REACTOME_SIGNAL_REGULATORY_PROTEIN_FAMILY_INTERACTIONS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [1] -0.20[2] 0.17[3] 0.05[4] 0.11[5] 0.63[6] 0.51[7]
2 GRB2 Growth factor receptor-bound protein 2 [8] 0.55[9] 0.33[10] 0.37[11] -0.22[12] -0.42[13] -0.45[14]
3 TYROBP TYRO protein tyrosine kinase-binding protein [15] -10.60[16] [17] [18] -9.83[19] [20] -2.41[21]
4 PTK2 Focal adhesion kinase 1 [22] 0.09[23] 0.52[24] 0.82[25] 1.17[26] 0.26[27] 0.02[28]
5 SIRPA Tyrosine-protein phosphatase non-receptor type substrate 1 [29] -2.64[30] -6.02[31] -0.86[32] -3.25[33] 0.15[34] 0.88[35]
6 PTPN6 Tyrosine-protein phosphatase non-receptor type 6 [36] -1.11[37] -0.98[38] -0.47[39] -7.92[40] -3.01[41] -0.92[42]
7 SKAP2 Src kinase-associated phosphoprotein 2 [43] 0.62[44] -0.09[45] 0.33[46] -0.60[47] 0.48[48] -0.40[49]
8 SRC Proto-oncogene tyrosine-protein kinase Src [50] 2.38[51] 2.30[52] 1.23[53] 1.62[54] 0.69[55] -1.60[56]
9 CD47 Leukocyte surface antigen CD47 [57] -1.47[58] -7.65[59] -4.87[60] 1.87[61] 1.08[62] 1.17[63]
10 PTK2B Protein-tyrosine kinase 2-beta [64] -1.45[65] -0.16[66] 0.73[67] -2.56[68] -0.04[69] 1.03[70]
11 SIRPB1 Signal-regulatory protein beta-1 [71] -3.71[72] -6.68[73] -1.78[74] -2.63[75] -3.27[76] -0.77[77]
12 SFTPD Pulmonary surfactant-associated protein D [78] -7.53[79] [80] [81] -5.06[82] -4.80[83] -1.41[84]
13 SIRPG Signal-regulatory protein gamma [85] [86] [87] -5.11[88] -6.37[89] -3.77[90] -0.09[91]
14 SFTPA1 Pulmonary surfactant-associated protein A1 [92] [93] [94] [95] [96] [97] [98]
15 SFTPA2 Pulmonary surfactant-associated protein A2 [99] [100] [101] [102] [103] [104] [105]
16 FYB1 FYN-binding protein 1 [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[2]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[3]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[4]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[5]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[6]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[7]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[8]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[9]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[10]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[11]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[12]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[13]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[14]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[15]
ref_hepatocyte TYROBP
Mean 12.2
Standard deviation 13
Values 0 1.1 17 12 31
[16]
HepG2 TYROBP
Mean 0.0272
Standard deviation 0.026
Values 0.046 0.0086
[17]
HepG2.C3A TYROBP
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 TYROBP
Mean 0
Standard deviation 0
Values 0 0 0
[19]
SNU475 TYROBP
Mean 0.0422
Standard deviation 0.045
Values 0.074 0.01
[20]
THLE TYROBP
Mean 0
Standard deviation 0
Values 0 0
[21]
liver TYROBP
Mean 5.48
Standard deviation 5
Values 9.3 1 10 1.4
[22]
ref_hepatocyte PTK2
Mean 8.92
Standard deviation 4.8
Values 15 11 11 4.1 3.9
[23]
HepG2 PTK2
Mean 32.8
Standard deviation 5.2
Values 29 36
[24]
HepG2.C3A PTK2
Mean 40.9
Standard deviation 2.3
Values 43 39
[25]
HuH.7 PTK2
Mean 51.1
Standard deviation 2.8
Values 53 52 48
[26]
SNU475 PTK2
Mean 63.1
Standard deviation 3.5
Values 66 61
[27]
THLE PTK2
Mean 40.6
Standard deviation 3.7
Values 38 43
[28]
liver PTK2
Mean 21.5
Standard deviation 4.9
Values 19 27 16 24
[29]
ref_hepatocyte SIRPA
Mean 6.97
Standard deviation 4.2
Values 2.2 3.6 6.8 12 10
[30]
HepG2 SIRPA
Mean 3.87
Standard deviation 0.26
Values 3.7 4.1
[31]
HepG2.C3A SIRPA
Mean 0.344
Standard deviation 0.092
Values 0.41 0.28
[32]
HuH.7 SIRPA
Mean 12.4
Standard deviation 3.7
Values 14 8.2 15
[33]
SNU475 SIRPA
Mean 2.3
Standard deviation 0.71
Values 1.8 2.8
[34]
THLE SIRPA
Mean 29.5
Standard deviation 5.9
Values 25 34
[35]
liver SIRPA
Mean 30.5
Standard deviation 17
Values 29 18 55 21
[36]
ref_hepatocyte PTPN6
Mean 5.33
Standard deviation 3
Values 2.2 3.1 4.4 7.6 9.3
[37]
HepG2 PTPN6
Mean 8.54
Standard deviation 0.054
Values 8.5 8.6
[38]
HepG2.C3A PTPN6
Mean 8.69
Standard deviation 0.18
Values 8.6 8.8
[39]
HuH.7 PTPN6
Mean 12.4
Standard deviation 1.9
Values 13 10 14
[40]
SNU475 PTPN6
Mean 0.0694
Standard deviation 0.026
Values 0.088 0.051
[41]
THLE PTPN6
Mean 2.52
Standard deviation 0.67
Values 2 3
[42]
liver PTPN6
Mean 6.69
Standard deviation 2
Values 7.5 4.8 9.1 5.4
[43]
ref_hepatocyte SKAP2
Mean 4.11
Standard deviation 5.4
Values 14 2.7 1 1.4 1.6
[44]
HepG2 SKAP2
Mean 21.8
Standard deviation 5.5
Values 18 26
[45]
HepG2.C3A SKAP2
Mean 12.4
Standard deviation 2.9
Values 10 14
[46]
HuH.7 SKAP2
Mean 16.7
Standard deviation 1
Values 17 17 16
[47]
SNU475 SKAP2
Mean 8.55
Standard deviation 1.2
Values 9.4 7.7
[48]
THLE SKAP2
Mean 21.8
Standard deviation 1.5
Values 23 21
[49]
liver SKAP2
Mean 7.42
Standard deviation 4.4
Values 7.5 6.1 13 2.8
[50]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[51]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[52]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[53]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[54]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[55]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[56]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[57]
ref_hepatocyte CD47
Mean 3.6
Standard deviation 2.5
Values 0.57 6.2 1.4 5.2 4.5
[58]
HepG2 CD47
Mean 4.48
Standard deviation 0.23
Values 4.6 4.3
[59]
HepG2.C3A CD47
Mean 0.0575
Standard deviation 0.04
Values 0.029 0.086
[60]
HuH.7 CD47
Mean 0.4
Standard deviation 0.066
Values 0.39 0.47 0.34
[61]
SNU475 CD47
Mean 41.4
Standard deviation 18
Values 54 28
[62]
THLE CD47
Mean 28.9
Standard deviation 0.63
Values 28 29
[63]
liver CD47
Mean 19.3
Standard deviation 7.4
Values 23 16 28 11
[64]
ref_hepatocyte PTK2B
Mean 1.68
Standard deviation 1.2
Values 0.39 0.56 2.1 2.2 3.2
[65]
HepG2 PTK2B
Mean 2.13
Standard deviation 0.072
Values 2.2 2.1
[66]
HepG2.C3A PTK2B
Mean 4.85
Standard deviation 0.49
Values 5.2 4.5
[67]
HuH.7 PTK2B
Mean 9.07
Standard deviation 0.34
Values 9.5 8.9 8.8
[68]
SNU475 PTK2B
Mean 0.901
Standard deviation 0.46
Values 1.2 0.57
[69]
THLE PTK2B
Mean 6.23
Standard deviation 0.98
Values 6.9 5.5
[70]
liver PTK2B
Mean 8.17
Standard deviation 0.99
Values 8.5 7.3 7.4 9.4
[71]
ref_hepatocyte SIRPB1
Mean 0.327
Standard deviation 0.37
Values 0 0 0.46 0.29 0.89
[72]
HepG2 SIRPB1
Mean 0.0866
Standard deviation 0.017
Values 0.074 0.099
[73]
HepG2.C3A SIRPB1
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[74]
HuH.7 SIRPB1
Mean 0.31
Standard deviation 0.071
Values 0.39 0.24 0.3
[75]
SNU475 SIRPB1
Mean 0.166
Standard deviation 0.13
Values 0.074 0.26
[76]
THLE SIRPB1
Mean 0.129
Standard deviation 0.0097
Values 0.14 0.12
[77]
liver SIRPB1
Mean 0.458
Standard deviation 0.28
Values 0.26 0.2 0.57 0.81
[78]
ref_hepatocyte SFTPD
Mean 0.23
Standard deviation 0.35
Values 0 0 0 0.78 0.37
[79]
HepG2 SFTPD
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[80]
HepG2.C3A SFTPD
Mean 0
Standard deviation 0
Values 0 0
[81]
HuH.7 SFTPD
Mean 0
Standard deviation 0
Values 0 0 0
[82]
SNU475 SFTPD
Mean 0.0217
Standard deviation 0.0021
Values 0.023 0.02
[83]
THLE SFTPD
Mean 0.0313
Standard deviation 0.014
Values 0.041 0.021
[84]
liver SFTPD
Mean 0.206
Standard deviation 0.19
Values 0.16 0.16 0.026 0.48
[85]
ref_hepatocyte SIRPG
Mean 0.0667
Standard deviation 0.15
Values 0 0 0 0 0.33
[86]
HepG2 SIRPG
Mean 0
Standard deviation 0
Values 0 0
[87]
HepG2.C3A SIRPG
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 SIRPG
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[89]
SNU475 SIRPG
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[90]
THLE SIRPG
Mean 0.0186
Standard deviation 0.026
Values 0 0.037
[91]
liver SIRPG
Mean 0.149
Standard deviation 0.11
Values 0.28 0.029 0.18 0.11
[92]
ref_hepatocyte SFTPA1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 SFTPA1
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 SFTPA1
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[97]
THLE SFTPA1
Mean 0
Standard deviation 0
Values 0 0
[98]
liver SFTPA1
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[99]
ref_hepatocyte SFTPA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[100]
HepG2 SFTPA2
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[101]
HepG2.C3A SFTPA2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[102]
HuH.7 SFTPA2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[103]
SNU475 SFTPA2
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[104]
THLE SFTPA2
Mean 0
Standard deviation 0
Values 0 0
[105]
liver SFTPA2
Mean 0
Standard deviation 0
Values 0 0 0 0
[106]
ref_hepatocyte FYB1
Missing
[107]
HepG2 FYB1
Missing
[108]
HepG2.C3A FYB1
Missing
[109]
HuH.7 FYB1
Missing
[110]
SNU475 FYB1
Missing
[111]
THLE FYB1
Missing
[112]
liver FYB1
Missing