REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | UBB | Polyubiquitin-B | [1] | -1.62[2] | -1.73[3] | -1.53[4] | -1.96[5] | -2.09[6] | -0.99[7] |
2 | RPS27A | Ubiquitin-40S ribosomal protein S27a | [8] | [9] | [10] | [11] | [12] | [13] | [14] |
3 | UBC | Polyubiquitin-C | [15] | -1.18[16] | -0.98[17] | -1.16[18] | -1.11[19] | -1.71[20] | -0.54[21] |
4 | RHOA | Transforming protein RhoA | [22] | -0.36[23] | -0.77[24] | -0.49[25] | -0.40[26] | -0.53[27] | -0.44[28] |
5 | NEDD8 | NEDD8 | [29] | -1.16[30] | -2.65[31] | -2.34[32] | -2.47[33] | -2.90[34] | -2.64[35] |
6 | SERPINE1 | Plasminogen activator inhibitor 1 | [36] | 1.71[37] | 2.02[38] | -4.66[39] | -2.99[40] | 3.10[41] | -2.99[42] |
7 | FKBP1A | Peptidyl-prolyl cis-trans isomerase FKBP1A | [43] | 0.47[44] | 0.15[45] | -1.36[46] | 0.56[47] | -0.44[48] | -0.49[49] |
8 | STRAP | Serine-threonine kinase receptor-associated protein | [50] | -0.63[51] | -0.59[52] | 0.09[53] | -0.53[54] | -0.28[55] | -0.89[56] |
9 | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 | [57] | -0.24[58] | 0.16[59] | 0.46[60] | 0.08[61] | -0.03[62] | 0.74[63] |
10 | UBA52 | Ubiquitin-60S ribosomal protein L40 | [64] | 1.26[65] | 1.25[66] | 2.35[67] | 0.29[68] | 0.52[69] | 0.23[70] |
11 | PPP1R15A | Protein phosphatase 1 regulatory subunit 15A | [71] | -1.17[72] | -2.04[73] | -1.47[74] | -1.40[75] | -1.02[76] | -2.73[77] |
12 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [78] | 0.56[79] | 0.37[80] | 1.64[81] | 2.35[82] | -0.63[83] | -0.07[84] |
13 | DRAP1 | Dr1-associated corepressor | [85] | -0.93[86] | -1.24[87] | -1.44[88] | -0.38[89] | -0.76[90] | -1.40[91] |
14 | JUNB | Transcription factor jun-B | [92] | -1.37[93] | -2.16[94] | -1.39[95] | -1.35[96] | -1.09[97] | -0.50[98] |
15 | PARP1 | Poly [ADP-ribose] polymerase 1 | [99] | 0.71[100] | 0.55[101] | 1.34[102] | 1.35[103] | 0.28[104] | 0.47[105] |
16 | FURIN | Furin | [106] | 2.21[107] | -1.46[108] | 0.76[109] | -0.45[110] | -0.57[111] | 2.54[112] |
17 | STUB1 | E3 ubiquitin-protein ligase CHIP | [113] | -1.40[114] | -1.30[115] | -1.90[116] | -1.84[117] | -2.10[118] | -1.37[119] |
18 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [120] | 0.34[121] | 0.99[122] | 1.14[123] | 1.58[124] | 0.82[125] | 1.38[126] |
19 | MYC | Myc proto-oncogene protein | [127] | 1.01[128] | 0.76[129] | -1.21[130] | -1.97[131] | -0.18[132] | -1.11[133] |
20 | F11R | Junctional adhesion molecule A | [134] | 1.14[135] | 1.58[136] | 0.97[137] | -1.64[138] | -1.09[139] | 1.51[140] |
21 | CCNC | Cyclin-C | [141] | -0.35[142] | 1.12[143] | 0.69[144] | -0.27[145] | -0.61[146] | 0.78[147] |
22 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | 1.26[148] | 2.13[149] | 2.41[150] | 1.06[151] | 0.58[152] | -0.19[153] | |
23 | SNW1 | SNW domain-containing protein 1 | [154] | -0.42[155] | -0.17[156] | -0.09[157] | 0.68[158] | -0.15[159] | -0.75[160] |
24 | HDAC1 | Histone deacetylase 1 | [161] | 1.09[162] | 1.19[163] | 1.93[164] | 1.46[165] | 0.66[166] | 0.42[167] |
25 | UBE2M | NEDD8-conjugating enzyme Ubc12 | [168] | -0.07[169] | -0.26[170] | 0.47[171] | 0.36[172] | -0.32[173] | -1.81[174] |
26 | TGIF1 | Homeobox protein TGIF1 | [175] | 0.28[176] | -0.28[177] | 0.61[178] | 0.43[179] | -0.51[180] | -0.97[181] |
27 | TFDP1 | Transcription factor Dp-1 | [182] | 1.24[183] | 0.66[184] | 0.79[185] | 1.42[186] | 1.42[187] | -0.26[188] |
28 | PARD3 | Partitioning defective 3 homolog | [189] | 0.69[190] | 1.32[191] | 1.37[192] | 1.67[193] | -0.30[194] | 1.06[195] |
29 | XPO1 | Exportin-1 | [196] | 1.94[197] | 2.74[198] | 2.82[199] | 2.95[200] | 2.45[201] | 1.74[202] |
30 | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | [203] | -0.44[204] | 0.50[205] | 0.19[206] | 1.32[207] | 0.30[208] | 0.67[209] |
31 | CDK9 | Cyclin-dependent kinase 9 | [210] | 0.21[211] | -0.08[212] | 0.06[213] | 0.66[214] | -0.22[215] | 1.04[216] |
32 | CCNK | Cyclin-K | [217] | 0.73[218] | -0.15[219] | 0.10[220] | 1.22[221] | 0.13[222] | -1.17[223] |
33 | TGFBR2 | TGF-beta receptor type-2 | [224] | 3.40[225] | 2.95[226] | 2.66[227] | 1.88[228] | 3.02[229] | 2.39[230] |
34 | MAPK1 | Mitogen-activated protein kinase 1 | [231] | 2.29[232] | 2.51[233] | 2.40[234] | 2.67[235] | 1.73[236] | 2.66[237] |
35 | E2F4 | Transcription factor E2F4 | [238] | 1.71[239] | 1.91[240] | 0.99[241] | 1.24[242] | 0.65[243] | 0.64[244] |
36 | FSTL1 | Follistatin-related protein 1 | [245] | -5.74[246] | -5.87[247] | -4.38[248] | 4.47[249] | 3.83[250] | 2.44[251] |
37 | CGN | Cingulin | [252] | -3.15[253] | -3.65[254] | 2.37[255] | -3.60[256] | -3.18[257] | 2.14[258] |
38 | PRKCZ | Protein kinase C zeta type | [259] | 1.05[260] | 1.52[261] | -0.43[262] | -1.48[263] | -4.26[264] | -0.76[265] |
39 | NCOR1 | Nuclear receptor corepressor 1 | [266] | 1.66[267] | 2.25[268] | 2.95[269] | 2.39[270] | 1.85[271] | 3.68[272] |
40 | MTMR4 | Myotubularin-related protein 4 | [273] | 1.22[274] | 2.15[275] | 2.57[276] | 0.24[277] | 0.29[278] | 3.23[279] |
41 | BAMBI | BMP and activin membrane-bound inhibitor homolog | [280] | 1.80[281] | 0.84[282] | 1.57[283] | 1.83[284] | 0.53[285] | -0.77[286] |
42 | FSTL3 | Follistatin-related protein 3 | [287] | 3.47[288] | 0.22[289] | 0.35[290] | 1.36[291] | 2.07[292] | -0.97[293] |
43 | SMAD3 | Mothers against decapentaplegic homolog 3 | [294] | 2.51[295] | 1.99[296] | 2.28[297] | 2.62[298] | 2.91[299] | 1.10[300] |
44 | MEN1 | Menin | [301] | 1.41[302] | 1.39[303] | 1.52[304] | 0.69[305] | 0.50[306] | 0.48[307] |
45 | BMP2 | Bone morphogenetic protein 2 | [308] | -4.40[309] | -7.44[310] | 1.71[311] | -1.06[312] | -1.41[313] | -1.30[314] |
46 | SMAD1 | Mothers against decapentaplegic homolog 1 | [315] | -0.47[316] | -0.13[317] | 0.22[318] | 0.09[319] | 0.06[320] | 1.51[321] |
47 | TGIF2 | Homeobox protein TGIF2 | [322] | 1.82[323] | 2.34[324] | 1.77[325] | -1.46[326] | -0.61[327] | 0.00[328] |
48 | CDK8 | Cyclin-dependent kinase 8 | [329] | -0.27[330] | 0.37[331] | -0.51[332] | 0.32[333] | -0.66[334] | -0.87[335] |
49 | WWTR1 | WW domain-containing transcription regulator protein 1 | [336] | 2.48[337] | 2.14[338] | 1.21[339] | 3.13[340] | 1.86[341] | 1.62[342] |
50 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | [343] | 3.11[344] | 3.11[345] | 2.98[346] | 0.89[347] | 1.22[348] | 1.62[349] |
51 | TGFBR1 | TGF-beta receptor type-1 | [350] | 0.91[351] | 1.22[352] | 0.78[353] | 1.16[354] | 1.69[355] | 2.22[356] |
52 | PPM1A | Protein phosphatase 1A | [357] | 0.91[358] | 1.94[359] | 1.97[360] | 2.04[361] | 1.52[362] | 3.09[363] |
53 | ACVR1B | Activin receptor type-1B | [364] | 1.27[365] | 1.32[366] | 3.29[367] | 1.90[368] | 1.63[369] | 1.90[370] |
54 | MAPK3 | Mitogen-activated protein kinase 3 | [371] | 2.43[372] | 2.56[373] | 2.66[374] | 1.24[375] | 0.68[376] | -0.16[377] |
55 | USP9X | Probable ubiquitin carboxyl-terminal hydrolase FAF-X | [378] | 2.42[379] | 3.22[380] | 4.12[381] | 4.55[382] | 3.87[383] | 5.08[384] |
56 | SMAD7 | Mothers against decapentaplegic homolog 7 | [385] | 2.44[386] | 0.64[387] | -0.32[388] | 1.40[389] | 0.52[390] | 0.88[391] |
57 | SP1 | Transcription factor Sp1 | [392] | 2.40[393] | 2.73[394] | 3.85[395] | 3.49[396] | 2.59[397] | 3.04[398] |
58 | SMURF1 | E3 ubiquitin-protein ligase SMURF1 | [399] | 2.02[400] | 1.55[401] | 2.52[402] | 2.03[403] | 1.34[404] | 2.27[405] |
59 | USP15 | Ubiquitin carboxyl-terminal hydrolase 15 | [406] | 0.70[407] | 2.65[408] | 2.12[409] | 2.81[410] | 2.14[411] | 3.53[412] |
60 | FST | Follistatin | [413] | 0.54[414] | 2.28[415] | -1.36[416] | -3.93[417] | -3.24[418] | 0.93[419] |
61 | CCNT1 | Cyclin-T1 | [420] | 1.61[421] | 2.65[422] | 2.66[423] | 2.73[424] | 2.11[425] | 2.51[426] |
62 | SKI | Ski oncogene | [427] | 3.05[428] | 2.83[429] | 2.37[430] | 2.98[431] | 2.75[432] | 1.91[433] |
63 | SMAD4 | Mothers against decapentaplegic homolog 4 | [434] | 1.97[435] | 2.69[436] | 2.71[437] | 2.73[438] | 2.51[439] | 3.67[440] |
64 | SMAD5 | Mothers against decapentaplegic homolog 5 | [441] | 2.41[442] | 3.19[443] | 3.03[444] | 3.47[445] | 2.92[446] | 3.84[447] |
65 | TRIM33 | E3 ubiquitin-protein ligase TRIM33 | [448] | 2.45[449] | 2.99[450] | 2.90[451] | 2.87[452] | 2.20[453] | 3.23[454] |
66 | BMPR1A | Bone morphogenetic protein receptor type-1A | [455] | 1.88[456] | 2.61[457] | 1.33[458] | 2.07[459] | 1.75[460] | 2.06[461] |
67 | ARHGEF18 | Rho guanine nucleotide exchange factor 18 | [462] | 3.26[463] | 2.43[464] | 3.30[465] | 2.15[466] | 1.90[467] | 2.48[468] |
68 | NCOR2 | Nuclear receptor corepressor 2 | [469] | 3.93[470] | 2.40[471] | 2.57[472] | 4.97[473] | 3.88[474] | 2.77[475] |
69 | SMAD2 | Mothers against decapentaplegic homolog 2 | [476] | 2.60[477] | 2.94[478] | 2.50[479] | 3.20[480] | 2.81[481] | 3.45[482] |
70 | UBE2D1 | Ubiquitin-conjugating enzyme E2 D1 | [483] | 1.37[484] | 2.33[485] | 2.73[486] | 2.34[487] | 1.52[488] | 1.39[489] |
71 | ZFYVE16 | Zinc finger FYVE domain-containing protein 16 | [490] | 1.32[491] | 3.15[492] | 3.13[493] | 3.42[494] | 2.45[495] | 3.51[496] |
72 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [497] | 0.95[498] | -3.44[499] | 0.47[500] | 1.98[501] | 1.70[502] | -1.20[503] |
73 | TGFB1 | Transforming growth factor beta-1 | [504] | 4.05[505] | 3.10[506] | 0.41[507] | 4.66[508] | 3.30[509] | -0.34[510] |
74 | SKIL | Ski-like protein | [511] | 2.24[512] | 2.37[513] | 3.88[514] | 3.46[515] | 2.90[516] | 4.04[517] |
75 | GREM2 | Gremlin-2 | [518] | -10.48[519] | -8.91[520] | -0.91[521] | 0.50[522] | -5.18[523] | 2.93[524] |
76 | SMURF2 | E3 ubiquitin-protein ligase SMURF2 | [525] | 2.30[526] | 2.41[527] | 0.98[528] | 2.01[529] | 1.87[530] | 1.02[531] |
77 | CCNT2 | Cyclin-T2 | [532] | 1.85[533] | 3.77[534] | 3.31[535] | 3.27[536] | 2.29[537] | 3.78[538] |
78 | TFDP2 | Transcription factor Dp-2 | [539] | 2.49[540] | 3.26[541] | 3.34[542] | 3.20[543] | 2.85[544] | 3.24[545] |
79 | ZFYVE9 | Zinc finger FYVE domain-containing protein 9 | [546] | 2.22[547] | 2.54[548] | 2.55[549] | 2.42[550] | 2.29[551] | 3.09[552] |
80 | RNF111 | E3 ubiquitin-protein ligase Arkadia | [553] | 2.19[554] | 2.09[555] | 2.70[556] | 3.24[557] | 2.35[558] | 3.18[559] |
81 | SMAD6 | Mothers against decapentaplegic homolog 6 | [560] | 1.99[561] | 0.34[562] | 0.81[563] | 2.27[564] | 0.14[565] | 1.74[566] |
82 | INHBB | Inhibin beta B chain | [567] | 3.74[568] | -2.85[569] | -4.75[570] | -1.59[571] | 3.82[572] | 1.18[573] |
83 | PARD6A | Partitioning defective 6 homolog alpha | [574] | 0.17[575] | 0.22[576] | -2.73[577] | -0.37[578] | -1.96[579] | -0.25[580] |
84 | INHBA | Inhibin beta A chain | [581] | -6.91[582] | -6.54[583] | -6.03[584] | 3.74[585] | -0.45[586] | 1.49[587] |
85 | BMPR2 | Bone morphogenetic protein receptor type-2 | [588] | 3.77[589] | 2.88[590] | 3.61[591] | 4.96[592] | 3.70[593] | 5.18[594] |
86 | E2F5 | Transcription factor E2F5 | [595] | 2.10[596] | 3.15[597] | 3.61[598] | 0.85[599] | -1.28[600] | -0.80[601] |
87 | ACVR2A | Activin receptor type-2A | [602] | 1.43[603] | 2.53[604] | 2.42[605] | 1.64[606] | 1.56[607] | 3.56[608] |
88 | RBL1 | Retinoblastoma-like protein 1 | [609] | 2.36[610] | 3.31[611] | 2.00[612] | 3.63[613] | 3.38[614] | 1.56[615] |
89 | ACVR2B | Activin receptor type-2B | [616] | 2.86[617] | 4.34[618] | 5.22[619] | 1.91[620] | 1.13[621] | 4.05[622] |
90 | CBL | E3 ubiquitin-protein ligase CBL | [623] | 5.03[624] | 4.06[625] | 4.34[626] | 5.95[627] | 4.85[628] | 4.64[629] |
91 | ACVRL1 | Serine/threonine-protein kinase receptor R3 | [630] | -3.52[631] | -3.82[632] | -2.83[633] | -1.39[634] | -1.68[635] | 3.89[636] |
92 | PMEPA1 | Protein TMEPAI | [637] | 4.01[638] | [639] | -4.43[640] | 4.53[641] | 4.43[642] | 2.85[643] |
93 | SMAD9 | Mothers against decapentaplegic homolog 9 | [644] | 4.56[645] | 4.34[646] | 3.66[647] | 3.01[648] | 3.94[649] | 3.76[650] |
94 | ACVR1C | Activin receptor type-1C | [651] | -0.70[652] | 0.38[653] | 5.66[654] | -0.22[655] | -1.71[656] | 4.67[657] |
95 | FOXH1 | Forkhead box protein H1 | [658] | -2.36[659] | 3.50[660] | -3.24[661] | -2.23[662] | -2.88[663] | -2.34[664] |
96 | ATP1B4 | Protein ATP1B4 | [665] | 0.32[666] | 1.73[667] | 1.14[668] | 0.97[669] | 0.76[670] | -0.36[671] |
97 | AMHR2 | Anti-Muellerian hormone type-2 receptor | [672] | 2.53[673] | 1.09[674] | -0.57[675] | -2.68[676] | -2.47[677] | 2.86[678] |
98 | AMH | Muellerian-inhibiting factor | [679] | -0.55[680] | 4.07[681] | 6.89[682] | 2.70[683] | 5.43[684] | 2.39[685] |
99 | BMP10 | Bone morphogenetic protein 10 | [686] | [687] | [688] | [689] | -2.22[690] | [691] | 8.68[692] |
100 | BMPR1B | Bone morphogenetic protein receptor type-1B | [693] | -0.43[694] | -1.18[695] | 4.53[696] | 6.60[697] | 2.65[698] | 7.45[699] |
101 | GDF2 | Growth/differentiation factor 2 | [700] | [701] | [702] | [703] | [704] | [705] | 10.41[706] |
102 | CHRDL1 | Chordin-like protein 1 | [707] | 0.13[708] | 1.79[709] | [710] | 9.57[711] | 1.01[712] | 6.96[713] |
103 | NOG | Noggin | [714] | [715] | [716] | [717] | [718] | [719] | [720] |
104 | CER1 | Cerberus | [721] | [722] | [723] | [724] | [725] | [726] | [727] |