REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.57[2] | -1.70[3] | -1.47[4] | -1.81[5] | -2.00[6] | -0.89[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.13[16] | -0.95[17] | -1.11[18] | -0.96[19] | -1.62[20] | -0.44[21] |
4 | RHOA | Transforming protein RhoA | [22] | -0.31[23] | -0.74[24] | -0.44[25] | -0.25[26] | -0.44[27] | -0.34[28] |
5 | NEDD8 | NEDD8 | [29] | -1.11[30] | -2.62[31] | -2.29[32] | -2.32[33] | -2.81[34] | -2.54[35] |
6 | SERPINE1 | Plasminogen activator inhibitor 1 | [36] | 1.76[37] | 2.05[38] | -4.61[39] | -2.83[40] | 3.19[41] | -2.89[42] |
7 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [43] | 0.51[44] | 0.18[45] | -1.31[46] | 0.71[47] | -0.35[48] | -0.39[49] |
8 | STRAP | Serine-threonine kinase receptor-associated protein | [50] | -0.59[51] | -0.56[52] | 0.14[53] | -0.37[54] | -0.19[55] | -0.78[56] |
9 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [57] | -0.20[58] | 0.19[59] | 0.51[60] | 0.23[61] | 0.06[62] | 0.84[63] |
10 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [64] | 1.31[65] | 1.28[66] | 2.40[67] | 0.44[68] | 0.61[69] | 0.33[70] |
11 | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | [71] | -1.12[72] | -2.01[73] | -1.42[74] | -1.24[75] | -0.93[76] | -2.63[77] |
12 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [78] | 0.61[79] | 0.40[80] | 1.69[81] | 2.50[82] | -0.54[83] | 0.03[84] |
13 | JUNB | Transcription factor jun-B | [85] | -1.33[86] | -2.12[87] | -1.34[88] | -1.20[89] | -1.00[90] | -0.40[91] |
14 | PARP1 | Poly [ADP-ribose] polymerase 1 | [92] | 0.75[93] | 0.58[94] | 1.39[95] | 1.50[96] | 0.37[97] | 0.57[98] |
15 | FURIN | Furin | [99] | 2.25[100] | -1.43[101] | 0.81[102] | -0.30[103] | -0.48[104] | 2.64[105] |
16 | STUB1 | E3 ubiquitin-protein ligase CHIP | [106] | -1.36[107] | -1.27[108] | -1.85[109] | -1.69[110] | -2.01[111] | -1.27[112] |
17 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [113] | 0.39[114] | 1.02[115] | 1.19[116] | 1.73[117] | 0.91[118] | 1.48[119] |
18 | MYC | Myc proto-oncogene protein | [120] | 1.06[121] | 0.79[122] | -1.16[123] | -1.82[124] | -0.09[125] | -1.01[126] |
19 | F11R | Junctional adhesion molecule A | [127] | 1.19[128] | 1.61[129] | 1.02[130] | -1.49[131] | -0.99[132] | 1.61[133] |
20 | CCNC | Cyclin-C | [134] | -0.30[135] | 1.15[136] | 0.74[137] | -0.12[138] | -0.52[139] | 0.88[140] |
21 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.30[141] | 2.16[142] | 2.46[143] | 1.21[144] | 0.67[145] | -0.09[146] | |
22 | SNW1 | SNW domain-containing protein 1 | [147] | -0.37[148] | -0.14[149] | -0.04[150] | 0.83[151] | -0.05[152] | -0.65[153] |
23 | HDAC1 | Histone deacetylase 1 | [154] | 1.13[155] | 1.22[156] | 1.98[157] | 1.62[158] | 0.75[159] | 0.52[160] |
24 | UBE2M | NEDD8-conjugating enzyme Ubc12 | [161] | -0.03[162] | -0.23[163] | 0.52[164] | 0.51[165] | -0.23[166] | -1.70[167] |
25 | TGIF1 | Homeobox protein TGIF1 | [168] | 0.32[169] | -0.25[170] | 0.66[171] | 0.59[172] | -0.42[173] | -0.86[174] |
26 | TFDP1 | Transcription factor Dp-1 | [175] | 1.29[176] | 0.69[177] | 0.84[178] | 1.58[179] | 1.51[180] | -0.16[181] |
27 | PARD3 | Partitioning defective 3 homolog | [182] | 0.73[183] | 1.35[184] | 1.43[185] | 1.82[186] | -0.21[187] | 1.16[188] |
28 | XPO1 | Exportin-1 | [189] | 1.99[190] | 2.77[191] | 2.87[192] | 3.10[193] | 2.54[194] | 1.85[195] |
29 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | [196] | -0.40[197] | 0.53[198] | 0.24[199] | 1.48[200] | 0.39[201] | 0.77[202] |
30 | CDK9 | Cyclin-dependent kinase 9 | [203] | 0.25[204] | -0.05[205] | 0.11[206] | 0.82[207] | -0.13[208] | 1.14[209] |
31 | CCNK | Cyclin-K | [210] | 0.78[211] | -0.12[212] | 0.15[213] | 1.37[214] | 0.22[215] | -1.06[216] |
32 | TGFBR2 | TGF-beta receptor type-2 | [217] | 3.44[218] | 2.98[219] | 2.71[220] | 2.03[221] | 3.11[222] | 2.49[223] |
33 | MAPK1 | Mitogen-activated protein kinase 1 | [224] | 2.34[225] | 2.54[226] | 2.45[227] | 2.82[228] | 1.82[229] | 2.76[230] |
34 | E2F4 | Transcription factor E2F4 | [231] | 1.76[232] | 1.94[233] | 1.04[234] | 1.39[235] | 0.74[236] | 0.74[237] |
35 | CGN | Cingulin | [238] | -3.10[239] | -3.62[240] | 2.42[241] | -3.45[242] | -3.09[243] | 2.24[244] |
36 | PRKCZ | Protein kinase C zeta type | [245] | 1.10[246] | 1.55[247] | -0.37[248] | -1.33[249] | -4.17[250] | -0.65[251] |
37 | NCOR1 | Nuclear receptor corepressor 1 | [252] | 1.71[253] | 2.28[254] | 3.01[255] | 2.54[256] | 1.94[257] | 3.78[258] |
38 | MTMR4 | Myotubularin-related protein 4 | [259] | 1.27[260] | 2.19[261] | 2.62[262] | 0.40[263] | 0.38[264] | 3.33[265] |
39 | BAMBI | BMP and activin membrane-bound inhibitor homolog | [266] | 1.85[267] | 0.87[268] | 1.62[269] | 1.98[270] | 0.62[271] | -0.67[272] |
40 | SMAD3 | Mothers against decapentaplegic homolog 3 | [273] | 2.56[274] | 2.02[275] | 2.33[276] | 2.77[277] | 3.00[278] | 1.20[279] |
41 | MEN1 | Menin | [280] | 1.45[281] | 1.42[282] | 1.57[283] | 0.85[284] | 0.59[285] | 0.58[286] |
42 | TGIF2 | Homeobox protein TGIF2 | [287] | 1.87[288] | 2.37[289] | 1.82[290] | -1.31[291] | -0.52[292] | 0.10[293] |
43 | CDK8 | Cyclin-dependent kinase 8 | [294] | -0.22[295] | 0.40[296] | -0.46[297] | 0.47[298] | -0.57[299] | -0.77[300] |
44 | WWTR1 | WW domain-containing transcription regulator protein 1 | [301] | 2.52[302] | 2.17[303] | 1.26[304] | 3.28[305] | 1.95[306] | 1.72[307] |
45 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | [308] | 3.16[309] | 3.14[310] | 3.03[311] | 1.04[312] | 1.31[313] | 1.72[314] |
46 | TGFBR1 | TGF-beta receptor type-1 | [315] | 0.96[316] | 1.25[317] | 0.83[318] | 1.31[319] | 1.78[320] | 2.32[321] |
47 | PPM1A | Protein phosphatase 1A | [322] | 0.95[323] | 1.97[324] | 2.02[325] | 2.20[326] | 1.61[327] | 3.19[328] |
48 | MAPK3 | Mitogen-activated protein kinase 3 | [329] | 2.48[330] | 2.59[331] | 2.71[332] | 1.39[333] | 0.77[334] | -0.05[335] |
49 | USP9X | Probable ubiquitin carboxyl-terminal hydrolase FAF-X | [336] | 2.47[337] | 3.25[338] | 4.17[339] | 4.70[340] | 3.96[341] | 5.18[342] |
50 | SMAD7 | Mothers against decapentaplegic homolog 7 | [343] | 2.48[344] | 0.67[345] | -0.27[346] | 1.56[347] | 0.61[348] | 0.99[349] |
51 | SP1 | Transcription factor Sp1 | [350] | 2.45[351] | 2.76[352] | 3.90[353] | 3.64[354] | 2.68[355] | 3.14[356] |
52 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [357] | 2.07[358] | 1.58[359] | 2.57[360] | 2.18[361] | 1.43[362] | 2.37[363] |
53 | USP15 | Ubiquitin carboxyl-terminal hydrolase 15 | [364] | 0.75[365] | 2.68[366] | 2.17[367] | 2.96[368] | 2.23[369] | 3.63[370] |
54 | CCNT1 | Cyclin-T1 | [371] | 1.66[372] | 2.68[373] | 2.71[374] | 2.88[375] | 2.20[376] | 2.61[377] |
55 | SKI | Ski oncogene | [378] | 3.10[379] | 2.86[380] | 2.42[381] | 3.14[382] | 2.84[383] | 2.02[384] |
56 | SMAD4 | Mothers against decapentaplegic homolog 4 | [385] | 2.02[386] | 2.72[387] | 2.76[388] | 2.88[389] | 2.60[390] | 3.78[391] |
57 | TRIM33 | E3 ubiquitin-protein ligase TRIM33 | [392] | 2.49[393] | 3.02[394] | 2.95[395] | 3.02[396] | 2.29[397] | 3.34[398] |
58 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [399] | 3.30[400] | 2.46[401] | 3.35[402] | 2.30[403] | 1.99[404] | 2.58[405] |
59 | NCOR2 | Nuclear receptor corepressor 2 | [406] | 3.97[407] | 2.43[408] | 2.62[409] | 5.12[410] | 3.97[411] | 2.88[412] |
60 | SMAD2 | Mothers against decapentaplegic homolog 2 | [413] | 2.65[414] | 2.97[415] | 2.55[416] | 3.35[417] | 2.90[418] | 3.56[419] |
61 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [420] | 1.42[421] | 2.36[422] | 2.78[423] | 2.49[424] | 1.61[425] | 1.49[426] |
62 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [427] | 0.99[428] | -3.41[429] | 0.52[430] | 2.13[431] | 1.79[432] | -1.10[433] |
63 | TGFB1 | Transforming growth factor beta-1 | [434] | 4.10[435] | 3.13[436] | 0.46[437] | 4.81[438] | 3.39[439] | -0.24[440] |
64 | SKIL | Ski-like protein | [441] | 2.29[442] | 2.40[443] | 3.93[444] | 3.61[445] | 2.99[446] | 4.14[447] |
65 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [448] | 2.34[449] | 2.44[450] | 1.03[451] | 2.16[452] | 1.96[453] | 1.12[454] |
66 | CCNT2 | Cyclin-T2 | [455] | 1.90[456] | 3.80[457] | 3.36[458] | 3.42[459] | 2.38[460] | 3.88[461] |
67 | TFDP2 | Transcription factor Dp-2 | [462] | 2.53[463] | 3.29[464] | 3.39[465] | 3.36[466] | 2.94[467] | 3.34[468] |
68 | ZFYVE9 | Zinc finger FYVE domain-containing protein 9 | [469] | 2.27[470] | 2.58[471] | 2.60[472] | 2.57[473] | 2.38[474] | 3.19[475] |
69 | RNF111 | E3 ubiquitin-protein ligase Arkadia | [476] | 2.24[477] | 2.12[478] | 2.76[479] | 3.40[480] | 2.44[481] | 3.28[482] |
70 | PARD6A | Partitioning defective 6 homolog alpha | [483] | 0.22[484] | 0.25[485] | -2.67[486] | -0.21[487] | -1.87[488] | -0.15[489] |
71 | E2F5 | Transcription factor E2F5 | [490] | 2.15[491] | 3.18[492] | 3.66[493] | 1.00[494] | -1.19[495] | -0.70[496] |
72 | RBL1 | Retinoblastoma-like protein 1 | [497] | 2.40[498] | 3.34[499] | 2.05[500] | 3.78[501] | 3.47[502] | 1.67[503] |
73 | CBL | E3 ubiquitin-protein ligase CBL | [504] | 5.07[505] | 4.09[506] | 4.39[507] | 6.11[508] | 4.94[509] | 4.74[510] |
74 | PMEPA1 | Protein TMEPAI | [511] | 4.05[512] | [513] | -4.38[514] | 4.68[515] | 4.52[516] | 2.95[517] |
75 | ATP1B4 | Protein ATP1B4 | [518] | 0.37[519] | 1.76[520] | 1.19[521] | 1.12[522] | 0.85[523] | -0.26[524] |