REACTOME_SIGNAL_ATTENUATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GRB2 Growth factor receptor-bound protein 2 [1] -0.12[2] -0.27[3] -0.46[4] -0.95[5] -0.87[6] -1.37[7]
2 SHC1 SHC-transforming protein 1 [8] -0.15[9] 0.08[10] -0.16[11] 1.15[12] 0.80[13] -0.89[14]
3 MAPK1 Mitogen-activated protein kinase 1 [15] 0.39[16] 0.54[17] 0.06[18] 0.34[19] 0.16[20] 0.11[21]
4 SOS1 Son of sevenless homolog 1 [22] -1.42[23] 0.13[24] -0.68[25] -0.66[26] -1.26[27] -1.13[28]
5 INSR Insulin receptor [29] -0.86[30] -0.19[31] 0.93[32] -4.59[33] -1.82[34] 2.34[35]
6 MAPK3 Mitogen-activated protein kinase 3 [36] 0.53[37] 0.59[38] 0.32[39] -1.08[40] -0.89[41] -2.70[42]
7 GRB10 Growth factor receptor-bound protein 10 [43] 1.19[44] -1.88[45] 0.19[46] -0.82[47] 0.22[48] 0.28[49]
8 IRS1 Insulin receptor substrate 1 [50] 0.78[51] 0.23[52] 1.35[53] 0.20[54] -0.05[55] 0.45[56]
9 IRS2 Insulin receptor substrate 2 [57] -6.97[58] [59] -4.41[60] -2.17[61] 1.82[62] 0.72[63]
10 INS Insulin [64] [65] [66] [67] [68] [69] [70]
[1]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[2]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[3]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[4]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[5]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[6]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[7]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[15]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 14 13 13 6.1 7.4
[16]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 62 93
[17]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 71 81
[18]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 73 60 61
[19]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 77 65
[20]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[21]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 39 68 41 61
[22]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[23]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[24]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[25]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[26]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[27]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[28]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[29]
ref_hepatocyte INSR
Mean 5.73
Standard deviation 1.4
Values 6.5 5 4.1 5.3 7.7
[30]
HepG2 INSR
Mean 17.4
Standard deviation 4.9
Values 21 14
[31]
HepG2.C3A INSR
Mean 24.3
Standard deviation 6.7
Values 29 20
[32]
HuH.7 INSR
Mean 62.9
Standard deviation 26
Values 58 91 39
[33]
SNU475 INSR
Mean 1.24
Standard deviation 0.29
Values 1.4 1
[34]
THLE INSR
Mean 8.45
Standard deviation 0.32
Values 8.2 8.7
[35]
liver INSR
Mean 131
Standard deviation 15
Values 1.4e+02 1.5e+02 1.1e+02 1.3e+02
[36]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 5.1 2.8 3.6 6 3.3
[37]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 37 29
[38]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 39 22
[39]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 34 25 32
[40]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 12 8.5
[41]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[42]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 5 0.81 4.8 0.82
[43]
ref_hepatocyte GRB10
Mean 3.75
Standard deviation 1.1
Values 2 3.4 4.9 4.1 4.3
[44]
HepG2 GRB10
Mean 47
Standard deviation 17
Values 59 35
[45]
HepG2.C3A GRB10
Mean 4.96
Standard deviation 0.92
Values 5.6 4.3
[46]
HuH.7 GRB10
Mean 24.7
Standard deviation 7
Values 22 33 19
[47]
SNU475 GRB10
Mean 11.1
Standard deviation 1.2
Values 12 10
[48]
THLE GRB10
Mean 22.6
Standard deviation 0.57
Values 22 23
[49]
liver GRB10
Mean 20.5
Standard deviation 8.3
Values 22 21 9.1 29
[50]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[51]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[52]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[53]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[54]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[55]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[56]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[57]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[58]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[59]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[61]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[62]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[63]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[64]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[65]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[66]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[69]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[70]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0 0.057 0 0.28