REACTOME_SOS_MEDIATED_SIGNALLING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] 0.62[2] 0.34[3] 0.06[4] -0.07[5] -0.11[6] -0.08[7]
2 NRAS GTPase NRas [8] 0.05[9] 0.37[10] 0.38[11] 0.37[12] -0.01[13] -0.63[14]
3 HRAS GTPase HRas [15] -1.59[16] -2.41[17] -3.60[18] -1.57[19] -1.74[20] -3.04[21]
4 KRAS GTPase KRas [22] -1.09[23] -1.23[24] -0.03[25] 0.18[26] -0.12[27] 0.30[28]
5 SOS1 Son of sevenless homolog 1 [29] -0.68[30] 0.74[31] -0.15[32] 0.22[33] -0.50[34] 0.16[35]
6 IRS1 Insulin receptor substrate 1 [36] 1.51[37] 0.84[38] 1.87[39] 1.08[40] 0.71[41] 1.74[42]
7 IRS2 Insulin receptor substrate 2 [43] -6.23[44] [45] -3.89[46] -1.29[47] 2.58[48] 2.01[49]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[9]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[10]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[11]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[12]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[13]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[14]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[15]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[16]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[17]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[18]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[19]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[20]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[21]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[22]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[23]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[24]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[25]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[26]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[27]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[28]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[29]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[30]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[31]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[32]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[33]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[34]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[35]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[36]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[37]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[38]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[39]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[40]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[41]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[42]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[43]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[44]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[45]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[46]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[47]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[48]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[49]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17