REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ITGB1 Integrin beta-1 [1] -0.09[2] 0.11[3] -0.04[4] 0.40[5] 0.44[6] 0.10[7]
2 RAC1 Ras-related C3 botulinum toxin substrate 1 [8] -0.72[9] -0.87[10] -0.44[11] -1.04[12] -1.10[13] -1.02[14]
3 CSNK2B Casein kinase II subunit beta [15] -0.67[16] -0.66[17] -1.56[18] -2.05[19] -2.36[20] -1.56[21]
4 CSNK2A1 Casein kinase II subunit alpha [22] -0.21[23] -0.16[24] -0.51[25] -1.42[26] -1.83[27] -1.79[28]
5 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [29] -1.25[30] -1.41[31] -1.11[32] -1.60[33] -1.14[34] -1.25[35]
6 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [36] -0.27[37] -0.42[38] 0.17[39] -1.90[40] -1.46[41] -1.76[42]
7 ITGAV Integrin alpha-V [43] 1.22[44] 1.19[45] 0.26[46] 1.22[47] 1.06[48] 0.38[49]
8 ITGA5 Integrin alpha-5 [50] -1.54[51] -7.79[52] -0.88[53] 1.67[54] 2.26[55] 1.08[56]
9 MAPK1 Mitogen-activated protein kinase 1 [57] 1.38[58] 1.70[59] 1.24[60] 0.79[61] 0.39[62] 1.72[63]
10 VAV2 Guanine nucleotide exchange factor VAV2 [64] 0.97[65] 1.40[66] 0.61[67] -1.59[68] -1.22[69] 0.45[70]
11 CSNK2A2 Casein kinase II subunit alpha' [71] -0.12[72] 0.11[73] -0.18[74] -1.47[75] -1.31[76] -2.26[77]
12 EGFR Epidermal growth factor receptor [78] -1.02[79] -1.22[80] 1.38[81] -0.62[82] -0.05[83] 2.59[84]
13 MAPK3 Mitogen-activated protein kinase 3 [85] 1.53[86] 1.75[87] 1.51[88] -0.63[89] -0.66[90] -1.10[91]
14 NRP1 Neuropilin-1 [92] 1.22[93] -0.79[94] 2.85[95] 2.89[96] 2.31[97] 3.15[98]
15 PAK1 Serine/threonine-protein kinase PAK 1 [99] -0.34[100] -0.92[101] 1.21[102] -2.91[103] 0.82[104] 0.21[105]
16 ITGB3 Integrin beta-3 [106] -1.96[107] -4.49[108] -1.25[109] 1.79[110] 1.42[111] 1.27[112]
17 FGFR1 Fibroblast growth factor receptor 1 [113] 4.25[114] 2.74[115] 4.11[116] 4.00[117] 3.22[118] 1.60[119]
18 L1CAM Neural cell adhesion molecule L1 [120] 5.53[121] 3.90[122] -4.17[123] 4.75[124] -1.17[125] -0.74[126]
19 ITGA9 Integrin alpha-9 [127] -3.04[128] -0.47[129] -0.58[130] -2.47[131] -4.65[132] 7.12[133]
20 NCAM1 Neural cell adhesion molecule 1 [134] 1.24[135] -2.70[136] -3.56[137] 3.97[138] 4.96[139] 4.55[140]
21 ITGA2B Integrin alpha-IIb [141] 3.28[142] 3.74[143] 3.46[144] 1.96[145] 0.28[146] 2.56[147]
[1]
ref_hepatocyte ITGB1
Mean 128
Standard deviation 1e+02
Values 91 3e+02 1.4e+02 58 51
[2]
HepG2 ITGB1
Mean 333
Standard deviation 10
Values 3.4e+02 3.3e+02
[3]
HepG2.C3A ITGB1
Mean 301
Standard deviation 47
Values 2.7e+02 3.3e+02
[4]
HuH.7 ITGB1
Mean 317
Standard deviation 16
Values 3.3e+02 3.3e+02 3e+02
[5]
SNU475 ITGB1
Mean 648
Standard deviation 88
Values 7.1e+02 5.9e+02
[6]
THLE ITGB1
Mean 768
Standard deviation 1.5e+02
Values 6.6e+02 8.8e+02
[7]
liver ITGB1
Mean 204
Standard deviation 85
Values 1.2e+02 3.2e+02 2.1e+02 1.6e+02
[8]
ref_hepatocyte RAC1
Mean 52
Standard deviation 20
Values 28 59 81 45 47
[9]
HepG2 RAC1
Mean 87.4
Standard deviation 1.9
Values 89 86
[10]
HepG2.C3A RAC1
Mean 62
Standard deviation 7.4
Values 67 57
[11]
HuH.7 RAC1
Mean 97.2
Standard deviation 9.7
Values 1e+02 86 1e+02
[12]
SNU475 RAC1
Mean 96.5
Standard deviation 10
Values 89 1e+02
[13]
THLE RAC1
Mean 107
Standard deviation 19
Values 94 1.2e+02
[14]
liver RAC1
Mean 37.8
Standard deviation 32
Values 63 12 67 9.5
[15]
ref_hepatocyte CSNK2B
Mean 47.1
Standard deviation 20
Values 41 16 68 60 50
[16]
HepG2 CSNK2B
Mean 81.8
Standard deviation 3.1
Values 84 80
[17]
HepG2.C3A CSNK2B
Mean 65.1
Standard deviation 0.84
Values 66 65
[18]
HuH.7 CSNK2B
Mean 40.6
Standard deviation 8.2
Values 44 31 47
[19]
SNU475 CSNK2B
Mean 43.3
Standard deviation 2.9
Values 45 41
[20]
THLE CSNK2B
Mean 40.5
Standard deviation 3.7
Values 38 43
[21]
liver CSNK2B
Mean 23.6
Standard deviation 19
Values 43 7 37 7.1
[22]
ref_hepatocyte CSNK2A1
Mean 34.5
Standard deviation 33
Values 84 48 27 7.5 5.3
[23]
HepG2 CSNK2A1
Mean 82.7
Standard deviation 0.48
Values 83 82
[24]
HepG2.C3A CSNK2A1
Mean 67.3
Standard deviation 0.14
Values 67 67
[25]
HuH.7 CSNK2A1
Mean 61.5
Standard deviation 9.2
Values 72 60 53
[26]
SNU475 CSNK2A1
Mean 49.2
Standard deviation 0.33
Values 49 49
[27]
THLE CSNK2A1
Mean 43
Standard deviation 7.4
Values 38 48
[28]
liver CSNK2A1
Mean 14.7
Standard deviation 1.4
Values 13 16 16 14
[29]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 27 39 32 15 27
[30]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 35 30
[31]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[32]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 33 27 40
[33]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 32 39
[34]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[35]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 28 11 18 12
[36]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 22 20 28 42 26
[37]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 79 48
[38]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 55 36
[39]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 87 82 69
[40]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[41]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[42]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 17 11 9.8 11
[43]
ref_hepatocyte ITGAV
Mean 15.6
Standard deviation 20
Values 9.2 51 13 2.1 2.7
[44]
HepG2 ITGAV
Mean 100
Standard deviation 13
Values 91 1.1e+02
[45]
HepG2.C3A ITGAV
Mean 77.8
Standard deviation 11
Values 70 85
[46]
HuH.7 ITGAV
Mean 47.4
Standard deviation 14
Values 52 58 32
[47]
SNU475 ITGAV
Mean 139
Standard deviation 57
Values 1.8e+02 99
[48]
THLE ITGAV
Mean 144
Standard deviation 29
Values 1.2e+02 1.6e+02
[49]
liver ITGAV
Mean 30
Standard deviation 16
Values 20 48 13 39
[50]
ref_hepatocyte ITGA5
Mean 11.5
Standard deviation 8.2
Values 0 18 20 12 7.1
[51]
HepG2 ITGA5
Mean 10.9
Standard deviation 9.4
Values 18 4.3
[52]
HepG2.C3A ITGA5
Mean 0.113
Standard deviation 0.037
Values 0.087 0.14
[53]
HuH.7 ITGA5
Mean 15.9
Standard deviation 2
Values 17 17 14
[54]
SNU475 ITGA5
Mean 140
Standard deviation 4.2
Values 1.4e+02 1.4e+02
[55]
THLE ITGA5
Mean 243
Standard deviation 37
Values 2.2e+02 2.7e+02
[56]
liver ITGA5
Mean 35.9
Standard deviation 6
Values 38 29 33 43
[57]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[58]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[59]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[60]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[61]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[62]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[63]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[64]
ref_hepatocyte VAV2
Mean 8.59
Standard deviation 2.9
Values 14 7.9 6.3 7.1 8
[65]
HepG2 VAV2
Mean 46.7
Standard deviation 3.7
Values 49 44
[66]
HepG2.C3A VAV2
Mean 49.5
Standard deviation 13
Values 59 40
[67]
HuH.7 VAV2
Mean 33.4
Standard deviation 2.3
Values 36 33 31
[68]
SNU475 VAV2
Mean 10.9
Standard deviation 1
Values 10 12
[69]
THLE VAV2
Mean 16.4
Standard deviation 4.7
Values 13 20
[70]
liver VAV2
Mean 17.4
Standard deviation 7.3
Values 10 22 12 25
[71]
ref_hepatocyte CSNK2A2
Mean 7.81
Standard deviation 3.7
Values 10 6.9 13 5.1 3.8
[72]
HepG2 CSNK2A2
Mean 19.8
Standard deviation 4.2
Values 23 17
[73]
HepG2.C3A CSNK2A2
Mean 18.4
Standard deviation 8.1
Values 24 13
[74]
HuH.7 CSNK2A2
Mean 17.6
Standard deviation 2.1
Values 19 19 15
[75]
SNU475 CSNK2A2
Mean 10.8
Standard deviation 0.38
Values 11 11
[76]
THLE CSNK2A2
Mean 13.9
Standard deviation 0.013
Values 14 14
[77]
liver CSNK2A2
Mean 2.41
Standard deviation 0.96
Values 2.1 3.4 1.2 2.9
[78]
ref_hepatocyte EGFR
Mean 5.53
Standard deviation 4.2
Values 0.94 8.5 11 3.5 3.5
[79]
HepG2 EGFR
Mean 7.53
Standard deviation 0.89
Values 6.9 8.2
[80]
HepG2.C3A EGFR
Mean 5.18
Standard deviation 0.67
Values 5.7 4.7
[81]
HuH.7 EGFR
Mean 36.6
Standard deviation 25
Values 32 63 15
[82]
SNU475 EGFR
Mean 13.7
Standard deviation 0.74
Values 13 14
[83]
THLE EGFR
Mean 23.6
Standard deviation 4.4
Values 20 27
[84]
liver EGFR
Mean 49.4
Standard deviation 14
Values 39 69 47 42
[85]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[86]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[87]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[88]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[89]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[90]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[91]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[92]
ref_hepatocyte NRP1
Mean 3.57
Standard deviation 2.4
Values 1.1 3.2 2.9 7.6 3
[93]
HepG2 NRP1
Mean 22.9
Standard deviation 1.8
Values 24 22
[94]
HepG2.C3A NRP1
Mean 4.49
Standard deviation 0.63
Values 4.9 4
[95]
HuH.7 NRP1
Mean 65.7
Standard deviation 11
Values 70 74 53
[96]
SNU475 NRP1
Mean 101
Standard deviation 18
Values 88 1.1e+02
[97]
THLE NRP1
Mean 78.4
Standard deviation 14
Values 68 89
[98]
liver NRP1
Mean 46.9
Standard deviation 15
Values 26 61 47 53
[99]
ref_hepatocyte PAK1
Mean 2.3
Standard deviation 0.59
Values 1.7 3 2.9 2.1 1.9
[100]
HepG2 PAK1
Mean 5.05
Standard deviation 1.5
Values 6.1 4
[101]
HepG2.C3A PAK1
Mean 2.65
Standard deviation 0.51
Values 3 2.3
[102]
HuH.7 PAK1
Mean 13.5
Standard deviation 2.2
Values 12 16 12
[103]
SNU475 PAK1
Mean 1.17
Standard deviation 0.24
Values 1 1.3
[104]
THLE PAK1
Mean 18
Standard deviation 0.72
Values 18 17
[105]
liver PAK1
Mean 3.94
Standard deviation 1.1
Values 5.3 4 3.9 2.6
[106]
ref_hepatocyte ITGB3
Mean 1.08
Standard deviation 1.3
Values 0 2.5 2.6 0.15 0.24
[107]
HepG2 ITGB3
Mean 0.771
Standard deviation 0.028
Values 0.79 0.75
[108]
HepG2.C3A ITGB3
Mean 0.105
Standard deviation 0.058
Values 0.15 0.064
[109]
HuH.7 ITGB3
Mean 1.16
Standard deviation 0.088
Values 1.2 1.2 1.1
[110]
SNU475 ITGB3
Mean 14.3
Standard deviation 13
Values 5.4 23
[111]
THLE ITGB3
Mean 12.8
Standard deviation 1.3
Values 14 12
[112]
liver ITGB3
Mean 3.86
Standard deviation 3.6
Values 0.66 8.8 1.7 4.2
[113]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[114]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[115]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[116]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[117]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[118]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[119]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[120]
ref_hepatocyte L1CAM
Mean 0.225
Standard deviation 0.42
Values 0.96 0 0.16 0 0
[121]
HepG2 L1CAM
Mean 28.6
Standard deviation 14
Values 38 19
[122]
HepG2.C3A L1CAM
Mean 7.31
Standard deviation 4.5
Values 11 4.1
[123]
HuH.7 L1CAM
Mean 0.0318
Standard deviation 0.019
Values 0.041 0.045 0.0094
[124]
SNU475 L1CAM
Mean 23.1
Standard deviation 10
Values 30 16
[125]
THLE L1CAM
Mean 0.442
Standard deviation 0.053
Values 0.48 0.4
[126]
liver L1CAM
Mean 0.2
Standard deviation 0.1
Values 0.12 0.16 0.18 0.34
[127]
ref_hepatocyte ITGA9
Mean 0.0808
Standard deviation 0.082
Values 0 0 0.079 0.15 0.18
[128]
HepG2 ITGA9
Mean 0.0272
Standard deviation 0.026
Values 0.046 0.0086
[129]
HepG2.C3A ITGA9
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[130]
HuH.7 ITGA9
Mean 0.137
Standard deviation 0.026
Values 0.12 0.17 0.12
[131]
SNU475 ITGA9
Mean 0.0559
Standard deviation 0.0069
Values 0.051 0.061
[132]
THLE ITGA9
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[133]
liver ITGA9
Mean 16.7
Standard deviation 17
Values 1.6 33 2.4 30
[134]
ref_hepatocyte NCAM1
Mean 0.0451
Standard deviation 0.048
Values 0 0 0.06 0.052 0.11
[135]
HepG2 NCAM1
Mean 0.294
Standard deviation 0.39
Values 0.57 0.021
[136]
HepG2.C3A NCAM1
Mean 0.0151
Standard deviation 0.0062
Values 0.019 0.011
[137]
HuH.7 NCAM1
Mean 0.00975
Standard deviation 0.0086
Values 0.016 0.013 0
[138]
SNU475 NCAM1
Mean 2.7
Standard deviation 2.9
Values 0.67 4.7
[139]
THLE NCAM1
Mean 6.19
Standard deviation 1.8
Values 7.5 4.9
[140]
liver NCAM1
Mean 1.56
Standard deviation 0.31
Values 1.4 1.8 1.8 1.2
[141]
ref_hepatocyte ITGA2B
Mean 0.0356
Standard deviation 0.034
Values 0 0.07 0 0.043 0.065
[142]
HepG2 ITGA2B
Mean 0.956
Standard deviation 1
Values 1.7 0.23
[143]
HepG2.C3A ITGA2B
Mean 1.04
Standard deviation 0.35
Values 1.3 0.79
[144]
HuH.7 ITGA2B
Mean 0.994
Standard deviation 0.15
Values 0.93 0.89 1.2
[145]
SNU475 ITGA2B
Mean 0.53
Standard deviation 0.0044
Values 0.53 0.53
[146]
THLE ITGA2B
Mean 0.191
Standard deviation 0.09
Values 0.25 0.13
[147]
liver ITGA2B
Mean 0.311
Standard deviation 0.17
Values 0.38 0.29 0.49 0.093