REACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 IGF2 Insulin-like growth factor II [1] -3.51[2] -1.72[3] -4.60[4] -13.76[5] -11.80[6] -7.56[7]
2 TRIB3 Tribbles homolog 3 [8] 0.37[9] 0.34[10] -0.87[11] -2.36[12] -1.78[13] -0.96[14]
3 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 [15] -0.10[16] 0.02[17] -0.13[18] 0.55[19] 1.25[20] 0.72[21]
4 GRB2 Growth factor receptor-bound protein 2 [22] 0.65[23] 0.18[24] 0.19[25] 0.21[26] 0.20[27] -0.25[28]
5 IGF1 Insulin-like growth factor I [29] -8.96[30] -10.21[31] -8.53[32] -1.88[33] -9.64[34] 0.38[35]
6 SHC1 SHC-transforming protein 1 [36] 0.62[37] 0.53[38] 0.50[39] 2.31[40] 1.87[41] 0.24[42]
7 FGFR4 Fibroblast growth factor receptor 4 [43] 1.41[44] 1.44[45] 1.92[46] -4.58[47] -4.63[48] -0.05[49]
8 NRAS GTPase NRas [50] 0.09[51] 0.21[52] 0.51[53] 0.65[54] 0.30[55] -0.79[56]
9 HRAS GTPase HRas [57] -1.55[58] -2.57[59] -3.47[60] -1.29[61] -1.44[62] -3.20[63]
10 AKT2 RAC-beta serine/threonine-protein kinase [64] 0.42[65] 0.38[66] 0.40[67] 0.52[68] 0.38[69] 0.59[70]
11 KLB Beta-klotho [71] 0.05[72] -0.43[73] 0.92[74] -6.31[75] -6.88[76] 1.01[77]
12 KRAS GTPase KRas [78] -1.06[79] -1.39[80] 0.10[81] 0.46[82] 0.19[83] 0.13[84]
13 FGFR3 Fibroblast growth factor receptor 3 [85] 2.19[86] 1.79[87] 2.01[88] -3.64[89] -2.22[90] -0.09[91]
14 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [92] -1.01[93] -1.21[94] -0.22[95] 1.72[96] 1.30[97] 2.46[98]
15 SOS1 Son of sevenless homolog 1 [99] -0.64[100] 0.57[101] -0.02[102] 0.50[103] -0.19[104] 0.00[105]
16 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [106] 1.33[107] 1.24[108] 1.75[109] 0.37[110] 0.99[111] -0.83[112]
17 PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3 [113] -0.16[114] 0.16[115] -0.86[116] 0.46[117] 0.74[118] 0.09[119]
18 FGF2 Fibroblast growth factor 2 [120] -7.23[121] -7.29[122] -3.24[123] 0.59[124] 2.24[125] -2.21[126]
19 PDPK1 3-phosphoinositide-dependent protein kinase 1 [127] 1.79[128] 2.67[129] 1.27[130] 1.09[131] 1.56[132] 1.96[133]
20 PDE3B cGMP-inhibited 3',5'-cyclic phosphodiesterase B [134] -0.09[135] 0.56[136] 0.70[137] -1.72[138] -2.09[139] 2.33[140]
21 PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0.67[141] 0.86[142] 0.92[143] 0.71[144] 0.94[145] 0.61[146]
22 IRS1 Insulin receptor substrate 1 [147] 1.55[148] 0.68[149] 2.00[150] 1.36[151] 1.01[152] 1.57[153]
23 IRS2 Insulin receptor substrate 2 [154] -6.19[155] [156] -3.76[157] -1.01[158] 2.89[159] 1.84[160]
24 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 [161] 0.62[162] 0.37[163] 1.23[164] 1.32[165] 1.87[166] 2.33[167]
25 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.92[168] 0.40[169] 0.48[170] 0.79[171] 1.06[172] 1.37[173]
26 THEM4 Acyl-coenzyme A thioesterase THEM4 [174] 0.10[175] 0.24[176] 0.67[177] 1.66[178] 1.15[179] 0.54[180]
27 FLT3LG Fms-related tyrosine kinase 3 ligand [181] -2.80[182] -3.02[183] -2.66[184] -2.68[185] -1.52[186] -2.70[187]
28 GAB2 GRB2-associated-binding protein 2 [188] 1.02[189] 0.50[190] 0.64[191] 0.58[192] 0.74[193] 0.00[194]
29 FGFR2 Fibroblast growth factor receptor 2 [195] -3.05[196] -2.16[197] 1.68[198] 1.11[199] -3.66[200] 2.88[201]
30 FRS2 Fibroblast growth factor receptor substrate 2 [202] 0.75[203] 1.53[204] 1.92[205] 2.56[206] 2.26[207] 2.80[208]
31 FGFR1 Fibroblast growth factor receptor 1 [209] 4.04[210] 2.04[211] 3.58[212] 4.71[213] 4.05[214] 1.12[215]
32 GAB1 GRB2-associated-binding protein 1 [216] 0.76[217] 1.53[218] 1.55[219] 1.59[220] 1.52[221] 2.33[222]
33 IGF1R Insulin-like growth factor 1 receptor [223] 4.20[224] 3.20[225] 1.76[226] 4.13[227] 3.75[228] 1.55[229]
34 FGF7 Fibroblast growth factor 7 [230] -9.84[231] -6.45[232] [233] -5.72[234] -1.38[235] -1.99[236]
35 KL Klotho [237] -6.60[238] [239] [240] -1.73[241] -6.91[242] -0.29[243]
36 FGF5 Fibroblast growth factor 5 [244] -1.53[245] -0.53[246] -0.70[247] 1.14[248] 0.90[249] 2.59[250]
37 FGF1 Fibroblast growth factor 1 [251] -3.31[252] -2.83[253] -7.40[254] 0.24[255] 1.89[256] -0.50[257]
38 FGF19 Fibroblast growth factor 19 [258] -2.60[259] -1.76[260] 4.87[261] 0.49[262] -2.91[263] [264]
39 FLT3 Receptor-type tyrosine-protein kinase FLT3 [265] [266] [267] -4.46[268] -3.13[269] [270] 2.38[271]
40 FGF8 Fibroblast growth factor 8 [272] -3.87[273] -3.84[274] 0.55[275] -2.26[276] [277] 2.15[278]
41 FGF18 Fibroblast growth factor 18 [279] 1.24[280] -3.19[281] -1.13[282] 0.27[283] 0.94[284] 0.04[285]
42 CILP Cartilage intermediate layer protein 1 [286] 2.69[287] 0.92[288] 0.00[289] 5.36[290] -1.15[291] 6.21[292]
43 IRS4 Insulin receptor substrate 4 [293] [294] [295] [296] -1.90[297] -2.93[298] [299]
44 FGF9 Fibroblast growth factor 9 [300] 1.72[301] -2.25[302] [303] 2.44[304] -2.60[305] -0.44[306]
45 FGF3 Fibroblast growth factor 3 [307] [308] [309] [310] [311] [312] [313]
46 FGF20 Fibroblast growth factor 20 [314] [315] [316] [317] [318] [319] [320]
47 FGF4 Fibroblast growth factor 4 [321] [322] [323] [324] [325] [326] [327]
48 TLR9 Toll-like receptor 9 [328] [329] [330] [331] [332] [333] [334]
49 FGF23 Fibroblast growth factor 23 [335] [336] [337] [338] [339] [340] [341]
50 FGF10 Fibroblast growth factor 10 [342] [343] [344] [345] [346] [347] [348]
51 FGF22 Fibroblast growth factor 22 [349] [350] [351] [352] [353] [354] [355]
52 FGF17 Fibroblast growth factor 17 [356] [357] [358] [359] [360] [361] [362]
53 FGF16 Fibroblast growth factor 16 [363] [364] [365] [366] [367] [368] [369]
54 FGF6 Fibroblast growth factor 6 [370] [371] [372] [373] [374] [375] [376]
[1]
ref_hepatocyte IGF2
Mean 101
Standard deviation 71
Values 1.4e+02 2.1 86 82 1.9e+02
[2]
HepG2 IGF2
Mean 28.5
Standard deviation 20
Values 42 15
[3]
HepG2.C3A IGF2
Mean 109
Standard deviation 33
Values 1.3e+02 86
[4]
HuH.7 IGF2
Mean 15.2
Standard deviation 9
Values 15 24 6.2
[5]
SNU475 IGF2
Mean 0.0169
Standard deviation 0.0024
Values 0.019 0.015
[6]
THLE IGF2
Mean 0.0701
Standard deviation 0.0013
Values 0.071 0.069
[7]
liver IGF2
Mean 1.11
Standard deviation 0.93
Values 2 0.19 1.9 0.42
[8]
ref_hepatocyte TRIB3
Mean 31.8
Standard deviation 22
Values 21 25 60 47 5.9
[9]
HepG2 TRIB3
Mean 132
Standard deviation 85
Values 1.9e+02 72
[10]
HepG2.C3A TRIB3
Mean 144
Standard deviation 1.1e+02
Values 2.2e+02 66
[11]
HuH.7 TRIB3
Mean 63.7
Standard deviation 8.9
Values 57 74 61
[12]
SNU475 TRIB3
Mean 14.5
Standard deviation 3.3
Values 12 17
[13]
THLE TRIB3
Mean 23
Standard deviation 5.7
Values 27 19
[14]
liver TRIB3
Mean 33.8
Standard deviation 26
Values 72 16 30 17
[15]
ref_hepatocyte PTPN11
Mean 22.2
Standard deviation 20
Values 33 53 10 7.5 7.4
[16]
HepG2 PTPN11
Mean 66.7
Standard deviation 12
Values 58 76
[17]
HepG2.C3A PTPN11
Mean 80.2
Standard deviation 17
Values 68 92
[18]
HuH.7 PTPN11
Mean 74.5
Standard deviation 12
Values 86 77 61
[19]
SNU475 PTPN11
Mean 75.4
Standard deviation 0.72
Values 75 76
[20]
THLE PTPN11
Mean 131
Standard deviation 5.1
Values 1.3e+02 1.3e+02
[21]
liver PTPN11
Mean 75.4
Standard deviation 18
Values 60 99 62 80
[22]
ref_hepatocyte GRB2
Mean 20.7
Standard deviation 5.5
Values 27 26 20 14 17
[23]
HepG2 GRB2
Mean 104
Standard deviation 4.7
Values 1e+02 1.1e+02
[24]
HepG2.C3A GRB2
Mean 83.1
Standard deviation 0.44
Values 83 83
[25]
HuH.7 GRB2
Mean 86.7
Standard deviation 7.6
Values 89 78 93
[26]
SNU475 GRB2
Mean 55.7
Standard deviation 1.4
Values 55 57
[27]
THLE GRB2
Mean 58.8
Standard deviation 3.7
Values 56 61
[28]
liver GRB2
Mean 36.1
Standard deviation 16
Values 50 22 50 22
[29]
ref_hepatocyte IGF1
Mean 17.2
Standard deviation 16
Values 0 18 5 24 39
[30]
HepG2 IGF1
Mean 0.111
Standard deviation 0.0052
Values 0.11 0.11
[31]
HepG2.C3A IGF1
Mean 0.0516
Standard deviation 0.018
Values 0.039 0.064
[32]
HuH.7 IGF1
Mean 0.171
Standard deviation 0.058
Values 0.11 0.22 0.19
[33]
SNU475 IGF1
Mean 10.9
Standard deviation 5.6
Values 15 6.9
[34]
THLE IGF1
Mean 0.0535
Standard deviation 0.008
Values 0.059 0.048
[35]
liver IGF1
Mean 46.3
Standard deviation 31
Values 92 24 31 39
[36]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 5.8 17 19 26 16
[37]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[38]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 77 93
[39]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 89 84 85
[40]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 2.2e+02 1.7e+02
[41]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[42]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 56 37
[43]
ref_hepatocyte FGFR4
Mean 15.1
Standard deviation 12
Values 30 2.5 2.2 18 23
[44]
HepG2 FGFR4
Mean 129
Standard deviation 13
Values 1.2e+02 1.4e+02
[45]
HepG2.C3A FGFR4
Mean 146
Standard deviation 22
Values 1.6e+02 1.3e+02
[46]
HuH.7 FGFR4
Mean 209
Standard deviation 68
Values 2.4e+02 1.3e+02 2.5e+02
[47]
SNU475 FGFR4
Mean 1.47
Standard deviation 0.43
Values 1.2 1.8
[48]
THLE FGFR4
Mean 1.51
Standard deviation 0.45
Values 1.8 1.2
[49]
liver FGFR4
Mean 30.3
Standard deviation 10
Values 43 18 31 29
[50]
ref_hepatocyte NRAS
Mean 14.4
Standard deviation 13
Values 32 23 9.3 3.3 4.6
[51]
HepG2 NRAS
Mean 49.3
Standard deviation 10
Values 42 57
[52]
HepG2.C3A NRAS
Mean 59.2
Standard deviation 18
Values 47 72
[53]
HuH.7 NRAS
Mean 75.6
Standard deviation 9.1
Values 86 70 71
[54]
SNU475 NRAS
Mean 52.9
Standard deviation 9.2
Values 59 46
[55]
THLE NRAS
Mean 44
Standard deviation 8.9
Values 38 50
[56]
liver NRAS
Mean 17.2
Standard deviation 2.6
Values 14 21 18 16
[57]
ref_hepatocyte HRAS
Mean 11.6
Standard deviation 9
Values 4 27 11 7.4 8.8
[58]
HepG2 HRAS
Mean 12.7
Standard deviation 1.1
Values 14 12
[59]
HepG2.C3A HRAS
Mean 6.96
Standard deviation 1.3
Values 6 7.9
[60]
HuH.7 HRAS
Mean 3.85
Standard deviation 1.6
Values 3.6 2.4 5.6
[61]
SNU475 HRAS
Mean 11
Standard deviation 0.62
Values 11 11
[62]
THLE HRAS
Mean 10.7
Standard deviation 2.3
Values 9.1 12
[63]
liver HRAS
Mean 2.6
Standard deviation 1.6
Values 4.1 1.1 3.8 1.4
[64]
ref_hepatocyte AKT2
Mean 10.6
Standard deviation 2.8
Values 7.2 8.4 11 13 14
[65]
HepG2 AKT2
Mean 45.6
Standard deviation 3.3
Values 48 43
[66]
HepG2.C3A AKT2
Mean 49.1
Standard deviation 8.9
Values 55 43
[67]
HuH.7 AKT2
Mean 51.5
Standard deviation 9.8
Values 59 41 55
[68]
SNU475 AKT2
Mean 35.3
Standard deviation 5.9
Values 39 31
[69]
THLE AKT2
Mean 34.2
Standard deviation 3.5
Values 32 37
[70]
liver AKT2
Mean 33
Standard deviation 9.4
Values 24 36 27 45
[71]
ref_hepatocyte KLB
Mean 9.92
Standard deviation 12
Values 30 1.9 0.71 6.7 9.9
[72]
HepG2 KLB
Mean 33.1
Standard deviation 23
Values 17 49
[73]
HepG2.C3A KLB
Mean 26.3
Standard deviation 0.12
Values 26 26
[74]
HuH.7 KLB
Mean 68.9
Standard deviation 30
Values 57 1e+02 46
[75]
SNU475 KLB
Mean 0.292
Standard deviation 0.04
Values 0.32 0.26
[76]
THLE KLB
Mean 0.21
Standard deviation 0.004
Values 0.21 0.21
[77]
liver KLB
Mean 41.2
Standard deviation 7.6
Values 52 37 40 36
[78]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 18 17 5.4 1.7 2.7
[79]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 12 16
[80]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 11 14
[81]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 40 30 36
[82]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 33 25
[83]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[84]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 33 16 19 14
[85]
ref_hepatocyte FGFR3
Mean 7.46
Standard deviation 9.2
Values 23 2.7 0.18 4.6 6.4
[86]
HepG2 FGFR3
Mean 109
Standard deviation 1.1
Values 1.1e+02 1.1e+02
[87]
HepG2.C3A FGFR3
Mean 91.5
Standard deviation 12
Values 1e+02 83
[88]
HuH.7 FGFR3
Mean 110
Standard deviation 12
Values 1.2e+02 97 1.2e+02
[89]
SNU475 FGFR3
Mean 1.4
Standard deviation 0.25
Values 1.6 1.2
[90]
THLE FGFR3
Mean 3.99
Standard deviation 0.31
Values 3.8 4.2
[91]
liver FGFR3
Mean 14.5
Standard deviation 8.7
Values 9.3 18 5.8 25
[92]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.1 7.4 4.2 8.1 14
[93]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 9.8 14
[94]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 9.6 13
[95]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 23 32 15
[96]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 80 35
[97]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[98]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 64 1e+02 32 1.4e+02
[99]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 27 1.9 2.2 1.3 1.5
[100]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 9.4 19
[101]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 39 33
[102]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 22 37 15
[103]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 25 20
[104]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[105]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 13 18 9.3 16
[106]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 11 3.2 3.1 4.9 3.8
[107]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 44 41
[108]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 53 35
[109]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 75 55 64
[110]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 18 13
[111]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[112]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 7.6 6 3.8 6.9
[113]
ref_hepatocyte PIK3C3
Mean 4.59
Standard deviation 2.3
Values 8 5.9 2.3 3.8 3
[114]
HepG2 PIK3C3
Mean 13.2
Standard deviation 3.3
Values 11 16
[115]
HepG2.C3A PIK3C3
Mean 18.2
Standard deviation 1.3
Values 17 19
[116]
HuH.7 PIK3C3
Mean 9.26
Standard deviation 1.9
Values 9.1 11 7.5
[117]
SNU475 PIK3C3
Mean 14.7
Standard deviation 3.2
Values 17 12
[118]
THLE PIK3C3
Mean 19.1
Standard deviation 0.92
Values 18 20
[119]
liver PIK3C3
Mean 10.1
Standard deviation 4.2
Values 6.9 15 6.8 11
[120]
ref_hepatocyte FGF2
Mean 4.04
Standard deviation 6.5
Values 0.052 15 3.7 0.37 0.73
[121]
HepG2 FGF2
Mean 0.0866
Standard deviation 0.08
Values 0.14 0.03
[122]
HepG2.C3A FGF2
Mean 0.092
Standard deviation 0.0064
Values 0.087 0.097
[123]
HuH.7 FGF2
Mean 1.57
Standard deviation 0.89
Values 0.98 2.6 1.1
[124]
SNU475 FGF2
Mean 14.2
Standard deviation 1.3
Values 13 15
[125]
THLE FGF2
Mean 47.5
Standard deviation 0.66
Values 48 47
[126]
liver FGF2
Mean 1.81
Standard deviation 0.66
Values 1.9 2.5 0.9 2
[127]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 6.9 3.4 3.6 1.8 2
[128]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 35 43
[129]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 89 71
[130]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 35 33 26
[131]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 17 18
[132]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[133]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 34 27 22 31
[134]
ref_hepatocyte PDE3B
Mean 3.29
Standard deviation 1.7
Values 4.3 2 1.3 3.2 5.6
[135]
HepG2 PDE3B
Mean 9.91
Standard deviation 5.3
Values 6.1 14
[136]
HepG2.C3A PDE3B
Mean 17.2
Standard deviation 3.4
Values 15 20
[137]
HuH.7 PDE3B
Mean 19.6
Standard deviation 4.7
Values 20 24 15
[138]
SNU475 PDE3B
Mean 2.32
Standard deviation 0.34
Values 2.6 2.1
[139]
THLE PDE3B
Mean 1.92
Standard deviation 0.37
Values 2.2 1.7
[140]
liver PDE3B
Mean 34.3
Standard deviation 15
Values 28 53 17 40
[141]
ref_hepatocyte PIK3CB
Mean 3.18
Standard deviation 1.5
Values 5.2 4.2 2.6 1.8 2.1
[142]
HepG2 PIK3CB
Mean 16.3
Standard deviation 2.1
Values 15 18
[143]
HepG2.C3A PIK3CB
Mean 20.6
Standard deviation 2.7
Values 23 19
[144]
HuH.7 PIK3CB
Mean 22.1
Standard deviation 2.1
Values 24 23 20
[145]
SNU475 PIK3CB
Mean 12.1
Standard deviation 2.7
Values 14 10
[146]
THLE PIK3CB
Mean 15.1
Standard deviation 0.94
Values 14 16
[147]
liver PIK3CB
Mean 10.1
Standard deviation 3.7
Values 6.4 15 7.9 11
[148]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 4.3 1.5 2.7 2.1 4.7
[149]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 35 23
[150]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 22 13
[151]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 49 48 37
[152]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 15 22
[153]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[154]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 23 18 12 22
[155]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 0.019 0.61 1.4 5.7 2.9
[156]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.14 0.043
[157]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.2 1.4 0.17
[159]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.1 2.8
[160]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[161]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 29 11 6.3 17
[162]
ref_hepatocyte PIK3R4
Mean 1.95
Standard deviation 0.81
Values 1.4 1.7 1.2 2.4 3.2
[163]
HepG2 PIK3R4
Mean 9.67
Standard deviation 3.2
Values 7.4 12
[164]
HepG2.C3A PIK3R4
Mean 8.97
Standard deviation 1.7
Values 7.8 10
[165]
HuH.7 PIK3R4
Mean 16.8
Standard deviation 2.8
Values 20 14 16
[166]
SNU475 PIK3R4
Mean 11.4
Standard deviation 0.1
Values 11 11
[167]
THLE PIK3R4
Mean 17.7
Standard deviation 1.3
Values 17 19
[168]
liver PIK3R4
Mean 20.3
Standard deviation 7.7
Values 15 27 12 27
[169]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 2.6 2.3 1.2 0.94
[170]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 2.1 4.3
[171]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 8 9.6
[172]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 10 12 7
[173]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 8.1 6.8
[174]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[175]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 6.1 15 6 13
[176]
ref_hepatocyte THEM4
Mean 1.85
Standard deviation 0.19
Values 1.8 1.7 2.1 2 1.7
[177]
HepG2 THEM4
Mean 6.4
Standard deviation 0.64
Values 5.9 6.9
[178]
HepG2.C3A THEM4
Mean 7.77
Standard deviation 1.9
Values 6.5 9.1
[179]
HuH.7 THEM4
Mean 10.9
Standard deviation 3.9
Values 12 6.4 14
[180]
SNU475 THEM4
Mean 13.7
Standard deviation 1.8
Values 12 15
[181]
THLE THEM4
Mean 10.2
Standard deviation 1.5
Values 9.2 11
[182]
liver THEM4
Mean 5.58
Standard deviation 2.4
Values 8.6 3.8 6.5 3.5
[183]
ref_hepatocyte FLT3LG
Mean 1.73
Standard deviation 1.8
Values 0 0 4.1 1.9 2.7
[184]
HepG2 FLT3LG
Mean 0.799
Standard deviation 0.045
Values 0.83 0.77
[185]
HepG2.C3A FLT3LG
Mean 0.761
Standard deviation 0.27
Values 0.95 0.57
[186]
HuH.7 FLT3LG
Mean 1.01
Standard deviation 0.09
Values 1 1.1 0.92
[187]
SNU475 FLT3LG
Mean 0.629
Standard deviation 0.022
Values 0.64 0.61
[188]
THLE FLT3LG
Mean 1.5
Standard deviation 0.22
Values 1.7 1.3
[189]
liver FLT3LG
Mean 0.55
Standard deviation 0.58
Values 1.3 0.1 0.62 0.15
[190]
ref_hepatocyte GAB2
Mean 1.62
Standard deviation 1.7
Values 1.2 1.9 4.5 0.25 0.31
[191]
HepG2 GAB2
Mean 10.6
Standard deviation 4.9
Values 14 7.1
[192]
HepG2.C3A GAB2
Mean 8.12
Standard deviation 3.2
Values 10 5.9
[193]
HuH.7 GAB2
Mean 9.24
Standard deviation 2.5
Values 9.6 12 6.6
[194]
SNU475 GAB2
Mean 5.63
Standard deviation 0.73
Values 6.1 5.1
[195]
THLE GAB2
Mean 6.7
Standard deviation 0.57
Values 7.1 6.3
[196]
liver GAB2
Mean 3.35
Standard deviation 1.3
Values 2.8 4.2 1.8 4.6
[197]
ref_hepatocyte FGFR2
Mean 1.34
Standard deviation 1.4
Values 0.47 0.46 0.084 2.4 3.2
[198]
HepG2 FGFR2
Mean 0.519
Standard deviation 0.3
Values 0.3 0.73
[199]
HepG2.C3A FGFR2
Mean 1.07
Standard deviation 0.3
Values 0.86 1.3
[200]
HuH.7 FGFR2
Mean 15.7
Standard deviation 0.71
Values 16 15 16
[201]
SNU475 FGFR2
Mean 6.74
Standard deviation 6.4
Values 11 2.2
[202]
THLE FGFR2
Mean 0.263
Standard deviation 0.0039
Values 0.27 0.26
[203]
liver FGFR2
Mean 20.4
Standard deviation 8
Values 18 19 13 32
[204]
ref_hepatocyte FRS2
Mean 1.15
Standard deviation 0.48
Values 1.3 1.9 0.69 0.74 1.2
[205]
HepG2 FRS2
Mean 6.18
Standard deviation 3
Values 4 8.3
[206]
HepG2.C3A FRS2
Mean 11.7
Standard deviation 4
Values 8.9 15
[207]
HuH.7 FRS2
Mean 15.9
Standard deviation 4.9
Values 16 21 11
[208]
SNU475 FRS2
Mean 15.7
Standard deviation 0.35
Values 16 15
[209]
THLE FRS2
Mean 13.6
Standard deviation 0.96
Values 14 13
[210]
liver FRS2
Mean 16.5
Standard deviation 3.3
Values 18 20 13 15
[211]
ref_hepatocyte FGFR1
Mean 0.81
Standard deviation 0.63
Values 1.2 0.49 1.6 0.06 0.62
[212]
HepG2 FGFR1
Mean 42.7
Standard deviation 4
Values 40 46
[213]
HepG2.C3A FGFR1
Mean 11.8
Standard deviation 3.5
Values 9.3 14
[214]
HuH.7 FGFR1
Mean 35.6
Standard deviation 13
Values 43 20 43
[215]
SNU475 FGFR1
Mean 49.5
Standard deviation 1.4
Values 50 49
[216]
THLE FGFR1
Mean 33.4
Standard deviation 3.3
Values 36 31
[217]
liver FGFR1
Mean 3.64
Standard deviation 0.67
Values 3 4.2 3.2 4.3
[218]
ref_hepatocyte GAB1
Mean 0.787
Standard deviation 0.67
Values 2 0.61 0.33 0.38 0.66
[219]
HepG2 GAB1
Mean 4.28
Standard deviation 2.2
Values 2.8 5.8
[220]
HepG2.C3A GAB1
Mean 8.12
Standard deviation 2.3
Values 6.5 9.8
[221]
HuH.7 GAB1
Mean 8.48
Standard deviation 1.4
Values 10 8.1 7.3
[222]
SNU475 GAB1
Mean 5.52
Standard deviation 1.6
Values 6.6 4.4
[223]
THLE GAB1
Mean 5.62
Standard deviation 0.39
Values 5.9 5.3
[224]
liver GAB1
Mean 8.2
Standard deviation 2.5
Values 7.1 10 5.3 10
[225]
ref_hepatocyte IGF1R
Mean 0.745
Standard deviation 1.4
Values 3.3 0.021 0.29 0.043 0.065
[226]
HepG2 IGF1R
Mean 44
Standard deviation 16
Values 55 33
[227]
HepG2.C3A IGF1R
Mean 24.3
Standard deviation 6.5
Values 29 20
[228]
HuH.7 IGF1R
Mean 9.29
Standard deviation 2.1
Values 12 7.5 8.8
[229]
SNU475 IGF1R
Mean 30.3
Standard deviation 1.7
Values 32 29
[230]
THLE IGF1R
Mean 24.8
Standard deviation 4.5
Values 22 28
[231]
liver IGF1R
Mean 4.51
Standard deviation 2.6
Values 2.4 5.8 2.2 7.6
[232]
ref_hepatocyte FGF7
Mean 0.61
Standard deviation 0.64
Values 0 0.3 0.46 0.6 1.7
[233]
HepG2 FGF7
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[234]
HepG2.C3A FGF7
Mean 0.0248
Standard deviation 0.02
Values 0.039 0.011
[235]
HuH.7 FGF7
Mean 0
Standard deviation 0
Values 0 0 0
[236]
SNU475 FGF7
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[237]
THLE FGF7
Mean 0.584
Standard deviation 0.1
Values 0.66 0.51
[238]
liver FGF7
Mean 0.317
Standard deviation 0.15
Values 0.28 0.31 0.51 0.16
[239]
ref_hepatocyte KL
Mean 0.258
Standard deviation 0.29
Values 0 0 0.4 0.2 0.69
[240]
HepG2 KL
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[241]
HepG2.C3A KL
Mean 0
Standard deviation 0
Values 0 0
[242]
HuH.7 KL
Mean 0
Standard deviation 0
Values 0 0 0
[243]
SNU475 KL
Mean 0.181
Standard deviation 0.026
Values 0.2 0.16
[244]
THLE KL
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[245]
liver KL
Mean 0.436
Standard deviation 0.32
Values 0.38 0.31 0.15 0.9
[246]
ref_hepatocyte FGF5
Mean 0.241
Standard deviation 0.27
Values 0.042 0.036 0.09 0.64 0.4
[247]
HepG2 FGF5
Mean 0.268
Standard deviation 0.022
Values 0.25 0.28
[248]
HepG2.C3A FGF5
Mean 0.596
Standard deviation 0.024
Values 0.61 0.58
[249]
HuH.7 FGF5
Mean 0.543
Standard deviation 0.15
Values 0.62 0.65 0.37
[250]
SNU475 FGF5
Mean 1.24
Standard deviation 0.35
Values 0.99 1.5
[251]
THLE FGF5
Mean 1.11
Standard deviation 0.17
Values 0.99 1.2
[252]
liver FGF5
Mean 3.01
Standard deviation 1.5
Values 2.3 4.5 1.2 4.1
[253]
ref_hepatocyte FGF1
Mean 0.126
Standard deviation 0.27
Values 0 0.6 0 0 0.024
[254]
HepG2 FGF1
Mean 0.0408
Standard deviation 0.04
Values 0.069 0.013
[255]
HepG2.C3A FGF1
Mean 0.0628
Standard deviation 0.048
Values 0.029 0.097
[256]
HuH.7 FGF1
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[257]
SNU475 FGF1
Mean 0.346
Standard deviation 0.077
Values 0.29 0.4
[258]
THLE FGF1
Mean 1.16
Standard deviation 0.44
Values 0.85 1.5
[259]
liver FGF1
Mean 0.184
Standard deviation 0.042
Values 0.14 0.21 0.15 0.23
[260]
ref_hepatocyte FGF19
Mean 0.122
Standard deviation 0.27
Values 0 0 0.61 0 0
[261]
HepG2 FGF19
Mean 0.0644
Standard deviation 0.0062
Values 0.069 0.06
[262]
HepG2.C3A FGF19
Mean 0.128
Standard deviation 0.0016
Values 0.13 0.13
[263]
HuH.7 FGF19
Mean 13.1
Standard deviation 3.4
Values 11 17 12
[264]
SNU475 FGF19
Mean 0.397
Standard deviation 0.15
Values 0.51 0.29
[265]
THLE FGF19
Mean 0.0402
Standard deviation 0.027
Values 0.059 0.021
[266]
liver FGF19
Mean 0
Standard deviation 0
Values 0 0 0 0
[267]
ref_hepatocyte FLT3
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[268]
HepG2 FLT3
Mean 0
Standard deviation 0
Values 0 0
[269]
HepG2.C3A FLT3
Mean 0
Standard deviation 0
Values 0 0
[270]
HuH.7 FLT3
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[271]
SNU475 FLT3
Mean 0.00992
Standard deviation 0.0075
Values 0.0046 0.015
[272]
THLE FLT3
Mean 0
Standard deviation 0
Values 0 0
[273]
liver FLT3
Mean 0.402
Standard deviation 0.15
Values 0.21 0.44 0.39 0.57
[274]
ref_hepatocyte FGF8
Mean 0.0195
Standard deviation 0.044
Values 0 0 0 0 0.098
[275]
HepG2 FGF8
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[276]
HepG2.C3A FGF8
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[277]
HuH.7 FGF8
Mean 0.105
Standard deviation 0.073
Values 0.19 0.051 0.075
[278]
SNU475 FGF8
Mean 0.00949
Standard deviation 0.0063
Values 0.014 0.0051
[279]
THLE FGF8
Mean 0
Standard deviation 0
Values 0 0
[280]
liver FGF8
Mean 0.18
Standard deviation 0.14
Values 0.047 0.34 0.077 0.25
[281]
ref_hepatocyte FGF18
Mean 0.0138
Standard deviation 0.031
Values 0 0 0 0.069 0
[282]
HepG2 FGF18
Mean 0.105
Standard deviation 0.039
Values 0.13 0.077
[283]
HepG2.C3A FGF18
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[284]
HuH.7 FGF18
Mean 0.0232
Standard deviation 0.02
Values 0 0.032 0.037
[285]
SNU475 FGF18
Mean 0.0388
Standard deviation 0.0024
Values 0.037 0.041
[286]
THLE FGF18
Mean 0.0657
Standard deviation 0.033
Values 0.089 0.043
[287]
liver FGF18
Mean 0.0294
Standard deviation 0.0072
Values 0.024 0.029 0.026 0.04
[288]
ref_hepatocyte CILP
Mean 0.0101
Standard deviation 0.014
Values 0 0 0 0.026 0.024
[289]
HepG2 CILP
Mean 0.209
Standard deviation 0.2
Values 0.35 0.069
[290]
HepG2.C3A CILP
Mean 0.0677
Standard deviation 0.041
Values 0.039 0.097
[291]
HuH.7 CILP
Mean 0.0368
Standard deviation 0.018
Values 0.025 0.058 0.028
[292]
SNU475 CILP
Mean 0.963
Standard deviation 0.11
Values 1 0.88
[293]
THLE CILP
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[294]
liver CILP
Mean 1.54
Standard deviation 1.1
Values 1 1.1 0.85 3.2
[295]
ref_hepatocyte IRS4
Mean 0.00813
Standard deviation 0.018
Values 0 0 0 0 0.041
[296]
HepG2 IRS4
Mean 0
Standard deviation 0
Values 0 0
[297]
HepG2.C3A IRS4
Mean 0
Standard deviation 0
Values 0 0
[298]
HuH.7 IRS4
Mean 0
Standard deviation 0
Values 0 0 0
[299]
SNU475 IRS4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[300]
THLE IRS4
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[301]
liver IRS4
Mean 0
Standard deviation 0
Values 0 0 0 0
[302]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0 0 0 0.033
[303]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[304]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[305]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[306]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.14 0.025
[307]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[308]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0 0 0 0.04
[309]
ref_hepatocyte FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[310]
HepG2 FGF3
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[311]
HepG2.C3A FGF3
Mean 0
Standard deviation 0
Values 0 0
[312]
HuH.7 FGF3
Mean 0.00487
Standard deviation 0.0043
Values 0.0082 0.0064 0
[313]
SNU475 FGF3
Mean 0.00717
Standard deviation 0.003
Values 0.0093 0.0051
[314]
THLE FGF3
Mean 0
Standard deviation 0
Values 0 0
[315]
liver FGF3
Mean 0
Standard deviation 0
Values 0 0 0 0
[316]
ref_hepatocyte FGF20
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[317]
HepG2 FGF20
Mean 0.0115
Standard deviation 0.016
Values 0.023 0
[318]
HepG2.C3A FGF20
Mean 0
Standard deviation 0
Values 0 0
[319]
HuH.7 FGF20
Mean 0
Standard deviation 0
Values 0 0 0
[320]
SNU475 FGF20
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[321]
THLE FGF20
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[322]
liver FGF20
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[323]
ref_hepatocyte FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[324]
HepG2 FGF4
Mean 0
Standard deviation 0
Values 0 0
[325]
HepG2.C3A FGF4
Mean 0
Standard deviation 0
Values 0 0
[326]
HuH.7 FGF4
Mean 0
Standard deviation 0
Values 0 0 0
[327]
SNU475 FGF4
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[328]
THLE FGF4
Mean 0
Standard deviation 0
Values 0 0
[329]
liver FGF4
Mean 0
Standard deviation 0
Values 0 0 0 0
[330]
ref_hepatocyte TLR9
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[331]
HepG2 TLR9
Mean 0.0229
Standard deviation 0.032
Values 0.046 0
[332]
HepG2.C3A TLR9
Mean 0.197
Standard deviation 0.2
Values 0.34 0.054
[333]
HuH.7 TLR9
Mean 1.11
Standard deviation 1.2
Values 0.44 2.5 0.37
[334]
SNU475 TLR9
Mean 0.0454
Standard deviation 0.021
Values 0.06 0.03
[335]
THLE TLR9
Mean 0.22
Standard deviation 0.12
Values 0.3 0.14
[336]
liver TLR9
Mean 0.227
Standard deviation 0.11
Values 0.12 0.23 0.18 0.38
[337]
ref_hepatocyte FGF23
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[338]
HepG2 FGF23
Mean 0
Standard deviation 0
Values 0 0
[339]
HepG2.C3A FGF23
Mean 0
Standard deviation 0
Values 0 0
[340]
HuH.7 FGF23
Mean 0.00312
Standard deviation 0.0054
Values 0 0 0.0094
[341]
SNU475 FGF23
Mean 0
Standard deviation 0
Values 0 0
[342]
THLE FGF23
Mean 0
Standard deviation 0
Values 0 0
[343]
liver FGF23
Mean 0.68
Standard deviation 0.31
Values 0.59 0.67 1.1 0.36
[344]
ref_hepatocyte FGF10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[345]
HepG2 FGF10
Mean 0
Standard deviation 0
Values 0 0
[346]
HepG2.C3A FGF10
Mean 0
Standard deviation 0
Values 0 0
[347]
HuH.7 FGF10
Mean 0
Standard deviation 0
Values 0 0 0
[348]
SNU475 FGF10
Mean 0
Standard deviation 0
Values 0 0
[349]
THLE FGF10
Mean 0
Standard deviation 0
Values 0 0
[350]
liver FGF10
Mean 0.0234
Standard deviation 0.038
Values 0 0.014 0 0.079
[351]
ref_hepatocyte FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[352]
HepG2 FGF22
Mean 0.01
Standard deviation 0.002
Values 0.011 0.0086
[353]
HepG2.C3A FGF22
Mean 0
Standard deviation 0
Values 0 0
[354]
HuH.7 FGF22
Mean 0.00625
Standard deviation 0.011
Values 0 0 0.019
[355]
SNU475 FGF22
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[356]
THLE FGF22
Mean 0
Standard deviation 0
Values 0 0
[357]
liver FGF22
Mean 0
Standard deviation 0
Values 0 0 0 0
[358]
ref_hepatocyte FGF17
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[359]
HepG2 FGF17
Mean 0.398
Standard deviation 0.15
Values 0.5 0.29
[360]
HepG2.C3A FGF17
Mean 1.23
Standard deviation 1.1
Values 2 0.46
[361]
HuH.7 FGF17
Mean 0.183
Standard deviation 0.2
Values 0.074 0.41 0.066
[362]
SNU475 FGF17
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[363]
THLE FGF17
Mean 0.0228
Standard deviation 0.0096
Values 0.03 0.016
[364]
liver FGF17
Mean 0.00588
Standard deviation 0.012
Values 0.024 0 0 0
[365]
ref_hepatocyte FGF16
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[366]
HepG2 FGF16
Mean 0
Standard deviation 0
Values 0 0
[367]
HepG2.C3A FGF16
Mean 0
Standard deviation 0
Values 0 0
[368]
HuH.7 FGF16
Mean 0
Standard deviation 0
Values 0 0 0
[369]
SNU475 FGF16
Mean 0
Standard deviation 0
Values 0 0
[370]
THLE FGF16
Mean 0
Standard deviation 0
Values 0 0
[371]
liver FGF16
Mean 0.0118
Standard deviation 0.024
Values 0.047 0 0 0
[372]
ref_hepatocyte FGF6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[373]
HepG2 FGF6
Mean 0.00287
Standard deviation 0.0041
Values 0.0057 0
[374]
HepG2.C3A FGF6
Mean 0
Standard deviation 0
Values 0 0
[375]
HuH.7 FGF6
Mean 0
Standard deviation 0
Values 0 0 0
[376]
SNU475 FGF6
Mean 0
Standard deviation 0
Values 0 0
[377]
THLE FGF6
Mean 0
Standard deviation 0
Values 0 0
[378]
liver FGF6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0