REACTOME_SIGNALLING_TO_RAS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RALB Ras-related protein Ral-B [1] -1.83[2] -1.97[3] -2.60[4] -2.12[5] -2.14[6] -1.74[7]
2 RALA Ras-related protein Ral-A [8] -1.79[9] -1.16[10] -0.78[11] -1.36[12] -0.76[13] -1.49[14]
3 GRB2 Growth factor receptor-bound protein 2 [15] 0.60[16] 0.32[17] 0.64[18] -0.23[19] -0.01[20] 0.55[21]
4 SHC1 SHC-transforming protein 1 [22] 0.57[23] 0.67[24] 0.95[25] 1.86[26] 1.66[27] 1.03[28]
5 NRAS GTPase NRas [29] 0.03[30] 0.34[31] 0.96[32] 0.21[33] 0.09[34] 0.00[35]
6 MAPKAPK2 MAP kinase-activated protein kinase 2 [36] -0.14[37] -1.22[38] -0.60[39] 0.61[40] 0.13[41] -0.69[42]
7 HRAS GTPase HRas [43] -1.61[44] -2.43[45] -3.02[46] -1.74[47] -1.64[48] -2.41[49]
8 SHC2 SHC-transforming protein 2 [50] -1.98[51] -1.75[52] -2.38[53] -5.45[54] -4.77[55] -0.13[56]
9 KRAS GTPase KRas [57] -1.11[58] -1.25[59] 0.55[60] 0.01[61] -0.02[62] 0.92[63]
10 MAPK14 Mitogen-activated protein kinase 14 [64] 0.87[65] 0.83[66] 0.61[67] 0.90[68] 0.68[69] 1.53[70]
11 MAPKAPK3 MAP kinase-activated protein kinase 3 [71] 0.41[72] 0.24[73] -0.46[74] -2.27[75] -0.24[76] 0.01[77]
12 SOS1 Son of sevenless homolog 1 [78] -0.70[79] 0.71[80] 0.43[81] 0.06[82] -0.40[83] 0.79[84]
13 MAPK13 Mitogen-activated protein kinase 13 [85] 1.74[86] 2.03[87] -0.44[88] -2.67[89] -0.84[90] -1.47[91]
14 SRC Proto-oncogene tyrosine-protein kinase Src [92] 2.42[93] 2.29[94] 1.50[95] 1.61[96] 1.10[97] -0.60[98]
15 RALGDS Ral guanine nucleotide dissociation stimulator [99] 2.45[100] 1.98[101] 0.98[102] 1.99[103] 1.87[104] 1.52[105]
16 MAPK12 Mitogen-activated protein kinase 12 [106] 2.22[107] 1.77[108] 3.08[109] 0.70[110] 2.26[111] -0.66[112]
17 MAPK11 Mitogen-activated protein kinase 11 [113] -0.77[114] -0.99[115] -1.67[116] -0.43[117] 1.87[118] 0.41[119]
18 SHC3 SHC-transforming protein 3 [120] 1.51[121] 3.77[122] -3.51[123] 2.67[124] 6.89[125] 2.07[126]
19 NTRK1 High affinity nerve growth factor receptor [127] [128] [129] [130] [131] [132] [133]
20 NGF Beta-nerve growth factor [134] [135] [136] [137] [138] [139] [140]
[1]
ref_hepatocyte RALB
Mean 35
Standard deviation 33
Values 76 66 17 10 6.2
[2]
HepG2 RALB
Mean 33
Standard deviation 2.3
Values 31 35
[3]
HepG2.C3A RALB
Mean 28.9
Standard deviation 1.5
Values 28 30
[4]
HuH.7 RALB
Mean 15.6
Standard deviation 3.6
Values 18 11 18
[5]
SNU475 RALB
Mean 25.5
Standard deviation 1.8
Values 27 24
[6]
THLE RALB
Mean 22.8
Standard deviation 4.3
Values 20 26
[7]
liver RALB
Mean 12.6
Standard deviation 5.4
Values 11 11 20 7.5
[8]
ref_hepatocyte RALA
Mean 21.2
Standard deviation 18
Values 26 49 21 5.5 5.1
[9]
HepG2 RALA
Mean 20.5
Standard deviation 1.4
Values 19 21
[10]
HepG2.C3A RALA
Mean 30.5
Standard deviation 1.2
Values 31 30
[11]
HuH.7 RALA
Mean 33.1
Standard deviation 1.5
Values 35 32 33
[12]
SNU475 RALA
Mean 26.1
Standard deviation 0.25
Values 26 26
[13]
THLE RALA
Mean 35.8
Standard deviation 8.4
Values 30 42
[14]
liver RALA
Mean 9.04
Standard deviation 6.3
Values 15 3.6 14 3.5
[15]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[16]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[17]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[18]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[19]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[20]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[21]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[22]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[23]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[24]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[25]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[26]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[27]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[28]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[29]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[30]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[31]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[32]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[33]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[34]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[35]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[36]
ref_hepatocyte MAPKAPK2
Mean 13.1
Standard deviation 7.6
Values 5.2 10 24 17 8.7
[37]
HepG2 MAPKAPK2
Mean 39.7
Standard deviation 1.4
Values 41 39
[38]
HepG2.C3A MAPKAPK2
Mean 18.1
Standard deviation 4.5
Values 21 15
[39]
HuH.7 MAPKAPK2
Mean 23.2
Standard deviation 2.9
Values 25 20 25
[40]
SNU475 MAPKAPK2
Mean 63.2
Standard deviation 4
Values 66 60
[41]
THLE MAPKAPK2
Mean 40.9
Standard deviation 0.33
Values 41 41
[42]
liver MAPKAPK2
Mean 9.67
Standard deviation 2.5
Values 10 11 6 11
[43]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[44]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[45]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[46]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[47]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[48]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[49]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[50]
ref_hepatocyte SHC2
Mean 10.3
Standard deviation 9.4
Values 4.4 2.6 3.4 20 21
[51]
HepG2 SHC2
Mean 8.74
Standard deviation 3.1
Values 11 6.5
[52]
HepG2.C3A SHC2
Mean 9.94
Standard deviation 7.2
Values 15 4.9
[53]
HuH.7 SHC2
Mean 5.31
Standard deviation 2.7
Values 3.7 8.5 3.7
[54]
SNU475 SHC2
Mean 0.746
Standard deviation 0.53
Values 1.1 0.37
[55]
THLE SHC2
Mean 1.08
Standard deviation 0.64
Values 1.5 0.63
[56]
liver SHC2
Mean 11.3
Standard deviation 2.7
Values 13 12 7.3 13
[57]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[58]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[59]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[60]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[61]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[62]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[63]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[64]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 12 8.5 7.2 7.5 8.3
[65]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 47 60
[66]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[67]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 37 36 34
[68]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 52 51
[69]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[70]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 24 38 22 37
[71]
ref_hepatocyte MAPKAPK3
Mean 8.03
Standard deviation 3.9
Values 5.9 12 13 4.9 4.9
[72]
HepG2 MAPKAPK3
Mean 35.8
Standard deviation 0.92
Values 36 35
[73]
HepG2.C3A MAPKAPK3
Mean 30.6
Standard deviation 0.36
Values 30 31
[74]
HuH.7 MAPKAPK3
Mean 15.7
Standard deviation 2.2
Values 17 13 16
[75]
SNU475 MAPKAPK3
Mean 5.29
Standard deviation 0.058
Values 5.2 5.3
[76]
THLE MAPKAPK3
Mean 19.5
Standard deviation 4.7
Values 16 23
[77]
liver MAPKAPK3
Mean 9.68
Standard deviation 1.8
Values 12 7.4 10 9.3
[78]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[79]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[80]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[81]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[82]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[83]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[84]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[85]
ref_hepatocyte MAPK13
Mean 5.46
Standard deviation 4.5
Values 11 4 9.1 2.7 0.39
[86]
HepG2 MAPK13
Mean 61.1
Standard deviation 22
Values 77 46
[87]
HepG2.C3A MAPK13
Mean 72
Standard deviation 5.6
Values 76 68
[88]
HuH.7 MAPK13
Mean 10.8
Standard deviation 1.6
Values 11 12 9.2
[89]
SNU475 MAPK13
Mean 2.71
Standard deviation 2.1
Values 1.2 4.2
[90]
THLE MAPK13
Mean 8.71
Standard deviation 2.1
Values 7.2 10
[91]
liver MAPK13
Mean 2.36
Standard deviation 1.5
Values 4.6 1.5 1.5 1.8
[92]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 9.6 4.7 2.2 0.77 1.2
[93]
HepG2 SRC
Mean 66
Standard deviation 21
Values 81 51
[94]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 71 45
[95]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 28 29 26
[96]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 38 33
[97]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[98]
liver SRC
Mean 2.9
Standard deviation 1
Values 4.1 2.5 1.7 3.2
[99]
ref_hepatocyte RALGDS
Mean 0.924
Standard deviation 0.46
Values 1.4 0.32 0.71 1.4 0.81
[100]
HepG2 RALGDS
Mean 16.9
Standard deviation 1.1
Values 18 16
[101]
HepG2.C3A RALGDS
Mean 11.8
Standard deviation 2.6
Values 14 9.9
[102]
HuH.7 RALGDS
Mean 4.9
Standard deviation 0.56
Values 4.4 5.5 4.8
[103]
SNU475 RALGDS
Mean 11.7
Standard deviation 5.2
Values 15 8
[104]
THLE RALGDS
Mean 9.68
Standard deviation 0.73
Values 9.2 10
[105]
liver RALGDS
Mean 3.17
Standard deviation 1.7
Values 1.7 3.6 2.1 5.3
[106]
ref_hepatocyte MAPK12
Mean 0.743
Standard deviation 0.94
Values 2.4 0.4 0.21 0.41 0.28
[107]
HepG2 MAPK12
Mean 11.6
Standard deviation 3.6
Values 14 9
[108]
HepG2.C3A MAPK12
Mean 8.16
Standard deviation 0.15
Values 8.1 8.3
[109]
HuH.7 MAPK12
Mean 16.9
Standard deviation 6.7
Values 18 9.7 23
[110]
SNU475 MAPK12
Mean 3.82
Standard deviation 1.9
Values 5.2 2.5
[111]
THLE MAPK12
Mean 10.2
Standard deviation 1.3
Values 9.2 11
[112]
liver MAPK12
Mean 0.564
Standard deviation 0.13
Values 0.47 0.43 0.67 0.69
[113]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0 0.34 0.22 0.71 0.64
[114]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.62 0.88
[115]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.53 0.71
[116]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.28 0.2 0.49
[117]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 1.1 0.66
[118]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[119]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.96 0.49 0.23 0.75
[120]
ref_hepatocyte SHC3
Mean 0.044
Standard deviation 0.057
Values 0.11 0 0.11 0 0.0081
[121]
HepG2 SHC3
Mean 0.419
Standard deviation 0.22
Values 0.26 0.57
[122]
HepG2.C3A SHC3
Mean 1.94
Standard deviation 0.52
Values 1.6 2.3
[123]
HuH.7 SHC3
Mean 0.0103
Standard deviation 0.013
Values 0.025 0.0064 0
[124]
SNU475 SHC3
Mean 0.888
Standard deviation 0.83
Values 0.3 1.5
[125]
THLE SHC3
Mean 14.9
Standard deviation 3.1
Values 13 17
[126]
liver SHC3
Mean 0.22
Standard deviation 0.069
Values 0.12 0.24 0.26 0.26
[127]
ref_hepatocyte NTRK1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 NTRK1
Mean 0.0172
Standard deviation 0.024
Values 0.034 0
[129]
HepG2.C3A NTRK1
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 NTRK1
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 NTRK1
Mean 0.439
Standard deviation 0.25
Values 0.26 0.62
[132]
THLE NTRK1
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[133]
liver NTRK1
Mean 0.0711
Standard deviation 0.026
Values 0.071 0.071 0.1 0.04
[134]
ref_hepatocyte NGF
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 NGF
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A NGF
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 NGF
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 NGF
Mean 1.32
Standard deviation 0.58
Values 0.91 1.7
[139]
THLE NGF
Mean 0.258
Standard deviation 0.011
Values 0.27 0.25
[140]
liver NGF
Mean 0.426
Standard deviation 0.42
Values 1 0.071 0.46 0.16