REACTOME_SIGNALING_BY_VEGF |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
ACTB |
Actin, cytoplasmic 1 |
[1] |
-1.06[2] |
-1.57[3] |
-0.85[4] |
-0.70[5] |
-0.91[6] |
-0.48[7] |
2 |
ACTG1 |
Actin, cytoplasmic 2 |
[8] |
0.22[9] |
-0.93[10] |
-0.74[11] |
-0.89[12] |
-0.33[13] |
-1.23[14] |
3 |
HSP90AA1 |
Heat shock protein HSP 90-alpha |
[15] |
-0.31[16] |
0.82[17] |
0.15[18] |
0.38[19] |
0.24[20] |
-0.56[21] |
4 |
HSPB1 |
Heat shock protein beta-1 |
[22] |
-3.16[23] |
-3.81[24] |
-2.96[25] |
-1.10[26] |
-3.10[27] |
-3.11[28] |
5 |
RHOA |
Transforming protein RhoA |
[29] |
-0.61[30] |
-0.94[31] |
-0.62[32] |
-0.93[33] |
-0.31[34] |
-0.63[35] |
6 |
CDC42 |
Cell division control protein 42 homolog |
[36] |
-0.50[37] |
0.39[38] |
-0.52[39] |
-0.24[40] |
-0.79[41] |
-1.38[42] |
7 |
BRK1 |
Protein BRICK1 |
[43] |
-1.05[44] |
-1.09[45] |
-0.42[46] |
-1.97[47] |
-0.86[48] |
-1.44[49] |
8 |
RAC1 |
Ras-related C3 botulinum toxin substrate 1 |
[50] |
-0.06[51] |
-0.22[52] |
0.58[53] |
0.31[54] |
0.46[55] |
-0.27[56] |
9 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[57] |
0.41[58] |
0.35[59] |
-0.63[60] |
0.24[61] |
0.43[62] |
0.45[63] |
10 |
CTNNB1 |
Catenin beta-1 |
[64] |
1.95[65] |
1.61[66] |
2.60[67] |
1.05[68] |
1.44[69] |
1.81[70] |
11 |
CTNNA1 |
Catenin alpha-1 |
[71] |
1.78[72] |
1.44[73] |
1.08[74] |
1.65[75] |
1.45[76] |
1.32[77] |
12 |
TRIB3 |
Tribbles homolog 3 |
[78] |
1.24[79] |
1.70[80] |
0.68[81] |
-1.72[82] |
-1.04[83] |
0.28[84] |
13 |
AAMP |
Angio-associated migratory cell protein |
[85] |
0.41[86] |
0.71[87] |
0.80[88] |
-0.62[89] |
-0.48[90] |
0.32[91] |
14 |
CALM1 |
Calmodulin-1 |
[92] |
0.41[93] |
0.61[94] |
1.17[95] |
1.88[96] |
1.32[97] |
2.32[98] |
15 |
CAV1 |
Caveolin-1 |
[99] |
-6.51[100] |
-9.16[101] |
-2.79[102] |
1.67[103] |
0.49[104] |
-1.30[105] |
16 |
AHCYL1 |
S-adenosylhomocysteine hydrolase-like protein 1 |
[106] |
0.57[107] |
0.83[108] |
1.50[109] |
1.31[110] |
1.34[111] |
1.00[112] |
17 |
CTNND1 |
Catenin delta-1 |
[113] |
-3.44[114] |
-3.79[115] |
-3.12[116] |
-3.80[117] |
-3.99[118] |
-3.05[119] |
18 |
JUP |
Junction plakoglobin |
[120] |
1.32[121] |
0.28[122] |
0.65[123] |
-0.26[124] |
-0.77[125] |
1.11[126] |
19 |
MAPKAP1 |
Target of rapamycin complex 2 subunit MAPKAP1 |
[127] |
0.32[128] |
0.24[129] |
0.56[130] |
0.37[131] |
0.73[132] |
0.52[133] |
20 |
CRK |
Adapter molecule crk |
[134] |
0.13[135] |
0.23[136] |
0.39[137] |
0.05[138] |
0.62[139] |
1.54[140] |
21 |
PRKACA |
cAMP-dependent protein kinase catalytic subunit alpha |
[141] |
0.17[142] |
0.16[143] |
0.26[144] |
-0.17[145] |
0.58[146] |
-0.08[147] |
22 |
ITGAV |
Integrin alpha-V |
[148] |
1.87[149] |
1.84[150] |
1.29[151] |
2.57[152] |
2.62[153] |
1.13[154] |
23 |
VEGFA |
Vascular endothelial growth factor A |
[155] |
1.55[156] |
3.05[157] |
1.75[158] |
0.73[159] |
1.61[160] |
1.48[161] |
24 |
CYBA |
Cytochrome b-245 light chain |
[162] |
1.82[163] |
2.03[164] |
1.03[165] |
0.51[166] |
0.57[167] |
-0.72[168] |
25 |
NRAS |
GTPase NRas |
[169] |
0.96[170] |
1.56[171] |
2.07[172] |
1.29[173] |
1.03[174] |
0.45[175] |
26 |
MAPKAPK2 |
MAP kinase-activated protein kinase 2 |
[176] |
0.79[177] |
0.00[178] |
0.51[179] |
1.69[180] |
1.07[181] |
-0.24[182] |
27 |
HRAS |
GTPase HRas |
[183] |
-0.68[184] |
-1.21[185] |
-1.91[186] |
-0.65[187] |
-0.70[188] |
-1.96[189] |
28 |
SPHK1 |
Sphingosine kinase 1 |
[190] |
1.90[191] |
2.77[192] |
0.38[193] |
-1.91[194] |
0.53[195] |
-4.30[196] |
29 |
ABI1 |
Abl interactor 1 |
[197] |
-0.45[198] |
0.68[199] |
0.85[200] |
0.99[201] |
0.21[202] |
0.59[203] |
30 |
NCF2 |
Neutrophil cytosol factor 2 |
[204] |
-1.48[205] |
-4.01[206] |
-7.68[207] |
-2.59[208] |
-9.04[209] |
-1.72[210] |
31 |
NCKAP1 |
Nck-associated protein 1 |
[211] |
1.49[212] |
2.67[213] |
2.86[214] |
3.09[215] |
2.92[216] |
2.06[217] |
32 |
NCK1 |
Cytoplasmic protein NCK1 |
[218] |
-1.26[219] |
-0.99[220] |
-0.79[221] |
-0.27[222] |
0.01[223] |
0.23[224] |
33 |
PAK2 |
Serine/threonine-protein kinase PAK 2 |
[225] |
1.78[226] |
1.69[227] |
2.09[228] |
1.05[229] |
1.76[230] |
2.06[231] |
34 |
CYFIP1 |
Cytoplasmic FMR1-interacting protein 1 |
[232] |
1.60[233] |
1.36[234] |
1.09[235] |
1.42[236] |
1.34[237] |
2.02[238] |
35 |
BCAR1 |
Breast cancer anti-estrogen resistance protein 1 |
[239] |
1.46[240] |
1.51[241] |
0.48[242] |
1.67[243] |
1.56[244] |
0.76[245] |
36 |
AKT2 |
RAC-beta serine/threonine-protein kinase |
[246] |
1.29[247] |
1.73[248] |
1.96[249] |
1.15[250] |
1.11[251] |
1.83[252] |
37 |
SHC2 |
SHC-transforming protein 2 |
[253] |
-1.05[254] |
-0.53[255] |
-1.28[256] |
-4.37[257] |
-3.83[258] |
0.32[259] |
38 |
MLST8 |
Target of rapamycin complex subunit LST8 |
[260] |
0.16[261] |
0.65[262] |
1.12[263] |
-0.68[264] |
-0.17[265] |
0.14[266] |
39 |
PXN |
Paxillin |
[267] |
1.33[268] |
1.22[269] |
1.35[270] |
2.41[271] |
2.54[272] |
0.35[273] |
40 |
KRAS |
GTPase KRas |
[274] |
-0.18[275] |
-0.04[276] |
1.66[277] |
1.10[278] |
0.92[279] |
1.37[280] |
41 |
PTK2 |
Focal adhesion kinase 1 |
[281] |
1.07[282] |
1.72[283] |
2.20[284] |
2.24[285] |
1.61[286] |
1.46[287] |
42 |
MAPK14 |
Mitogen-activated protein kinase 14 |
[288] |
1.80[289] |
2.04[290] |
1.72[291] |
1.98[292] |
1.62[293] |
1.98[294] |
43 |
VAV2 |
Guanine nucleotide exchange factor VAV2 |
[295] |
1.63[296] |
2.05[297] |
1.64[298] |
-0.24[299] |
0.35[300] |
1.21[301] |
44 |
BAIAP2 |
Brain-specific angiogenesis inhibitor 1-associated protein 2 |
[302] |
0.18[303] |
-0.28[304] |
-0.95[305] |
0.55[306] |
0.65[307] |
1.75[308] |
45 |
MAPKAPK3 |
MAP kinase-activated protein kinase 3 |
[309] |
1.34[310] |
1.45[311] |
0.65[312] |
-1.19[313] |
0.70[314] |
0.46[315] |
46 |
PRKCZ |
Protein kinase C zeta type |
[316] |
0.80[317] |
1.35[318] |
-0.55[319] |
-2.00[320] |
-4.04[321] |
-0.94[322] |
47 |
PIK3R1 |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
[323] |
-0.14[324] |
0.15[325] |
1.34[326] |
2.36[327] |
2.03[328] |
3.70[329] |
48 |
PRR5 |
Proline-rich protein 5 |
[330] |
-0.26[331] |
-0.03[332] |
-0.85[333] |
-1.99[334] |
-4.62[335] |
-0.08[336] |
49 |
ROCK1 |
Rho-associated protein kinase 1 |
[337] |
-0.62[338] |
1.07[339] |
1.94[340] |
1.66[341] |
1.17[342] |
2.28[343] |
50 |
WASF2 |
Wiskott-Aldrich syndrome protein family member 2 |
[344] |
2.34[345] |
1.75[346] |
2.86[347] |
3.23[348] |
2.69[349] |
2.26[350] |
51 |
ITPR2 |
Inositol 1,4,5-trisphosphate receptor type 2 |
[351] |
1.24[352] |
2.87[353] |
1.42[354] |
0.30[355] |
0.60[356] |
4.57[357] |
52 |
ELMO2 |
Engulfment and cell motility protein 2 |
[358] |
1.30[359] |
1.63[360] |
0.12[361] |
1.74[362] |
0.91[363] |
0.86[364] |
53 |
MAPK13 |
Mitogen-activated protein kinase 13 |
[365] |
2.67[366] |
3.24[367] |
0.66[368] |
-1.59[369] |
0.10[370] |
-1.02[371] |
54 |
PIK3R2 |
Phosphatidylinositol 3-kinase regulatory subunit beta |
[372] |
2.20[373] |
2.60[374] |
3.30[375] |
1.00[376] |
1.73[377] |
0.41[378] |
55 |
ROCK2 |
Rho-associated protein kinase 2 |
[379] |
1.81[380] |
3.21[381] |
1.78[382] |
2.93[383] |
0.87[384] |
2.62[385] |
56 |
VEGFB |
Vascular endothelial growth factor B |
[386] |
0.28[387] |
0.26[388] |
0.40[389] |
1.04[390] |
0.91[391] |
-1.01[392] |
57 |
NCK2 |
Cytoplasmic protein NCK2 |
[393] |
1.13[394] |
0.88[395] |
-0.60[396] |
-0.04[397] |
0.88[398] |
-0.12[399] |
58 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[400] |
3.35[401] |
3.51[402] |
2.61[403] |
2.69[404] |
2.04[405] |
-0.15[406] |
59 |
PRKCD |
Protein kinase C delta type |
[407] |
1.43[408] |
1.85[409] |
1.42[410] |
-0.21[411] |
1.12[412] |
-0.37[413] |
60 |
NRP1 |
Neuropilin-1 |
[414] |
1.87[415] |
-0.15[416] |
3.88[417] |
4.24[418] |
3.88[419] |
3.91[420] |
61 |
PDPK1 |
3-phosphoinositide-dependent protein kinase 1 |
[421] |
2.66[422] |
4.02[423] |
2.83[424] |
1.73[425] |
2.29[426] |
3.20[427] |
62 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
3.82[428] |
3.61[429] |
3.04[430] |
3.12[431] |
2.78[432] |
1.04[433] |
63 |
SHB |
SH2 domain-containing adapter protein B |
[434] |
2.85[435] |
1.91[436] |
0.05[437] |
0.77[438] |
1.88[439] |
1.37[440] |
64 |
MTOR |
Serine/threonine-protein kinase mTOR |
[441] |
2.86[442] |
4.05[443] |
3.71[444] |
2.98[445] |
3.22[446] |
4.15[447] |
65 |
PIK3CB |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
1.54[448] |
2.22[449] |
2.48[450] |
1.34[451] |
1.67[452] |
1.86[453] |
66 |
PRKACB |
cAMP-dependent protein kinase catalytic subunit beta |
[454] |
-0.50[455] |
0.44[456] |
1.83[457] |
2.53[458] |
1.55[459] |
2.41[460] |
67 |
RASA1 |
Ras GTPase-activating protein 1 |
[461] |
0.71[462] |
1.79[463] |
1.99[464] |
2.21[465] |
1.43[466] |
1.91[467] |
68 |
DOCK1 |
Dedicator of cytokinesis protein 1 |
[468] |
2.31[469] |
3.02[470] |
3.10[471] |
-2.35[472] |
2.62[473] |
3.22[474] |
69 |
PRKCA |
Protein kinase C alpha type |
[475] |
3.17[476] |
3.38[477] |
3.84[478] |
2.44[479] |
2.97[480] |
2.62[481] |
70 |
ABI2 |
Abl interactor 2 |
[482] |
2.01[483] |
2.89[484] |
3.29[485] |
3.01[486] |
3.20[487] |
2.30[488] |
71 |
PAK1 |
Serine/threonine-protein kinase PAK 1 |
[489] |
0.32[490] |
-0.27[491] |
2.24[492] |
-1.56[493] |
2.39[494] |
0.97[495] |
72 |
ITPR3 |
Inositol 1,4,5-trisphosphate receptor type 3 |
[496] |
5.62[497] |
4.64[498] |
3.22[499] |
2.65[500] |
4.99[501] |
0.93[502] |
73 |
FYN |
Tyrosine-protein kinase Fyn |
[503] |
1.27[504] |
-7.16[505] |
1.51[506] |
1.77[507] |
3.46[508] |
1.67[509] |
74 |
CYFIP2 |
Cytoplasmic FMR1-interacting protein 2 |
[510] |
3.45[511] |
3.27[512] |
-4.09[513] |
0.40[514] |
-0.31[515] |
3.72[516] |
75 |
PIK3CA |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
-0.05[517] |
1.76[518] |
2.04[519] |
1.42[520] |
1.79[521] |
2.61[522] |
76 |
THEM4 |
Acyl-coenzyme A thioesterase THEM4 |
[523] |
0.98[524] |
1.59[525] |
2.23[526] |
2.30[527] |
1.89[528] |
1.78[529] |
77 |
PTK2B |
Protein-tyrosine kinase 2-beta |
[530] |
-0.48[531] |
1.05[532] |
2.11[533] |
-1.48[534] |
1.31[535] |
2.47[536] |
78 |
RICTOR |
Rapamycin-insensitive companion of mTOR |
[537] |
1.06[538] |
3.31[539] |
4.08[540] |
2.65[541] |
3.02[542] |
4.21[543] |
79 |
NCF1 |
Neutrophil cytosol factor 1 |
[544] |
-6.83[545] |
-8.72[546] |
[547] |
[548] |
-8.83[549] |
-2.10[550] |
80 |
WASF1 |
Wiskott-Aldrich syndrome protein family member 1 |
[551] |
1.67[552] |
1.52[553] |
2.96[554] |
1.45[555] |
2.27[556] |
1.09[557] |
81 |
ELMO1 |
Engulfment and cell motility protein 1 |
[558] |
-5.48[559] |
-3.62[560] |
0.67[561] |
-3.26[562] |
-5.90[563] |
3.55[564] |
82 |
CYBB |
Cytochrome b-245 heavy chain |
[565] |
[566] |
[567] |
-9.62[568] |
-4.18[569] |
-9.57[570] |
3.75[571] |
83 |
WASF3 |
Wiskott-Aldrich syndrome protein family member 3 |
[572] |
1.89[573] |
2.01[574] |
3.31[575] |
2.71[576] |
1.67[577] |
1.61[578] |
84 |
ITGB3 |
Integrin beta-3 |
[579] |
-1.30[580] |
-3.84[581] |
-0.22[582] |
3.15[583] |
2.98[584] |
2.03[585] |
85 |
PGF |
Placenta growth factor |
[586] |
1.92[587] |
2.85[588] |
2.75[589] |
-0.83[590] |
1.02[591] |
0.08[592] |
86 |
AXL |
Tyrosine-protein kinase receptor UFO |
[593] |
3.03[594] |
0.80[595] |
-2.73[596] |
4.87[597] |
5.77[598] |
4.07[599] |
87 |
MAPK12 |
Mitogen-activated protein kinase 12 |
[600] |
3.15[601] |
2.98[602] |
4.19[603] |
1.78[604] |
3.20[605] |
-0.21[606] |
88 |
NCF4 |
Neutrophil cytosol factor 4 |
[607] |
-5.43[608] |
-7.58[609] |
[610] |
-7.76[611] |
[612] |
1.61[613] |
89 |
VAV3 |
Guanine nucleotide exchange factor VAV3 |
[614] |
2.14[615] |
0.60[616] |
2.87[617] |
3.98[618] |
-1.83[619] |
2.05[620] |
90 |
CDH5 |
Cadherin-5 |
[621] |
-1.25[622] |
-3.23[623] |
[624] |
-4.61[625] |
-5.00[626] |
5.23[627] |
91 |
NCKAP1L |
Nck-associated protein 1-like |
[628] |
[629] |
[630] |
[631] |
-3.70[632] |
-5.01[633] |
3.79[634] |
92 |
VAV1 |
Proto-oncogene vav |
[635] |
-8.17[636] |
-3.17[637] |
-4.78[638] |
-5.79[639] |
-6.89[640] |
1.88[641] |
93 |
ITPR1 |
Inositol 1,4,5-trisphosphate receptor type 1 |
[642] |
3.47[643] |
3.52[644] |
4.77[645] |
3.15[646] |
4.18[647] |
5.35[648] |
94 |
NRP2 |
Neuropilin-2 |
[649] |
4.42[650] |
-2.61[651] |
0.68[652] |
5.34[653] |
3.95[654] |
4.95[655] |
95 |
AKT3 |
RAC-gamma serine/threonine-protein kinase |
[656] |
-1.51[657] |
-3.90[658] |
-3.11[659] |
6.14[660] |
5.26[661] |
4.31[662] |
96 |
KDR |
Vascular endothelial growth factor receptor 2 |
[663] |
-5.30[664] |
-6.78[665] |
-5.98[666] |
-1.45[667] |
5.19[668] |
7.00[669] |
97 |
MAPK11 |
Mitogen-activated protein kinase 11 |
[670] |
0.16[671] |
0.22[672] |
-0.57[673] |
0.65[674] |
2.81[675] |
0.86[676] |
98 |
FLT4 |
Vascular endothelial growth factor receptor 3 |
[677] |
-1.04[678] |
0.37[679] |
-0.74[680] |
-0.94[681] |
-0.87[682] |
5.22[683] |
99 |
PRKCB |
Protein kinase C beta type |
[684] |
-6.48[685] |
-5.12[686] |
[687] |
2.78[688] |
-2.36[689] |
4.23[690] |
100 |
NOS3 |
Nitric oxide synthase, endothelial |
[691] |
5.10[692] |
2.37[693] |
1.93[694] |
0.35[695] |
1.85[696] |
3.47[697] |
101 |
SH2D2A |
SH2 domain-containing protein 2A |
[698] |
1.99[699] |
1.25[700] |
-1.42[701] |
0.60[702] |
-0.64[703] |
-0.27[704] |
102 |
FLT1 |
Vascular endothelial growth factor receptor 1 |
[705] |
-1.18[706] |
-0.64[707] |
-0.98[708] |
0.00[709] |
-0.77[710] |
6.80[711] |
103 |
PAK3 |
Serine/threonine-protein kinase PAK 3 |
[712] |
-6.08[713] |
[714] |
[715] |
-1.31[716] |
0.58[717] |
1.48[718] |
104 |
VEGFC |
Vascular endothelial growth factor C |
[719] |
-0.10[720] |
-3.03[721] |
-3.84[722] |
3.90[723] |
7.71[724] |
3.98[725] |
105 |
VEGFD |
Vascular endothelial growth factor D |
[726] |
[727] |
[728] |
[729] |
[730] |
[731] |
[732] |
106 |
PRKACG |
cAMP-dependent protein kinase catalytic subunit gamma |
[733] |
[734] |
[735] |
[736] |
[737] |
[738] |
[739] |
|
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