REACTOME_SIGNALING_BY_RNF43_MUTANTS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 LRP5 Low-density lipoprotein receptor-related protein 5 [1] -0.31[2] -0.27[3] -0.01[4] 0.10[5] -0.42[6] -0.43[7]
2 FZD5 Frizzled-5 [8] -1.45[9] -0.25[10] 0.37[11] -2.77[12] -3.14[13] 0.00[14]
3 RNF43 E3 ubiquitin-protein ligase RNF43 [15] 0.66[16] 0.10[17] -1.28[18] -3.17[19] -1.06[20] -2.43[21]
4 FZD4 Frizzled-4 [22] 1.67[23] 0.93[24] -0.40[25] -0.95[26] -0.67[27] 0.36[28]
5 LRP6 Low-density lipoprotein receptor-related protein 6 [29] -0.60[30] 0.40[31] 1.38[32] 0.22[33] 1.71[34] 2.20[35]
6 FZD6 Frizzled-6 [36] -0.63[37] 0.52[38] -2.36[39] 3.09[40] 2.80[41] -1.47[42]
7 FZD8 Frizzled-8 [43] -5.54[44] -10.56[45] -3.55[46] -4.60[47] -2.45[48] -2.78[49]
8 WNT3A Protein Wnt-3a [50] [51] [52] [53] [54] [55] [56]
[1]
ref_hepatocyte LRP5
Mean 11.4
Standard deviation 3.9
Values 8.8 10 7.3 17 13
[2]
HepG2 LRP5
Mean 108
Standard deviation 24
Values 1.3e+02 91
[3]
HepG2.C3A LRP5
Mean 79.2
Standard deviation 20
Values 93 65
[4]
HuH.7 LRP5
Mean 117
Standard deviation 36
Values 1.5e+02 81 1.2e+02
[5]
SNU475 LRP5
Mean 69.8
Standard deviation 26
Values 88 52
[6]
THLE LRP5
Mean 28.3
Standard deviation 7.2
Values 23 33
[7]
liver LRP5
Mean 71.8
Standard deviation 33
Values 39 93 50 1.1e+02
[8]
ref_hepatocyte FZD5
Mean 6.07
Standard deviation 3.7
Values 12 4.4 2.3 5.6 5.8
[9]
HepG2 FZD5
Mean 26.3
Standard deviation 2.4
Values 28 25
[10]
HepG2.C3A FZD5
Mean 42.7
Standard deviation 15
Values 53 32
[11]
HuH.7 FZD5
Mean 81.4
Standard deviation 28
Values 76 1.1e+02 56
[12]
SNU475 FZD5
Mean 5.07
Standard deviation 1.9
Values 6.5 3.7
[13]
THLE FZD5
Mean 2.29
Standard deviation 0.46
Values 2 2.6
[14]
liver FZD5
Mean 51.7
Standard deviation 15
Values 73 42 47 44
[15]
ref_hepatocyte RNF43
Mean 3.83
Standard deviation 6
Values 15 1.1 0.59 1.1 1.9
[16]
HepG2 RNF43
Mean 71.6
Standard deviation 11
Values 79 64
[17]
HepG2.C3A RNF43
Mean 34.4
Standard deviation 9.6
Values 28 41
[18]
HuH.7 RNF43
Mean 16.4
Standard deviation 1.2
Values 18 16 16
[19]
SNU475 RNF43
Mean 2.44
Standard deviation 0.81
Values 3 1.9
[20]
THLE RNF43
Mean 6.13
Standard deviation 1.6
Values 7.3 5
[21]
liver RNF43
Mean 6.06
Standard deviation 1.1
Values 7.3 6.5 4.6 5.8
[22]
ref_hepatocyte FZD4
Mean 2.69
Standard deviation 3.7
Values 9.2 0.68 0.82 1.2 1.5
[23]
HepG2 FZD4
Mean 101
Standard deviation 33
Values 78 1.2e+02
[24]
HepG2.C3A FZD4
Mean 43.1
Standard deviation 1.2
Values 42 44
[25]
HuH.7 FZD4
Mean 21.2
Standard deviation 1.5
Values 22 22 20
[26]
SNU475 FZD4
Mean 7.99
Standard deviation 1.3
Values 8.9 7
[27]
THLE FZD4
Mean 5.63
Standard deviation 0.2
Values 5.5 5.8
[28]
liver FZD4
Mean 29.5
Standard deviation 13
Values 17 44 19 38
[29]
ref_hepatocyte LRP6
Mean 1.95
Standard deviation 0.83
Values 2.8 2.6 0.7 1.7 1.9
[30]
HepG2 LRP6
Mean 15.2
Standard deviation 4.8
Values 12 19
[31]
HepG2.C3A LRP6
Mean 21.5
Standard deviation 0.56
Values 21 22
[32]
HuH.7 LRP6
Mean 52.6
Standard deviation 14
Values 58 64 37
[33]
SNU475 LRP6
Mean 13
Standard deviation 2
Values 14 12
[34]
THLE LRP6
Mean 21.2
Standard deviation 0.26
Values 21 21
[35]
liver LRP6
Mean 76.1
Standard deviation 40
Values 42 1.1e+02 40 1.1e+02
[36]
ref_hepatocyte FZD6
Mean 1.28
Standard deviation 0.91
Values 2.4 1.3 1.9 0.49 0.28
[37]
HepG2 FZD6
Mean 9.74
Standard deviation 0.56
Values 9.3 10
[38]
HepG2.C3A FZD6
Mean 15.4
Standard deviation 0.43
Values 15 16
[39]
HuH.7 FZD6
Mean 2.59
Standard deviation 0.88
Values 2.1 3.6 2.1
[40]
SNU475 FZD6
Mean 62.6
Standard deviation 37
Values 89 36
[41]
THLE FZD6
Mean 29.7
Standard deviation 3.7
Values 27 32
[42]
liver FZD6
Mean 3.95
Standard deviation 1.6
Values 3 5.8 2.3 4.7
[43]
ref_hepatocyte FZD8
Mean 0.963
Standard deviation 1
Values 0 0.036 2.3 0.92 1.5
[44]
HepG2 FZD8
Mean 0.243
Standard deviation 0.2
Values 0.38 0.1
[45]
HepG2.C3A FZD8
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[46]
HuH.7 FZD8
Mean 0.853
Standard deviation 0.068
Values 0.81 0.93 0.82
[47]
SNU475 FZD8
Mean 0.227
Standard deviation 0.034
Values 0.25 0.2
[48]
THLE FZD8
Mean 0.588
Standard deviation 0.15
Values 0.48 0.7
[49]
liver FZD8
Mean 1.19
Standard deviation 0.79
Values 0.54 1.3 0.64 2.3
[50]
ref_hepatocyte WNT3A
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[51]
HepG2 WNT3A
Mean 0.0093
Standard deviation 0.005
Values 0.0057 0.013
[52]
HepG2.C3A WNT3A
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 WNT3A
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 WNT3A
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[55]
THLE WNT3A
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[56]
liver WNT3A
Mean 0.0165
Standard deviation 0.033
Values 0 0 0 0.066