REACTOME_SIGNALLING_TO_ERKS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAB | 14-3-3 protein beta/alpha | [1] | 0.41[2] | 0.09[3] | -0.56[4] | 0.49[5] | 0.22[6] | -0.17[7] |
2 | RALB | Ras-related protein Ral-B | [8] | -1.86[9] | -1.91[10] | -2.67[11] | -2.15[12] | -2.17[13] | -2.06[14] |
3 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [15] | -1.56[16] | -1.92[17] | -1.26[18] | -1.35[19] | -0.55[20] | -1.27[21] |
4 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [22] | -0.58[23] | -0.93[24] | 0.02[25] | -1.65[26] | -0.87[27] | -1.78[28] |
5 | RALA | Ras-related protein Ral-A | [29] | -1.82[30] | -1.11[31] | -0.86[32] | -1.38[33] | -0.80[34] | -1.81[35] |
6 | GRB2 | Growth factor receptor-bound protein 2 | [36] | 0.57[37] | 0.37[38] | 0.57[39] | -0.26[40] | -0.04[41] | 0.22[42] |
7 | CRK | Adapter molecule crk | [43] | -0.83[44] | -0.93[45] | -0.79[46] | -1.05[47] | -0.35[48] | 0.77[49] |
8 | RAP1A | Ras-related protein Rap-1A | [50] | -1.68[51] | -1.77[52] | -0.86[53] | -1.03[54] | -0.97[55] | -1.37[56] |
9 | SHC1 | SHC-transforming protein 1 | [57] | 0.53[58] | 0.72[59] | 0.87[60] | 1.84[61] | 1.62[62] | 0.70[63] |
10 | NRAS | GTPase NRas | [64] | 0.00[65] | 0.40[66] | 0.89[67] | 0.19[68] | 0.06[69] | -0.33[70] |
11 | MAPKAPK | MAP kinase-activated protein kinase 2 | [71] | -0.17[72] | -1.16[73] | -0.68[74] | 0.59[75] | 0.09[76] | -1.02[77] |
12 | HRAS | GTPase HRas | [78] | -1.64[79] | -2.37[80] | -3.09[81] | -1.76[82] | -1.68[83] | -2.74[84] |
13 | MAPK1 | Mitogen-activated protein kinase 1 | [85] | 1.08[86] | 1.19[87] | 1.09[88] | 1.04[89] | 0.99[90] | 1.70[91] |
14 | SHC2 | SHC-transforming protein 2 | [92] | -2.01[93] | -1.69[94] | -2.46[95] | -5.48[96] | -4.81[97] | -0.45[98] |
15 | KRAS | GTPase KRas | [99] | -1.15[100] | -1.19[101] | 0.48[102] | -0.01[103] | -0.05[104] | 0.60[105] |
16 | MAPK14 | Mitogen-activated protein kinase 14 | [106] | 0.84[107] | 0.89[108] | 0.53[109] | 0.87[110] | 0.64[111] | 1.21[112] |
17 | MAPKAPK | MAP kinase-activated protein kinase 3 | [113] | 0.38[114] | 0.30[115] | -0.54[116] | -2.29[117] | -0.27[118] | -0.31[119] |
18 | CRKL | Crk-like protein | [120] | 1.07[121] | 1.14[122] | 1.82[123] | 0.31[124] | 0.81[125] | 1.38[126] |
19 | SOS1 | Son of sevenless homolog 1 | [127] | -0.73[128] | 0.77[129] | 0.35[130] | 0.03[131] | -0.43[132] | 0.46[133] |
20 | MAPK13 | Mitogen-activated protein kinase 13 | [134] | 1.71[135] | 2.09[136] | -0.52[137] | -2.70[138] | -0.88[139] | -1.79[140] |
21 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [141] | 1.46[142] | 1.26[143] | 1.05[144] | 0.45[145] | 0.41[146] | 1.10[147] |
22 | MAPK3 | Mitogen-activated protein kinase 3 | [148] | 1.22[149] | 1.24[150] | 1.35[151] | -0.39[152] | -0.07[153] | -1.12[154] |
23 | SRC | Proto-oncogene tyrosine-protein kinase Src | [155] | 2.39[156] | 2.35[157] | 1.42[158] | 1.59[159] | 1.06[160] | -0.93[161] |
24 | KIDINS220 | Kinase D-interacting substrate of 220 kDa | [162] | 0.96[163] | 1.56[164] | 1.24[165] | 2.11[166] | 1.86[167] | 3.19[168] |
25 | RIT1 | GTP-binding protein Rit1 | [169] | -0.02[170] | 0.38[171] | 0.50[172] | 2.62[173] | 1.03[174] | 0.28[175] |
26 | FRS2 | Fibroblast growth factor receptor substrate 2 | [176] | 0.66[177] | 1.72[178] | 2.29[179] | 2.09[180] | 2.02[181] | 3.27[182] |
27 | BRAF | Serine/threonine-protein kinase B-raf | [183] | -0.38[184] | -0.68[185] | 1.42[186] | -0.07[187] | -0.08[188] | 1.78[189] |
28 | RALGDS | Ral guanine nucleotide dissociation stimulator | [190] | 2.42[191] | 2.04[192] | 0.90[193] | 1.97[194] | 1.84[195] | 1.20[196] |
29 | MAPK12 | Mitogen-activated protein kinase 12 | [197] | 2.19[198] | 1.82[199] | 3.01[200] | 0.67[201] | 2.22[202] | -0.98[203] |
30 | MAPK11 | Mitogen-activated protein kinase 11 | [204] | -0.80[205] | -0.93[206] | -1.75[207] | -0.46[208] | 1.84[209] | 0.09[210] |
31 | SHC3 | SHC-transforming protein 3 | [211] | 1.48[212] | 3.83[213] | -3.59[214] | 2.65[215] | 6.85[216] | 1.74[217] |
32 | RIT2 | GTP-binding protein Rit2 | [218] | [219] | [220] | [221] | [222] | -3.28[223] | -0.14[224] |
33 | NTRK1 | High affinity nerve growth factor receptor | [225] | [226] | [227] | [228] | [229] | [230] | [231] |
34 | NGF | Beta-nerve growth factor | [232] | [233] | [234] | [235] | [236] | [237] | [238] |