27[401] | -0.94[402] | 0.61[403] | 1.88[404] | -0.19[405] |
59 | STS | Steryl-sulfatase | [406] | -0.27[407] | -0.64[408] | 0.58[409] | -0.85[410] | 1.52[411] | 1.90[412] |
60 | GLB1L | Beta-galactosidase-1-like protein | [413] | -0.52[414] | 0.23[415] | 0.21[416] | -0.28[417] | 0.45[418] | -0.49[419] |
61 | ARSK | Arylsulfatase K | [420] | 0.00[421] | 1.22[422] | 1.26[423] | 1.26[424] | 1.92[425] | 1.67[426] |
62 | B3GALNT1 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 | [427] | -7.49[428] | -7.48[429] | 1.03[430] | 2.10[431] | 2.28[432] | -1.13[433] |
63 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | [434] | -1.99[435] | -0.17[436] | 1.89[437] | 0.81[438] | 1.13[439] | 2.79[440] |
64 | SMPD3 | Sphingomyelin phosphodiesterase 3 | [441] | -0.31[442] | 0.34[443] | -0.36[444] | 0.05[445] | -0.69[446] | 2.71[447] |
65 | CERS1 | Ceramide synthase 1 | [448] | 0.95[449] | 0.09[450] | 1.84[451] | -1.63[452] | -1.54[453] | [454] |
66 | NEU3 | Sialidase-3 | [455] | 2.52[456] | 2.00[457] | 1.62[458] | 1.72[459] | 2.05[460] | 2.27[461] |
67 | ARSG | Arylsulfatase G | [462] | 2.29[463] | 1.97[464] | 2.18[465] | -0.56[466] | -2.76[467] | 1.60[468] |
68 | ARSI | Arylsulfatase I | [469] | 4.21[470] | 2.29[471] | -3.56[472] | 3.90[473] | 4.22[474] | -1.39[475] |
69 | ESYT3 | Extended synaptotagmin-3 | [476] | 1.18[477] | -0.81[478] | -6.08[479] | 0.68[480] | 0.16[481] | -0.53[482] |
70 | PPM1L | Protein phosphatase 1L | [483] | -0.73[484] | 0.18[485] | 3.34[486] | -2.36[487] | -1.15[488] | 3.03[489] |
71 | ASAH2 | Neutral ceramidase | [490] | 0.63[491] | 2.34[492] | -0.60[493] | -1.49[494] | -0.92[495] | 0.19[496] |
72 | B4GALNT1 | Beta-1,4 N-acetylgalactosaminyltransferase 1 | [497] | 3.15[498] | 3.58[499] | 3.35[500] | 4.03[501] | 4.65[502] | -1.01[503] |
73 | ARSF | Arylsulfatase F | [504] | -5.49[505] | -4.03[506] | -6.50[507] | -4.22[508] | -5.84[509] | -0.42[510] |
74 | ACER2 | Alkaline ceramidase 2 | [511] | 2.36[512] | 1.59[513] | 0.55[514] | -0.94[515] | 1.83[516] | 2.75[517] |
75 | PRKD1 | Serine/threonine-protein kinase D1 | [518] | 1.49[519] | 1.57[520] | 3.99[521] | 4.36[522] | 4.53[523] | 2.93[524] |
76 | FA2H | Fatty acid 2-hydroxylase | [525] | 0.44[526] | 0.29[527] | -1.94[528] | -1.37[529] | -1.99[530] | 0.19[531] |
77 | SPTSSB | Serine palmitoyltransferase small subunit B | [532] | 2.02[533] | 1.02[534] | 8.04[535] | -2.94[536] | -2.65[537] | 0.69[538] |
78 | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 | [539] | 4.35[540] | -1.41[541] | 0.51[542] | 0.86[543] | -1.43[544] | 2.81[545] |
79 | SGPP2 | Sphingosine-1-phosphate phosphatase 2 | [546] | [547] | [548] | [549] | [550] | [551] | [552] |
80 | ARSL | [553] | [554] | [555] | [556] | [557] | [558] | [559] | |
81 | PLPP3 | Phospholipid phosphatase 3 | [560] | [561] | [562] | [563] | [564] | [565] | [566] |
82 | PLPP2 | Phospholipid phosphatase 2 | [567] | [568] | [569] | [570] | [571] | [572] | [573] |
83 | PLPP1 | Phospholipid phosphatase 1 | [574] | [575] | [576] | [577] | [578] | [579] | [580] |
84 | ACER1 | Alkaline ceramidase 1 | [581] | [582] | [583] | [584] | [585] | [586] | [587] |
85 | ALDH3B2 | Aldehyde dehydrogenase family 3 member B2 | [588] | [589] | [590] | [591] | [592] | [593] | [594] |
86 | NEU2 | Sialidase-2 | [595] | [596] | [597] | [598] | [599] | [600] | [601] |
87 | CERS3 | Ceramide synthase 3 | [602] | [603] | [604] | [605] | [606] | [607] | [608] |
88 | ARSH | Arylsulfatase H | [609] | [610] | [611] | [612] | [613] | [614] | [615] |
89 | CERT1 | [616] | [617] | [618] | [619] | [620] | [621] | [622] | |
90 | CPTP | Ceramide-1-phosphate transfer protein | [623] | [624] | [625] | [626] | [627] | [628] | [629] |